keyword
MENU ▼
Read by QxMD icon Read
search

Beta3

keyword
https://www.readbyqxmd.com/read/28877454/a-stat6-pten-axis-links-regulatory-t-cells-with-adipose-tissue-function
#1
Stefanie Kälin, Maike Becker, Verena B Ott, Isabelle Serr, Fabian Hosp, Mohammad M H Mollah, Susanne Keipert, Daniel Lamp, Francoise Rohner-Jeanrenaud, Victoria K Flynn, Martin G Scherm, Lucas F R Nascimento, Katharina Gerlach, Vanessa Popp, Sarah Dietzen, Tobias Bopp, Purna Krishnamurthy, Mark H Kaplan, Manuel Serrano, Stephen C Woods, Philipp Tripal, Ralf Palmisano, Martin Jastroch, Matthias Blüher, Christian Wolfrum, Benno Weigmann, Anette-Gabriele Ziegler, Matthias Mann, Matthias H Tschöp, Carolin Daniel
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction...
September 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28860979/childhood-trauma-associated-with-enhanced-high-frequency-band-powers-and-induced-subjective-inattention-of-adults
#2
Seung-Hwan Lee, Yeonsoo Park, Min Jin Jin, Yeon Jeong Lee, Sang Woo Hahn
Childhood trauma can lead to various psychological and cognitive symptoms. It has been demonstrated that high frequency electroencephalogram (EEG) powers could be closely correlated with inattention. In this study, we explored the relationship between high frequency EEG powers, inattention, symptoms of adult attention deficit hyperactivity disorder (ADHD), and childhood traumatic experiences. A total of 157 healthy Korean adult volunteers were included and divided into two groups using the Childhood Trauma Questionnaire (CTQ) score...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28774775/mir-15a-16-inhibits-tgf-beta3-vegf-signaling-and-increases-retinal-endothelial-cell-barrier-proteins
#3
Eun-Ah Ye, Li Liu, Jena J Steinle
Hyperglycemia is a significant risk factor for diabetic retinopathy and induces multiple biochemical changes, including inflammation and endothelial dysfunction in the retina. Alterations in microRNA expression have been implicated in the pathological responses of diabetic retinopathy and the manipulation of microRNA may provide powerful strategy for therapeutics. Among the predicted targets of miR-15a and -16 are TGF-beta3, SMAD2/3, and VEGF, all of which are known to play a role in vascular endothelial functions...
July 31, 2017: Vision Research
https://www.readbyqxmd.com/read/28723418/beta3-adrenergic-receptor-stimulation-in-human-macrophages-inhibits-nadphoxidase-activity-and-induces-catalase-expression-via-ppar%C3%AE-activation
#4
Tarik Hadi, Romain Douhard, Alexandre M M Dias, Maeva Wendremaire, Maria Pezzè, Marc Bardou, Paul Sagot, Carmen Garrido, Frédéric Lirussi
The beta3 adrenergic receptor (β3-AR) stimulation plays a protective role against preterm labor by blocking myometrial contraction, cytokine production, remodeling and apoptosis. We previously demonstrated that macrophage-induced ROS production in the myometrium was a key element leading to the induction of all these labor-associated features. We thus aimed to investigate if the β3-AR could be expressed in human macrophages and could trigger its protective role in the myometrium by directly inhibiting ROS production...
July 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28667462/the-evaluation-of-cartilage-differentiations-using-transforming-growth-factor-beta3-alone-and-with-combination-of-bone-morphogenetic-protein-6-on-adult-stem-cells
#5
C C Ude, H C Chen, M Y Norhamdan, B M Azizi, B S Aminuddin, B H I Ruszymah
In our quest to standardize our formula for a clinical trial, transforming growth factor-beta3 (TGF-β3) alone and in combination with bone morphogenetic protein-6 (BMP-6) were evaluated for their effectiveness in cartilage differentiation. Bone Marrow Stem Cells (BMSCs) and Adipose Derived Stem Cells (ADSCs) were induced to chondrogenic lineage using two different media. Native chondrocytes served as positive control. ADSCs and BMSCs proved multipotency by tri-lineage differentiations. ADSC has significantly higher growth kinetics compare to Chondrocyte only p ≤ 0...
