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https://www.readbyqxmd.com/read/28456092/occupation-and-risk-of-prostate-cancer-in-canadian-men-a-case-control-study-across-eight-canadian-provinces
#1
Jeavana Sritharan, Paul A Demers, Shelley A Harris, Donald C Cole, Cheryl E Peters
BACKGROUND: The etiology of prostate cancer continues to be poorly understood, including the role of occupation. Past Canadian studies have not been able to thoroughly examine prostate cancer by occupation with detailed information on individual level factors. METHODS: Occupation, industry and prostate cancer were examined using data from the National Enhanced Cancer Surveillance System, a large population-based case-control study conducted across eight Canadian provinces from 1994 to 1997...
April 26, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28456074/the-paradox-of-public-holidays-hospital-treated-self-harm-and-associated-factors
#2
Eve Griffin, Christina B Dillon, Grace O'Regan, Paul Corcoran, Ivan J Perry, Ella Arensman
BACKGROUND: Recent research on the patterns of self-harm around public holidays is lacking. This study used national data to examine the patterns of hospital-treated self-harm during public holidays, and to examine associated factors. METHODS: Data on self-harm presentations to all emergency departments were obtained from the National Self-Harm Registry Ireland. The association between self-harm presentations and public holidays was examined using univariate and multivariate Poisson regression analyses...
April 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28455474/contemporary-failure-aetiologies-of-the-primary-posterior-stabilised-total-knee-arthroplasty
#3
M P Abdel, C K Ledford, A Kobic, M J Taunton, A D Hanssen
AIMS: The number of revision total knee arthroplasties (TKA) that are performed is expected to increase. However, previous reports of the causes of failure after TKA are limited in that they report the causes at specific institutions, which are often dependent on referral patterns. Our aim was to report the most common indications for re-operations and revisions in a large series of posterior-stabilised TKAs undertaken at a single institution, excluding referrals from elsewhere, which may bias the causes of failure...
May 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28455181/discharge-to-inpatient-facilities-after-total-hip-arthroplasty-is-associated-with-increased-postdischarge-morbidity
#4
Michael C Fu, Andre M Samuel, Peter K Sculco, Catherine H MacLean, Douglas E Padgett, Alexander S McLawhorn
BACKGROUND: Discharge disposition accounts for significant variability in costs after elective total hip arthroplasty (THA). Therefore, institutions must evaluate the short-term clinical outcomes associated with postdischarge care options. The present study intends to characterize the associations between short-term morbidity after primary THA and discharge destination. METHODS: Primary elective unilateral THA cases performed for osteoarthritis were identified in the American College of Surgeons National Surgical Quality Improvement Program registry from 2011 to 2014...
March 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28454980/are-the-results-of-intravenous-thrombolysis-trials-reproduced-in-clinical-practice-comparison-of-observed-and-expected-outcomes-with-the-stroke-thrombolytic-predictive-instrument-stpi
#5
A Decourcelle, S Moulin, N Dequatre-Ponchelle, M Bodenant, C Rossi, M Girot, H Hénon, E Wiel, R Bordet, P Goldstein, J P Pruvo, C Cordonnier, D Leys
AIM: In patients with cerebral ischemia, intravenous (i.v.) recombinant tissue plasminogen activator (rt-PA) increases survival without handicap or dependency despite an increased risk of bleeding. This study evaluated whether the results of randomized controlled trials are reproduced in clinical practice. METHOD: Data from a registry of consecutive patients treated by rt-PA at Lille University Hospital were retrospectively analyzed for outcomes, using modified Rankin Scale (mRS) scores, at 3 months...
