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JOURNAL ARTICLE
Manav V Vyas, Moira K Kapral, Rea Alonzo, Jiming Fang, Dalia L Rotstein
BACKGROUND AND OBJECTIVES: While immigrants to high-income countries have a lower risk of multiple sclerosis (MS) compared with host populations, it is unknown whether this lower risk among immigrants increases over time. Our objective was to evaluate the association between proportion of life spent in Canada and the hazard of incident MS in Canadian immigrants. METHODS: We conducted a population-based retrospective cohort study in Ontario, using linked health administrative databases...
May 2024: Neurology
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JOURNAL ARTICLE
Sin Yi Lee, Hirotaka Shoji, Aki Shimozawa, Hirofumi Aoyagi, Yoshiaki Sato, Kazuya Tsumagari, Mika Terumitsu, Haruhiko Motegi, Kensuke Okada, Koji Sekiguchi, Junro Kuromitsu, Jin Nakahara, Tsuyoshi Miyakawa, Daisuke Ito
BACKGROUND AND OBJECTIVES: Anti-IgLON5 disease is an autoimmune neurodegenerative disorder characterized by various phenotypes, notably sleep and movement disorders and tau pathology. Although the disease is known to be associated with the neuronal cell adhesion protein IgLON5, the physiologic function of IgLON5 remains elusive. There are conflicting views on whether autoantibodies cause loss of function, activation of IgLON5, or inflammation-associated neuronal damage, ultimately leading to the disease...
May 2024: Neurology® Neuroimmunology & Neuroinflammation
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JOURNAL ARTICLE
Dawn R White, Patrick A Palmieri
BACKGROUND: Parkinson's disease is a progressive neurodegenerative disorder. The majority of the nearly 9 million people living with Parkinson's disease are men. As such, caregiving is often assumed by wives as the disease progresses. However, there is little research about the lived experience of wives as they transition to caregivers. OBJECTIVE: To describe the lived experience of wife caregivers of male spouses living at home with Parkinson's disease. METHODS: A descriptive phenomenological study...
December 2024: International Journal of Qualitative Studies on Health and Well-being
#24
JOURNAL ARTICLE
Yuki Shinohara, Tomomi Ohmura, Fumiaki Sasaki, Yuichiro Sato, Takato Inomata, Toshihide Itoh, Toshibumi Kinoshita
OBJECTIVE: Hyperdense artery sign (HAS) on noncontrast brain computed tomography (CT) indicates an acute thrombus within the cerebral artery. It is a valuable imaging biomarker for diagnosing large-vessel occlusion; however, its identification may be challenging with the presence of vascular calcification. Dual-energy CT virtual noncalcium (VNCa) imaging using a 3-material decomposition algorithm is helpful for differentiating between calcification and hemorrhage. This study aimed to clarify the potential of VNCa imaging for differentiating HAS from vascular calcification...
April 24, 2024: Journal of Computer Assisted Tomography
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REVIEW
I F Rodríguez-Rodríguez, P Navarro-Torres-Arpi, A Dryjanski-Lerner, J G Gómez-Mont-Landerreche, G A Levy-Holden, F Gil-Orbezo
Discoid meniscus is a congenital morphological variant of the meniscus, which tends to occur more frequently in its lateral form than in the medial form. This anomaly is characterized by central hypertrophy of the meniscus and a larger diameter than the normal meniscus, resulting in an abnormal shape and greater coverage of the tibial plateau. The clinical presentation of this condition varies depending on the stability of the meniscus. In pediatric patients, in particular, it is common to experience progressive and atraumatic symptoms, such as pain and limited mobility...
2024: Acta Ortopédica Mexicana
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JOURNAL ARTICLE
F E García-Dobarganes-Barlow, J M Valadez-Soto, N Saavedra-Islas, V M García-Romo, J Mata-Coronado, E Villavicencio-Ocampo, M I Encalada-Díaz
Long COVID is a term used to describe the long-terms effects of COVID-19 infection that continue for weeks or months after the patient has recovered from COVID-19. Long COVID is defined by the persistence of symptoms beyond 12 weeks from the onset of the disease. Corticosteroids are part of the treatment in this period with good results in controlling the disease; however, it is a predisposing factor for the development of avascular necrosis. We present a clinic case of a young man of 39 years old with diagnosis of avascular necrosis in his left hip, before the administration of corticosteroids for the treatment of COVID-19...