June 30, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28652806/characterization-of-cortical-source-generators-based-on-electroencephalography-during-tonic-pain
#6
Tine Maria Hansen, Esben Bolvig Mark, Søren Schou Olesen, Mikkel Gram, Jens Brøndum Frøkjær, Asbjørn Mohr Drewes
OBJECTIVE: The aim of the present study was to characterize the cortical source generators evoked by experimental tonic pain. METHODS: Electroencephalography (EEG) was recorded on two separate days during rest and with immersion of the hand in ice water for 2 minutes (cold pressor test). Exact low-resolution brain electromagnetic tomography source localization was performed in 31 healthy volunteers to characterize the cortical source generators. RESULTS: Reliability was high in all eight frequency bands during rest and cold pressor conditions (intraclass coefficients =0...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28602143/mutation-in-the-beta3-subunit-of-guanine-nucleotide-binding-protein-gnb3-gene-is-not-associated-with-type-ii-diabetes-mellitus-risk-a-case-control-study-of-a-north-indian-population
#7
Saliha Rizvi, Syed Tasleem Raza, Qamar Rahman, Farzana Mahdi, Zeashan Haider Zaidi, Alina Zaidi
CONTEXT: Genetics play major role in development and pathophysiology of Type 2 diabetes mellitus (T2DM). OBJECTIVE: To asses association of GNB3 (C825T) gene's polymorphism with T2DM. MATERIALS AND METHODS: A case-control study including 400 North Indians was performed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) approach to analyze genetic polymorphism. RESULTS: No significant difference was observed in genotype and allele frequencies of GNB3 gene on comparing cases with controls...
June 12, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28421794/relation-of-trp64arg-polymorphism-of-beta-3-adrenoreceptor-gene-with-metabolic-syndrome-and-insulin-resistance-in-obese-women
#8
Daniel Antonio De Luis Román, David Primo, Olatz Izaola, Rocío Aller
BACKGROUND AND AIM: Trp64Arg variant in beta 3 adrenoreceptor has been reported to be associated with increased body weight and insulin resistance. These risk factors are the ones that make up the so-called metabolic syndrome. The aim of our study was to investigate the relationship between metabolic syndrome and Trp64Arg polymorphism in the beta3 adrenoreceptor gene in obese women. METHODS: A population of 531 obese women was analyzed in cross-sectional survey...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28369516/comprehensive-chromosome-screening-and-gene-expression-analysis-from-the-same-biopsy-in-human-preimplantation-embryos
#9
Diego Marin, Yujue Wang, Xin Tao, Richard T Scott, Nathan R Treff
STUDY QUESTION: Can simultaneous comprehensive chromosome screening (CCS) and gene expression analysis be performed on the same biopsy of preimplantation human embryos? SUMMARY ANSWER: For the first time, CCS and reliable gene expression analysis have been performed on the same human preimplantation embryo biopsy. WHAT IS KNOWN ALREADY: A single trophectoderm (TE) biopsy is routinely used for many IVF programs offering CCS for selection of only chromosomally normal embryos for transfer...
May 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28198065/cardiac-beta3-adrenergic-receptors-in-the-clinical-arena-the-end-of-the-beginning
#10
EDITORIAL
Jean-Luc Balligand
No abstract text is available yet for this article.
April 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28120428/influence-of-random-and-oriented-electrospun-fibrous-poly-lactic-co-glycolic-acid-scaffolds-on-neural-differentiation-of-mouse-embryonic-stem-cells
#11
Laura E Sperling, Karina P Reis, Laura G Pozzobon, Carolina S Girardi, Patricia Pranke
Engineering neural tissue by combining biodegradable materials, cells and growth factors is a promising strategy for the treatment of central and peripheral nervous system injuries. In this study, neural differentiation of mouse embryonic stem cells (mESCs) was investigated in combination with three dimensional (3D) electrospun nanofibers as a substitute for the extracellular matrix (ECM). Nano/microfibrous poly(lactic-co-glycolic acid) (PLGA) 3D scaffolds were fabricated through electrospinning and characterized...
