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https://www.readbyqxmd.com/read/28226676/quantitative-evaluation-of-alveolar-bone-resorption-on-dental-panoramic-radiographs-by-standardized-dentition-image-transformation-and-probability-estimation
#1
Chisako Muramtsu, Ryo Takahashi, Tatsuro Hayashi, Takeshi Hara, Tatsumasa Fukui, Akitoshi Katsumata, Hiroshi Fujita, Chisako Muramtsu, Ryo Takahashi, Tatsuro Hayashi, Takeshi Hara, Tatsumasa Fukui, Akitoshi Katsumata, Hiroshi Fujita, Akitoshi Katsumata, Ryo Takahashi, Tatsuro Hayashi, Takeshi Hara, Chisako Muramtsu, Tatsumasa Fukui, Hiroshi Fujita
Alveolar bone resorption, which can be observed on dental panoramic radiographs (DPRs), is one of the most important signs of the progression of periodontal disease. However, quantitative and consistent evaluation of alveolar bone resorption is labor intense, because of a large number of DPR examinations performed each year. In our previous study, we developed an automated scheme for detection of three lines, corresponding to an occlusion line, an alveolar line and a root apex line, to measure the alveolar bone ratio (ABR), which may be useful to dentists in early detection of periodontal disease...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222099/morphological-study-of-tooth-development-in-podoplanin-deficient-mice
#2
Kenyo Takara, Naoki Maruo, Kyoko Oka, Chiaki Kaji, Yuji Hatakeyama, Naruhiko Sawa, Yukinari Kato, Junro Yamashita, Hiroshi Kojima, Yoshihiko Sawa
Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial cells, glia cells, and others. It has been reported that podoplanin-RhoA interaction induces cytoskeleton relaxation and cell process stretching in fibroblastic cells and osteocytes, and that podoplanin plays a critical role in type I alveolar cell differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/28220264/treatment-of-stage-ii-medication-related-osteonecrosis-of-the-jaw-with-necrosectomy-and-autologous-bone-marrow-mesenchymal-stem-cells
#3
Pit Jacob Voss, Akihiko Matsumoto, Esteban Alvarado, Rainer Schmelzeisen, Fabian Duttenhöfer, Philipp Poxleitner
Treatment strategies for medication-related osteonecrosis of the jaw (MRONJ) remain controversial. Although the AAOMS suggests a conservative approach, a surgical management with necrosectomy is often required when conservative management has failed. Moreover, recent studies have shown promising results using an early stage surgical treatment. Over the past decade, cell-based bone regeneration utilizing bone marrow mesenchymal stem cells (MSCs) received increased attention. MSCs are known to promote wound healing and induce new bone formation in compromised tissue...
February 20, 2017: Odontology
https://www.readbyqxmd.com/read/28216417/expression-profiling-of-clinical-specimens-supports-the-existence-of-neural-progenitor-like-stem-cells-in-basal-breast-cancers
#4
Alex Panaccione, Yan Guo, Wendell G Yarbrough, Sergey V Ivanov
BACKGROUND: We previously characterized in salivary adenoid cystic carcinoma (ACC) a novel population of cancer stem cells (CSCs) marked by coexpression of 2 stemness genes, sex-determining region Y (SRY)-related HMG box-containing factor 10 (SOX10) and CD133. We also reported that in ACC and basal-like breast carcinoma (BBC), a triple-negative breast cancer subtype, expression of SOX10 similarly demarcates a highly conserved gene signature enriched with neural stem cell genes. On the basis of these findings, we hypothesized that BBC might be likewise driven by SOX10-positive (SOX10(+))/CD133(+) cells with neural stem cell properties...
