keyword
MENU ▼
Read by QxMD icon Read
search

lipid—loaded cell

keyword
https://www.readbyqxmd.com/read/29775717/temozolomide-loaded-nano-lipid-based-chitosan-hydrogel-for-nose-to-brain-delivery-characterization-nasal-absorption-histopathology-and-cell-line-study
#1
Anam Khan, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Yasmin Sultana, Asgar Ali, Khalid Khan
The present study was designed to develop and optimize Temozolomide nano lipid chitosan gel delivery (TMZNLCHG) to target the brain through nasal route. The formulation was developed using chitosan as a gelling agent and Vit E: gelucire 44/14 blend as lipid. The formulations were evaluated for particle size, drug loading, morphology, drug release, nasal diffusion, cell line study, and histopathology study. The average particle size, PDI, %EE, loading, drug release, and % permeation were found to be 134 nm, 0...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29774075/plectin-targeted-liposomes-enhance-the-therapeutic-efficacy-of-a-parp-inhibitor-in-the-treatment-of-ovarian-cancer
#2
Siva Sai Krishna Dasa, Galina Diakova, Ryo Suzuki, Anne M Mills, Michael F Gutknecht, Alexander L Klibanov, Jill K Slack-Davis, Kimberly A Kelly
Advances in genomics and proteomics drive precision medicine by providing actionable genetic alterations and molecularly targeted therapies, respectively. While genomic analysis and medicinal chemistry have advanced patient stratification with treatments tailored to the genetic profile of a patient's tumor, proteomic targeting has the potential to enhance the therapeutic index of drugs like poly(ADP-ribose) polymerase (PARP) inhibitors. PARP inhibitors in breast and ovarian cancer patients with BRCA1/2 mutations have shown promise...
2018: Theranostics
https://www.readbyqxmd.com/read/29773873/therapeutic-nanoparticles-penetrate-leaves-and-deliver-nutrients-to-agricultural-crops
#3
Avishai Karny, Assaf Zinger, Ashima Kajal, Janna Shainsky-Roitman, Avi Schroeder
As the world population grows, there is a need for efficient agricultural technologies to provide global food requirements and reduce environmental toll. In medicine, nanoscale drug delivery systems grant improved therapeutic precision by overcoming biological barriers and enhancing drug targeting to diseased tissues. Here, we loaded nanoscale drug-delivery systems with agricultural nutrients, and applied them to the leaves of tomato plants. We show that the nanoparticles - liposomes composed of plant-derived lipids, penetrate the leaf and translocate in a bidirectional manner, distributing to other leaves and to the roots...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29770748/the-effect-of-switching-protease-inhibitors-to-raltegravir-on-endothelial-function-in-hiv-infected-patients
#4
Maaike Krikke, Kiki Tesselaar, Guido E L van den Berk, Sigrid A Otto, Laura H Freriks, Steven F L van Lelyveld, Frank J L Visseren, Andy I M Hoepelman, Joop E Arends
Objective Lipid management is one of the cornerstones of cardiovascular risk reduction. Treatment of HIV infection with protease inhibitors (PIs) may cause dyslipidaemia, whilst the integrase inhibitor raltegravir (RAL) has a relatively favorable effect on plasma lipids. We examined the effect of switching from PIs to RAL on endothelial function, and its effect on immunological and inflammatory parameters. Methods We performed a 16-week open-label prospective crossover study: 8 weeks intervention (switch PIs to RAL) and 8 weeks control (unchanged cART regimen)...
April 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29768881/lipophilic-prodrug-of-floxuridine-loaded-into-solid-lipid-nanoparticles-in-vitro-cytotoxicity-studies-on-different-human-cancer-cell-lines
#5
Daniela Chirio, Elena Peira, Luigi Battaglia, Benedetta Ferrara, Alessandro Barge, Simona Sapino, Susanna Giordano, Chiara Dianzani, Marina Gallarate
Floxuridine is a very effective drug with high potency in the treatment of various tumors but its utility is limited by its low efficiency of cellular uptake. In order to improve the floxuridine efficiency of cellular uptake, lipophilic prodrug of floxuridine (3',5'-distearoyl-5-fluoro-2'-deoxyuridine) was synthetized and loaded into behenic acid nanoparticles produced by fatty acid coacervation technique. Generally, spherical shaped SLN with mean diameters below 300 nm were obtained. Distearoyl-floxuridine was loaded in SLN with high entrapment efficiency (from 70...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29762040/orally-bioavailable-and-effective-buparvaquone-lipid-based-nanomedicines-for-visceral-leishmaniasis
#6
Lindsay A Smith, Dolores Remedios Serrano, Marion Mauger, Francisco Bolás-Fernández, Maria Auxiliadora Dea-Ayuela, Aikaterini Lalatsa
Nano-enabled lipid based drug delivery systems offer a platform to overcome challenges encountered with current failed leads in the treatment of parasitic and infectious diseases. When prepared with FDA or EMA approved excipients, they can be readily translated without the need for further toxicological studies, while they remain affordable and amenable to scale-up. Buparvaquone (BPQ), a hydroxynapthoquinone with in vitro activity in the nanomolar range, failed to clinically translate as a viable treatment for visceral leishmaniasis due to its poor oral bioavailability limited by its poor aqueous solubility (BCS Class II drug)...
