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https://www.readbyqxmd.com/read/28213094/aspirin-triggered-resolvin-d1-modified-materials-promote-the-accumulation-of-pro-regenerative-immune-cell-subsets-and-enhance-vascular-remodeling
#1
Mary Caitlin P Sok, Maxianne C Tria, Claire E Olingy, Cheryl L San Emeterio, Edward A Botchwey
: Many goals in tissue engineering rely on modulating cellular localization and polarization of cell signaling, including the inhibition of inflammatory infiltrate, facilitation of inflammatory cell egress, and clearance of apoptotic cells. Omega-3 polyunsaturated fatty acid-derived resolvins are gaining increasing recognition for their essential roles in inhibition of neutrophil invasion into inflamed tissue and promotion of macrophage phagocytosis of cellular debris as well as their egress to the lymphatics...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28208831/resveratrol-and-grape-extract-loaded-solid-lipid-nanoparticles-for-the-treatment-of-alzheimer-s-disease
#2
Joana A Loureiro, Stephanie Andrade, Ana Duarte, Ana Rute Neves, Joana Fontes Queiroz, Cláudia Nunes, Emmanuel Sevin, Laurence Fenart, Fabien Gosselet, Manuel A N Coelho, Maria Carmo Pereira
The aggregation of amyloid-β peptide (Aβ) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer's disease (AD). Various natural compounds have been suggested as therapeutics for AD. Among these compounds, resveratrol has aroused great interest due to its neuroprotective characteristics. Here, we provide evidence that grape skin and grape seed extracts increase the inhibition effect on Aβ aggregation. However, after intravenous injection, resveratrol is rapidly metabolized into both glucuronic acid and sulfate conjugations of the phenolic groups in the liver and intestinal epithelial cells (within less than 2 h), which are then eliminated...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28203076/light-triggered-liposomal-cargo-delivery-platform-incorporating-photosensitizers-and-gold-nanoparticles-for-enhanced-singlet-oxygen-generation-and-increased-cytotoxicity
#3
Zofia Kautzka, Sandhya Clement, Ewa M Goldys, Wei Deng
We developed light-triggered liposomes incorporating 3-5 nm hydrophobic gold nanoparticles and Rose Bengal (RB), a well-known photosensitizer used for photodynamic therapy. Singlet oxygen generated by these liposomes with 532 nm light illumination was characterized for varying the molar ratio of lipids and gold nanoparticles while keeping the amount of RB constant. Gold nanoparticles were found to enhance the singlet oxygen generation rate, with a maximum enhancement factor of 1.75 obtained for the molar ratio of hydrogenated soy l-α-phosphatidylcholine:1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(hexanoylamine):gold of 57:5:17 compared with liposomes loaded with RB alone...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28199887/killing-colon-cancer-cells-through-pcd-pathways-by-a-novel-hyaluronic-acid-modified-shell-core-nanoparticle-loaded-with-rip3-in-combination-with-chloroquine
#4
Xueyan Hou, Chengli Yang, Lijing Zhang, Tingting Hu, Dan Sun, Hua Cao, Fan Yang, Gang Guo, Changyang Gong, Xiaoning Zhang, Aiping Tong, Rui Li, Yu Zheng
Due to extensive apoptosis defects and multidrug resistance, there is great interest regarding non-apoptotic programmed cell death (PCD) pathways, such as lysosomal-mediated programmed cell death (LM-PCD), necroptosis and autophagy. Because there is an intricate effector network among these PCD pathways, it is expected that they may act synergistically in cancer therapy. In this study, chloroquine (CQ) was found to significantly upregulate receptor-interacting protein kinase 3 (RIP3) expression, and RIP3 were involved in CQ-related autophagy...
