keyword
MENU ▼
Read by QxMD icon Read
search

lipid—loaded cell

keyword
https://www.readbyqxmd.com/read/28525949/capsaicin-loaded-folic-acid-conjugated-lipid-nanoparticles-for-enhanced-therapeutic-efficacy-in-ovarian-cancers
#1
Lin Lv, Yu-Xin Zhuang, Hui-Wu Zhang, Nan-Nan Tian, Wen-Zhen Dang, Shao-Yu Wu
In this study, folic acid-conjugated lipid nanoparticles were successfully prepared to enhance the active targeting of capsaicin (CAP) in ovarian cancers. The particles were nanosized and exhibited a controlled release of drug in the physiological conditions. The folic acid (FA)-conjugated system exhibited a remarkably higher uptake of nanoparticles in the cancer cells compared to that of non-targeted system. The folate-conjugated CAP-loaded lipid nanoparticles (CFLN) upon interacting with cancer cells were internalized via receptor-mediated endocytosis mechanism and resulted in higher concentration in the cancer cells...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28514759/charge-reversible-calcium-phosphate-lipid-hybridnanoparticle-for-sirna-delivery
#2
Rong-Qiao Cai, Dao-Zhou Liu, Han Cui, Ying Cheng, Miao Liu, Bang-Le Zhang, Qi-Bing Mei, Si-Yuan Zhou
Bcl-2 gene is an important target to treat lung cancer. The small interference RNA (siRNA) of Bcl-2 gene (siBcl-2) can specifically silence Bcl-2 gene. However, naked siBcl-2 is difficult to accumulate in the tumor tissue to exert its activity. In this paper, a calcium phosphate lipid hybrid nanoparticle that possessed charge reversible property was prepared to enhance the activity of siBcl-2 in vivo. The average diameter and zeta potential of siBcl-2 loaded calcium phosphate lipid hybrid nanoparticles (LNPS@siBcl-2) were 80 nm and -13 mV at pH7...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512733/a-lipidomic-cell-based-assay-for-studying-drug-induced-phospholipidosis-and-steatosis
#3
Juan Carlos García-Cañaveras, Manuel David Peris-Díaz, M Isabel Alcoriza, Manuela Cerdán-Calero, M Teresa Donato, Agustín Lahoz
Phospholipidosis and steatosis are two toxic effects, which course with overaccumulation of different classes of lipids in the liver. MS-based lipidomics has become a powerful tool for the comprehensive determination of lipids. LC-MS lipid profiling of HepG2 cells is proposed as an in vitro assay to study and anticipate phospholipidosis and steatosis. Cells with and without pre-incubation with a mixture of free fatty acids (FFA) (i.e., oleic and palmitic) were exposed to a set of well-known steatogenic and phospholipidogenic compounds...
May 17, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28504884/d-%C3%AE-tocopheryl-succinate-phosphatidyl-ethanolamine-conjugated-amphiphilic-polymer-based-nanomicellar-system-for-the-efficient-delivery-of-curcumin-and-to-overcome-multiple-drug-resistance-in-cancer
#4
Omkara Swami Muddineti, Preeti Kumari, Balaram Ghosh, Vladimir P Torchilin, Swati Biswas
Nanomedicines have emerged as a promising treatment strategy for cancer. Multiple drug resistance due to overexpression of various drug efflux transporters and upregulation of apoptotic inhibitory pathways in cancer cells are major barriers that limit the success of chemotherapy. Here, we developed a d-α-tocopherol (α-TOS)/lipid-based copolymeric nanomicellar system (VPM) by conjugating phosphatidyl ethanolamine (PE) and α-TOS with poly(ethylene glycol) (PEG) via an amino acid linkage. The synthesized polymers were characterized by Fourier transform IR, gas-phase chromatography, and (1)H and (13)C NMR spectroscopy...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28502895/nanostructured-lipid-carriers-employing-polyphenols-as-promising-anticancer-agents-quality-by-design-qbd-approach
#5
Ketki Bhise, Sushil Kumar Kashaw, Samaresh Sau, Arun K Iyer
Cancer is one of the leading causes of death worldwide. There are several hurdles in cancer therapy because of side-effects which limits its usage. Nanoparticulate drug delivery systems have been tested against cancer in a range of scientific studies. In the recent years, advanced research on Nanostructured Lipid Carriers (NLCs) has garnered considerable attention owing to the advantages over their first-generation counterparts, Solid Lipid Nanoparticles (SLN). NLCs facilitate efficient loading of poorly water soluble drugs with simple methods of drug loading...
