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https://www.readbyqxmd.com/read/29334438/in-vitro-and-in-vivo-evaluations-of-the-anticalculus-effect-of-a-novel-stabilized-stannous-fluoride-dentifrice
#1
Tao He, Mary Kay Anastasia, Marianne Zsiska, Teresa Farmer, Eva Schneiderman, Jeffery L Milleman
OBJECTIVES: To evaluate the effect of a novel stannous fluoride dentifrice with zinc citrate on calculus inhibition using both in vitro and clinical models. METHODS: Each investigation tested a novel stabilized 0.454% stannous fluoride dentifrice with zinc citrate as an anticalculus agent (Crest® Pro-Health™ smooth formula) compared to a negative control fluoride dentifrice. The in vitro study used the modified Plaque Growth and Mineralization Model (mPGM). Plaque biofilms were prepared and mineralized by alternate immersion of glass rods in human saliva and artificial mineralization solution...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334437/a-randomized-clinical-trial-to-measure-the-erosion-protection-benefits-of-a-novel-stabilized-stannous-fluoride-dentifrice-versus-a-control-dentifrice
#2
Xinyi Zhao, Tao He, Yanyan He, Cathy Cheng, Haijing Chen
OBJECTIVES: The aim of this investigation was to assess the erosion protection ability of a novel stabilized stannous fluoride (SnF2) dentifrice and a control sodium fluoride dentifrice (NaF) using a well-credentialed human in situ model. METHODS: A novel smooth texture 0.454% stabilized SnF2 dentifrice (Crest® Pro-Health™ smooth formula) and a 0.23% NaF marketed control dentifrice with 5% potassium nitrate (Sensodyne® Pronamel®) were compared in a 10-day, single center, randomized, controlled, double-blind, two-treatment, three-period crossover in situ clinical trial...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334436/assessment-of-the-effects-of-a-novel-stabilized-stannous-fluoride-dentifrice-on-gingivitis-in-a-two-month-positive-controlled-clinical-study
#3
Tao He, Rachelle Eusebio, C R Goyal, Jimmy G Qaqish
OBJECTIVES: The aim of this study was to compare the antibleeding/antigingivitis effectiveness of a newly formulated 0.454% stabilized stannous fluoride dentifrice and a marketed positive control triclosan-containing dentifrice in adults with mild-to-moderate gingivitis. METHODS: This single-center, two-month, randomized and controlled, double-blind, parallel group clinical trial involved adults with preexisting mild-to-moderate gingivitis. Baseline bleeding and gingivitis levels were assessed with the Gingival Bleeding Index (GBI) and Lobene Modified Gingival Index (MGI)...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334435/comparative-antiplaque-effect-of-two-antimicrobial-dentifrices-laboratory-and-clinical-evaluations
#4
Lynn R Friesen, C R Goyal, Jimmy G Qaqish, Tao He, Rachelle Eusebio, Marianne Zsiska, Teresa Farmer, Eva Schneiderman
OBJECTIVES: To compare the effect of a stannous fluoride dentifrice versus a triclosan-containing dentifrice on the reduction of plaque using in vitro and clinical models. METHODS: Both investigations evaluated a novel 0.454% stabilized stannous fluoride dentifrice (Crest® Pro-Health™ smooth formula) versus a sodium fluoride/triclosan positive control dentifrice (Colgate® Total®). The in vitro evaluation utilized the Plaque Glycolysis and Regrowth Model (PGRM), wherein the metabolic effects (acid production/glycolysis inhibition) of the dentifrices were assessed on plaque biofilms grown on glass rods after three days growth and a single dentifrice treatment...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29334434/the-case-for-stabilized-stannous-fluoride-dentifrice-an-advanced-formulation-designed-for-patient-preference
#5
Tao He, Svetlana Farrell
