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https://www.readbyqxmd.com/read/28445584/chronic-opioid-use-following-surgery-for-oral-cavity-cancer
#1
John Pang, Kathryn R Tringale, Viridiana J Tapia, William J Moss, Megan E May, Timothy Furnish, Linda Barnachea, Kevin T Brumund, Assuntina G Sacco, Robert A Weisman, Quyen T Nguyen, Jeffrey P Harris, Charles S Coffey, Joseph A Califano
Importance: Opioid misuse and overuse has become an epidemic. Chronic opioid use among oral cavity cancer patients after surgery has not been described. Objectives: To assess the prevalence of chronic opioid use in patients undergoing surgery for oral cavity cancer, and evaluate possible associated clinical factors; and the association between opioid use and survival. Design, Setting, and Participants: For this retrospective cohort study of patients undergoing surgery for oral cavity cancer a consecutive sample of 99 patients between January 1, 2011, and September 30, 2016, were identified through the institutional cancer registry from a single academic center...
April 26, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28444948/medication-overuse-headache
#2
Deborah Tepper
No abstract text is available yet for this article.
May 2017: Headache
https://www.readbyqxmd.com/read/28443360/overview-of-procalcitonin-assays-and-procalcitonin-guided-protocols-for-the-management-of-patients-with-infections-and-sepsis
#3
Philipp Schuetz, Celine Bretscher, Luca Bernasconi, Beat Mueller
Procalcitonin is a surrogate infection blood marker whose levels help estimate the likelihood of bacterial infections and correlate with their resolution. Recent trials have revealed the benefits of inclusion of procalcitonin in antibiotic stewardship protocols for initiation and discontinuation of antimicrobial therapy. Areas covered: Procalcitonin-guided antibiotic stewardship protocols have shown appreciable reductions in antibiotic use and duration of therapy in respiratory infections, sepsis, and other infections, with positive effects on clinical outcomes...
April 26, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28439058/-calcium-and-bone-metabolism-across-women-s-life-stages-stress-fracture-in-female-athletes
#4
Kazuyoshi Yagishita
Stress fractures are common overuse injuries in athletes, especially in long-distance runner, jumping sports and gymnastics in female athletes. The pathology of stress fracture mainly includes repeated biomechanical loading, which leads to bone micro-damage and failure of bone structure. Female athlete triad(FAT), which includes low energy availability with or without an eating disorder, functional hypothalamic amenorrhea, and osteoporosis, is a serious healthcare concern in female athletes. For prevention and treatment of stress fracture, management of biomechanical factors modifying the load applied to a bone is important, and especially in female athletes, management for FAT is one of the important factors...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28430992/identifying-practice-related-factors-for-high-volume-prescribers-of-antibiotics-in-danish-general-practice
#5
Rune Aabenhus, Volkert Siersma, Håkon Sandholdt, Rasmus Køster-Rasmussen, Malene Plejdrup Hansen, Lars Bjerrum
Objectives: In Denmark, general practice is responsible for 75% of antibiotic prescribing in the primary care sector. We aimed to identify practice-related factors associated with high prescribers, including prescribers of critically important antibiotics as defined by WHO, after accounting for case mix by practice. Methods: We performed a nationwide register-based survey of antibiotic prescribing in Danish general practice from 2012 to 2013. The unit of analysis was the individual practice...
April 19, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28430016/the-use-of-intravenous-lidocaine-for-the-management-of-acute-pain-secondary-to-traumatic-ankle-injury
#6
Billy Sin, Diana Gritsenko, Grace Tam, Kimberly Koop, Eva Mok
Sports-related injuries are a frequent cause of visits to the emergency department (ED) across the United States. A majority of these injuries affect the lower extremities with the ankle as the most frequently reported site. Most sports-related injuries are not severe enough to require inpatient hospitalization; however, they often lead to acute distress and pain which require prompt treatment with analgesics. Approximately 22% of patients who presented to the ED required pharmacotherapy for acute pain management...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28428160/simulated-conversations-with-virtual-humans-to-improve-patient-provider-communication-and-reduce-unnecessary-prescriptions-for-antibiotics-a-repeated-measure-pilot-study
#7
Antoinette Schoenthaler, Glenn Albright, Judith Hibbard, Ron Goldman
BACKGROUND: Despite clear evidence that antibiotics do not cure viral infections, the problem of unnecessary prescribing of antibiotics in ambulatory care persists, and in some cases, prescribing patterns have increased. The overuse of antibiotics for treating viral infections has created numerous economic and clinical consequences including increased medical costs due to unnecessary hospitalizations, antibiotic resistance, disruption of gut bacteria, and obesity. Recent research has underscored the importance of collaborative patient-provider communication as a means to reduce the high rates of unnecessary prescriptions for antibiotics...