2024: Acta Ortopédica Mexicana
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JOURNAL ARTICLE
S Velázquez-Rodríguez, M A Clara-Altamirano, D Y García-Ortega, A R Lizcano-Suárez, H Martínez-Said, V Villavicencio-Valencia, M Cuellar-Hubbe
INTRODUCTION: reconstruction of large bone defects using modular knee arthroplasty (MKA) presents a significant challenge in terms of functionality. The objective of the present work was to identify the different prognostic factors associated with failure of MKA in cancer patients. MATERIAL AND METHODS: a retrospective cohort study was conducted, including patients with a diagnosis of musculoskeletal tumor in the distal femur or proximal tibia, who underwent MKA between January 1, 2010, and December 31, 2021...
2024: Acta Ortopédica Mexicana
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COMPARATIVE STUDY
A D Navarro-Vergara, A S Portillo-Candia, C L Sánchez-Silva, R A Arréllaga-Alonso, A A Portillo-Vanni
INTRODUCTION: health promotion policy requires the identification of barriers to the adoption of public policies. Paraguay's national healthcare system is inequitable, expensive, and inefficient. The Ministry of Public Health and Social Welfare (MSPyBS) is the entity responsible for covering the needs of a significant portion of the population. In January 2022, the MSPyBS financed the purchase of titanium elastic nails through a National Public Tender for Osteosynthesis Materials (LPN 02/22) to provide them for free in the pediatric service...
2024: Acta Ortopédica Mexicana
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JOURNAL ARTICLE
C A Valdivia-Zúñiga, G Bobadilla-Lescano, F A Martínez-Escalante, A J Balam-May, F Cámara-Arrigunaga
INTRODUCTION: the analysis of spinopelvic imbalance in patients undergoing total hip arthroplasty has gained significance in recent years, being recognized as a risk factor for instability. Few reports exist regarding the prevalence of spinopelvic alterations in Latin American literature. The aim of this study is to determine the frequency of spinopelvic imbalance in our patients and to associate them with functional outcomes. MATERIAL AND METHODS: 29 patients who underwent total hip arthroplasty using a lateral approach (32 arthroplasties) were included...
2024: Acta Ortopédica Mexicana
#30
JOURNAL ARTICLE
Ronald Gonçalves, Adesola Odunayo, Nicole Blystone, Zenithson Ng, Xiaojuan Zhu
OBJECTIVES: The aim of the present study was to assess the accuracy of weight estimation in cats provided by pet owners, veterinary technicians, house officers (interns and residents) and attending clinicians in an emergency room (ER). An additional objective was to determine whether carrying the cat contributed to a more accurate weight estimate. METHODS: A total of 72 cats presented to an ER and were enrolled in the study. Pet owners, veterinary technicians, house officers and attending clinicians were asked to record the cats' estimated weights on individual data collection cards...
April 2024: Journal of Feline Medicine and Surgery
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JOURNAL ARTICLE
Mohammad Abdolsamadi, Sharareh Rasouli, Ali Alizadeh Severi, Mohammad Reza Khirehgesh, Fatemeh Safari, Nejat Mahdieh, Habibolah Khazaie, Bijan Soleymani, Bahman Akbari
Introduction: Sleep is one of the most significant parts of everyone's life. Most people sleep for about one-third of their lives. Sleep disorders negatively impact the quality of life. Obstructive sleep apnea (OSA) is a severe sleep disorder that significantly impacts the patient's life and their family members. This study aimed to investigate the relationship between rs6313 and rs6311 polymorphisms in the serotonin receptor type 2A gene and OSA in the Kurdish population. Materials and Methods: The study's population comprises 100 OSA sufferers and 100 healthy people...
April 2024: Genetic Testing and Molecular Biomarkers
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JOURNAL ARTICLE
Wen Bi, Jingjing Li, Mengqiu Xiong, Lubanga Nasifu, Mingjuan Tan, Ping Tai, Qing Jin, Lingyun Zhang, Chengbin Zhu, Bangshun He
Objective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) ( EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of schizophrenia (SZ) in a Chinese population. Materials and Methods: We conducted a case-control study, including 248 patients with SZ and 236 healthy controls matched for age and sex. The Mass-array platform was used to detect all the genotypes of the SNPs. Results: The results revealed that the EGR3 rs1996147 AA genotype was associated with borderline decreased SZ risk (AA vs...