Oral diseases, particularly caries and gingivitis, continue to be widespread. Incorporating a stabilized stannous fluoride dentifrice into patients' daily oral hygiene routine is a convenient, cost effective approach to improve and protect their oral health and the appearance of their smile. Unlike other common fluorides that only provide anti-caries benefits (e.g., sodium fluoride and sodium monofluorophosphate), stabilized stannous fluoride formulations have demonstrated broader and significantly greater protection, also reducing plaque, gingivitis, erosion, sensitivity, and halitosis...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29333323/alveolar-ridge-preservation-with-an-open-healing-approach-using-single-layer-or-double-layer-coverage-with-collagen-membranes
#6
Ho-Keun Choi, Hag-Yeon Cho, Sung-Jo Lee, In-Woo Cho, Hyun-Seung Shin, Ki-Tae Koo, Hyun-Chang Lim, Jung-Chul Park
Purpose: The aim of this prospective pilot study was to compare alveolar ridge preservation (ARP) procedures with open-healing approach using a single-layer and a double-layer coverage with collagen membranes using radiographic and clinical analyses. Methods: Eleven molars from 9 healthy patients requiring extraction of the maxillary or mandibular posterior teeth were included and allocated into 2 groups. After tooth extraction, deproteinized bovine bone mineral mixed with 10% collagen was grafted into the socket and covered either with a double-layer of resorbable non-cross-linked collagen membranes (DL group, n=6) or with a single-layer (SL group, n=5)...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29332764/pelvic-musculoskeletal-dysfunctions-in-women-with-and-without-chronic-pelvic-pain
#7
Najmeh Sedighimehr, Farideh Dehghan Manshadi, Nasim Shokouhi, Alireza Akbarzadeh Baghban
AIM: This study aimed to compare the prevalence of pelvic musculoskeletal dysfunctions in women with and without Chronic Pelvic Pain (CPP). MATERIALS &METHODS: A total of 84 women with and without CPP (42 in each group), participated in this cross-sectional analytical study. After collecting demographic information, clinical examinations were carried out to compare pelvic musculoskeletal dysfunctions between two groups. Kolmogorov-Smirnov (K-S) goodness-of-fit, Independent t, X2 and Pearson correlation tests were used for data analysis...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29331289/titanium-scaffolding-an-innovative-modality-for-salvage-of-failed-first-ray-procedures
#8
Natalie Coriaty, Katherine Pettibone, Nicholas Todd, Shannon Rush, Ryan Carter, Colin Zdenek
Shortening of the first ray is a potential complication associated with first metatarsal procedures. Correction of this deformity conventionally has required the use of a tricortical bone graft to lengthen the bone. Graft complications, including donor site morbidity, poor graft stability, and graft resorption, have revealed a need for an alternative procedure. The present report shows that titanium cage scaffolding has lower extremity applications beyond its previous uses in the ankle and spine. Two patients underwent surgical correction for failed first ray procedures using a titanium cage apparatus with a calcaneal autograft and other biologic agents...
January 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29330906/generating-retinoic-acid-gradients-by-local-degradation-during-craniofacial-development-one-cell-s-cue-is-another-cell-s-poison
#9
REVIEW
Aditi Dubey, Rebecca E Rose, Drew R Jones, Jean-Pierre Saint-Jeannet
Retinoic acid (RA) is a vital morphogen for early patterning and organogenesis in the developing embryo. RA is a diffusible, lipophilic molecule that signals via nuclear RA receptor heterodimeric units that regulate gene expression by interacting with RA response elements in promoters of a significant number of genes. For precise RA signaling, a robust gradient of the morphogen is required. The developing embryo contains regions that produce RA, and specific intracellular concentrations of RA are created through local degradation mediated by Cyp26 enzymes...