May 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29760047/nanoparticles-that-reshape-the-tumor-milieu-create-a-therapeutic-window-for-effective-t-cell-therapy-in-solid-malignancies
#7
Fan Zhang, Sirkka B Stephan, Chibawanye I Ene, Tyrel T Smith, Eric C Holland, Matthias T Stephan
A major obstacle to the success rate of chimeric antigen receptor (CAR-) T cell therapy against solid tumors is the microenvironment antagonistic to T cells that solid tumors create. Conventional checkpoint blockade can silence lymphocyte anti-survival pathways activated by tumors, but because they are systemic, these treatments disrupt immune homeostasis and induce autoimmune side effects. Thus, new technologies are required to remodel the tumor milieu without causing systemic toxicities. Here we demonstrate that targeted nanocarriers that deliver a combination of immune-modulatory agents can remove pro-tumor cell populations and simultaneously stimulate anti-tumor effector cells...
May 14, 2018: Cancer Research
https://www.readbyqxmd.com/read/29758547/ultrasound-assisted-gene-and-photodynamic-synergistic-therapy-with-multifunctional-foxa1-sirna-loaded-porphyrin-microbubbles-for-enhancing-therapeutic-efficacy-for-breast-cancer
#8
Ranran Zhao, Xiaolong Liang, Bo Zhao, Min Chen, Renfa Liu, Sujuan Sun, Xiuli Yue, Shumin Wang
To improve the non-invasive therapeutic efficacy for ER positive breast cancer (ER+ BC), we fabricated a multifunctional FOXA1 loaded porphyrin microbubble to combine photodynamic therapy (PDT) and gene therapy of FOXA1 knockdown (KD) with ultrasound targeted microbubble destruction (UTMD) technology under the guidance of contrast enhanced ultrasound (CEUS). Cationic porphyrin microbubbles (CpMBs) were firstly fabricated from a porphyrin grafted lipid with two cationic amino groups (PGL-NH2) and fluorocarbon inert gas of C3 F8 ...
May 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29757014/co-delivery-of-paclitaxel-and-tanespimycin-in-lipid-nanoparticles-enhanced-anti-gastric-tumor-effect-in-vitro-and-in-vivo
#9
Liang Ma, Dawei Yang, Zhaoxin Li, Xin Zhang, Lei Pu
Combined administration regimens are commonly used in cancer therapy to reduce cell toxicity and drug resistance. In this study, we use solid lipid nanoparticles (SLNs) as drug carriers and sought to investigate the effect of combined administration of paclitaxel (PTX) and tanespimycin (17-AAG) in gastric cancer. The SLNs loaded with paclitaxel and tanespimycin were prepared using the solvent injection method. The effect of encapsulated SLNs on cell viability and colony formation were measured in three human gastric cell lines...
May 14, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29752404/low-density-lipoprotein-receptor-related-protein-1-dysfunction-synergizes-with-dietary-cholesterol-to-accelerate-steatohepatitis-progression
#10
Allyson N Hamlin, Sivaprakasam Chinnarasu, Yinyuan Ding, Xunde Xian, Joachim Herz, Anja Jaeschke, David Y Hui
Reduced low density lipoprotein receptor-related protein-1 (LRP1) expression in the liver is associated with poor prognosis of liver cirrhosis and hepatocellular carcinoma.  Previous studies have shown that hepatic LRP1 deficiency exacerbates palmitate-induced steatosis and toxicity in vitro and also promotes high fat diet-induced hepatic insulin resistance and hepatic steatosis in vivo   The current study examined the impact of liver-specific LRP1 deficiency in disease progression to steatohepatitis.  hLrp1+/+ mice with normal LRP1 expression and hLrp1-/- mice with hepatocyte-specific LRP1 inactivation were fed a high fat-high cholesterol (HFHC) diet for 16 weeks...