April 19, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28426703/effects-of-over-expressing-a-native-gene-encoding-5-enolpyruvylshikimate-3-phosphate-synthase-epsps-on-glyphosate-resistance-in-arabidopsis-thaliana
#8
Xiao Yang, Zachery T Beres, Lin Jin, Jason T Parrish, Wanying Zhao, David Mackey, Allison A Snow
Widespread overuse of the herbicide glyphosate, the active ingredient in RoundUp®, has led to the evolution of glyphosate-resistant weed biotypes, some of which persist by overproducing the herbicide's target enzyme, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). EPSPS is a key enzyme in the shikimic acid pathway for biosynthesis of aromatic amino acids, lignin, and defensive compounds, but little is known about how overproducing EPSPS affects downstream metabolites, growth, or lifetime fitness in the absence of glyphosate...
2017: PloS One
https://www.readbyqxmd.com/read/28424882/effectiveness-of-dry-needling-and-high-volume-image-guided-injection-in-the-management-of-chronic-mid-portion-achilles-tendinopathy-in-adult-population-a-literature-review
#9
REVIEW
F A Chaudhry
Achilles tendinopathy is a common overuse condition affecting the adult population. The incidence is on the rise because of greater participation of people in recreational or competitive sporting activities. There are several treatment options available both non-operative and operative. Ultrasound-guided dry needling and high-volume image-guided injection is relatively a new procedure. The aim of this study was to find out the effectiveness of dry needling and HVIGI in the management of mid-portion chronic Achilles tendinopathy by performing a literature review...
April 19, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28424831/-recurrent-and-catheter-associated-urinary-tract-infections-prophylaxis-and-prevention
#10
H Piechota
Urinay tract infection (UTI) as one of the most frequent bacterial infections in humans is of utmost relevance. Because of the rising prevalence of antimicrobial resistance, urinalysis should always include urine culture and a resistogram in order to avoid an unspecific selection and overuse of antibiotics. Prevention of recurrent UTI must first of all rule out predisposing uropathogenic conditions. Nowadays, a great variety of drugs, behavioral, and supportive treatment options can effectively minimize UTI recurrence...
April 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28420998/instant-biofeedback-provided-by-wearable-sensor-technology-can-help-to-optimize-exercise-and-prevent-injury-and-overuse
#11
Peter Düking, Hans-Christer Holmberg, Billy Sperlich
No abstract text is available yet for this article.
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28414853/-excessive-osteoporosis-screening-in-women-under-65-years-a-cross-sectional-study
#12
María de Las Nieves Ganiele, Sergio Adrián Terrasa, Karin Silvana Kopitowski
Overuse of osteoporosis screening in women at low risk of fracture may lead to overdiagnosis, inappropriate treatment and medicalization. The objective of this work was to estimate the proportion of women aged 45 to 64 enrolled in a private health insurance plan in Buenos Aires undergoing hip dual-energy x-ray absorptiometry (DXA) in 2011 without meeting osteoporosis screening criteria. In this cross-sectional study, 4310 women of this age range that had undergone a hip DXA were identified. A randomly selected sub-group of 401 women was then assessed for the presence of risk factors for osteoporosis and complete data were retrieved for 178 women...
July 2016: Salud Colectiva
https://www.readbyqxmd.com/read/28413207/rate-of-active-helicobacter-pylori-infection-among-symptomatic-patients-of-pakistan
#13
F Rasheed, A Yameen, T Ahmad, R Bilal
Only few epidemiological studies have examined the rate of active H. pylori infection in the symptomatic population in Pakistan. This retrospective study presents the laboratory data collected during the past 13 years (2002 to 2015) from 2315 symptomatic patients referred to the BreathMAT Lab, Nuclear Medicine, Oncology and Radiotherapy Institute, Islamabad for the diagnosis of active H. pylori infection using the (13)C Urea Breath Test. Rate of infection and its association with gender and age were evaluated...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28411737/neck-posture-during-lifting-and-its-effect-on-trunk-muscle-activation-and-lumbar-spine-posture
#14
Thomas M Hlavenka, Vanessa F K Christner, Diane E Gregory
Neck and head posture have been found to have a significant influence on the posture of the lower spine region during lifting and both an extended/upward gaze and a flexed/downward gaze have been hypothesized to lead to increased pain and/or overuse of the neck musculature. As a result, strength training recommendations have turned to the use of a retracted neck posture as being the safer posture to assume during lifting. This study examined trunk and neck muscle activity and lumbar spine posture in seven participants while performing moderate load lifts using a retracted neck posture (chin drawn in posteriorly; recently gaining popularity among coaches, trainers, and physical therapists to reduce neck pain during lifting, and freestyle neck posture (no instructions given)...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28410572/incidence-of-infection-following-internal-fixation-of-open-and-closed-tibia-fractures-in-india-infiniti-a-multi-centre-observational-cohort-study
#15
Prakash Doshi, Hitesh Gopalan, Sheila Sprague, Chetan Pradhan, Sunil Kulkarni, Mohit Bhandari
BACKGROUND: Trauma is a major public health problem, particularly in India due to the country's rapid urbanization. Tibia fractures are a common and often complicated injury that is at risk of infection following surgical fixation. The primary objectives of this cohort study were to determine the incidence of infection within one year of surgery and to describe the distribution of infections by location and time of diagnosis for tibia fractures in India. METHODS: We conducted a multi-center, prospective cohort study...
