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https://www.readbyqxmd.com/read/29908131/low-body-mass-index-is-a-risk-factor-for-hyperkalaemia-associated-with-angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-treatments
#1
T Hirai, R Yamaga, A Fujita, T Itoh
WHAT IS KNOWN AND OBJECTIVE: Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) represent the cornerstones of hypertension and congestive heart failure treatment. Risk factors for hyperkalaemia associated with ACEI and ARB are chronic kidney disease and concomitant medications which increase serum potassium level. Body mass index (BMI) also affects pharmacokinetics of ACEI and ARB and potassium disposition. We evaluated the relationship between BMI and hyperkalaemia associated with ACEI and ARB treatments...
June 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29898676/improved-short-and-long-term-survival-associated-with-percutaneous-coronary-intervention-in-the-elderly-patients-with-acute-coronary-syndrome
#2
Xiaojing Chen, Salim Bary Barywani, Runa Sigurjonsdottir, Michael Fu
BACKGROUND: Percutaneous coronary intervention (PCI) are increasingly used in daily clinical practice in elderly patients with acute coronary syndrome (ACS) despite limited evidence. The purpose of this study was to assess the impact of PCI on short and long term survivals in a large cohort of elderly patients with ACS from a "real world". METHODS: We enrolled 491 patients aged ≥70 years admitted to our institution with ACS from 2006 to 2012. Effect of PCI on short and long term survival was evaluated in both overall and a propensity score-matched cohort...
June 7, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29895587/characteristics-and-treatments-of-patients-enrolled-in-the-champ-hf-registry-compared-with-patients-enrolled-in-the-paradigm-hf-trial
#3
Adam D DeVore, Xiaojuan Mi, Laine Thomas, Puza P Sharma, Nancy M Albert, Javed Butler, Adrian F Hernandez, J Herbert Patterson, John A Spertus, Fredonia B Williams, Carol I Duffy, Kevin McCague, Gregg C Fonarow
BACKGROUND: The US Food and Drug Administration approved sacubitril/valsartan for patients with chronic heart failure (HF) with reduced ejection fraction in 2015 on the basis of the results of the PARADIGM-HF (Prospective Comparison of ARNI [Angiotensin Receptor Neprilysin Inhibitor] With ACEI [Angiotensin-Converting Enzyme Inhibitor] to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial. There are limited data assessing the generalizability of PARADIGM-HF trial participants to a broader population of patients with HF with reduced ejection fraction routinely encountered in outpatient clinical practice...
June 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29889841/fixed-dose-combination-antihypertensive-medications-adherence-and-clinical-outcomes-a-population-based-retrospective-cohort-study
#4
Amol A Verma, Wayne Khuu, Mina Tadrous, Tara Gomes, Muhammad M Mamdani
BACKGROUND: The majority of people with hypertension require more than one medication to achieve blood pressure control. Many patients are prescribed multipill antihypertensive regimens rather than single-pill fixed-dose combination (FDC) treatment. Although FDC use may improve medication adherence, the impact on patient outcomes is unclear. We compared clinical outcomes and medication adherence with FDC therapy versus multipill combination therapy in a real-world setting using linked clinical and administrative databases...
June 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29887217/addition-of-digoxin-improves-cardiac-function-in-children-with-the-dilated-cardiomyopathy-with-ataxia-syndrome-a-mitochondrial-cardiomyopathy
#5
Steven C Greenway, Frederic Dallaire, Hassan Hazari, Dhwani Patel, Aneal Khan
BACKGROUND: The dilated cardiomyopathy with ataxia syndrome (DCMA) is a rare mitochondrial disorder characterized by progressive cardiomyopathy, prolonged QT interval and early death in childhood related to intractable heart failure. We present a case series of 9 children with DCMA who demonstrated functional improvement and favourable left ventricular remodeling only after digoxin was added to their medical therapy. METHODS: A retrospective review of 46 patients with DCMA followed at the Alberta Children's Hospital from 2005 to 2017 identified 9 patients who were treated with digoxin and had serial echocardiography data...
March 1, 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29872491/olmesartan-attenuates-pressure-overload-or-post-infarction-induced-cardiac-remodeling-in-mice
#6
Qiancheng Wang, Zhenhuan Chen, Xiaobo Huang, Lin Chen, Baihe Chen, Yingqi Zhu, Shiping Cao, Wangjun Liao, Jianping Bin, Masafumi Kitakaze, Yulin Liao
Either angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor 1 blocker (ARB) attenuates cardiac remodeling. However, the overall molecular modulation of the reversing remodeling process in response to the ACEI or ARB treatment is not yet well determined. In this study, we examined whether gene expressions are modulated by ACEI (temocapril), ARB (olmesartan) or both in a murine model with transverse aortic constriction (TAC) and confirm whether periostin is a target gene of olmesartan in mice with myocardial infarction (MI)...