May 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28502199/ceramide-lipid-based-nanosuspension-for-enhanced-delivery-of-docetaxel-with-synergistic-antitumor-efficiency
#6
Tianqi Wang, Lixia Feng, Shaomei Yang, Yongjun Liu, Na Zhang
Ceramide (CE), a bioactive lipid with tumor suppression, has been widely used as a drug carrier and enhancer for cancer therapy. CE-based combination therapy was prone to be attractive in cancer therapy. In our previous study, the combination of CE and docetaxel (DTX) was proved to be an effective strategy for cancer therapy. To further improve the antitumor efficiency of DTX, the CE lipid-based nanosuspensions (LNS) was prepared for the delivery of DTX to exhibit synergistic therapeutic effect. The enhanced delivery and synergistic therapeutic effect of DTX-loaded CE-LNS (CE + DTX-LNS) were evaluated...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28502107/a-nano-particle-vector-comprised-of-poly-lactic-co-glycolic-acid-and-monophosphoryl-lipid-a-and-recombinant-mycobacterium-avium-subsp-paratuberculosis-peptides-stimulate-a-pro-immune-profile-in-bovine-macrophages
#7
Cleverson D Souza, John P Bannantine, Wendy C Brown, M Grant Norton, William C Davis, Julianne K Hwang, Parissa Ziaei, Gaber S Abdellrazeq, Meaghan V Eren, James R Deringer, Elizabeth Laws, Maria Clara D Cardieri
AIMS: We evaluated the potential of a nanoparticle (NP) delivery system to improve methods of delivery of candidate peptide based vaccines for Paratuberculosis in cattle. METHODS AND RESULTS: Peptides derived from Mycobacterium avium subsp paratuberculosis (Map), and the proinflammatory monophosphoryl lipid A (MPLA) were incorporated in polymeric NPs based on poly (D, L-lactide-co-glycolide) (PLGA). The PLGA/MPLA NPs carriers were incubated with macrophages to examine their effects on survival and function...
May 14, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28500977/endocytosis-and-intracellular-traffic-of-cholesterol-pdmaema-liposome-complexes-in-human-epithelial-like-cells
#8
F Szymanowski, A A Hugo, P Alves, P N Simões, A Gómez-Zavaglia, Pablo F Pérez
Liposomes are generally used as delivery systems, as they are capable of encapsulating a wide variety of molecules (i.e. plasmids, recombinant proteins, therapeutic drugs). However, liposomal drug delivery have to fulfill different requirements, such as the effective internalization by the target cells and avoidance of the degradative activity of the intracellular compartments. The use of polymer lipid complexes (PLCs), by including different polymers in the liposome formulation, could improve internalization and intracellular release of drugs...
May 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28497202/exosomes-and-their-application-in-biomedical-field-difficulties-and-advantages
#9
REVIEW
Jafar Rezaie, Saeed Ajezi, Çığır Biray Avci, Mohammad Karimipour, Mohammad Hossein Geranmayeh, Alireza Nourazarian, Emel Sokullu, Aysa Rezabakhsh, Reza Rahbarghazi
The science of gene therapy has experienced a controversial history. At first, the initial concept that various disorders become curable by gene transferring was very exciting and challengeable. However, the problems and difficulties related to emerging techniques and unwanted side effects seen in some patients who have undergone gene therapy make some questions against the safety of novel molecular medicine approach. In line with this statement, discovery and developing a good bio-vector possessing low toxicity and high efficiency rate are the most important issues in gene therapy field...