January 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28197373/systemic-activation-of-antigen-presenting-cells-via-rna-loaded-nanoparticles
#5
Elias J Sayour, Gabriel De Leon, Christina Pham, Adam Grippin, Hanna Kemeny, Joshua Chua, Jianping Huang, John H Sampson, Luis Sanchez-Perez, Catherine Flores, Duane A Mitchell
While RNA-pulsed dendritic cell (DC) vaccines have shown promise, the advancement of cellular therapeutics is fraught with developmental challenges. To circumvent the challenges of cellular immunotherapeutics, we developed clinically translatable nanoliposomes that can be combined with tumor-derived RNA to generate personalized tumor RNA-nanoparticles (NPs) with considerable scale-up capacity. RNA-NPs bypass MHC restriction, are amenable to central distribution, and can provide near immediate immune induction...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28196351/fabrication-and-functional-attributes-of-lipidic-nanoconstructs-of-lycopene-an-innovative-endeavour-for-enhanced-cytotoxicity-in-mcf-7-breast-cancer-cells
#6
Ashay Jain, Gajanand Sharma, Varun Kushwah, Kanika Thakur, Gargi Ghoshal, Bhupinder Singh, Sanyog Jain, U S Shivhare, O P Katare
The present study investigates the anticancer efficacy of lycopene loaded lipidic nanostructured particles. With a homogenization-evaporation technique, lycopene loaded solid lipid nanoparticles (LYC-SLNs) were fabricated with different ratios of biocompatible viz. compritol ATO 888 and gelucire, and evaluated for their micromeretics properties, in vitro release, in vitro cytotoxicity, cellular uptake and apoptosis induced in MCF-7 cells. Effects of anticancer potential of LYC-SLNs on the efficacy of methotrexate (MTX), a well-established anticancer agent, was evaluated thereafter...
February 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28193860/investigations-of-human-myosin-vi-targeting-using-optogenetically-controlled-cargo-loading
#7
Alexander R French, Tobin R Sosnick, Ronald S Rock
Myosins play countless critical roles in the cell, each requiring it to be activated at a specific location and time. To control myosin VI with this specificity, we created an optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa phototropin1 LOV2 domain to a peptide from Dab2 (LOVDab), a myosin VI cargo protein. Our approach harnesses the native targeting and activation mechanism of myosin VI, allowing direct inferences on myosin VI function. LOVDab robustly recruits human full-length myosin VI to various organelles in vivo and hinders peroxisome motion in a light-controllable manner...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28190740/protective-efficacy-of-a-lipid-antigen-vaccine-in-a-guinea-pig-model-of-tuberculosis
#8
Gérald Larrouy-Maumus, Emilie Layre, Simon Clark, Jacques Prandi, Emma Rayner, Marco Lepore, Gennaro de Libero, Ann Williams, Germain Puzo, Martine Gilleron
The bacillus Calmette Guérin (BCG) vaccine, the only licensed vaccine against TB, displays partial and variable efficacy, thus making the exploitation of novel vaccination strategies a major priority. Most of the current vaccines in pre-clinical or clinical development are based on the induction of T cells recognizing protein antigens. However, a large number of T cells specific for mycobacterial lipids are induced during infection, suggesting that lipid-based vaccines might represent an important component of novel sub-unit vaccines...
February 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28187243/arginine-modified-nanostructured-lipid-carriers-with-charge-reversal-and-ph-sensitive-membranolytic-properties-for-anticancer-drug-delivery
#9
Minjie Sun, Jing Li, Cuiting Zhang, Ying Xie, Hongzhi Qiao, Zhigui Su, David Oupický, Qineng Ping
The ability to escape endo/lysosomal trafficking is critically important to prevent entrapment of nanomedicines in lysosomes and to achieve maximum therapeutic efficacy of drugs delivered to cells through endocytosis. In this study, a novel pH-sensitive chitosan carrier with the ability to reverse its charge during endo/lysosomal trafficking is developed as a way of improving lysosomal disruption. N-Arginine-N-octyl chitosan (AOCS) is synthesized by grafting l-arginine onto carboxymethyl chitosan. The AOCS is used to modify the surface of nanostructured lipid carriers (NLC) to prepare pH-sensitive charge-reversal lysosomolytic nanocarriers (ANLC)...
February 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28186465/solid-lipid-nanoparticles-by-coacervation-loaded-with-a-methotrexate-prodrug-preliminary-study-for-glioma-treatment
#10
Luigi Battaglia, Elisabetta Muntoni, Daniela Chirio, Elena Peira, Laura Annovazzi, Davide Schiffer, Marta Mellai, Chiara Riganti, Iris Chiara Salaroglio, Michele Lanotte, Pierpaolo Panciani, Maria Teresa Capucchio, Alberto Valazza, Elena Biasibetti, Marina Gallarate
AIM: Methotrexate-loaded biocompatible nanoparticles were tested for preliminary efficacy in glioma treatment. MATERIALS & METHODS: Behenic acid nanoparticles, prepared by the coacervation method, were loaded with the ester prodrug didodecylmethotrexate, which was previously tested in vitro against glioblastoma human primary cultures. Nanoparticle conjugation with an ApoE mimicking chimera peptide was performed to obtain active targeting to the brain. RESULTS & CONCLUSION: Biodistribution studies in healthy rats assessed the superiority of ApoE-conjugated formulation, which was tested on an F98/Fischer glioma model...