January 13, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29330377/phenotypic-and-functional-characterization-of-peripheral-sensory-neurons-derived-from-human-embryonic-stem-cells
#10
Abdullah Jawad Alshawaf, Serena Viventi, Wanzhi Qiu, Giovanna D'Abaco, Bryony Nayagam, Michael Erlichster, Gursharan Chana, Ian Everall, Jason Ivanusic, Efstratios Skafidas, Mirella Dottori
The dorsal root ganglia (DRG) consist of a multitude of sensory neuronal subtypes that function to relay sensory stimuli, including temperature, pressure, pain and position to the central nervous system. Our knowledge of DRG sensory neurons have been predominantly driven by animal studies and considerably less is known about the human DRG. Human embryonic stem cells (hESC) are valuable resource to help close this gap. Our previous studies reported an efficient system for deriving neural crest and DRG sensory neurons from hESC...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29327972/albert-dereymaeker-and-joseph-cyriel-mulier-s-description-of-anterior-cervical-discectomy-with-fusion-in-1955
#11
Ronald H M A Bartels, Jan Goffin
Anterior cervical discectomy with fusion (ACDF) is a very well-known and often-performed procedure in the practice of spine surgeons. The earliest descriptions of the technique have always been attributed to Cloward, Smith, and Robinson. However, in the French literature, this procedure was also described by others during the exact same time period (in the 1950s). At a meeting in Paris in 1955, Belgians Albert Dereymaeker and Joseph Cyriel Mulier, a neurosurgeon and an orthopedic surgeon, respectively, described the technique that involved an anterior cervical discectomy and the placement of an iliac crest graft in the intervertebral disc space...
January 12, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29327452/regenerative-effects-of-human-embryonic-stem-cell-derived-neural-crest-cells-for-treatment-of-peripheral-nerve-injury
#12
Iwan Jones, Liudmila N Novikova, Lev N Novikov, Monika Renardy, Andreas Ullrich, Mikael Wiberg, Leif Carlsson, Paul J Kingham
Surgical intervention is the current gold standard treatment following peripheral nerve injury. However, this approach has limitations and full recovery of both motor and sensory modalities often remains incomplete. The development of artificial nerve grafts that either complement or replace current surgical procedures is therefore of paramount importance. An essential component of artificial grafts are biodegradable conduits and transplanted cells that provide trophic support during the regenerative process...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29327303/differential-osteopontin-expression-in-human-osteoblasts-derived-from-iliac-crest-and-alveolar-bone-and-its-role-in-early-stages-of-angiogenesis
#13
Martin Wein, Diana Huelter-Hassler, Katja Nelson, Tobias Fretwurst, Susanne Nahles, Guenter Finkenzeller, Brigitte Altmann, Thorsten Steinberg
In our previous study, we revealed significant differences of osteopontin (OPN) gene expression in primary human osteoblasts (HOBs) derived from iliac crest bone (iHOBs) and alveolar bone (aHOBs). The present study aims at assigning this discriminative expression to a possible biologic function. OPN is known to be involved in several pathologic and physiologic processes, among others angiogenesis. Therefore, we studied the reaction of human umbilical vein endothelial cells (HUVECs) to HOB-derived OPN regarding angiogenesis...
January 11, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29322554/transcription-factor-foxc1-is-involved-in-anterior-part-of-cranial-base-formation
#14
Nandar Mya, Toshiko Furutera, Shigeru Okuhara, Tsutomu Kume, Masaki Takechi, Sachiko Iseki
The cranial base is a structure mainly formed through endochondral ossification, and integrated into the craniofacial complex acting as an underlying platform for developing brain. Foxc1 is an indispensable regulator during intramembranous and endochondral ossification. In this study, we found that the spontaneous loss of Foxc1 function mouse (congenital hydrocephalous), Foxc1ch/ch , showed the anterior cranial base defects including unossified presphenoid and lack of middle part of the basisphenoid bone. Consistently, hypoplastic presphenoid primordial cartilage (basal portion of the trabecular cartilage) and lack of the middle part of basisphenoid primordial cartilage (the hypophyseal cartilage) were observed at earlier developmental stage...