May 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28494629/cisplatin-and-paclitaxel-co-delivered-by-folate-decorated-lipid-carriers-for-the-treatment-of-head-and-neck-cancer
#10
Jiying Yang, Zengjuan Ju, Shufang Dong
CONTEXT: For head and neck cancer therapy, co-delivery of two drugs, cisplatin (DDP) plus paclitaxel (PTX), are more effective than single drug therapy. Lipid carriers are promising drug carriers for anti-cancer delivery. OBJECTIVE: The aim of this study is to construct a folate (FA) decorated nanostructured lipid carriers (NLCs) as nanocarriers for DDP and PTX delivery. MATERIALS AND METHODS: In this study, DDP and PTX were incorporated into NLCs...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/28490783/multiple-biomarker-responses-serum-biochemistry-oxidative-stress-genotoxicity-and-histopathology-in-channa-punctatus-exposed-to-heavy-metal-loaded-waste-water
#11
Mehjbeen Javed, Md Irshad Ahmad, Nazura Usmani, Masood Ahmad
Experiments were conducted to investigate the health of fish Channa punctatus inhabiting heavy metal-loaded waste water. Heavy metals in the order of Fe > Mn > Zn > Co > Ni > Cu = Cr were present in the waste water. Gills had high metal load followed by liver and then kidney. Albumin, albumin to globulin (A:G) ratio, triglyceride, high density lipoprotein (HDL) and very low density lipoprotein (VLDL) were found to be lower but phospholipid, low density lipoprotein (LDL), total protein, lipid and cholesterol were higher as compared to the reference...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28482541/liquid-formulation-containing-doxorubicin-loaded-lipid-core-nanocapsules-cytotoxicity-in-human-breast-cancer-cell-line-and-in-vitro-uptake-mechanism
#12
Michelli B Antonow, Ana Carolina C Asbahr, Paula Raddatz, Aline Beckenkamp, Andréia Buffon, Sílvia S Guterres, Adriana R Pohlmann
Cancer is a major public health problem in the world, being breast cancer the most frequent cancer affecting women. Despite advances in detection and treatment, mortality rates remain high. Therefore, new approaches for breast cancer treatments are necessary. In this study, our objective was to develop a liquid formulation containing doxorubicin-loaded lipid-core nanocapsules (DOX-LNC), to evaluate the in vitro antiproliferative activity and to determine the nanocapsules uptake by MCF-7 cells. Lipid-core nanocapsules (LNC), blank formulation, and DOX-LNC, proposed treatment, were prepared by self-assembling using the solvent displacement method...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28477212/efficacy-and-tolerability-of-switching-to-a-dual-therapy-with-darunavir-ritonavir-plus-raltegravir-in-hiv-infected-patients-with-hiv-1-rna-%C3%A2-50%C3%A2-cp-ml
#13
Giordano Madeddu, Stefano Rusconi, Alessandro Cozzi-Lepri, Simona Di Giambenedetto, Stefano Bonora, Alessia Carbone, Andrea De Luca, Nicola Gianotti, Antonio Di Biagio, Andrea Antinori
BACKGROUND: Nucleos(t)ide reverse transcriptase inhibitors (NRTI) toxicity may represent a threat for long-term success of combined antiretroviral therapy. Some studies have suggested a possible improvement of NRTI-related toxicity after switching to NRTI-sparing regimens. OBJECTIVES: We aimed to explore the efficacy and tolerability of switching to darunavir/ritonavir (DRV/r) plus raltegravir (RAL) while having a viral load (VL) ≤50 copies/mL in the clinical setting...
May 5, 2017: Infection
https://www.readbyqxmd.com/read/28472908/targeted-nanostructured-lipid-carriers-for-delivery-of-paclitaxel-to-cancer-cells-preparation-characterization-and-cell-toxicity
#14
Mahboubeh Rezazadeh, Jaber Emami, Farshid Hassanzadeh, Hojjat Sadeghi, Mahboubeh Rostami, Hamid Mohammadkhani
Low water solubility, high systemic toxicity and insignificant cellular uptake has limited efficient clinical applications of the anti-tumor agent paclitaxel (PTX). To overcome these limitations, a novel nanostructured lipid carrier (NLC) modified with folic acid (FA) and polyethylene glycol (PEG) was prepared by emulsion solvent evaporation method using cholesterol, α-tocopherol, lecithin and Poloxamer. A partial factorial design was applied to determine the appropriate levels of variables for optimized formulation...
May 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28471177/topical-formulation-of-self-assembled-antiviral-prodrug-nanomicelles-for-targeted-retinal-delivery
#15
Abhirup Mandal, Kishore Cholkar, Varun Khurana, Ankit Shah, Vibhuti Agrahari, Rohit Bisht, Dhananjay Pal, Ashim K Mitra
Topical drug administration for back of the eye delivery is extremely challenging due to the presence of protection mechanisms and physiological barriers. Self-assembled polymeric nanomicelles have emerged as promising vehicles for drug delivery. Apart from serving as an inert nanocarrier for therapeutic agents, polymeric nanomicelles are known to bypass mononuclear phagocytic system (MPS) and efflux transporters thereby improving drug bioavailability. In this investigation, a highly efficacious biotinylated lipid prodrug of cyclic cidofovir (B-C12-cCDF) was formulated within polymeric nanomicelles as a carrier for targeted retinal delivery...
