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Topical and systemic antimicrobial therapy for venous leg ulcers.

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https://www.readbyqxmd.com/read/26833351/infection-in-venous-leg-ulcers-considerations-for-optimal-management-in-the-elderly
#1
Douglas J Pugliese
Venous leg ulcers are the most common cause of chronic leg wounds, accounting for up to 70 % of all chronic leg ulcers and carrying with them a significant morbidity, especially for elderly patients. Among people aged 65 years and older, the annual prevalence is 1.7 %. Billions of dollars per year are spent caring for patients with these often difficult-to-heal and sometimes recurrent chronic wounds. Chronic non-healing wounds of the lower extremities are susceptible to microbial invasion and can lead to serious complications, such as delayed healing, cellulitis, enlargement of wound size, debilitating pain, and deeper wound infections causing systemic illness...
February 2016: Drugs & Aging
https://www.readbyqxmd.com/read/25058087/topical-and-systemic-antimicrobial-therapy-for-venous-leg-ulcers
#2
COMMENT
Susan O'Meara, Rachel Richardson, Benjamin A Lipsky
CLINICAL QUESTION: Is treatment with topical or systemic antimicrobial agents associated with better venous leg ulcer healing compared with usual care (dressings and bandages without antimicrobials) or an alternative topical or systemic antimicrobial agent? BOTTOM LINE: Available evidence, from underpowered pooled data, neither supports nor refutes an association of systemic antibiotic therapy with improved venous leg ulcer healing. Among topical antimicrobials, cadexomer iodine may be associated with better healing compared with usual care...
June 25, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/22189344/venous-leg-ulcers
#3
REVIEW
E Andrea Nelson
INTRODUCTION: Leg ulcers usually occur secondary to venous reflux or obstruction, but 20% of people with leg ulcers have arterial disease, with or without venous disorders. Between 1.5 and 3.0/1000 people have active leg ulcers. Prevalence increases with age to about 20/1000 in people aged over 80 years. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of standard treatments, adjuvant treatments, and organisational interventions for venous leg ulcers? What are the effects of advice about self-help interventions in people receiving usual care for venous leg ulcers? What are the effects of interventions to prevent recurrence of venous leg ulcers? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2011 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review)...
December 21, 2011: Clinical Evidence
https://www.readbyqxmd.com/read/19445798/venous-leg-ulcers
#4
REVIEW
E Andrea Nelson, June Jones
INTRODUCTION: Leg ulcers usually occur secondary to venous reflux or obstruction, but 20% of people with leg ulcers have arterial disease, with or without venous disorders. Between 1.5 and 3.0/1000 people have active leg ulcers. Prevalence increases with age to about 20/1000 in people aged over 80 years. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of standard treatments, adjuvant treatments, and organisational interventions for venous leg ulcers? What are the effects of interventions to prevent recurrence of venous leg ulcers? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2007 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review)...
September 15, 2008: Clinical Evidence
https://www.readbyqxmd.com/read/16490980/quality-control-in-chronic-wound-management-the-role-of-local-povidone-iodine-betadine-therapy
#5
RANDOMIZED CONTROLLED TRIAL
Judit Daróczy
BACKGROUND: The treatment of venous leg ulcers is often inadequate, because of incorrect diagnosis, overuse of systemic antibiotics and inadequate use of compression therapy. Stasis dermatitis related to chronic venous insufficiency accompanied by infected superficial ulcers must be differentiated from erysipelas, cellulitis and contact eczema. OBJECTIVES: To assess the effectiveness of (1) topical povidone-iodine with and (2) without compression bandages, (3) to compare the efficacy of systemic antibiotics and topical antimicrobial agents to prevent the progression of superficial skin ulcers...
2006: Dermatology: International Journal for Clinical and Investigative Dermatology
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