January 11, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29321285/cranial-neural-crest-transplants
#15
Hélène Cousin
The transplantation of cranial neural crest (CNC) expressing green fluorescent protein (GFP) in Xenopus laevis has allowed researchers not only to assess CNC migration in vivo but also to address many other experimental questions. Coupled with loss- or gain-of-function experiments, this technique can be used to characterize the function of specific genes during CNC migration and differentiation. Although targeted injection can also be used to assess gene function during CNC migration, CNC transplantation allows one to answer specific questions, such as whether a gene's function is tissue autonomous, cell autonomous, or exerted in the tissues surrounding the CNC...
January 10, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29321283/cranial-neural-crest-explants
#16
Hélène Cousin, Dominique Alfandari
The cranial neural crest (CNC) explant assay was originally designed to assess the basic requirements for CNC migration in vitro. This protocol describes the key parameters of CNC explants in Xenopus laevis, with a focus on how to extirpate CNC cells and assay their migration in vitro. The protocol can be adapted according to the needs of the experimenter, some examples of which are discussed here.
January 10, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29317532/alkals-are-in-vivo-ligands-for-alk-family-receptor-tyrosine-kinases-in-the-neural-crest-and-derived-cells
#17
Andrey Fadeev, Patricia Mendoza-Garcia, Uwe Irion, Jikui Guan, Kathrin Pfeifer, Stephanie Wiessner, Fabrizio Serluca, Ajeet Pratap Singh, Christiane Nüsslein-Volhard, Ruth H Palmer
Mutations in anaplastic lymphoma kinase (ALK) are implicated in somatic and familial neuroblastoma, a pediatric tumor of neural crest-derived tissues. Recently, biochemical analyses have identified secreted small ALKAL proteins (FAM150, AUG) as potential ligands for human ALK and the related leukocyte tyrosine kinase (LTK). In the zebrafish Danio rerio, DrLtk, which is similar to human ALK in sequence and domain structure, controls the development of iridophores, neural crest-derived pigment cells. Hence, the zebrafish system allows studying Alk/Ltk and Alkals involvement in neural crest regulation in vivo...
January 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29315345/identification-and-functional-analysis-of-sox10-phosphorylation-sites-in-melanoma
#18
Julia C Cronin, Stacie K Loftus, Laura L Baxter, Steve Swatkoski, Marjan Gucek, William J Pavan
The transcription factor SOX10 plays an important role in vertebrate neural crest development, including the establishment and maintenance of the melanocyte lineage. SOX10 is also highly expressed in melanoma tumors, and SOX10 expression increases with tumor progression. The suppression of SOX10 in melanoma cells activates TGF-β signaling and can promote resistance to BRAF and MEK inhibitors. Since resistance to BRAF/MEK inhibitors is seen in the majority of melanoma patients, there is an immediate need to assess the underlying biology that mediates resistance and to identify new targets for combinatorial therapeutic approaches...
2018: PloS One
https://www.readbyqxmd.com/read/29308290/cutaneous-calcinosis-in-a-patient-with-limited-scleroderma-crest-syndrome
#19
Nurşen Düzgün
No abstract text is available yet for this article.
December 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29307282/foxd3-foxd4-is-required-for-the-development-of-hindgut-in-the-rat-model-of-anorectal-malformation
#20
Luo-Jia Wang, Wei-Lin Wang, Hong Gao, Yu-Zuo Bai, Shu-Cheng Zhang
Congenital anorectal malformation is the most common digestive tract malformation in newborns. It has been reported that FOXD3/FOXD4, a forkhead transcription factor, regulates the generation, migration, and differentiation of neural crest cells. However, whether FOXD3/FOXD4 takes part in anorectal malformation remains unclear. In the present study, we used ethylene thiourea to induce the animal models of anorectal malformation in rat embryos and to interrogate the role of FOXD3/FOXD4 in anorectal malformation pathogenesis...
January 1, 2018: Experimental Biology and Medicine
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