April 25, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28454812/factors-associated-with-rhythm-control-treatment-decisions-in-patients-with-atrial-fibrillation-insights-from-the-ncdr-pinnacle-registry
#6
Anil K Gehi, Gheorghe Doros, Thomas J Glorioso, Gary K Grunwald, Jonathan Hsu, Yang Song, Mintu P Turakhia, Alexander Turchin, Salim S Virani, Thomas M Maddox
BACKGROUND: Decisions to use rhythm control in atrial fibrillation (AF) should generally be dictated by patient factors, such as quality of life, heart failure, and other comorbidities. Whether or not other factors affect decisions about the use of rhythm control, and catheter ablation in particular, is unknown. METHODS: A cohort of all patients diagnosed with nonvalvular AF were identified from the National Cardiovascular Data Registry's Practice Innovation and Clinical Excellence (PINNACLE) AF registry of US outpatient cardiology practices during the study period from May 1, 2008, to December 31, 2014...
May 2017: American Heart Journal
https://www.readbyqxmd.com/read/28454553/ambulatory-oxygen-in-fibrotic-lung-disease-ambox-study-protocol-for-a-randomised-controlled-trial
#7
Dina Visca, Vicky Tsipouri, Letizia Mori, Ashi Firouzi, Sharon Fleming, Morag Farquhar, Elizabeth Leung, Toby M Maher, Paul Cullinan, Nick Hopkinson, Athol U Wells, Winston Banya, Jennifer A Whitty, Huzaifa Adamali, Lisa G Spencer, Piersante Sestini, Elisabetta A Renzoni
BACKGROUND: Fibrotic interstitial lung diseases (ILDs) are chronic and often progressive conditions resulting in substantial morbidity and mortality. Shortness of breath, a symptom often linked to oxygen desaturation on exertion, is tightly linked to worsening quality of life in these patients. Although ambulatory oxygen is used empirically in their treatment, there are no ILD-specific guidelines on its use. To our knowledge, no studies are available on the effects of ambulatory oxygen on day-to-day life in patients with ILD...
April 28, 2017: Trials
https://www.readbyqxmd.com/read/28453646/protecting-confidentiality-in-cancer-registry-data-with-geographic-identifiers
#8
Mandi Yu, Jerome Phillip Reiter, Li Zhu, Benmei Liu, Kathleen A Cronin, Eric J Rocky Feuer
The National Cancer Institute's Surveillance, Epidemiology, and End Results Program releases research files of cancer registry data. These files include geography at the county level, but no finer. Access to finer geography, such as tract identifiers, would enable richer analyses, for example, examination of health disparities across neighborhoods. To date, tract identifiers are left off the research files because they could compromise the confidentiality of patients' identities. We present an approach to include tract identifiers based on multiply-imputed, synthetic data...
April 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28453098/-causes-of-death-from-breast-cancer-in-colombia
#9
Mario A González-Mariño
Objective To review the direct causes of death from breast cancer in Colombia according to data from death certificates in 2008. Material and Methods We reviewed the direct causes of death in patients whose code of underlying cause of death was malignant tumor of the breast according to the National Statistics Department of Colombia's (DANE from Spanish initials) records of death in 2008. Distribution is evaluated by diagnostic code, age, educational level, marital status, social security and place of death...
June 2016: Revista de Salud Pública
https://www.readbyqxmd.com/read/28451688/boosting-quality-registries-with-clinical-decision-support-functionality-user-acceptance-of-a-prototype-applied-to-hiv-tb-drug%C3%A2-therapy
#10
Carolina Wannheden, Helena Hvitfeldt-Forsberg, Elena Eftimovska, Katarina Westling, Johan Ellenius
BACKGROUND: The care of HIV-related tuberculosis (HIV/TB) is complex and challenging. Clinical decision support (CDS) systems can contribute to improve quality of care, but more knowledge is needed on factors determining user acceptance of CDS. OBJECTIVES: To analyze physicians' and nurses' acceptance of a CDS prototype for evidence-based drug therapy recommendations for HIV/TB treatment. METHODS: Physicians and nurses were involved in designing a CDS prototype intended for future integration with the Swedish national HIV quality registry...
