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https://www.readbyqxmd.com/read/29034839/pharmacogenetics-of-angiotensin-converting-enzyme-inhibitors-in-patients-with-alzheimer-s-disease-dementia
#1
Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
BACKGROUND: While the angiotensin-converting enzyme degrades amyloid-β, angiotensin-converting enzyme inhibitors (ACEis) may slow cognitive decline by way of cholinergic effects, by increasing brain substance P and boosting the activity of neprilysin, and by modulating glucose homeostasis and augmenting the secretion of adipokines to enhance insulin sensitivity in patients with Alzheimer's disease dementia (AD). We aimed to investigate whether ACE gene polymorphisms rs1800764 and rs4291 are associated with cognitive and functional change in patients with AD, while also taking APOE haplotypes and anti-hypertensive treatment with ACEis into account for stratification...
October 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29033112/gap-between-guidelines-and-clinical-practice-in-heart-failure-with-reduced-ejection-fraction-results-from-tsoc-hfref-registry
#2
Hung-Yu Chang, Chun-Chieh Wang, Jeng Wei, Chong-Yi Chang, Yi-Cheng Chuang, Chien-Long Huang, Eric Chong, Jiunn-Lee Lin, Guang-Yuan Mar, Kuei-Chuan Chan, Jen-Yuan Kuo, Ji-Hung Wang, Zhih-Cherng Chen, Wei-Kung Tseng, Wen-Jin Cherng, Wei-Hsian Yin
BACKGROUND: Heart failure (HF) is a global health problem. Guidelines for the management of HF have been established in Western countries and in Taiwan. However, data from the Taiwan Society of Cardiology-Heart Failure with reduced Ejection Fraction (TSOC-HFrEF) registry showed suboptimal prescription of guideline-recommended medications. We aimed to analyze the reason of non-prescription and clinical outcomes as a result of under-prescription of medications. METHODS: A total of 1509 patients hospitalized for acute HFrEF were recruited in 21 hospitals in Taiwan by the end of October 2014...
October 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29029965/contemporary-epidemiology-management-and-outcomes-of-patients-hospitalized-for-heart-failure-in-china-results-from-the-china-heart-failure-china-hf-registry
#3
Yuhui Zhang, Jian Zhang, Javed Butler, Xiaomin Yang, Peiyi Xie, Dongshuang Guo, Tiemin Wei, Jing Yu, Zhenli Wu, Yingchun Gao, Xiumin Han, Xuelian Zhang, Susheng Wen, Stefan D Anker, Gerasimos Filippatos, Gregg C Fonarow, Tianyi Gan, Rongcheng Zhang
BACKGROUND: Contemporary data on the epidemiology of heart failure (HF) in China are scarce. The China HF Registry was designed to investigate clinical characteristics, management, and outcomes of patients hospitalized for HF in China. DESIGN AND SUBJECTS: Data were collected prospectively on 13687 patients with a primary discharge diagnosis of HF who were enrolled from 132 participating hospitals between January 2012 to September 2015. Data from the China HF registry was compared with previously published literature...
October 10, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29019079/pharmacotherapy-choice-is-associated-with-2-year-mortality-for-patients-with-heart-failure-and-reduced-ejection-fraction
#4
Nancy M Albert, Dana A Drzayich Antol, Richard W DeClue, Adrianne Waldman Casebeer, Yong Li, Stephen Stemkowski, Chun-Lan Chang
INTRODUCTION: Factors associated with mortality for patients with heart failure and reduced ejection fraction (HFrEF) are known; however, the association between initial pharmacotherapy (IPT) and mortality is unclear in real-world settings. METHODS: Using a retrospective design and claims database, 14,359 Medicare patients with HFrEF from August 2010 to July 2015 were identified. Index date was first HF claim. IPT was mono- or combo-angiotensin-converting enzyme inhibitor (ACEI), angiotensin II receptor blocker (ARB), beta-blocker (BB), hydralazine-nitrate (HN), and aldosterone antagonist (AA) within 1 year post-index...
