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Reiko Iida, Misuzu Ueki, Toshihiro Yasuda
Mpv17-like protein (M-LP) is a protein that has been suggested to be involved in the metabolism of reactive oxygen species. To elucidate the molecular basis of M-LP expression, we recently searched for regulatory elements of M-LP and identified a novel mouse KRAB-containing protein, Rhit (regulator of heat-induced transcription), as a repressor of the transcriptional regulation of M-LP. In this study, we identified zinc-finger protein 205 as a candidate human Rhit (RhitH) and subsequently confirmed its participation in transcriptional regulation of human M-LP (M-LPH)...
April 15, 2012: Free Radical Biology & Medicine
Reiko Iida, Misuzu Ueki, Toshihiro Yasuda
Mpv17-like protein (M-LP) is a protein that has been suggested to be involved in the metabolism of reactive oxygen species. The two M-LP isoforms in mouse, M-LP(S) and M-LP(L), are generated by the alternative usage of promoters. M-LP(S) is expressed exclusively in kidneys after the age of 6 weeks, whereas M-LP(L) is expressed ubiquitously. To elucidate the molecular basis of M-LP(S) expression, we searched for cis-regulatory elements in the promoter region of M-LP(S) and identified heat shock element half-sites as positive elements and a Tramtrack 69K (Ttk 69K) binding site as a negative element...
May 2010: Molecular and Cellular Biology
Shihui Yang, Nicole T Perna, Donald A Cooksey, Yasushi Okinaka, Steven E Lindow, A Mark Ibekwe, Noel T Keen, Ching-Hong Yang
A green fluorescent protein-based in vivo expression technology leaf array was used to identify genes in Erwinia chrysanthemi 3937 that were specifically upregulated in plants compared with growth in a laboratory culture medium. Of 10,000 E. chrysanthemi 3937 clones, 61 were confirmed as plant upregulated. On the basis of sequence similarity, these were recognized with probable functions in metabolism (20%), information transfer (15%), regulation (11%), transport (11%), cell processes (11%), and transposases (2%); the function for the remainder (30%) is unknown...
September 2004: Molecular Plant-microbe Interactions: MPMI
Nicole Hugouvieux-Cotte-Pattat
Erwinia chrysanthemi causes soft-rot diseases of various plants by enzymatic degradation of the pectin in plant cell walls. The linear regions of pectin are composed of an acidic sugar, D-galacturonic acid. The ramified regions of pectin also include neutral sugars, and are rich in L-rhamnose residues. E. chrysanthemi is able to degrade these polysaccharides, polygalacturonate and rhamnogalacturonate. In E. chrysanthemi, the production of pectinases acting on linear regions is induced in the presence of polygalacturonate by a mechanism involving the repressor KdgR...
March 2004: Molecular Microbiology
P Spath
The simplest way to profile physicians' hospital practices is to rank them by their patients' length of stay and hospital charges, asserts guest columnist Patrice Spath, RHIT, a health care consultant with Brown-Spath Associates. The assumption is that those physicians whose patients have a higher length of stay and/or charges are the physicians who have high complication rates, provide less-than-adequate patient care, or are not practicing cost-effective care.
June 2001: Hospital Case Management: the Monthly Update on Hospital-based Care Planning and Critical Paths
P Spath
Many states have adopted trauma program legislation that includes a statewide trauma registry and performance evaluation activities. Hospitals participating in the trauma network are required to support the statewide activities through submission of data about the trauma patients they treat. By analyzing the quality of care provided to trauma patients, the trauma team members work to improve their services. Consulting editor Patrice Spath, RHIT, provides in-depth advice on how to measure and improve performance in trauma care...
May 2001: Hospital Peer Review
P Spath
The Joint Commission's performance improvement standard requires that organizations do an effective job of designing new processes. New processes may be those that have been revamped in a way that makes the process dramatically different or new services/activities that never existed before in your organization. Consulting editor Patrice Spath, RHIT, discusses how to approach systematic process development.
December 2000: Hospital Peer Review
P Spath
Although it's difficult to measure an institution's culture, it is possible to measure the factors that affect patient safety, says quality consultant Patrice Spath, RHIT. Areas to evaluate include management systems, safety systems, and individual attitudes and perceptions about patient safety improvement. In this month's Quality-Co$t Connection, Spath examines the elements that contribute to a patient-safe climate.
June 2000: Hospital Peer Review
P Spath
In this month's Quality-Co$t Connection, consulting editor Patrice Spath, RHIT, emphasizes that undesirable patient incidents are often caused by slight changes in the usual process of care. Deviations in system operations can be planned and desired or unintended and unwanted. Change analysis can help you analyze the effects of such deviations and can be a useful tool during sentinel event investigations.
May 2000: Hospital Peer Review
P Spath
Performance measures are generally easiest to determine for social work activities that have clearly defined goals. According to Patrice Spath, RHIT, by using a patient and family satisfaction survey, the case management team can collect data about patient and family perceptions of staff performance, set goals, and make constant improvements in quality.
December 2000: Hospital Case Management: the Monthly Update on Hospital-based Care Planning and Critical Paths
G B Harnett, C A Palmer, E M Mackay-Scollay
The single-radial-hemolysis test (SRHT) is a simple, convenient, and sensitive method that provides accurate measurement of IgG antibody to rubella virus. Lipoprotein inhibitors of rubella hemagglutination do not interfere with the SRHT; thus the assay of low levels of antibody is more reliable by SRHT than by the rubella hemagglutination-inhibition test (RHIT). The technique for the SRHT in a form suitable for large numbers of tests is detailed and compared with that of the RHIT, and the reproducibility of the SRHT in routine operation is assessed...
December 1979: Journal of Infectious Diseases
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