April 2024: Genetic Testing and Molecular Biomarkers
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JOURNAL ARTICLE
Somayya Naguib, Lamiaa A Mansour, Neveen A Soliman, Hadeel M El-Hanafy, Yosra A Fahmy, Mohamed A Elmonem, Radwa M Abdel Halim
Introduction: Approximately 80% of primary hyperoxaluria cases are caused by primary hyperoxaluria type 1 (PH1, OMIM# 259900), which is characterized by pathogenic variants in the AGXT gene, resulting in deficiency of the liver-specific enzyme alanine-glyoxylate aminotransferase (AGT). This leads to increased production of oxalate, which cannot be effectively eliminated from the body, resulting in its accumulation primarily in the kidneys and other organs. Subjects and Methods: This study included 17 PH1 Egyptian patients from 12 unrelated families, recruited from the Inherited Kidney Disease Outpatient Clinic and the Dialysis Units, Cairo University Hospitals, during the period from January 2018 to December 2019, aiming to identify the pathogenic variants in the AGXT gene...
April 2024: Genetic Testing and Molecular Biomarkers
#34
JOURNAL ARTICLE
Yuta Ito, Amira Marouf, Yasunori Kogure, Junji Koya, Raphaël Liévin, Julie Bruneau, Mariko Tabata, Yuki Saito, Sumito Shingaki, Mitsuhiro Yuasa, Kentaro Yamaguchi, Koichi Murakami, Robert Weil, Manon Vavasseur, Guillaume P Andrieu, Mehdi Latiri, Layla Veleanu, Michaël Dussiot, Isabelle André, Akshay Joshi, Chantal Lagresle-Peyrou, Aude Magerus, Sammara Chaubard, David Lavergne, Emmanuel Bachy, Erika Brunet, Virginie Fataccioli, Chantal Brouzes, Camille Laurent, Laurence De Leval, Alexandra Traverse-Glehen, Céline Bossard, Marie-Cécile Parrens, Véronique Meignin, Laure Philippe, Julien Rossignol, Felipe Suarez, Jean-Marie Michot, Olivier Tournilhac, Gandhi Damaj, François Lemonnier, Christine Bôle-Feysot, Patrick Nitschké, Bruno Tesson, Cécile Laurent, Thierry Molina, Vahid Asnafi, Yosaku Watatani, Kenichi Chiba, Ai Okada, Yuichi Shiraishi, Sachiko Tsukita, Koji Izutsu, Hiroaki Miyoshi, Koichi Ohshima, Seiji Sakata, Akito Dobashi, Kengo Takeuchi, Masashi Sanada, Philippe Gaulard, Arnaud Jaccard, Seishi Ogawa, Olivier Hermine, Keisuke Kataoka, Lucile Couronné
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1...
April 24, 2024: Cancer Research
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JOURNAL ARTICLE
Benjamin Talei, Dan Gould, Hedyeh Ziai
BACKGROUND: The vector of aging and consequently the vector of lift in rhytidectomy has aided surgeons to improve movement of tissues during facial rejuvenation procedures. OBJECTIVES: To analyze the vector of lift in patients undergoing primary and revision facelift in order to achieve proper vectorial lifting. METHODS: Patients undergoing deep plane facelift surgery were included for analysis. Intraoperative photographs and measurements were taken of the skin, SMAS and platysmal suture suspension with mastoid crevasse inset...
April 24, 2024: Aesthetic Surgery Journal
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JOURNAL ARTICLE
Yuzhi Sun, Renwang Sheng, Zhicheng Cao, Chuanquan Liu, Jiaxiang Li, Po Zhang, Yan Du, Qingyun Mo, Qingqiang Yao, Jialin Chen, Wei Zhang
Myotendinous junction (MTJ) injuries are prevalent in clinical practice, yet the treatment approaches are limited to surgical suturing and conservative therapy, exhibiting a high recurrence rate. Current research on MTJ tissue engineering is scarce and lacks in vivo evaluation of repair efficacy. Here, we developed a three-dimensional-printed bioactive fiber-reinforced hydrogel containing mesenchymal stem cells (MSCs) and Klotho for structural and functional MTJ regeneration. In a rat MTJ defect model, the bioactive fiber-reinforced hydrogel promoted the structural restoration of muscle, tendon, and muscle-tendon interface and enhanced the functional recovery of injured MTJ...