October 10, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29018420/molecular-characterization-of-reduced-susceptibility-to-biocides-in-clinical-isolates-of-acinetobacter-baumannii
#5
Fei Lin, Ying Xu, Yaowen Chang, Chao Liu, Xu Jia, Baodong Ling
Active efflux is regarded as a common mechanism for antibiotic and biocide resistance. However, the role of many drug efflux pumps in biocide resistance in Acinetobacter baumannii remains unknown. Using biocide-resistant A. baumannii clinical isolates, we investigated the incidence of 11 known/putative antimicrobial resistance efflux pump genes (adeB, adeG, adeJ, adeT1, adeT2, amvA, abeD, abeM, qacE, qacEΔ1, and aceI) and triclosan target gene fabI through PCR and DNA sequencing. Reverse transcriptase quantitative PCR was conducted to assess the correlation between the efflux pump gene expression and the reduced susceptibility to triclosan or chlorhexidine...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29018174/prognostic-value-of-n-terminal-pro-b-type-natriuretic-peptide-levels-in-heart-failure-patients-with-and-without-atrial-fibrillation
#6
Søren Lund Kristensen, Pardeep S Jhund, Ulrik M Mogensen, Rasmus Rørth, William T Abraham, Akshay Desai, Kenneth Dickstein, Jean L Rouleau, Michael R Zile, Karl Swedberg, Milton Packer, Scott D Solomon, Lars Køber, John J V McMurray
BACKGROUND: Patients with heart failure (HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) than HF patients without AF. There is uncertainty about the prognostic importance of a given concentration of NT-proBNP in HF patients with and without AF. We investigated this question in a large cohort of patients with HF and reduced ejection fraction. METHODS AND RESULTS: We studied 14 737 patients with HF and reduced ejection fraction and a measurement of NT-proBNP at time of screening, enrolled in either the PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) or the ATMOSPHERE trial (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure), of whom 3575 (24%) had AF on their baseline ECG...
October 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29016737/diverging-effects-of-enalapril-or-eplerenone-in-primary-prevention-against-doxorubicin-induced-cardiotoxicity
#7
Roger Hullin, Mélanie Métrich, Alexandre Sarre, Denis Basquin, Marc Maillard, Julien Regamey, David Martin
Aims: Clinical studies suggest beneficial effects of renin-angiotensin system blockade for prevention of left ventricular (LV) dysfunction after chemotherapy. However, the efficacy of this strategy as primary prevention has been poorly studied. This study aimed at identifying the pathophysiological mechanisms by which mineralocorticoid receptor antagonism (MRA) or angiotensin converting enzyme inhibition (ACEi) provide protection against doxorubicin-induced cardiotoxicity (DIC) in mouse models of acute and chronic toxicity...
September 7, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28994183/angiotensin-converting-enzyme-inhibitor-induced-angioedema-a-review-of-the-literature
#8
REVIEW
Teresa Brown, Jimmy Gonzalez, Catherine Monteleone
According to the National Health and Nutrition Examination Survey 2012, one third of antihypertensive prescriptions in the United States in the past decade were for angiotensin-converting enzyme inhibitors (ACEIs). An important and serious side effect of ACEIs is angioedema caused by a reduction in bradykinin degradation. In a national medical chart abstraction study conducted at the US Veterans Affairs Health Care System in 2008, 0.20% of ACEI initiators developed angioedema while on the medication. The angiotensin-converting enzyme is a part of the renin-angiotensin system that converts angiotensin I to angiotensin II...
October 10, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28982651/mortality-reduction-associated-with-%C3%AE-adrenoceptor-inhibition-in-chronic-heart-failure-is-greater-in-patients-with-diabetes
#9
Klaus K Witte, Michael Drozd, Andrew M N Walker, Peysh A Patel, Jessica C Kearney, Sally Chapman, Robert J Sapsford, John Gierula, Maria F Paton, Judith Lowry, Mark T Kearney, Richard M Cubbon
OBJECTIVE: Diabetes increases mortality in patients with chronic heart failure (CHF) and reduced left ventricular ejection fraction. Studies have questioned the safety of β-adrenoceptor blockers (β-blockers) in some patients with diabetes and reduced left ventricular ejection fraction. We examined whether β-blockers and ACE inhibitors (ACEI) are associated with differential effects on mortality in CHF patients with and without diabetes. RESEARCH DESIGN AND METHODS: We conducted a prospective cohort study of 1,797 patients with CHF recruited between 2006 and 2014, with mean follow-up of 4 years...