January 27, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28216225/molecular-characterization-of-myoglobin-from-sciurus-vulgaris-meridionalis-primary-structure-kinetics-and-spectroscopic-studies
#5
Antonella M A Di Giuseppe, Luigi Russo, Rosita Russo, Sara Ragucci, J Valentina Caso, Carla Isernia, Angela Chambery, Antimo Di Maro
Myoglobins (Mbs) are heme-proteins involved in dioxygen storage necessary for metabolic respiration. Mbs are intensely investigated as archetype to investigate structure/function relationship in globular proteins. In this work, the myoglobin from S. vulgaris meridionalis has been for the first time isolated and purified with a high yield and homogeneity. The primary structure characterization has been performed by applying a strategy based on high resolution tandem mass spectrometry. Proximal (position 93, α-helix F8) and distal histidinyl residues (position 64, α-helix E7) as well as most of the amino acid residues (i...
February 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28216145/a-human-neural-crest-stem-cell-derived-dopaminergic-neuronal-model-recapitulates-biochemical-abnormalities-in-gba1-mutation-carriers
#6
Shi-Yu Yang, Michelle Beavan, Kai-Yin Chau, Jan-Willem Taanman, Anthony H V Schapira
Numerically the most important risk factor for the development of Parkinson's disease (PD) is the presence of mutations in the glucocerebrosidase GBA1 gene. In vitro and in vivo studies show that GBA1 mutations reduce glucocerebrosidase (GCase) activity and are associated with increased α-synuclein levels, reflecting similar changes seen in idiopathic PD brain. We have developed a neural crest stem cell-derived dopaminergic neuronal model that recapitulates biochemical abnormalities in GBA1 mutation-associated PD...
February 15, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28215852/lingual-nerve-measurements-in-cadaveric-dissections-clinical-applications
#7
Somsak Sittitavornwong, Michael Babston, Douglas Denson, Steven Zehren, Jonathan Friend
PURPOSE: Lingual nerve (LN) injury is quite prevalent despite its long-known anatomic course. The purpose of this study was to accurately predict the LN pathway by identifying and measuring close anatomic landmarks; these measurements should help lessen the incidence of LN injury. MATERIALS AND METHODS: LN dissection was carried out on 15 halved cadaver skulls (total, 28 specimens). RESULTS: On average, the LN position was approximately 7 mm below the alveolar crest at the distal end of the mandibular second molar, 5...
January 26, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28214971/complete-occipitalization-of-the-atlas-with-bilateral-external-auditory-canal-atresia
#8
Janez Dolenšek, Erika Cvetko, Žiga Snoj, Marija Meznaric
Fusion of the atlas with the occipital bone is a rare congenital dysplasia known as occipitalization of the atlas, occipitocervical synostosis, assimilation of the atlas, or atlanto-occipital fusion. It is a component of the paraxial mesodermal maldevelopment and commonly associated with other dysplasias of the craniovertebral junction. External auditory canal atresia or external aural atresia is a rare congenital absence of the external auditory canal. It occurs as the consequence of the maldevelopment of the first pharyngeal cleft due to defects of cranial neural crest cells migration and/or differentiation...
February 18, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28213764/presence-of-root-canal-treatment-has-no-influence-on-periodontal-bone-loss
#9
Fabiola-Regina Rodriguez, Nadine Paganoni, Peter Eickholz, Roland Weiger, Clemens Walter
AIM: The aim of this study was to compare the interproximal bone level at root canal-filled teeth and non-root canal-filled teeth. MATERIALS AND METHODS: The records of patients from the department were consecutively screened from January 2009 to October 2011. The distance between the coronal reference point to the alveolar bone crest (AC) was assessed at the mesial and distal aspects of root canal-filled teeth (RCF+) and their contralateral non-root canal-filled teeth (RCF-) on periapical radiographs...
