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https://www.readbyqxmd.com/read/28240002/cholesterol-homeostasis-in-isolated-lymphocytes-a-differential-correlation-between-male-control-and-chronic-lymphocytic-leukemia-subjects
#1
Shrimanjunath Sankanagoudar, Govind Singh, Manaranjan Mahapatra, Lalit Kumar, Nimai Chand Chandra
Background: This study was performed to investigate any association between cellular cholesterol homeostasis and chronic lymphocytic leukemia (CLL). CLL is characterized primarily by an abnormal accumulation of neoplastic B cells in the blood, bone marrow, lymph nodes and spleen. Methods: Men aged >50 years participated in this study. Enzyme-based plasma lipid profile estimations, peripheral blood lymphocyte isolation, lysate preparations, SDS-PAGE, western blotting, dil-LDL uptake and ultracentrifugation were employed...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239997/effects-of-different-doses-of-silk-peptide-on-energy-metabolism-during-exercise-in-mice
#2
Suh Heajung, Kim Jisu, Park Jonghoon, Kim Bokyung, Lee Chi-Ho, Lim Kiwon
Purpose: This study was carried out to determine the optimal dose of silk peptide for enhancing fat metabolism during exercise. Methods: Fifty male ICR mice were randomly divided into five groups: Sed, SP0, SP200, SP400, and SP800. All SP mice underwent training by running on a treadmill 5 times a week for 2 weeks (20 m/min, 8° slope, 50 min/day for the first week and 25 m/min, 8° slope, 50 min/day at about 70-75% of maximum oxygen uptake for the second week)...
February 24, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28239989/advance-male-urethral-sling-medium-term-results-in-an-australian-cohort
#3
Alexander Papachristos, Sarah Mann, Kay Talbot, Daniel Moon
BACKGROUND: Since 2008, the AdVance male urethral sling has emerged as a minimally invasive option for stress urinary incontinence. We aimed to evaluate the success of the AdVance sling using validated continence outcome measures. METHODS: A total of 72 patients treated with the AdVance sling completed validated questionnaires reporting on quality of life and functional outcomes. Incontinence was assessed according to pad weight, pad usage per day (PPD), International Consultation on Incontinence Questionnaire scores and Patient Global Impression of Improvement scores...
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28239958/differential-sex-effects-of-systolic-blood-pressure-and-ldl-c-on-type-2-diabetes-life-course-data-from-the-bogalusa-heart-study
#4
Benjamin D Pollock, Wei Chen, Emily W Harville, Tian Shu, Vivian Fonseca, Franck Mauvais-Jarvis, Tanika N Kelly, Lydia A Bazzano
BACKGROUND: There may be sex-specific cardiometabolic mechanisms early in life that affect the development of type 2 diabetes (T2DM) through mid-adulthood. Yet, there have been few studies examining whether early life-course interactions between cardiometabolic risk factors and sex are associated with incident T2DM. METHODS: We followed n = 7,725 children from the Bogalusa Heart Study through mid-adulthood to examine whether low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), body mass index (BMI), or systolic blood pressure (SBP) differentially impact the risk of T2DM for females versus males...
February 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28239920/neuropsychiatric-symptoms-in-south-east-asian-patients-with-mild-cognitive-impairment-and-dementia-prevalence-subtypes-and-risk-factors
#5
Chathuri Yatawara, Shaun Hiu, Laura Tan, Nagaendran Kandiah
BACKGROUND: The subtypes and risk factors of neuropsychiatric symptoms remain largely unexplored in South-East Asian populations. OBJECTIVE: We investigated the prevalence, subtypes, and risk factors, namely, demographic, medical morbidity, and cognitive impairment associated with neuropsychiatric symptoms in a South-East Asian cohort of patients with mild cognitive impairment (MCI) and dementia. METHODS: A clinical cohort of 38 MCI and 198 mild-moderate dementia patients were assessed using the Neuropsychiatric Inventory-Questionnaire...
February 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28239909/ledipasvir-sofosbuvir-is-effective-and-well-tolerated-in-post-kidney-transplant-patients-with-chronic-hepatitis-c-virus
#6
Amilcar L Morales, Luz Liriano-Ward, Amber Tierney, Michelle Sang, Alexander Lalos, Mohamed Hassan, Vinay Nair, Thomas Schiano, Rohit Satoskar, Coleman Smith
Patients with end stage renal diseases on hemodialysis have a high prevalence of hepatitis C infection (HCV). In most patients treatment for HCV is delayed until post renal transplant. We assessed the effectiveness and tolerance of ledipasvir/sofosbuvir (LDV/SOF) in 32 post-kidney transplant patients infected with HCV. The group was composed predominantly of treatment naïve (75%) African American (68.75%) males (75%) infected with genotype 1a (62.5%). Most patients received a deceased donor kidney graft (78...