October 5, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28982370/effect-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-on-cardiovascular-events-in-patients-with-heart-failure-a-meta-analysis-of-randomized-controlled-trials
#10
Chenhui Tai, Tianyi Gan, Liling Zou, Yuxi Sun, Yi Zhang, Wei Chen, Jue Li, Jian Zhang, Yawei Xu, Huihe Lu, Dachun Xu
BACKGROUND: Heart failure (HF) remains a significant cause of morbidity and mortality. Multiple trials over the past several years have examined the effects of both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in the treatment of left ventricular dysfunction, both acutely after myocardial infarction and in chronic heart failure. Yet, there is still confusion regarding the relative efficacy of rennin-angiotensin-aldosterone system (RAAS) inhibition...
October 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28980280/renin-angiotensin-system-inhibition-is-associated-with-reduced-risk-of-left-atrial-appendage-thrombosis-formation-in-patients-with-atrial-fibrillation
#11
Ya Suo, Yue Zhang, Yuanyuan Wang, Meng Yuan, Sayuri Kariyawasam, Gary Tse, Tong Liu, Huaying Fu, Guangping Li
BACKGROUND: Inhibition of the renin-angiotensin axis can reduce the likelihood of atrial fibrillation (AF). However, the effects of angiotensin-converting-enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on thrombogenicity in AF remain incompletely elucidated. Thisretrospective case-control study was conducted to evaluate whether the use of ACEI or ARB could reduce the incidence of left atrial appendage thrombus (LAAT) and spontaneous echocardiographic contrast (SEC) in patients with AF...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28979697/the-zdsd-rat-a-novel-model-of-diabetic-nephropathy
#12
Richard G Peterson, Charles Van Jackson, Karen M Zimmerman
The ZDSD rat is a new obese-diabetic rat model that expresses type 2 diabetes in the presence of an intact leptin pathway. During a long pre-diabetic state, the animals exhibit most of the features of metabolic syndrome including obesity, hyperlipidemia, hypertension, insulin resistance and decreased glucose disposal. The animals used in these studies were either allowed to become spontaneously diabetic at 16-30 weeks of age, or diabetes was induced with a diabetogenic diet. In the presence of either spontaneous or diet-induced diabetes, they develop progressive albuminuria as well as increases in other urinary markers of impaired renal function (kidney injury molecule-1 (KIM-1), β2-microglobulin, clusterin and cystatin C)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28978235/the-effect-of-monthly-medication-on-mortality-after-a-coronary-event
#13
María C Montero-Balosa, Rocío Fernández-Urrusuno, Angel Vilches-Arenas
AIM: The aim of this study was to analyze how the consumption of medication over time affects the survival rate in patients with a coronary event and whether there is a gender difference. METHODS: The study included 804 patients admitted to 4 hospitals with a coronary event during 2007. Monitoring after coronary event was carried out during 2007 and every 6 months in the subsequent 2 years (2008 and 2009) throughout the review of the clinical history of the patient...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28977968/antihypertensive-drug-use-and-breast-cancer-risk-a-meta-analysis-of-observational-studies
#14
Haibo Ni, Qin Rui, Xiaojue Zhu, Zhenquan Yu, Rong Gao, Huixiang Liu
We conducted a meta-analysis of observational studies to examine the hypothesized association between breast cancer and antihypertensive drug (AHT) use. Fixed- or random- effect models were used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs) for all AHTs and individual classes (i.e., angiotensin-converting enzyme inhibitors, [ACEi]; angiotensin-receptor blockers, [ARBs]; calcium channel blockers, [CCBs]; beta-blockers, [BBs], and diuretics). Twenty-one studies with 3,116,266 participants were included...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28957687/trends-in-the-prevalence-of-antihypertensive-drug-treatment-in-the-beijing-longitudinal-study-of-aging
#15
Lina Ma, Rui Han, Li Li, Zhenzhen Li, Fei Sun, Lijun Diao, Zhe Tang
OBJECTIVE: This study aimed to explore the epidemiological characteristics of antihypertensive drug use by community residents in Beijing, China. METHODS: Based on well-established statistical sampling techniques such as cluster, stratification, and random selection, 2832, 1828, and 2277 elderly residents aged ≥60 years in Beijing in 2000, 2004, and 2007, respectively, were included. The trend in antihypertensive drug use by elderly patients with hypertension was analyzed...
