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https://www.readbyqxmd.com/read/28431402/micrometastasis-of-endometriosis-to-distant-organs-in-a-murine-model
#1
Elham N Samani, Ramanaiah Mamillapalli, Fei Li, Levent Mutlu, Demetra Hufnagel, Graciela Krikun, Hugh S Taylor
Endometriosis is an inflammatory gynecological disorder among reproductive-aged women caused by the engraftment and proliferation of endometrial cells outside the uterus, most commonly in the pelvis. It is thought that the disease arises primarily from retrograde menstruation where cells from the endometrium travel through the fallopian tubes to the peritoneal cavity. However, migration of endometriosis-derived cells to distant organs outside of the peritoneal cavity have not been explored. In the present study, we developed and validated a mouse model of disseminated endometriosis using syngeneic DsRed endometrial tissue introduced into the peritoneum of immunocompetent mice...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28431246/fatty-acids-regulate-germline-sex-determination-through-acs-4-dependent-myristoylation
#2
Hongyun Tang, Min Han
Fat metabolism has been linked to fertility and reproductive adaptation in animals and humans, and environmental sex determination potentially plays a role in the process. To investigate the impact of fatty acids (FA) on sex determination and reproductive development, we examined and observed an impact of FA synthesis and mobilization by lipolysis in somatic tissues on oocyte fate in Caenorhabditis elegans. The subsequent genetic analysis identified ACS-4, an acyl-CoA synthetase and its FA-CoA product, as key germline factors that mediate the role of FA in promoting oocyte fate through protein myristoylation...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28430696/sequential-analysis-of-a-panel-of-biomarkers-and-pathologic-findings-in-a-resuscitated-rat-model-of-sepsis-and-recovery
#3
Nishkantha Arulkumaran, Marije L Sixma, Elisa Jentho, Elias Ceravola, Paul S Bass, John A Kellum, Robert J Unwin, Fred W K Tam, Mervyn Singer
OBJECTIVES: To characterize the temporal pattern of a panel of blood and urinary biomarkers in an animal model of fecal peritonitis and recovery. DESIGN: Prospective observational animal study. SETTING: University research laboratory. SUBJECTS: Male Wistar rats. INTERVENTIONS: A fluid-resuscitated, long-term (3 d) rat model of sepsis (fecal peritonitis) and recovery was used to understand the temporal association of sepsis biomarkers in relation to systemic hemodynamics, inflammation, and renal function...
April 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28430618/t-2-mycotoxin-toxicological-effects-and-decontamination-strategies
#4
REVIEW
Manish Adhikari, Bhawana Negi, Neha Kaushik, Anupriya Adhikari, Abdulaziz A Al-Khedhairy, Nagendra Kumar Kaushik, Eun Ha Choi
Mycotoxins are highly diverse secondary metabolites produced in nature by a wide variety of fungus which causes food contamination, resulting in mycotoxicosis in animals and humans. In particular, trichothecenes mycotoxin produced by genus fusarium is agriculturally more important worldwide due to the potential health hazards they pose. It is mainly metabolized and eliminated after ingestion, yielding more than 20 metabolites with the hydroxy trichothecenes-2 toxin being the major metabolite. Trichothecene is hazardously intoxicating due to their additional potential to be topically absorbed, and their metabolites affect the gastrointestinal tract, skin, kidney, liver, and immune and hematopoietic progenitor cellular systems...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429281/impact-of-thyroid-disease-on-testicular-function
#5
REVIEW
Sandro La Vignera, Roberto Vita, Rosita A Condorelli, Laura M Mongioì, Silvia Presti, Salvatore Benvenga, Aldo E Calogero
INTRODUCTION: Testis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility. REVIEW: Thyrotoxicosis and hypothyroidism are associated with changes affecting the endocrine, sexual, or reproductive functions...
April 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28428871/does-wintering-north-or-south-of-the-sahara-correlate-with-timing-and-breeding-performance-in-black-tailed-godwits
#6
Rosemarie Kentie, Rocío Marquez-Ferrando, Jordi Figuerola, Laura Gangoso, Jos C E W Hooijmeijer, A H Jelle Loonstra, Frédéric Robin, Mathieu Sarasa, Nathan Senner, Haije Valkema, Mo A Verhoeven, Theunis Piersma
Migrating long distances requires time and energy, and may interact with an individual's performance during breeding. These seasonal interactions in migratory animals are best described in populations with disjunct nonbreeding distributions. The black-tailed godwit (Limosa limosa limosa), which breeds in agricultural grasslands in Western Europe, has such a disjunct nonbreeding distribution: The majority spend the nonbreeding season in West Africa, while a growing number winters north of the Sahara on the Iberian Peninsula...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28428805/edible-dormice-glis-glis-avoid-areas-with-a-high-density-of-their-preferred-food-plant-the-european-beech
#7
Jessica S Cornils, Franz Hoelzl, Birgit Rotter, Claudia Bieber, Thomas Ruf
BACKGROUND: Numerous species, especially among rodents, are strongly affected by the availability of pulsed resources. The intermittent production of large seed crops in northern hemisphere tree species (e.g., beech Fagus spec.,oak Quercus spec., pine trees Pinus spec.) are prime examples of these resource pulses. Adult edible dormice are highly dependent on high energy seeds to maximize their reproductive output. For juvenile dormice the energy rich food is important to grow and fatten in a very short time period prior to hibernation...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28427326/no-evidence-for-strong-cytonuclear-conflict-over-sex-allocation-in-a-simultaneously-hermaphroditic-flatworm
#8
Nikolas Vellnow, Dita B Vizoso, Gudrun Viktorin, Lukas Schärer
BACKGROUND: Cytoplasmic sex allocation distorters, which arise from cytonuclear conflict over the optimal investment into male versus female reproductive function, are some of the best-researched examples for genomic conflict. Among hermaphrodites, many such distorters have been found in plants, while, to our knowledge, none have been clearly documented in animals. METHODS: Here we provide a quantitative test for cytonuclear conflict over sex allocation in the simultaneously hermaphroditic flatworm Macrostomum lignano...