February 26, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28239897/population-pharmacokinetics-of-rituximab-in-patients-with-diffuse-large-b-cell-lymphoma-and-association-with-clinical-outcome
#7
S Rozman, I Grabnar, S Novaković, A Mrhar, B J Novaković
AIMS: Pharmacokinetic (PK) studies suggest that there is a room for improvement in clinical use of rituximab through more individualized treatment. The objective of this study was to characterize rituximab PK in 29 newly diagnosed patients with diffuse large B-cell lymphoma treated with rituximab in combination with cyclophosphamide, doxorubicin, vincristine and methylprednisolone every three weeks. We also evaluated the association of rituximab PK with clinical outcome. METHODS: Rituximab serum levels were determined by enzyme-linked immunosorbent assay and evaluated by a population PK analysis applying non-linear mixed effects modelling...
February 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28239863/roaming-behaviour-of-dogs-in-four-remote-aboriginal-communities-in-the-northern-territory-australia-preliminary-investigations
#8
S Molloy, A Burleigh, S Dürr, M P Ward
OBJECTIVE: To estimate the home range (HR) and investigate the potential predictors for roaming of 58 dogs in four Aboriginal communities in the Northern Territory. DESIGN: Prospective study. PROCEDURE: Global positioning system (GPS) collars were attached to the dogs for 1-4 days, recording location fixes every 1-3 min. Utilisation distributions (UDs) and extended (95% isopleth) and core (50% isopleth) HRs of dogs were determined. Potential predictors of roaming were assessed...
March 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28239861/glucocorticoid-deficient-hypoadrenocorticism-secondary-to-intravascular-lymphoma-in-the-adrenal-glands-of-a-dog
#9
M E Buckley, P S Chapman, A Walsh
CASE REPORT: A 2-year-old neutered male German Shepherd dog was presented with weakness, poor appetite and weight loss. Glucocorticoid-deficient hypoadrenocorticism was diagnosed with undetectable pre- and post-ACTH cortisol concentrations but normal sodium and potassium concentrations. Despite appropriate supplementation with glucocorticoids, the patient's weakness progressed and neurological deficits developed. The patient was euthanased. Histopathological analysis of multiple organs, including the adrenal glands, showed an accumulation of neoplastic lymphocytes within blood vessels, consistent with a diagnosis of intravascular lymphoma...
March 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28239849/correlates-of-treatment-satisfaction-and-well-being-among-patients-with-type-ii-diabetes
#10
B Abu Sheikh, D H Arabiat, S L Holmes, Y Khader, D Hiyasat, D Collyer, S Abu-Shiekh
AIM: To examine the impact of patient characteristics, anthropometric measurement and patient clinical variables on their appraisal of treatment satisfaction and well-being. BACKGROUND: Treatment satisfaction and well-being are instrumental in achieving diabetes care goals. Nursing practices and healthcare policies may inform interventions in these areas. INTRODUCTION: The prevalence of diabetes is high in the Middle East. An understanding of relationships between clinical and socio-demographic variables and well-being and treatment satisfaction is needed to improve care and patient outcomes...
February 26, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28239838/which-matters-more-a-retrospective-cohort-study-of-headache-characteristics-and-diagnosis-type-in-soldiers-with-mtbi-concussion
#11
Alan G Finkel, Brian J Ivins, Juanita A Yerry, John S Klaric, Ann Scher, Y Sammy Choi
OBJECTIVE: To describe the diagnostic types and characteristics of headaches in soldiers with mild traumatic brain injury during the wars in Afghanistan and Iraq. BACKGROUND: Persistent post-traumatic headache interferes with returns to activity or duty. The most commonly cited headache diagnosis after concussion is migraine. We hypothesize that headache diagnosis type, eg, migraine, is not sufficient to predict relationships with occupational outcomes after concussion...