May 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28067546/association-of-g-protein-beta3-subunit-gene-c825t-polymorphism-with-cardiac-and-cerebrovascular-events-in-chinese-hypertensive-patients
#12
Weiwei Zhu, Jing Li, Xipeng Sun, Qi Hua
Several recent studies showed that C825T polymorphism is related to cardiovascular diseases in normal population. However, studies on whether 825T allele influences the incidence of cardiovascular diseases in hypertensive patients are rare. In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28002512/pharmacotoxicological-screening-on-new-derivatives-of-beta-phenylethylamine-potential-agonists-of-beta3-adrenergic-receptors
#13
Simona Negreş, Anca Zanfirescu, Floriana Elvira Ionică, Elena Moroşan, Bruno Ştefan Velescu, Oana Cristina Şeremet, Cristina Elena Zbârcea, Emil Ştefănescu, Manuella Militaru, Andreea LetiŢia Arsene, Denisa Marilena Margină, Livia Uncu, Corina Scutari, Cornel ChiriŢă
BACKGROUND AND AIMS: Beta3-adrenergic receptors (beta3-ARs) have been initially characterized in 1989. Afterwards, their tissue distribution was established: white and brown adipose tissue, central nervous system, myocardium (atrial and ventricular), blood vessels, smooth gastrointestinal muscles (stomach, small intestine, colon), gallbladder, urinary bladder, prostate, skeletal muscles. Non-clinical trials have demonstrated the major implication of beta3-ARs in glucose metabolism, implicitly, in insulin release, and also in obesity...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27990717/the-first-in-man-randomized-trial-of-a-beta3-adrenoceptor-agonist-in-chronic-heart-failure-the-beat-hf-trial
#14
Henning Bundgaard, Anna Axelsson, Jakob Hartvig Thomsen, Mathias Sørgaard, Klaus F Kofoed, Rasmus Hasselbalch, Natasha A S Fry, Nana Valeur, Søren Boesgaard, Finn Gustafsson, Lars Køber, Kasper Iversen, Helge H Rasmussen
AIMS: The third isotype of beta adrenergic receptors (β3 ARs) has distinctly different effects on cardiomyocytes compared with β1 and β2 ARs. Stimulation of β3 ARs may reduce cardiomyocyte Na(+) overload and reduce oxidative stress in heart failure (HF). We examined if treatment with the β3 AR agonist mirabegron increases LVEF in patients with HF. METHODS AND RESULTS: In a double-blind trial we randomly assigned 70 patients with NYHA class II-III HF and LVEF <40% at screening-echocardiography to receive mirabegron or placebo for 6 months as add-on to optimized standard therapy...
April 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27986616/thermogenesis-fatty-acid-synthesis-with-oxidation-and-inflammation-in-the-brown-adipose-tissue-of-ob-ob-mice
#15
Fabiane Ferreira Martins, Thereza Cristina Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Brown adipose tissue (BAT) is specialized in heat production, but its metabolism in ob/ob mice is still a matter of debate. We aimed to verify ob/ob mice BAT using C57Bl/6 male mice (as the wild-type, WT) and leptin-deficient ob/ob mice (on the C57Bl/6 background strain), at three months of age (n=10/group). At euthanasia, animals had their interscapular BAT weighed, and prepared for analysis (Western blot, and RT-qPCR). In comparison with the WT group, the ob/ob group showed reduced thermogenic signaling markers (gene expression of beta 3-adrenergic receptor, beta3-AR; PPARgamma coactivator 1 alpha, PGC1alpha, and uncoupling protein 1, UCP1)...