April 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28410309/will-artificial-intelligence-contribute-to-overuse-in-healthcare
#16
Matthieu Komorowski, Leo Anthony Celi
No abstract text is available yet for this article.
May 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28409893/spotlight-on-anti-cgrp-monoclonal-antibodies-in-migraine-the-clinical-evidence-to-date
#17
REVIEW
Lanfranco Pellesi, Simona Guerzoni, Luigi Alberto Pini
Migraine, a common neurovascular brain disorder, represents a severe and widespread health problem; along with medication-induced (medication-overuse) headache, it is the third-leading cause of disability worldwide. Currently, its therapeutic management remains unsatisfactory for several reasons; up to 40% of migraineurs are eligible for prophylactic treatment, but there are issues of efficacy, safety, and adherence. In recent years the evidence on the role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology has been consolidated, so new and promising treatments for migraine pain and its possible prevention have been developed...
April 14, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28407777/automatic-migraine-classification-via-feature-selection-committee-and-machine-learning-techniques-over-imaging-and-questionnaire-data
#18
Yolanda Garcia-Chimeno, Begonya Garcia-Zapirain, Marian Gomez-Beldarrain, Begonya Fernandez-Ruanova, Juan Carlos Garcia-Monco
BACKGROUND: Feature selection methods are commonly used to identify subsets of relevant features to facilitate the construction of models for classification, yet little is known about how feature selection methods perform in diffusion tensor images (DTIs). In this study, feature selection and machine learning classification methods were tested for the purpose of automating diagnosis of migraines using both DTIs and questionnaire answers related to emotion and cognition - factors that influence of pain perceptions...
April 13, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28405868/droplet-based-non-faradaic-impedance-sensors-for-assessment-of-susceptibility-of-escherichia-coli-to-ampicillin-in-60-min
#19
Aida Ebrahimi, Muhammad A Alam
Direct antibiotic susceptibility tests (AST) are essential for rapid detection of bacterial infection and administration of appropriate antibiotics. Conventional AST systems are usually slow as they rely on cell growth for an indirect assessment of antibiotics' effectiveness. Therefore, a faster method is desirable, especially for emergency cases. In this work, we studied the performance of label-free, droplet-based impedance sensors for rapid characterization of the effects of ampicillin (Amp) on Escherichia coli...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28404944/recombinant-methioninase-effectively-targets-a-ewing-s-sarcoma-in-a-patient-derived-orthotopic-xenograft-pdox-nude-mouse-model
#20
Takashi Murakami, Shukuan Li, Qinghong Han, Yuying Tan, Tasuku Kiyuna, Kentaro Igarashi, Kei Kawaguchi, Ho Kyoung Hwang, Kentaro Miyake, Arun S Singh, Scott D Nelson, Sarah M Dry, Yunfeng Li, Yukihiko Hiroshima, Thinzar M Lwin, Jonathan C DeLong, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Fritz C Eilber, Robert M Hoffman
Methionine dependence is due to the overuse of methionine for aberrant transmethylation reactions in cancer. Methionine dependence may be the only general metabolic defect in cancer. In order to exploit methionine dependence for therapy, our laboratory previously cloned L-methionine α-deamino-γ-mercaptomethane lyase [EC 4.4.1.11]). The cloned methioninase, termed recombinant methioninase, or rMETase, has been tested in mouse models of human cancer cell lines. Ewing's sarcoma is recalcitrant disease even though development of multimodal therapy has improved patients'outcome...
March 1, 2017: Oncotarget
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