February 27, 2017: Headache
https://www.readbyqxmd.com/read/28239827/quantitative-difference-of-acute-intraoperative-expansion-in-various-body-regions
#12
E Raposio, N Bertozzi
OBJECTIVE: To investigate the efficacy of intraoperative sustained limited expansion (ISLE) by examining the ex vivo biomechanical properties of acutely expanded skin flaps. MATERIALS AND METHODS: Fourteen fresh male cadavers were tested. On both sides of each cadaver, a 4 × 10 cm, the laterally based flap was raised at the external auditory canal of the scalp and a 15 × 8 cm, the proximately based flap was raised at the lateral arm, anterior thorax, and lateral thigh...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239811/the-expression-and-significance-of-il-6-ifn-%C3%AE-sm22%C3%AE-and-mmp-2-in-rat-model-of-aortic-dissection
#13
Y-L Cai, Z-W Wang
OBJECTIVE: To examine the expression of interleukin-6 (IL-6), interferon-γ (IFN-γ), smooth muscle 22α (SM22α), and matrix metalloproteinase-2 (MMP-2) and their possible roles in aortic dissections (AD). MATERIALS AND METHODS: Male SD rats (3 weeks) were induced for AD using 0.25% β-aminopropionitrile (BAPN) treatment for 6 weeks and were subsequently divided into the model I (with AD) and model II (no AD). Aorta was separated and observed, while TUNEL staining observed apoptosis of aortic vascular smooth muscle cells...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239803/nasal-hppsis-administration-enhances-ngf-and-tumor-suppressor-protein-p73-in-human-brain-cancer-tissues-preliminary-data
#14
L Aloe, M L Rocco, E Stigliano, F Angelini, M Iacoangeli, V Frari, F Salvinelli
OBJECTIVE: Nerve Growth Factor (NGF) is a neurotrophic factor known to play a critical role in growth, survival, differentiation and neuroprotection of peripheral sensory and sympathetic neurons, as well as brain neurons. We have recently reported that nasal administration of high-pressure isotonic physiological saline solution (HPpSIS) enhances the level of NGF and the expression of NGF receptors in neurons of the olfactory bulbs and forebrain cholinergic neurons of laboratory animals...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239801/curcumin-protects-against-tartrazine-mediated-oxidative-stress-and-hepatotoxicity-in-male-rats
#15
G E El-Desoky, A Abdel-Ghaffar, Z A Al-Othman, M A Habila, Y A Al-Sheikh, H K Ghneim, J P Giesy, M A M Aboul-Soud
OBJECTIVE: Synthetic dyes have been reported to exert detrimental effects on the health of humans. This study evaluated the effects of a diet containing tartrazine (Tz) on rats which included: i) biochemical parameters including hepatic enzymes, kidney functions and profiles of lipids; ii) markers of oxidative stress in cells by measuring concentrations of malondialdehyde (MDA) and glutathione (GSH); iii) activities of selected, key hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx); iv) pathologies of liver...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239784/effects-of-afobazole-on-postnatal-development-of-rat-offspring
#16
L I Bugaeva, T D Denisova, S A Sergeeva, Yu A Morozova, I V Kharlamov
Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pathologies by the age of 2 months. During the infantile period, the rat pups demonstrated reduced body weight gain, delayed eye opening and pupillary response formation, decreased muscle force, and suppressed motor behavior...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239673/effectiveness-of-a-walnut-enriched-diet-on-murine-sperm-involvement-of-reduced-peroxidative-damage
#17
Lauren S Coffua, Patricia A Martin-DeLeon
A walnut supplement for a Western-style diet in men was shown to improve sperm motility, vitality, and morphology. To gain further insights into factors underlying this improvement, we administered a parallel walnut-enriched diet to mice [including those with a defect in sperm motility due to deletion of Plasma Membrane Ca(2+)-ATPase 4 (Pmca4(-/-) )] to determine if there is a similar improvement that is accompanied by reduced sperm membrane peroxidative damage. Although sperm vitality and acrosome reaction rate were unaffected, the diet led to a significant improvement in motility (P < 0...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28239631/early-adverse-life-events-are-associated-with-altered-brain-network-architecture-in-a-sex-dependent-manner
#18
Arpana Gupta, Emeran A Mayer, Jonathan R Acosta, Kareem Hamadani, Carinna Torgerson, John D van Horn, Lin Chang, Bruce Naliboff, Kirsten Tillisch, Jennifer S Labus
INTRODUCTION: Early adverse life events (EALs) increase the risk for chronic medical and psychiatric disorders by altering early neurodevelopment. The aim of this study was to examine associations between EALs and network properties of core brain regions in the emotion regulation and salience networks, and to test the influence of sex on these associations. METHODS: Resting-state functional and diffusion tensor magnetic resonance imaging were obtained in healthy individuals (61 men, 63 women)...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28239594/subluxation-of-the-cricoarytenoid-joint-after-external-laryngeal-trauma-a-rare-case-and-review-of-the-literature
#19
Eviatar Friedlander, Paula Martínez Pascual, Julia Da Costa Belisario, Daniel Poletti Serafini
Cricoarytenoid joint subluxation is rare condition. There are <200 cases reported in the English literature. The most frequent cause of this condition is a traumatic tracheal intubation which account for approximately 80 % of all cases. The most common symptoms are dysphonia and pain of the anterior region of the neck which appear after upper airway manipulation or cervical trauma. In this report we present a well-documented case of a 31 year old male that was referred to the outpatient clinic because of acute dysphonia and pain that appeared immediately after receiving a blow of a soccer ball...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239592/hand-dominance-and-blood-group-association-in-epistaxis
#20
Leena Jain, Sadat Qureshi, Ashish Maurya, Shalini Jadia, S Mrityunjay
The present work was undertaken to study the association of epistaxis with hand dominance and blood group. The present cross sectional study was conducted among 360 cases of epistaxis who reported to the E.N.T outpatient department of tertiary care centre in central India during the period of July 2014 to July 2015. Examination was carried out by self prepared Performa which included demographic information, detailed history and clinical examination findings. Total of 360 patients were included in the study, the mean age being 31...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
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