May 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29748834/qbd-based-development-of-%C3%AE-linolenic-acid-potentiated-nanoemulsion-for-targeted-delivery-of-doxorubicin-in-dmba-induced-mammary-gland-carcinoma-in-vitro-and-in-vivo-evaluation
#11
Chandra Bhushan Tripathi, Poonam Parashar, Malti Arya, Mahendra Singh, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
Breast cancer is the most common cancer of occurrence in women and has the highest mortality incidence rate therein. The present study envisaged to develop doxorubicin (Dox) loaded folate functionalized nanoemulsion (NE) for profound therapeutic activity against mammary gland cancer. NE was prepared using pseudo-ternary phase diagrams utilizing α-linolenic acid (ALA) as lipid phase, to further enhance the anticancer potential of Dox. Box-Behnken design was employed to systematically develop the NE. Optimized NE (f-Dox-NE) was evaluated for in vitro and in vivo performance...
May 10, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29748577/reversible-glycosidic-switch-for-secure-delivery-of-molecular-nanocargos
#12
Pierre-Alain Burnouf, Yu-Lin Leu, Yu-Cheng Su, Kenneth Wu, Wei-Chi Lin, Steve R Roffler
Therapeutic drugs can leak from nanocarriers before reaching their cellular targets. Here we describe the concept of a chemical switch which responds to environmental conditions to alternate between a lipid-soluble state for efficient cargo loading and a water-soluble state for stable retention of cargos inside liposomes. A cue-responsive trigger allows release of the molecular cargo at specific cellular sites. We demonstrate the utility of a specific glycosidic switch for encapsulation of potent anticancer drugs and fluorescent compounds...
May 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/29738983/facile-synthesis-of-ph-responsive-polymersomes-based-on-lipidized-peg-for-intracellular-co-delivery-of-curcumin-and-methotrexate
#13
Manuela Curcio, Loredana Mauro, Giuseppina Daniela Naimo, Diana Amantea, Giuseppe Cirillo, Lorena Tavano, Ivan Casaburi, Fiore Pasquale Nicoletta, Carmen Alvarez-Lorenzo, Francesca Iemma
pH-responsive polymersomes were obtained by self-assembling of a carboxyl-terminated PEG amphiphile achieved via esterification of PEG diacid with PEG40stearate. The obtained vesicular systems had spherical shape and a mean diameter of 70 nm. The pH sensitivity was assessed by measuring the variations of particles mean diameter after incubation in media mimicking the physiological (pH 7.4) or tumor (pH 5.0) conditions, recording a significant increase of the vesicles dimensions at acidic pH. The ability of the polymersomes to carry both hydrophobic and hydrophilic drugs was evaluated by loading the vesicles with curcumin and methotrexate, respectively, obtaining high encapsulation efficiencies and pH-dependent release profiles...
April 27, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29737834/ph-controlled-liposomes-for-enhanced-cell-penetration-in-tumor-environment
#14
Michela Barattin, Andrea Mattarei, Anna Balasso, Cristina Paradisi, Laura Cantù, Elena Del Favero, Tapani Viitala, Francesca Mastrotto, Paolo Caliceti, Stefano Salmaso
An innovative pH-switchable colloidal system that can be exploited for site-selective anticancer drug delivery has been generated by liposomes decoration with a new novel synthetic non-peptidic oligo-Arginine cell-penetration enhancer (CPE) and a quenching PEGylated counterpart that detaches from the vesicle surface under the acidic conditions of tumors. The CPE module (Arg4-DAG) is formed by four arginine units conjugated to a first generation (G1) 2,2-bis(hydroxymethyl)propionic acid (bis-MPA)/2,2-bis(aminomethyl)propionic acid (bis-AMPA) polyester dendron terminating with 1,2-distearoyl-3-azidopropane for liposome bilayer insertion...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29736804/influence-of-fatty-acid-modification-on-uptake-of-lovastatin-loaded-reconstituted-high-density-lipoprotein-by-foam-cells
#15
Yun Yang, Ji Wang, Hongliang He, Wenli Zhang, Yuansheng Zhang, Jianping Liu
PURPOSE: Spherical reconstituted high density lipoprotein (rHDL) can target atherosclerotic lesions by the very low density lipoprotein (VLDL) receptor, which is seldom expressed in liver. By promoting this pathway, the targeting efficiency was hyphothesized to be improved due to avoiding undesired uptake in liver mediated by the scavenger receptor class B type I (SR-BI). In this study, how fatty acid modification in spherical rHDL influenced the VLDL receptor-mediated endocytosis pathway was investigated...