February 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28211522/structure-and-polymorphisms-of-the-major-histocompatibility-complex-in-the-oriental-stork-ciconia-boyciana
#10
Hiroki Tsuji, Yukio Taniguchi, Shintaro Ishizuka, Hirokazu Matsuda, Takahisa Yamada, Kazuaki Naito, Hiroaki Iwaisaki
The major histocompatibility complex (MHC) is highly polymorphic and plays a central role in the vertebrate immune system. Despite its functional consistency, the MHC genomic structure differs substantially among organisms. In birds, the MHCs of Galliformes and the Japanese crested ibis (Pelecaniformes) are well-characterized, but information about other avian MHCs remains scarce. The Oriental stork (Ciconia boyciana, order Ciconiiformes) is a large endangered migrant. The current Japanese population of this bird originates from a few founders; thus, understanding the genetic diversity among them is critical for effective population management...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210748/risk-factors-associated-with-abdominal-obesity-in-suburban-adolescents-from-a-malaysian-district
#11
Wai Fong Chew, Pooi Pooi Leong, Sook Fan Yap, A Malik Yasmin, Kong Bung Choo, Gary Kim Kuan Low, Nem Yun Boo
INTRODUCTION: We aimed to determine the risk factors associated with abdominal obesity (AO) in suburban adolescents. METHODS: This cross-sectional study included adolescents aged 15-17 years from five randomly selected secondary schools in the Hulu Langat district of Selangor State, Malaysia. Waist circumference (WC) was measured at the midpoint between the lower margin of last palpable rib and the top of iliac crest. Information on sociodemographic data, dietary habits, physical activity levels and duration of sleep was obtained via interviewer-administered questionnaires...
February 17, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28210450/repercussions-of-intraalveolar-placement-of-combination-of-0-2-chlorhexidine-10-mg-metronidazole-gel-on-the-occurrence-of-dry-sockets-a-randomized-control-trial
#12
Jasleen Kaur, Rushik Raval, Anupam Bansal, Vinod Kumawat
BACKGROUND: To evaluate the effects of intraalveolar placement of gel containing 0.2% chlorhexidine and 10gm of metronidazole on the incidence of alveolar osteitis. MATERIAL AND METHODS: A total of 300 impacted third molars were extracted in 150 patients enrolled in this trial. In each subject a socket was randomly selected and packed to the crest of alveolar ridge with the gel. The contralateral socket was packed with placebo dressing. The occurrence of dry socket was assessed during 3rd and 5th postoperative days ...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28208578/role-of-cortico-cancellous-heterologous-bone-in-human-periodontal-ligament-stem-cell-xeno-free-culture-studied-by-synchrotron-radiation-phase-contrast-microtomography
#13
Serena Mazzoni, Sara Mohammadi, Giuliana Tromba, Francesca Diomede, Adriano Piattelli, Oriana Trubiani, Alessandra Giuliani
This study was designed to quantitatively demonstrate via three-dimensional (3D) images, through the Synchrotron Radiation Phase-Contrast Microtomography (SR-PhC-MicroCT), the osteoinductive properties of a cortico-cancellous scaffold (Osteobiol Dual Block-DB) cultured with human Periodontal Ligament Stem Cells (hPDLSCs) in xeno-free media. In vitro cultures of hPDLSCs, obtained from alveolar crest and horizontal fibers of the periodontal ligament, were seeded onto DB scaffolds and cultured in xeno-free media for three weeks...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28207623/feasibility-of-percutaneous-posterolateral-spinal-fusion-with-recombinant-bone-morphogenetic-protein-2-rhbmp-2-a-comparison-with-standard-methods-using-an-animal-model-study
#14
Chris Yin Wei Chan, Mun Keong Kwan, Lim Beng Saw, Hussin Paisal
BACKGROUND CONTEXT: The clinical application of recombinant bone morphogenetic protein in spinal surgery has been shown to be safe and effective. However, its use in minimally invasive spine surgery has been limited to anterior interbody fusion procedures. To date, no study has evaluated the feasibility of percutaneous posterolateral fusion in the spine utilizing recombinant bone morphogenetic protein-2 (rhBMP-2). PURPOSE: To evaluate the feasibility of percutaneous posterolateral fusion in the spine utilizing rhBMP-2...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28207619/iliac-crest-regeneration-a-retrospective-study-of-14-years-of-follow-up
#15
Anastasios Christodoulou, Achilleas Boutsiadis, Evangellos Christodoulou, Petros Antonarakos, Panagiotis Givissis, Ippokratis Hatzokos
STUDY DESIGN: This is a retrospective study analysis. OBJECTIVE: The purpose of our study was to evaluate the healing process of the ilium after being used as a bone graft donor site in the treatment of adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Iliac crest bone grafts have been proven to be the most reliable means for solid fusion in spine surgery. Nevertheless, few reports in the literature describe the ability of the iliac crest to regenerate...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28206675/a-multi-zoo-investigation-of-nutrient-provision-for-captive-red-crested-turacos
#16
Alexander J Hulbert, Kerry A Hunt, Paul E Rose
Turacos (Musophagidae) are common zoo birds; the 14 species of Tauraco being most often exhibited. Turacos possess unique non-structural, copper-based feather pigments, and a specialized dietary strategy. Tauraco inhabit tropical woodlands, foraging for predominantly folivorous and/or frugivorous food items. Using a study population of 16 red-crested turacos (T. erythrolophus) at seven zoos in the United Kingdom, the nutrient composition of diets from diet sheets was calculated, using Zootrition v.2.6, Saint Louis Zoo, USA for analyses of important nutrients within each diet, and compared against an example of currently available literature...