April 28, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28451508/thirty-day-morbidity-associated-with-pelvic-fixation-in-adult-patients-undergoing-fusion-for-spinal-deformity-a-propensity-matched-analysis
#11
Parth Kothari, Sulaiman Somani, Nathan J Lee, Javier Z Guzman, Dante M Leven, Branko Skovrlj, Jeremy Steinberger, Jun Kim, Samuel K Cho
STUDY DESIGN: Retrospective study of prospectively collected data. OBJECTIVE: To determine if patients undergoing spinal deformity surgery with pelvic fixation are at an increased risk of morbidity. METHODS: The American College of Surgeons National Surgical Quality Improvement Program is a large multicenter clinical registry that prospectively collects preoperative risk factors, intraoperative variables, and 30-day postoperative morbidity and mortality outcomes from ~400 hospitals nationwide...
February 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451449/benefit-of-tolvaptan-in-the-management-of-hyponatraemia-in-patients-with-diuretic-refractory-congestive-heart-failure-the-semi-sec-project
#12
Antonio Pose, Luis Almenar, Juan José Gavira, Amador López-Granados, Teresa Blasco, Juan Delgado, Oscar Aramburu, Avelino Rodríguez, Luis Manzano, Nicolás Manito
AIMS: Hyponatraemia is an electrolyte disorder that occurs in advanced congestive heart failure (HF) and worsens prognosis. We explored the usefulness of tolvaptan, which has shown promising results in the treatment of this condition. METHODS AND RESULTS: This study is based on a retrospective national registry (2011-15) of patients hospitalized with refractory HF and hyponatraemia who agreed to receive tolvaptan when standard treatment was ineffective. The benefit of tolvaptan was analysed according to the following criteria: normalization ([Na(+)] ≥ 135 mmol/L) or increased sodium levels [Na(+)] ≥ 4 mEq/L on completion of treatment, and increase in urine output by 300 or 500 mL at 48 h...
May 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28451063/bayesian-adjustment-of-gastric-cancer-mortality-rate-in-the-presence-of-misclassification
#13
Nastaran Hajizadeh, Mohamad Amin Pourhoseingholi, Ahmad Reza Baghestani, Alireza Abadi, Mohammad Reza Zali
AIM: To correct for misclassification error in registering causes of death in Iran death registry using Bayesian method. METHODS: National death statistic from 2006 to 2010 for gastric cancer which reported annually by the Ministry of Health and Medical Education included in this study. To correct the rate of gastric cancer mortality with reassigning the deaths due to gastric cancer that registered as cancer without detail, a Bayesian method was implemented with Poisson count regression and beta prior for misclassified parameter, assuming 20% misclassification in registering causes of death in Iran...
April 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28449849/alzheimer-s-disease-in-primary-care-the-significance-of-early-detection-diagnosis-and-intervention
#14
Lawrence Herman, Alireza Atri, Stephen Salloway
The field of Alzheimer's disease (AD) is undergoing a profound and rapid change: clinical trials have been redesigned to focus on individuals in the earliest stages of the disease and are including more sensitive measurement tools to better capture changes in cognition and other outcomes. (Online access: http://courses.elseviercme.com/adwebcast/674 ). Trial participants undergo PET imaging for amyloid load as a hallmark for dementia, as well as genetic testing to determine likelihood of disease progression and response to therapeutic intervention...
April 24, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28449276/the-efficacy-of-thrombolysis-in-lacunar-stroke-evidence-from-the-austrian-stroke-unit-registry
#15
C C J Eggers, C Bocksrucker, L Seyfang
BACKGROUND AND PURPOSE: Intravenous thrombolysis (ivT) with recombinant tissue plasminogen activator is established in acute ischaemic stroke. Little is known, however, about its efficacy in different stroke subtypes. METHODS: A retrospective analysis of 128 733 patients from the Austrian Stroke Unit Registry was performed. Patients were classified as lacunar (LacS) or non-lacunar ischaemic stroke (nonLacS) by use of the clinical syndrome and technical findings...
