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hypoxic ischemic encephalopathy

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https://www.readbyqxmd.com/read/29331314/chloroquine-inhibits-autophagy-and-deteriorates-the-mitochondrial-dysfunction-and-apoptosis-in-hypoxic-rat-neurons
#1
Peng Li, Lei Hao, Yan-Yan Guo, Guang-Lu Yang, Hua Mei, Xiao-Hua Li, Qiong-Xiang Zhai
AIMS: Mitochondrial dysfunction (MD) and apoptosis in the neurons are associated with neonatal hypoxic-ischemic (HI) encephalopathy (HIE). The present study was to explore the influence of autophagy on the induction of MD and apoptosis in the neurons in a neonatal HIE rats and in hypoxia-treated neurons in vitro. MATERIALS AND METHODS: Ten-day-old HI rat pups were sacrificed for brain pathological examination and immunohistochemical analysis. The induction of autophagy, apoptosis and MD were also determined in the neurons under hypoxia, with or without autophagy inhibitor, chloroquine (CQ) treatment...
January 10, 2018: Life Sciences
https://www.readbyqxmd.com/read/29318859/-xingnao-kaiqiao-acupuncture-acupuncture-technique-for-restoring-consciousness-combined-with-hyperbaric-oxygen-in-patients-with-hypoxic-ischemic-encephalopathy-clinical-observation-and-its-influence-on-blood-rheology
#2
Sheng-Yu Zhang, Shao-Bing Liu, Hong-Wu Xie, Yi-Min Chen, Kang-Lin Liao, Yong Xiang, Dun Pan
OBJECTIVE: To observe the effect of "Xingnao Kaiqiao" acupuncture(acupuncture technique for restoring consciousness) combined with hyperbaric oxygen in patients with hypoxic ischemic encephalopathy and assess its influence on blood rheology. METHODS: Forty patients with hypoxic ischemic encephalopathy were randomly divided into treatment group and control group with 20 cases in each group. The treatment group received "Xingnao Kaiqiao" acupuncture combined with hyperbaric oxygen, and the control group received hyperbaric oxygen only...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29318119/mild-hypothermia-therapy-for-moderate-or-severe-hypoxicischemic-encephalopathy-in-neonates
#3
Weihua Liao, Huiying Xu, Jing Ding, Hong Huang
Background: To study the nursing method of mild hypothermia therapy for moderate or severe hypoxic-ischemic encephalopathy (HIE) in neonates. Methods: According to the inclusion and exclusion criteria, 48 patients were selected from Nanfang Hospital from December 2015 to October 2016 and randomly divided into the control group (n=24) and observation group (n=24). The control group received routine treatment and nursing, while the observation group received the same treatment as the control group combined with mild hypothermia treatment and nursing...
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29310429/infant-percutaneous-endoscopic-gastrostomy-risks-or-benefits
#4
Francesco Macchini, Andrea Zanini, Giorgio Farris, Anna Morandi, Giulia Brisighelli, Valerio Gentilino, Giorgio Fava, Ernesto Leva
Background/Aims: To present a single center's experience with percutaneous endoscopic gastrostomy (PEG) tube placement in infants. Methods: Clinical records of infants who underwent PEG tube placement between January 2010 and December 2015 were reviewed. All patients underwent an upper gastrointestinal contrast study and an abdominal ultrasonography before the procedure. PEGs were performed with a 6-mm endoscope using the standard pull-through technique. Data regarding gestational age, birth weight, age and weight, days to feeding start, days to full diet, and complications were reviewed...
January 9, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29287296/risk-of-neonatal-neurologic-morbidity-in-advancing-term-gestations
#5
Adam K Lewkowitz, Molly J Stout, Methodius G Tuuli, Julia D López, George A Macones, Alison G Cahill
OBJECTIVE:  Placental insufficiency is associated with neonatal neurologic morbidity and late-term gestations (410/7-416/7 weeks). Whether late-term infants are at increased risk of neurologic morbidity compared with term infants (390/7-406/7 weeks) remains unclear. We aim to compare risk of neurologic morbidity among late-term and term infants. STUDY DESIGN:  This secondary analysis of a single-institution prospective cohort study included all liveborn, nonanomalous singleton term and late-term infants, with data on adverse neonatal outcomes up until 28 days of life...