March 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27965369/pharmacological-characterization-of-a-novel-beta-3-adrenergic-agonist-vibegron-evaluation-of-antimuscarinic-receptor-selectivity-for-combination-therapy-for-overactive-bladder
#16
J Di Salvo, H Nagabukuro, L A Wickham, C Abbadie, J A DeMartino, A Fitzmaurice, L Gichuru, A Kulick, M J Donnelly, N Jochnowitz, A L Hurley, A Pereira, A Sanfiz, G Veronin, K Villa, J Woods, B Zamlynny, E Zycband, G M Salituro, T Frenkl, A E Weber, S D Edmondson, M Struthers
Although the physiologic role of muscarinic receptors in bladder function and the therapeutic efficacy of muscarinic antagonists for the treatment of overactive bladder are well established, the role of β3-adrenergic receptors (β3ARs) and their potential as therapeutics is just emerging. In this manuscript, we characterized the pharmacology of a novel β3AR agonist vibegron (MK-4618, KRP-114V) and explored mechanistic interactions of β3AR agonism and muscarinic antagonism in urinary bladder function. Vibegron is a potent, selective full β3AR agonist across species, and it dose dependently increased bladder capacity, decreased micturition pressure, and increased bladder compliance in rhesus monkeys...
February 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27896223/urokinase-type-plasminogen-activator-receptor-upar-as-a-new-therapeutic-target-in-cancer
#17
Nunzia Montuori, Ada Pesapane, Francesca W Rossi, Valentina Giudice, Amato De Paulis, Carmine Selleri, Pia Ragno
The urokinase (uPA)-type plasminogen activator receptor (uPAR) is a GPI-anchored receptor that focuses urokinase (uPA) proteolytic activity on the cell surface. uPAR also regulates cell adhesion, migration and proliferation, protects from apoptosis and contributes to epithelial mesenchymal transition (EMT), independently of uPA enzymatic activity. Indeed, uPAR interacts with beta1, beta2 and beta3 integrins, thus regulating their activities. uPAR cross-talks with receptor tyrosine kinases through integrins and regulates cancer cell dormancy, proliferation and angiogenesis...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27883117/combination-therapies-for-improved-management-of-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#18
REVIEW
C De Nunzio, F Presicce, A Tubaro
Several urological and non-urological conditions can contribute to the onset of lower urinary tract symptoms (LUTS), including benign prostatic hyperplasia (BPH), which is one of the main underlying causes in male patients. Six pharmacological classes (alpha-adrenoceptor blockers [ABs], 5alpha-reductase inhibitors [5ARIs], phytotherapeutics, antimuscarinics [AMs], beta3-adrenoceptor agonists and phosphodiesterase type 5 inhibitors [PDE5Is]) are available, alone or in combination, for the treatment of male LUTS...
September 2016: Drugs of Today
https://www.readbyqxmd.com/read/27822038/rgd-conjugated-mesoporous-silica-encapsulated-gold-nanorods-enhance-the-sensitization-of-triple-negative-breast-cancer-to-megavoltage-radiation-therapy
#19
Ning Zhao, Zhangru Yang, Bingxin Li, Jin Meng, Zeliang Shi, Ping Li, Shen Fu
Multifunctional nanoprobes have great potential as effective radiosensitizers and drug carriers. RGD-modified gold nanorods could increase the uptake of nanoparticles via receptor-mediated endocytosis in integrin alphaV beta3-overexpressing breast cancer cells, which could enhance the effects of radiation on tumor cells, leading to further radiosensitization. The purpose of our study was to demonstrate that RGD-conjugated mesoporous silica-encapsulated gold nanorods significantly enhanced the sensitization of triple-negative breast cancer to megavoltage energy...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27816783/default-mode-network-activation-and-transcendental-meditation-practice-focused-attention-or-automatic-self-transcending
#20
Frederick Travis, Niyazi Parim
This study used subjective reports and eLORETA analysis to assess to what extent Transcendental Meditation (TM) might involve focused attention-voluntary control of mental content. Eighty-seven TM subjects with one month to five years TM experience participated in this study. Regression analysis of years TM practice and self-reported transcendental experiences (lack of time, space and body sense) during meditation practice was flat (r=.07). Those practicing Transcendental Meditation for 1month reported as much transcending as those with 5years of practice...
February 2017: Brain and Cognition
keyword
keyword
35844
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"