April 20, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28426261/a-morphological-study-of-uterine-alterations-in-mice-due-to-exposure-to-cadmium
#9
M Sapmaz-Metin, Y Topcu-Tarladacalisir, I Kurt-Omurlu, B Karaoz Weller, S Unsal-Atan
We investigated the morphologic and molecular effects of exposure to cadmium (Cd) for 30 and 60 days on the uteri of mice. We assessed uterine morphometric measurements, eosinophilia, mast cell numbers, endometrial apoptosis, proliferation and estrogen receptor alpha (ERα) immunoreactivity. We examined vaginal smears that reflected the hormonal alterations in the female reproductive tract. Because the female reproductive tract exhibits different morphology at each stage of the estrous cycle, we sacrificed all animals at estrus to make appropriate comparisons...
April 20, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28424285/equine-arteritis-virus-has-specific-tropism-for-stromal-cells-and-cd8-t-and-cd21-b-lymphocytes-but-not-glandular-epithelium-at-the-primary-site-of-persistent-infection-in-the-stallion-reproductive-tract
#10
Mariano Carossino, Alan T Loynachan, Igor F Canisso, R Frank Cook, Juliana R Campos, Bora Nam, Yun Young Go, Edward L Squires, Mats H T Troedsson, Thomas Swerczek, Fabio Del Piero, Ernest Bailey, Peter J Timoney, Udeni B R Balasuriya
Equine arteritis virus (EAV) has a global impact on the equine industry being the causative agent of equine viral arteritis (EVA), a respiratory, systemic, and reproductive disease of equids. A distinctive feature of EAV infection is that it establishes long-term persistent infection in 10 to 70% of infected stallions (carriers). In these stallions, EAV is only detectable in the reproductive tract and viral persistence occurs despite the presence of high serum neutralizing antibodies. Carrier stallions constitute the natural reservoir of the virus as they continuously shed EAV in their semen...
April 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28424257/an-animal-source-food-supplement-increases-micronutrient-intakes-and-iron-status-among-reproductive-age-women-in-rural-vietnam
#11
Andrew G Hall, Tu Ngu, Hoang T Nga, Phi N Quyen, Pham T Hong Anh, Janet C King
Background: Few studies have examined the impact of local animal-source foods (ASFs) on the nutritional status of reproductive-age women in developing countries.Objective: We hypothesized that a midmorning snack of local ASF for 6 mo would reduce dietary micronutrient deficiencies [usual intake less than the estimated average requirement (EAR)] and improve blood biomarkers of iron, zinc, and vitamins A and B-12 status among nonpregnant, reproductive-age women in rural Vietnam.Methods: One hundred seventeen women, 18-30 y old, were randomly assigned to receive either an ASF (mean: 144 kcal, 8...
April 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28422140/the-evolutionary-history-of-bears-is-characterized-by-gene-flow-across-species
#12
Vikas Kumar, Fritjof Lammers, Tobias Bidon, Markus Pfenninger, Lydia Kolter, Maria A Nilsson, Axel Janke
Bears are iconic mammals with a complex evolutionary history. Natural bear hybrids and studies of few nuclear genes indicate that gene flow among bears may be more common than expected and not limited to polar and brown bears. Here we present a genome analysis of the bear family with representatives of all living species. Phylogenomic analyses of 869 mega base pairs divided into 18,621 genome fragments yielded a well-resolved coalescent species tree despite signals for extensive gene flow across species. However, genome analyses using different statistical methods show that gene flow is not limited to closely related species pairs...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421502/chapter-18-vitrification-a-reliable-method-for-cryopreservation-of-animal-embryos
#13
B Singh, G Mal, S K Singla
The impact of cryopreservation in assisted reproduction is increasingly appreciated. Cells, oocytes, and embryos preserved under ultralow temperature can endure storage for indefinite time with almost no alteration in their metabolic and genetic components. Advances in cryopreservation and its applications to preserve cells, gametes, and embryos offer opportunities in conservation of biodiversity and dissemination of elite livestock germplasm. This chapter describes the vitrification for cryopreservation of livestock embryos...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28419839/near-infrared-laser-irradiation-improves-the-development-of-mouse-pre-implantation-embryos
#14
Masaki Yokoo, Miho Mori
The aim of the present study was to assess the effects of near-infrared laser irradiation on the in vitro development of mouse embryos. Female ICR mice were superovulated with pregnant mare serum gonadotropin and human chorionic gonadotropin (hCG), and mated with male mice. Two-cell stage embryos were collected 40 h after administering hCG and cultured in M16 medium. Two-cell embryos (0 h after culture), 8-cell embryos (approx. 30 h after culture), morula (approx. 48 h after culture), and blastocysts (approx...