May 7, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29734808/enhanced-glioblastoma-targeting-ability-of-carfilzomib-enabled-by-d-a7r-modified-lipid-nanodisk
#16
Mingfei Zhang, Linwei Lu, Man Ying, Huitong Ruan, Xiaoyi Wang, Huan Wang, Zhilan Chai, Songli Wang, Changyou Zhan, Jun Pan, Weiyue Lu
The robust proliferation of tumors relies on rich neovasculature for nutrients supply. Therefore, a basic strategy of tumor targeting therapy should include not only killing regular cancer cells but also blocking tumor neovasculature. D-peptide DA7R, which was previously reported to specifically bind vascular endothelial growth factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1), could achieve the goal of multi-targets recognition. Accordingly, the main purposes of this work were to establish a carfilzomib loaded lipid nanodisk modified with multifunctional peptide DA7R (DA7R-ND/CFZ) and to evaluate its anti-glioblastoma efficacy in vitro and in vivo...
May 7, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29734771/a-method-for-efficient-loading-of-ciprofloxacin-hydrochloride-in-cationic-solid-lipid-nanoparticles-formulation-and-microbiological-evaluation
#17
Rosario Pignatello, Antonio Leonardi, Virginia Fuochi, Giulio Petronio Petronio, Antonio S Greco, Pio Maria Furneri
The aim of the study was the production of solid lipid nanoparticles (SLN) loaded with ciprofloxacin (CIP) through two different production techniques, quasi-emulsion solvent diffusion (QESD) and solvent injection (SI). In order to efficaciously entrap the commercial salt form (hydrochloride) of the antibiotic in these lipid systems, a conversion of CIP hydrochloride to the free base was realized in situ, through the addition of triethylamine. To ensure physical stability to the carriers over time and ameliorate the interaction with bacterial cell membranes, positively charged SLN were produced by addition of the cationic lipid didecyldimethylammonium bromide (DDAB)...
May 6, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29734420/the-complementary-effect-of-cholesterol-and-vitamin-e-preloaded-in-cyclodextrins-on-frozen-bovine-semen-motility-parameters-membrane-integrity-and-lipid-peroxidation
#18
A Khellouf, K Benhenia, S Fatami, M Iguer-Ouada
BACKGROUND: During cryopreservation sperm cells suffer from two major deleterious impacts: oxidative stress and cold shock. OBJECTIVE: To investigate in bovine species the benefit of cholesterol and vitamin E, both loaded in cyclodextrins, as a double protection against oxidative stress and cold shock. MATERIALS AND METHODS: Semen was collected from nine mature bulls using an artificial vagina and each ejaculate was split into four equal aliquots...
March 2018: Cryo Letters
https://www.readbyqxmd.com/read/29732970/development-of-curcumin-loaded-solid-lipid-nanoparticles-utilizing-glyceryl-monostearate-as-single-lipid-using-qbd-approach-characterization-and-evaluation-of-anticancer-activity-against-human-breast-cancer-cell-line
#19
Himanshu Bhatt, Sri Vishnu Kiran Rompicharla, Neeraja Komanduri, Aashma Shah, Sateja Paradkar, Balaram Ghosh, Swati Biswas
BACKGROUND: Solid lipid nanoparticles (SLNs) represent an affordable, easily scalable, stable and biocompatible drug delivery system with a high drug to lipid ratio which also improves solubility of poorly soluble drugs. OBJECTIVE: SLNs were developed by using glyceryl monostearate as the single lipid in presence of surfactant Poloxamer 188 and evaluated the efficiency of the SLNs to load the therapeutic cargo, curcumin (CUR). METHOD: The nano-formulation was optimized by Quality by Design approach to understand the effect of various process parameters on various quality attributes, including drug loadability, particle size and polydispersity...
May 3, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29732888/nanoencapsulation-of-cyanidin-3-o-glucoside-enhances-protection-against-uvb-induced-epidermal-damage-through-regulation-of-p53-mediated-apoptosis-in-mice
#20
Zhaohan Liu, Yunfeng Hu, Xia Li, Zhouxiong Mei, Shi Wu, Yong He, Xinwei Jiang, Jianxia Sun, Jianbo Xiao, Liehua Deng, Weibin Bai
Excess ultraviolet (UV) radiation causes numerous forms of skin damage. The aim of the present study was to assess and compare the photoprotective effects of cyanidin-3-O-glucoside (C3G) alone and encapsulated in chitosan nanoparticles (Nano-C3G) in a UVB-induced acute photodamage mouse model. Nano-C3G was developed from chitosan and sodium tripolyphosphate (TPP) by ionic gelation. The particle size, zeta potential, entrapment efficiency, drug loading, and in vitro release in 6 days were determined. Kunming (KM) mice were treated with Nano-C3G (125, 250, 500 µM) or C3G (500 µM) after part of the dorsal skin area was dehaired, and then exposed to 2 J/cm2 of UVB...
May 7, 2018: Journal of Agricultural and Food Chemistry
keyword
keyword
35845
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"