February 10, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28181464/physicochemical-characterization-of-chitosan-hyaluronan-coated-solid-lipid-nanoparticles-for-the-targeted-delivery-of-paclitaxel-a-proof-of-concept-study-in-breast-cancer-cells
#11
Javier Campos, Manuel Varas-Godoy, Ziyad Samir Haidar
AIM: To investigate the potential of modified solid lipid nanoparticles (SLN) for the delivery of paclitaxel (PAX). MATERIALS & METHODS: SLN loaded with PAX were prepared via modified high-pressure hot homogenization. Formulation parameters were optimized to obtain a high-quality delivery system. SLN cores were coated, layer-by-layer, with a chitosan and hyaluronan (HA) shell. Selectivity toward HA receptors was tested in a breast cancer cell line, MCF-7. RESULTS: Stable and reproducible nano-sized and negatively charged nanoparticles resulted...
February 9, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28167424/construction-of-near-infrared-light-triggered-nanodumbbell-for-cancer-photodynamic-therapy
#12
Beibei Hou, Bin Zheng, Weitao Yang, Chunhong Dong, Hanjie Wang, Jin Chang
The application of photodynamic therapy (PDT) in deep tissue has been severely restricted by the poor photosensitizers loading and tissue-penetration of visible light for exciting the photosensitizers. How to prepare a nanocarrier with high drug loading amount and remote controllability still remains the challenge. In this article, a novel drug delivery system nanodumbbell was designed. The nanodumbbell was assembled from the hydrophobic upconverting nanoparticle (UCN) core and hydrophilic polymersome shell...
May 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28167390/hyper-cell-permeable-micelles-as-a-drug-delivery-carrier-for-effective-cancer-therapy
#13
Phei Er Saw, Mikyung Yu, Minsuk Choi, Eunbeol Lee, Sangyong Jon, Omid C Farokhzad
Although PEGylated liposomes (PEG-LS) have been intensively studied as drug-delivery vehicles, the rigidity and the hydrophilic PEG corona of liposomal membranes often limits cellular uptake, resulting in insufficient drug delivery to target cells. Thus, it is necessary to develop a new type of lipid-based self-assembled nanoparticles capable of enhanced cellular uptake, tissue penetration, and drug release than conventional PEGylated liposomes. Herein, we describe a simple modification of bicellar formulation in which the addition of a PEGylated phospholipid produced a dramatic physicochemical change in morphology, i...
January 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/28167263/asialoglycoprotein-receptor-targeted-liposomes-loaded-with-a-norcantharimide-derivative-for-hepatocyte-selective-targeting
#14
Xiaolin Liu, Mengting Han, Jiawen Xu, Sicong Geng, Yu Zhang, Xaohui Ye, Jingxin Gou, Tian Yin, Haibing He, Xing Tang
In order to overcome the shortcomings associated with the clinical application of norcantharidin (NCTD), including intense irritation and a short half-life, and to obtain a hepatocyte-selective liposome system with high encapsulation efficiency (EE) and low leakage, we synthesized a C14 alkyl chain norcantharimide derivative of NCTD (2-tetradecylhexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione, N-14NCTDA). Asialoglycoprotein receptor-targeted, galactosylated liposomes loaded with N-14NCTDA (GAL-Lipo) were prepared by the lipid film hydration method...