April 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28419309/influence-of-dietary-inclusion-of-untreated-or-heat-treated-jatropha-meal-on-productive-and-reproductive-performances-and-biochemical-blood-parameters-of-laying-japanese-quail
#15
M E Abd El-Hack, M Alagawany, S A A El-Sayed, J Fowler
Jatropha meal (JM) has been characterized as a potential animal feedstuff due to its high crude protein content and high levels of essential amino acids. However, it contains anti-nutritive and toxic compounds that may hinder its use. The present study was conducted to evaluate the effects of a dietary inclusion of raw Jatropha meal (RJM) and heat-treated Jatropha meal on the growth and production of laying Japanese quail using productive, reproductive, and biochemical blood parameters. A total number of 180 mature Japanese quail at 2 months of age (120 females and 60 males) was randomly divided into 4 treatment groups: control (0% JM); 3...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28416366/2-year-animal-carcinogenicity-results-for-crisaborole-a-novel-phosphodiesterase-4-inhibitor-for-atopic-dermatitis
#16
Vic Ciaravino, Dina Coronado, Cheryl Lanphear, Sanjay Chanda
BACKGROUND: Crisaborole is a novel, topical nonsteroidal, anti-inflammatory, phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild to moderate atopic dermatitis. OBJECTIVE: As part of a nonclinical safety testing program, these 2-year studies tested the carcinogenic potential of crisaborole. METHODS: Crisaborole ointment, 2%, 5%, or 7%, was applied once daily topically to mice, and crisaborole was administered orally to rats at doses of 30, 100, or 300mg/kg/day for up to 104 weeks...
March 30, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28416118/a-magnetic-map-leads-juvenile-european-eels-to-the-gulf-stream
#17
Lewis C Naisbett-Jones, Nathan F Putman, Jessica F Stephenson, Sam Ladak, Kyle A Young
Migration allows animals to track the environmental conditions that maximize growth, survival, and reproduction [1-3]. Improved understanding of the mechanisms underlying migrations allows for improved management of species and ecosystems [1-4]. For centuries, the catadromous European eel (Anguilla anguilla) has provided one of Europe's most important fisheries and has sparked considerable scientific inquiry, most recently owing to the dramatic collapse of juvenile recruitment [5]. Larval eels are transported by ocean currents associated with the Gulf Stream System from Sargasso Sea breeding grounds to coastal and freshwater habitats from North Africa to Scandinavia [6, 7]...
April 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28416032/physiological-metabolic-and-transcriptional-postnatal-phenotypes-of-in-vitro-fertilization-ivf-in-the-mouse
#18
S K Feuer, P F Rinaudo
Approximately 1-4% of children today are conceived using assisted reproductive technologies (ARTs), including in vitro fertilization (IVF). IVF is considered safe and the great majority of these children are healthy, yet there is increasing physiological and molecular evidence from animal models that ART is associated with postnatal metabolic and cardiovascular alterations. Understanding the mechanisms underlying these changes and determining whether they have biological significance is of paramount importance for optimizing the design of culture conditions and improving the health of ART children across the life course...
April 18, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28414086/deadbeats-or-losers-discretionary-male-parental-investment-can-make-females-less-choosy
#19
Frazer Meacham, Thomas Getty
Two of the most important reproductive decisions that animals face are how to choose mates and how to invest in offspring. In species where both males and females provide offspring care, these selection pressures will often be reciprocally intertwined: mate preferences may depend on parental investment patterns while parental investment patterns may depend on mate preferences. We describe and analyze a mathematical model of this interaction, in which females can choose amongst males who have high attractiveness or low attractiveness, while males can decide whether to provide offspring care...
April 13, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28411496/exposure-to-environmental-noise-and-risk-for-male-infertility-a%C3%A2-2population-based-cohort-study
#20
Kyoung-Bok Min, Jin-Young Min
BACKGROUND: Noise is associated with poor reproductive health. A number of animal studies have suggested the possible effects of exposure to high noise levels on fertility; to date, a little such research has been performed on humans. OBJECTIVES: We examined an association between daytime and nocturnal noise exposures over four years (2002-2005) and subsequent male infertility. METHODS: We used the National Health Insurance Service-National Sample Cohort (2002-2013), a population-wide health insurance claims dataset...
April 12, 2017: Environmental Pollution
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