December 29, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29274721/cpg-odn-exerts-a-neuroprotective-effect-via-the-tlr9-pampk-signaling-pathway-by-activation-of-autophagy-in-a-neonatal-hie-rat-model
#6
Lan Ye, Zhanhui Feng, Desislava Doycheva, Jay Malaguit, Brandon Dixon, Ningbo Xu, John H Zhang, Jiping Tang
Hypoxic Ischemic Encephalopathy (HIE) is an injury caused to the brain due to prolonged lack of oxygen and blood supply which results in death or long-term disabilities. The main aim of this study was to investigate the role of Cytosine-phospho-guanine oligodeoxynucleotide (CpG-ODN) in autophagy after HIE. Ten-day old (P10) rat pups underwent right common carotid artery ligation followed by 2.5h of hypoxia as previously described by Rice-Vannucci. At 1h post HIE, rats were intranasally administered with recombinant CpG-ODN...
December 21, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29261798/therapeutic-potential-of-mesenchymal-stromal-cells-for-hypoxic-ischemic-encephalopathy-a-systematic-review-and-meta-analysis-of-preclinical-studies
#7
Jamie Archambault, Alvaro Moreira, Dawn McDaniel, Lauryn Winter, LuZhe Sun, Peter Hornsby
INTRODUCTION: Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating neurologic condition with high mortality rates and long-term complications for surviving infants. Mesenchymal stem/stromal cells (MSCs) have emerged as novel therapeutic agents with promising results in experimental studies of HIE. The purpose of this study is to (a) methodically review the current preclinical literature describing MSC therapy in animal models of HIE, (b) quantify the effect size in regards to functional neurologic outcome, and (c) identify research gaps/limitations that should be addressed prior to future preclinical and clinical studies...
2017: PloS One
https://www.readbyqxmd.com/read/29246356/a-novel-magnetic-resonance-imaging-score-predicts-neurodevelopmental-outcome-after-perinatal-asphyxia-and-therapeutic-hypothermia
#8
Lauren C Weeke, Floris Groenendaal, Kalyani Mudigonda, Mats Blennow, Maarten H Lequin, Linda C Meiners, Ingrid C van Haastert, Manon J Benders, Boubou Hallberg, Linda S de Vries
OBJECTIVE: To assess the predictive value of a novel magnetic resonance imaging (MRI) score, which includes diffusion-weighted imaging as well as assessment of the deep grey matter, white matter, and cerebellum, for neurodevelopmental outcome at 2 years and school age among term infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia. STUDY DESIGN: This retrospective cohort study (cohort 1, The Netherlands 2008-2014; cohort 2, Sweden 2007-2012) including infants born at >36 weeks of gestational age treated with therapeutic hypothermia who had an MRI in the first weeks of life...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29242417/phase-changing-material-for-therapeutic-hypothermia-in-neonates-with-hypoxic-ischemic-encephalopathy-a-multi-centric-study
#9
Niranjan Thomas, Thangaraj Abiramalatha, Vishnu Bhat, Manoj Varanattu, Suman Rao, Sanjay Wazir, Leslie Lewis, Umamaheswari Balakrishnan, Srinivas Murki, Jaikrishnan Mittal, Ashish Dongara, Y N Prashantha, Somashekhar Nimbalkar
OBJECTIVE: To assess the feasibility and safety of cooling asphyxiated neonates using phase changing material based device across different neonatal intensive care units in India. DESIGN: Multi-centric uncontrolled clinical trial. SETTING: 11 level 3 neonatal units in India from November 2014 to December 2015. PARTICIPANTS: 103 newborn infants with perinatal asphyxia, satisfying pre-defined criteria for therapeutic hypothermia...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29237520/-patterns-of-brain-injury-in-neonatal-hypoxic-ischemic-encephalopathy-on-magnetic-resonance-imaging-recommendations-on-classification
#10
Jian Mao
Although there are unified criteria for the clinical diagnosis and grading of neonatal hypoxic-ischemic encephalopathy (HIE), clinical features and neuropathological patterns vary considerably among the neonates with HIE due to birth asphyxia in the same classification. The patterns and progression of brain injury in HIE, which is closely associated with long-term neurodevelopment outcomes, can be well shown on magnetic resonance imaging (MRI), but different sequences may lead to different MRI findings at the same time...