May 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28471040/farnesylthiosalicylic-acid-loaded-lipid-polyethylene-glycol-polymer-hybrid-nanoparticles-for-treatment-of-glioblastoma
#16
Abbas Kaffashi, Sevda Lüle, Sibel Bozdağ Pehlivan, Can Sarısözen, İmran Vural, Hüsnü Koşucu, Taner Demir, Kadir Emre Buğdaycı, Figen Söylemezoğlu, Kader Karlı Oğuz, Melike Mut
OBJECTIVES: We aimed to develop lipid-polyethylene glycol (PEG)-polymer hybrid nanoparticles, which have high affinity to tumour tissue with active ingredient, a new generation antineoplastic drug, farnesylthiosalicylic acid (FTA) for treatment of glioblastoma. METHOD: Farnesylthiosalicylic acid-loaded poly(lactic-co-glycolic acid)-1,2 distearoyl-glycerol-3-phospho-ethanolamine-N [methoxy (PEG)-2000] ammonium salt (PLGA-DSPE-PEG) with or without 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) hybrid nanoparticles has been prepared and evaluated for in-vitro characterization...
May 4, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28470171/co-delivery-of-paclitaxel-and-tetrandrine-via-irgd-peptide-conjugated-lipid-polymer-hybrid-nanoparticles-overcome-multidrug-resistance-in-cancer-cells
#17
Jinming Zhang, Lu Wang, Hon Fai Chan, Wei Xie, Sheng Chen, Chengwei He, Yitao Wang, Meiwan Chen
One of the promising strategies to overcome tumor multidrug resistance (MDR) is to deliver anticancer drug along with P-glycoprotein (P-gp) inhibitor simultaneously. To enhance the cancer cellular internalization and implement the controlled drug release, herein an iRGD peptide-modified lipid-polymer hybrid nanosystem (LPN) was fabricated to coload paclitaxel (PTX) and tetrandrine (TET) at a precise combination ratio. In this co-delivery system, PTX was covalently conjugated to poly (D,L-lactide-co-glycolide) polymeric core by redox-sensitive disulfide bond, while TET was physically capsulated spontaneously for the aim to suppress P-gp in advance by the earlier released TET in cancer cells...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28463792/co-delivery-of-vincristine-and-quercetin-by-nanocarriers-for-lymphoma-combination-chemotherapy
#18
Baomin Zhu, Lianling Yu, QingCai Yue
PURPOSE: Chemotherapy is the current standard treatment for Non-Hodgkin's lymphoma (NHL). Combination therapy is emerging as an important strategy for a better long-term prognosis with decreased side effects, maximized therapeutic effect. The aim of this study is to deliver vincristine (VCR) and quercetin (QU) with synergistic drug ratios through lipid-polymeric nanocarriers (LPNs) for the lymphoma combination chemotherapy METHODS: In this present study, we constructed VCR and QU dual-loaded LPNs (VCR/QU LPNs) and investigated their antitumor efficacy in vitro cell culture models and a tumor xenograft mouse model...
April 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28461264/development-of-nanostructured-lipid-carriers-for-intraoral-delivery-of-domperidone
#19
Carolin Tetyczka, Martin Griesbacher, Markus Absenger-Novak, Eleonore Fröhlich, Eva Roblegg
The oral cavity displays one potentially attractive route that is not associated with gastric transit and hepatic first pass metabolism. However, poorly soluble active candidates require a drug delivery system to facilitate their transport through oral biological membranes. To this end, nanostructured lipid carriers (NLC) were loaded with Domperidone and produced with high pressure homogenization. NLC were characterized regarding particle size, particle size distribution, zeta potential, entrapment efficiency and crystallinity...
April 29, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28460227/transcription-activator-hyaluronic-acid-and-tocopheryl-succinate-multi-functionalized-novel-lipid-carriers-encapsulating-etoposide-for-lymphoma-therapy
#20
Hongyun Wang, Guodong Sun, Zhigang Zhang, Yang Ou
Delivery of chemotherapeutic drugs using nanocarriers is emerging as a promising approach for the treatment of cancer. The aim of this research was to develop a dual targeted d-α-tocopheryl succinate (TOS) functionalized nanostructured lipid carriers (NLCs), using etoposide (ETP) as a model drug to prove their in vitro and in vivo anti-tumor effects. Novel ETP loaded NLCs were constructed (ETP-NLCs). Hyaluronic acid (HA) and cell-penetrating peptide transcription activator (TAT) was applied for the surface decoration of ETP NLCs (HATOS/TATTOS-ETP-NLCs)...
April 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
keyword
keyword
35845
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"