April 27, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28449018/accuracy-of-ethnicity-data-recorded-in-hospital-based-patient-clinical-records-and-the-australia-and-new-zealand-dialysis-and-transplant-registry
#16
Matthew Page, Emma H Wyeth, Ari Samaranayaka, Bronwen McNoe, Rachael Walker, John Schollum, Mark Marshall, Robert Walker, Sarah Derrett
AIM: Sustained health inequities are experienced by indigenous and minority populations. Accurate ethnicity data are fundamental to healthcare planning and provision and monitoring of health outcomes to address such inequities. This study investigated the accuracy of ethnicity data in a large clinical registry of end-stage kidney disease patients (the Australia and New Zealand Dialysis and Transplant Registry; ANZDATA) and hospital-based patient clinical records compared with self-reported ethnicity data collected in the 'Dialysis Outcomes in those aged ≥65 years' (DOS65+) study...
April 28, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28448665/trends-in-the-incidence-prevalence-and-survival-outcomes-in-patients-with-neuroendocrine-tumors-in-the-united-states
#17
Arvind Dasari, Chan Shen, Daniel Halperin, Bo Zhao, Shouhao Zhou, Ying Xu, Tina Shih, James C Yao
Importance: The incidence and prevalence of neuroendocrine tumors (NETs) are thought to be rising, but updated epidemiologic data are lacking. Objective: To explore the evolving epidemiology and investigate the effect of therapeutic advances on survival of patients with NETs. Design, Setting, and Participants: A retrospective, population-based study using nationally representative data from the Surveillance, Epidemiology, and End Results (SEER) program was conducted to evaluate 64 971 patients with NETs from 1973 to 2012...
April 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28448195/design-characteristics-of-the-corrona-japan-rheumatoid-arthritis-registry
#18
Hisashi Yamanaka, Mitsumasa Kishimoto, Dimitrios A Pappas, Jeffrey D Greenberg, Joel M Kremer, Yoshiya Tanaka
OBJECTIVES: The primary objective is to prospectively study the comparative safety and effectiveness of older and newer classes of nonbiologic DMARDs (Disease-modifying antirheumatic drugs), biologic DMARDs and targeted synthetic therapies approved for rheumatoid arthritis (RA) in a real-world patient population in Japan. METHODS: Prospective, multicenter, noninterventional, observational study across geographic distribution of both private and public institutions for patients with RA who are newly prescribed one of the following medications: (1) methotrexate; (2) anti-TNF biologic DMARDs; (3) non-TNF biologic DMARDs; and (4) approved JAK inhibitors at the time of enrollment into the registry...
April 27, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28447921/the-effectiveness-of-acute-normolvolemic-hemodilution-and-autologous-prime-on-intraoperative-blood-management-during-cardiac-surgery
#19
Alfred H Stammers, Linda B Mongero, Eric Tesdahl, Andrew Stasko, Samuel Weinstein
OBJECTIVE: Intraoperative blood management during cardiac surgery is a multifaceted process incorporating various interventions directed at optimizing oxygen delivery and enhancing hemostasis. The purpose of this study was to evaluate the effects of acute normovolemic hemodilution (ANH) and autologous priming (AP) on preserving the hematocrit during cardiopulmonary bypass (CPB). METHOD: Case records from a national registry of adult patients who underwent cardiac surgery between January and October 2016 were reviewed...
April 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28447913/testosterone-replacement-therapy-and-risk-of-favorable-and-aggressive-prostate-cancer
#20
Stacy Loeb, Yasin Folkvaljon, Jan-Erik Damber, Joseph Alukal, Mats Lambe, Pär Stattin
Purpose The association between exposure to testosterone replacement therapy (TRT) and prostate cancer risk is controversial. The objective was to examine this association through nationwide, population-based registry data. Methods We performed a nested case-control study in the National Prostate Cancer Register of Sweden, which includes all 38,570 prostate cancer cases diagnosed from 2009 to 2012, and 192,838 age-matched men free of prostate cancer. Multivariable conditional logistic regression was used to examine associations between TRT and risk of prostate cancer (overall, favorable, and aggressive)...
May 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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