December 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29234383/goreisan-inhibits-upregulation-of-aquaporin-4-and-formation-of-cerebral-edema-in-the-rat-model-of-juvenile-hypoxic-ischemic-encephalopathy
#11
Yoshiaki Yano, Hajime Yano, Hisaaki Takahashi, Kouhei Yoshimoto, Shinji Tsuda, Kenta Fujiyama, Yusuke Izumo-Shimizu, Ryota Motoie, Masanori Ito, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukuda
Secondary cerebral edema regulation is of prognostic significance in hypoxic-ischemic encephalopathy (HIE), and aquaporin 4 (AQP4) plays an important role in the pathogenesis of cerebral edema. The traditional Japanese herbal medicine Goreisan relieves brain edema in adults; however, its effect and pharmacological mechanism in children are unknown. We investigated the effects of Goreisan on HIE-associated brain edema and AQP4 expression in a juvenile rat model, established by combined occlusion of middle cerebral and common carotid arteries...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29228911/intrapartum-factors-associated-with-neonatal-hypoxic-ischemic-encephalopathy-a-case-controlled-study
#12
Vanessa E Torbenson, Mary Catherine Tolcher, Kate M Nesbitt, Christopher E Colby, Sherif A El-Nashar, Bobbie S Gostout, Amy L Weaver, Michaela E Mc Gree, Abimbola O Famuyide
BACKGROUND: Neonatal encephalopathy (NE) affects 2-4/1000 live births with outcomes ranging from negligible neurological deficits to severe neuromuscular dysfunction, cerebral palsy and death. Hypoxic ischemic encephalopathy (HIE) is the sub cohort of NE that appears to be driven by intrapartum events. Our objective was to identify antepartum and intrapartum factors associated with the development of neonatal HIE. METHODS: Hospital databases were searched using relevant diagnosis codes to identify infants with neonatal encephalopathy...
December 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29223591/mild-hypothermia-protects-hippocampal-neurons-from-oxygen-glucose-deprivation-injury-through-inhibiting-caspase-3-activation
#13
Tianen Zhou, Hui Lin, Longyuan Jiang, Tao Yu, Chaotao Zeng, Juanhua Liu, Zhengfei Yang
Mild hypothermia (MH) is thought to be one of the most effective therapeutic methods to treat hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). However, its precise mechanisms remain unclear. In this research, hippocampal neurons were cultured and treated with mild hypothermia and Ac-DEVD-CHO after oxygen-glucose deprivation (OGD). The activity of caspase-3 was detected, in order to find the precise concentration of Ac-DEVD-CHO with the same protective role in OGD injury as MH treatment. Western blot and immunofluorescence staining were conducted to analyze the effects of MH and Ac-DEVD-CHO on the expressions of caspase-3, caspase-8, and PARP...
December 6, 2017: Cryobiology
https://www.readbyqxmd.com/read/29220856/prevalence-and-characteristics-of-intracranial-hemorrhages-in-neonates-with-hypoxic-ischemic-encephalopathy
#14
Rani A Bashir, Sakeer Vayalthrikkovil, Liza Espinoza, Leigh Irvine, James Scott, Khorshid Mohammad
No abstract text is available yet for this article.
December 8, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29213143/lactate-as-an-early-predictor-of-psychomotor-development-in-neonates-with-asphyxia-receiving-therapeutic-hypothermia
#15
Renata Polackova, Dana Salounova, Lumir Kantor
AIMS: This prospective study aimed to evaluate the relationship between persistently elevated lactate values in the arterial blood of newborns with grade II and III hypoxic ischemic encephalopathy (treated with therapeutic hypothermia) and psychomotor development at 24 months. METHODS: 51 neonates of gestational age from 36 to 41 weeks receiving therapeutic hypothermia for moderate to severe hypoxic ischaemic encephalopathy had arterial blood lactate levels regularly analysed...