February 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28165858/plga-nanoparticles-for-the-oral-delivery-of-nuciferine-preparation-physicochemical-characterization-and-in-vitro-in-vivo-studies
#15
Ying Liu, Xin Wu, Yushuai Mi, Bimeng Zhang, Shengying Gu, Gaolin Liu, Xiaoyu Li
This article reports a promising approach to enhance the oral delivery of nuciferine (NUC), improve its aqueous solubility and bioavailability, and allow its controlled release as well as inhibiting lipid accumulation. NUC-loaded poly lactic-co-glycolic acid nanoparticles (NUC-PLGA-NPs) were prepared according to a solid/oil/water (s/o/w) emulsion technique due to the water-insolubility of NUC. PLGA exhibited excellent loading capacity for NUC with adjustable dosing ratios. The drug loading and encapsulation efficiency of optimized formulation were 8...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165821/successful-delivery-of-docetaxel-to-rat-brain-using-experimentally-developed-nanoliposome-a-treatment-strategy-for-brain-tumor
#16
Tapan Kumar Shaw, Dipika Mandal, Goutam Dey, Murari Mohan Pal, Paramita Paul, Samrat Chakraborty, Kazi Asraf Ali, Biswajit Mukherjee, Amal Kumar Bandyopadhyay, Mahitosh Mandal
Docetaxel (DTX) is found to be very effective against glioma cell in vitro. However, in vivo passage of DTX through BBB is extremely difficult due to the physicochemical and pharmacological characteristics of the drug. No existing formulation is successful in this aspect. Hence, in this study, effort was made to send DTX through blood-brain barrier (BBB) to brain to treat diseases such as solid tumor of brain (glioma) by developing DTX-loaded nanoliposomes. Primarily drug-excipients interaction was evaluated by FTIR spectroscopy...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165814/targeting-delivery-of-simvastatin-using-icam-1-antibody-conjugated-nanostructured-lipid-carriers-for-acute-lung-injury-therapy
#17
Shu-Juan Li, Xiao-Juan Wang, Jing-Bo Hu, Xu-Qi Kang, Li Chen, Xiao-Ling Xu, Xiao-Ying Ying, Sai-Ping Jiang, Yong-Zhong Du
Acute lung injury (ALI) is a critical illness without effective therapeutic modalities currently. Recent studies indicated potential efficacy of statins for ALI, while high-dose statins was suggested to be significant for attenuating inflammation in vivo. Therefore, a lung-targeted drug delivery system (DDS) delivering simvastatin (SV) for ALI therapy was developed, attempting to improve the disease with a decreased dose and minimize potential adverse effects. SV-loaded nanostructured lipid carriers (SV/NLCs) with different size were prepared primarily...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165811/nanoemulsion-for-improving-solubility-and-permeability-of-vitex-agnus-castus-extract-formulation-and-in-vitro-evaluation-using-pampa-and-caco-2-approaches
#18
Vieri Piazzini, Elena Monteforte, Cristina Luceri, Elisabetta Bigagli, Anna Rita Bilia, Maria Camilla Bergonzi
The purpose of this study was to develop new formulation for an improved oral delivery of Vitex agnus-castus (VAC) extract. After the optimization and validation of analytical method for quali-quantitative characterization of extract, nanoemulsion (NE) was selected as lipid-based nanocarrier. The composition of extract-loaded NE resulted in triacetin as oil phase, labrasol as surfactant, cremophor EL as co-surfactant and water. NE contains until 60 mg/mL of extract. It was characterized by DLS and TEM analyses and its droplets appear dark with an average diameter of 11...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165548/enhanced-antitumor-efficacy-of-resveratrol-loaded-nanocapsules-in-colon-cancer-cells-physicochemical-and-biological-characterization
#19
M Feng, L-X Zhong, Z-Y Zhan, Z-H Huang, J-P Xiong
OBJECTIVE: The aim of present work was to prepare resveratrol-loaded lipid-core-nanocapsule (RSV-LNC) and to characterize its ability to target the colon cancer cells. MATERIALS AND METHODS: The lipid-core nanocapsule was prepared by precipitation method. The nanoparticle was prepared and evaluated regarding physical, chemical and biological parameters. RESULTS: The average size of optimized nanocapsule was ~159 nm with a uniform size distribution index of 0...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28161466/cmrna-lipoplex-encapsulation-in-plga-microspheres-enables-transfection-via-calcium-phosphate-cement-cpc-plga-composites
#20
Maximilian Utzinger, Anita Jarzebinska, Nicolas Haag, Martin Schweizer, Gerhard Winter, Christian Dohmen, Carsten Rudolph, Christian Plank
In this study lipoplexes containing chemically modified messenger RNA (cmRNA) were incorporated into poly (lactic-co-glycolic acid) (PLGA) microspheres via water-in-oil-in-water (W/O/W) double emulsion solvent evaporation technique. The nanoparticle encapsulation by microparticle formation was optimized to achieve lipoplex release and maximum transfection efficiency in surrounding cells. It was possible to adjust characteristic features in surface topology and size of the PLGA-microspheres by varying the extent of lipoplex loading into the polymer matrix...
February 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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