February 16, 2017: Zoo Biology
https://www.readbyqxmd.com/read/28205023/low-serum-culture-with-novel-medium-promotes-maxillary-mandibular-bone-marrow-stromal-cell-proliferation-and-osteogenic-differentiation-ability
#17
Fumio Suehiro, Masakazu Ishii, Izumi Asahina, Hiroshi Murata, Masahiro Nishimura
OBJECTIVES: The purpose of this study was to evaluate the effect of low-serum STK2 medium on the isolation and osteogenic differentiation of human maxillary/mandibular bone marrow stromal cells (MBMSCs). MATERIALS AND METHODS: Human MBMSCs were obtained from patients undergoing dental implant treatment. These cells were cultured in serum-free medium or STK2 medium containing 1  % fetal bovine serum (low-serum) or α-MEM containing 10  % fetal bovine serum (control)...
February 16, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28203609/zeb2-inhibiting-the-inhibitors-in-schwann-cells
#18
Bastian G Brinkmann, Susanne Quintes
Development of Schwann cells is tightly regulated by concerted action of activating and inhibiting factors. Most of the regulatory feedback loops identified to date are transcriptional activators promoting induction of genes coding for integral myelin proteins and lipids. The mechanisms by which inhibitory factors are silenced during Schwann cell maturation are less well understood. We could recently show a pivotal function for the transcription factor zinc finger E-box binding homeobox 2 (Zeb2) during Schwann cell development and myelination as a transcriptional repressor of maturation inhibitors...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28203006/-observation-of-bone-morphology-in-furcation-defects-of-mandibular-molars-using-cone-beam-computed-tomography
#19
J Zhu, X Y Ouyang
OBJECTIVE: To observe mesial-distal bone morphology in classes II and III furcation involvements (FI) of mandibular molars using cone beam computed tomography (CBCT), to develop a classification system of mesial-distal bone morphology of furcation defects and to observe the intrabony defects on CBCT images. METHODS: Based on the existing CBCT data, the mandibular molars with horizontal bone defects in furcation area were observed. One hundred and seventeen sites of 81 mandibular molars with class II or class III FIclassified on CBCT images were included...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28203000/-effect-of-molar-ligation-and-local-porphyromonas-gingivalis-inoculation-on-alveolar-bone-loss-in-the-mouse
#20
L Gao, X Q Yu, Y Cai
OBJECTIVE: To compare the extent and time course of alveolar bone loss and osteoclast activation in two murine models of periodontal disease: molar ligation and Porphyromonas gingivalis (P. gingivalis) oral inoculation. METHODS: A split-mouth design was applied to two groups of mice (C57BL6, 6-8 weeks old, n=24 in both groups), resulting in four treatment groups: (1) Control group: unligated upper right 2nd molars receiving CMC only, (2)Ligature group: ligation of a 9-0 suture around the upper left 2nd molar, (3) P...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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