December 4, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29213095/evolution-of-energy-related-metabolites-in-plasma-from-newborns-with-hypoxic-ischemic-encephalopathy-during-hypothermia-treatment
#16
Ángel Sánchez-Illana, Antonio Núñez-Ramiro, María Cernada, Anna Parra-Llorca, Eva Valverde, Dorotea Blanco, Maria Teresa Moral-Pumarega, Fernando Cabañas, Hector Boix, Antonio Pavon, Mercedes Chaffanel, Isabel Benavente-Fernández, Inés Tofe, Begoña Loureiro, José R Fernández-Lorenzo, Belén Fernández-Colomer, Ana García-Robles, Julia Kuligowski, Máximo Vento
Therapeutic hypothermia (TH) initiated within 6 h from birth is the most effective therapeutic approach for moderate to severe hypoxic-ischemic encephalopathy (HIE). However, underlying mechanisms and effects on the human metabolism are not yet fully understood. This work aims at studying the evolution of several energy related key metabolites in newborns with HIE undergoing TH employing gas chromatography - mass spectrometry. The method was validated following stringent FDA requirements and applied to 194 samples from a subgroup of newborns with HIE (N = 61) enrolled in a multicenter clinical trial (HYPOTOP) for the determination of lactate, pyruvate, ketone bodies and several Krebs cycle metabolites at different sampling time points...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29176553/notoginsenoside-r1-alleviates-oxygen-glucose-deprivation-reoxygenation-injury-by-suppressing-endoplasmic-reticulum-calcium-release-via-plc
#17
Yan Wang, Liu Tu, Yingbo Li, Di Chen, Zhao Liu, Xuelian Hu, Shali Wang
As documented in our previous study, notoginsenoside R1 (NGR1) can inhibit neuron apoptosis and the expression of endoplasmic reticulum (ER) stress-associated pro-apoptotic proteins in hypoxic-ischemic encephalopathy. Recent evidence indicates that the Phospholipase C (PLC)/inositol 1,4,5-trisphosphate receptor (IP3R) is important for the regulation of Ca2+ release in the ER. Ca2+ imbalance can stimulate ER stress, CAMKII, and cell apoptosis. The purpose of this study was to further investigate the neuroprotective effect of NGR1 and elucidate how NGR1 regulates ER stress and cell apoptosis in the oxygen-glucose deprivation/reoxygenation (OGD/R) model...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29172116/bilateral-loss-of-cortical-seps-predict-severe-mri-lesions-in-neonatal-hypoxic-ischemic-encephalopathy-treated-with-hypothermia
#18
Agnese Suppiej, Ambra Cappellari, Giacomo Talenti, Elisa Cainelli, Matteo Di Capua, Augusta Janes, Daniela Longo, Rodica Mardari, Cristina Marinaccio, Stefano Pro, Paola Sciortino, Daniele Trevisanuto, Roberta Vittorini, Renzo Manara
OBJECTIVE: The introduction of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy calls for reevaluation of the prognostic role of somatosensory evoked potentials (SEPs). METHODS: Among 80 consecutive neonates undergoing hypothermia for hypoxic-ischemic encephalopathy, 58 performed SEPs and MRI at 4-14 days of life and were recruited in this multicenter study. SEPs were scored as: 0 (bilaterally/unilaterally recorded N20) or 1 (bilaterally absent N20)...
November 6, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29171431/effect-of-erythropoietin-combined-with-hypothermia-on-serum-tau-protein-levels-and-neurodevelopmental-outcome-in-neonates-with-hypoxic-ischemic-encephalopathy
#19
Hong-Yan Lv, Su-Jing Wu, Qiu-Li Wang, Li-Hong Yang, Peng-Shun Ren, Bao-Jun Qiao, Zhi-Ying Wang, Jia-Hong Li, Xiu-Ling Gu, Lian-Xiang Li
Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy, many neonatal patients die or suffer from severe neurological dysfunction. Erythropoietin is considered one of the most promising neuroprotective agents. We hypothesized that erythropoietin combined with hypothermia will improve efficacy of neonatal hypoxic-ischemic encephalopathy treatment. In this study, 41 neonates with moderate/severe hypoxic-ischemic encephalopathy were randomly divided into a control group (hypothermia alone for 72 hours, n = 20) and erythropoietin group (hypothermia + erythropoietin 200 IU/kg for 10 days, n = 21)...
October 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29171427/baicalin-protects-neonatal-rat-brains-against-hypoxic-ischemic-injury-by-upregulating-glutamate-transporter-1-via-the-phosphoinositide-3-kinase-protein-kinase-b-signaling-pathway
#20
Zhi-Qing Zhou, Yong-Liang Li, Zhen-Bo Ao, Zhi-Li Wen, Qi-Wen Chen, Zheng-Gang Huang, Bing Xiao, Xiao-Hua Yan
Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root. Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke. Here, we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy. Seven-day-old pups underwent left common carotid artery ligation followed by hypoxia (8% oxygen at 37°C) for 2 hours, before being injected with baicalin (120 mg/kg intraperitoneally) and examined 24 hours later. Baicalin effectively reduced cerebral infarct volume and neuronal loss, inhibited apoptosis, and upregulated the expression of p-Akt and glutamate transporter 1...
October 2017: Neural Regeneration Research
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