April 26, 2024: Science Advances
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JOURNAL ARTICLE
Justin Merondun, Cristiana I Marques, Pedro Andrade, Swetlana Meshcheryagina, Ismael Galván, Sandra Afonso, Joel M Alves, Pedro M Araújo, Gennadiy Bachurin, Jennifer Balacco, Miklós Bán, Olivier Fedrigo, Giulio Formenti, Frode Fossøy, Attila Fülöp, Mikhail Golovatin, Sofia Granja, Chris Hewson, Marcel Honza, Kerstin Howe, Greger Larson, Attila Marton, Csaba Moskát, Jacquelyn Mountcastle, Petr Procházka, Yaroslav Red'kin, Ying Sims, Michal Šulc, Alan Tracey, Jonathan M D Wood, Erich D Jarvis, Mark E Hauber, Miguel Carneiro, Jochen B W Wolf
Sex-limited polymorphism has evolved in many species including our own. Yet, we lack a detailed understanding of the underlying genetic variation and evolutionary processes at work. The brood parasitic common cuckoo ( Cuculus canorus ) is a prime example of female-limited color polymorphism, where adult males are monochromatic gray and females exhibit either gray or rufous plumage. This polymorphism has been hypothesized to be governed by negative frequency-dependent selection whereby the rarer female morph is protected against harassment by males or from mobbing by parasitized host species...
April 26, 2024: Science Advances
#38
JOURNAL ARTICLE
Ben Rein, Kendall Raymond, Cali Boustani, Sabrena Tuy, Jie Zhang, Robyn St Laurent, Matthew B Pomrenze, Parnaz Boroon, Boris Heifets, Monique Smith, Robert C Malenka
MDMA (3,4-methylenedioxymethamphetamine) is a psychoactive drug with powerful prosocial effects. While MDMA is sometimes termed an "empathogen," empirical studies have struggled to clearly demonstrate these effects or pinpoint underlying mechanisms. Here, we paired the social transfer of pain and analgesia-behavioral tests modeling empathy in mice-with region-specific neuropharmacology, optogenetics, and transgenic manipulations to explore MDMA's action as an empathogen. We report that MDMA, given intraperitoneally or infused directly into the nucleus accumbens (NAc), robustly enhances the social transfer of pain and analgesia...
April 26, 2024: Science Advances
#39
JOURNAL ARTICLE
Cansu Koc, Cigdem Inci Aydemir, Berna Salman, Aysen Cakir, Nursel Hasanoglu Akbulut, Pinar Levent Karabarut, Gonca Topal, Aycan Yigit Cinar, Gokce Taner, Ozhan Eyigor, Mehmet Cansev
OBJECTIVES: This study aimed to compare the efficacy of royal jelly (RJ) and its major fatty acid 10-hydroxy-2-decenoic acid (10-HDA) on ischemic stroke-related pathologies using histological and molecular approaches. METHODS: Male rats were subjected to middle cerebral artery occlusion (MCAo) to induce ischemic stroke and were supplemented daily with either vehicle (control group), RJ or 10-HDA for 7 days starting on the day of surgery. On the eighth day, rats were sacrificed and brain tissue and blood samples were obtained to analyze brain infarct volume, DNA damage as well as apoptotic, inflammatory and epigenetic parameters...
April 24, 2024: Nutritional Neuroscience
#40
JOURNAL ARTICLE
Youngbin Tchoe, Tianhai Wu, Hoi Sang U, David M Roth, Dongwoo Kim, Jihwan Lee, Daniel R Cleary, Patricia Pizarro, Karen J Tonsfeldt, Keundong Lee, Po Chun Chen, Andrew M Bourhis, Ian Galton, Brian Coughlin, Jimmy C Yang, Angelique C Paulk, Eric Halgren, Sydney S Cash, Shadi A Dayeh
Functional mapping during brain surgery is applied to define brain areas that control critical functions and cannot be removed. Currently, these procedures rely on verbal interactions between the neurosurgeon and electrophysiologist, which can be time-consuming. In addition, the electrode grids that are used to measure brain activity and to identify the boundaries of pathological versus functional brain regions have low resolution and limited conformity to the brain surface. Here, we present the development of an intracranial electroencephalogram (iEEG)-microdisplay that consists of freestanding arrays of 2048 GaN light-emitting diodes laminated on the back of micro-electrocorticography electrode grids...
April 24, 2024: Science Translational Medicine
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