September 21, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28955417/prescription-pattern-of-antihypertensive-medications-and-blood-pressure-control-among-hypertensive-outpatients-at-the-university-of-benin-teaching-hospital-in-benin-city-nigeria
#16
Oluseyi Adejumo, Enajite Okaka, Ikponmwosa Iyawe
BACKGROUND: The prevalence of hypertension and attendant cardiovascular disease burden is increasing globally. Auditing antihypertensive prescriptions and assessing patients with hypertension for blood pressure (BP) control are important steps on the path to reducing hypertension-related morbidity, mortality, and health expenditure. This study assessed the prescription pattern of antihypertensive medications and BP control among hypertensive outpatients at the University of Benin Teaching Hospital in Benin City, Nigeria...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28951664/use-of-the-guidelines-directed-medical-therapy-after-coronary-artery-bypass-graft-surgery-in-saudi-arabia
#17
Khalid A Alburikan, Rakan I Nazer
Background: incidence of cardiovascular diseases in Saudi Arabia is growing and more patients are expected to have cardiac revascularization surgery. Optimal pharmacotherapy management with Guideline Directed Medical Therapy (GDMT) post coronary artery bypass grafting (CABG) plays an important role in the prevention of adverse cardiovascular outcomes. The objective of this study was to assess the utilization of GDMT for secondary prevention in CABG patients and determine whether specific patients' characteristics can influence GDMT utilization...
September 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28939460/pharmacotherapy-use-in-older-patients-with-heart-failure-and-reduced-ejection-fraction-after-a-skilled-nursing-facility-stay
#18
Lin Li, Bill M Jesdale, Anne Hume, Giovanni Gambassi, Robert J Goldberg, Kate L Lapane
BACKGROUND: Little is known about guideline-directed pharmacotherapy use in patients with heart failure and reduced ejection fraction (HFrEF) discharged to skilled nursing facilities (SNFs). This study aimed to describe the use of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) and evidence-based β-blocker (EBBB) among older patients with HFrEF within 90 days after the SNF admission and to identify factors associated with receipt of these medications...
September 19, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28939396/novel-therapies-for-angiotensin-converting-enzyme-inhibitor-induced-angioedema-a-systematic-review-of-current-evidence
#19
Heidi M Riha, Bryant B Summers, Jessica V Rivera, Megan A Van Berkel
BACKGROUND: Angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema can occur at any point during therapy and, when severe, can require mechanical ventilation. Standard agents for anaphylactic reactions have limited efficacy for bradykinin-mediated angioedema and, therefore, agents approved for hereditary angioedema are increasingly prescribed for these patients. OBJECTIVE OF THE REVIEW: This systematic review critically evaluates evidence describing the off-label use of fresh frozen plasma (FFP), prothrombin complex concentrate (PCC), complement 1 esterase inhibitor (C1-INH), icatibant, and ecallantide for treatment of ACEI-induced angioedema...
September 19, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28935030/adherence-tradeoff-to-multiple-preventive-therapies-and-all-cause-mortality-after-acute-myocardial-infarction
#20
Maarit J Korhonen, Jennifer G Robinson, Izabela E Annis, Ryan P Hickson, J Simon Bell, Juha Hartikainen, Gang Fang
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARB), beta-blockers and statins are recommended after acute myocardial infarction (AMI). Patients may adhere to some, but not all, therapies. OBJECTIVES: The authors investigated the effect of tradeoffs in adherence to ACE inhibitors/ARBs, beta-blockers, and statins on survival among older people after AMI. METHODS: The authors identified 90,869 Medicare beneficiaries ≥65 years of age who had prescriptions for ACE inhibitors/ARBs, beta-blockers, and statins, and survived ≥180 days after AMI hospitalization in 2008 to 2010...
September 26, 2017: Journal of the American College of Cardiology
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