W M Da, Y Liu, J T Zhong, H Bai, M J Ji, C B Wang, J Z Lu, J M Chen, Y L Wang, X X Wu, S F Xu, Q Zhang, Y M Wei
We have previously demonstrated that syngeneic marrow mixed with H-2 haploidentical marrow transplantation could provide not only protection against graft-versus-host disease (GVHD) but also anti-leukemic (GVL) effects in mice. In the present studies, we report clinical observations using autologous marrow mixed with HLA-haploidentical allogeneic marrow transplantation for treatment of patients with malignant blood diseases. Sixteen cases, including 12 with acute leukemia and four with advanced malignant lymphoma, were treated by autologous marrow, which was purged in vitro by hyperthemia (42...
January 1997: Bone Marrow Transplantation