May 15, 2018: Oncotarget
https://www.readbyqxmd.com/read/29866077/effects-of-the-concomitant-administration-of-xanthine-oxidase-inhibitors-with-zofenopril-or-other-ace-inhibitors-in-post-myocardial-infarction-patients-a-meta-analysis-of-individual-data-of-four-randomized-double-blind-prospective-studies
#7
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
BACKGROUND: Oxidative stress is increased in hyperuricemic patients with acute myocardial infarction (AMI). Use of sulfhydryl ACE-inhibitors (ACEIs), such as zofenopril or captopril, plus xanthine oxidase inhibitors (XOIs), may potentially result in enhanced antioxidant effects and improved survival. OBJECTIVE: We verified the benefit of such combination in a randomly stratified sample of 525 of the 3630 post-AMI patients of the four randomized prospective SMILE (Survival of Myocardial Infarction Long-term Evaluation) studies...
June 5, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29859479/neural-mechanism-of-angiotensin-converting-enzyme-inhibitors-in-improving-heart-rate-variability-and-sleep-disturbance-after-myocardial-infarction
#8
Wei-Lun Lin, Yu-Ruey Chen, Chun-Ting Lai, Shinya Yamada, Shin-Huei Liu, Yu-Hui Chou, Yun-Ching Fu, Cheryl C H Yang, Terry B J Kuo, Li-Wei Lo, Shih-Ann Chen
BACKGROUND: Sympathetic hyperactivity and poor sleep quality are reported in myocardial infarction (MI) patients and angiotensin-converting enzyme inhibitors (ACEI) can improve long-term survival in these patients. We aimed to evaluate ACEI effects on cardiac autonomic activity (CAA) and disordered sleep patterns in ambulatory rats after MI. METHODS: Polysomnographic recording was performed in sham (n = 8) and MI (n = 9) male rats during normal daytime sleep before and after captopril treatment...
May 1, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29859236/perindopril-fosinopril-and-losartan-inhibited-the-progression-of-diethylnitrosamine-induced-hepatocellular-carcinoma-in-mice-via-the-inactivation-of-nuclear-transcription-factor-kappa-b
#9
Sameh Saber, Amr A A Mahmoud, Reham Goda, Noha S Helal, Eman El-Ahwany, Rasha H Abdelghany
Hepatocellular carcinoma (HCC) is a major global health problem. Therapeutic interventions of HCC are still limited because of its complicated molecular pathogenesis. Many reports showed that renin-angiotensin system (RAS) contributes to the development of different types of malignancies. Therefore, the present study aimed to examine the effect of RAS inhibition using perindopril (1 mg/kg), fosinopril (2 mg/kg), or losartan (10 mg/kg) on diethylnitrosamine-induced HCC compared to sorafenib (30 mg/kg)...
May 30, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29850980/focused-treatment-of-heart-failure-with-reduced-ejection-fraction-using-sacubitril-valsartan
#10
REVIEW
Rex C Liu
The clinical syndrome of heart failure (HF) can be described as the reduced capacity of the heart to deliver blood throughout the body. To compensate for inadequate tissue perfusion, the renin-angiotensin aldosterone system (RAAS) and the sympathetic nervous system (SNS) become activated, resulting in increased blood pressure, heart rate, and blood volume. Consequent activation of the natriuretic peptide system (NPS) typically balances these effects; however, the NPS is unable to sustain compensation for excessive neurohormonal activation over time...
May 31, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29850387/angioedema-a-life-threatening-complication-of-tissue-plasminogen-activator
#11
Muhammad Khalid, Majd Kanaa, Yazan Alkawaleet, Muhammad Talha Ayub
Angioedema is a localized, non-pitting, non-dependent, submucosal, and subcutaneous swelling resulting from the extravasation of fluid into the interstitium due to the increased production of plasma kinins and histamine. It can present with urticaria or anaphylaxis and is usually associated with angiotensin-converting enzyme inhibitors (ACEis), complement deficiencies, or the side effects of tissue plasminogen activator (tPA). Orolingual angioedema following tPA for acute ischemic stroke is a transient, self-resolving hemifacial swelling contralateral to neurological deficits that can rarely progress to the airway, compromising it and leading to a life-threatening situation if not managed promptly...
March 29, 2018: Curēus
https://www.readbyqxmd.com/read/29848495/use-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-for-geriatric-ischemic-stroke-patients-are-the-rates-right
#12
John M Brooks, Cole G Chapman, Manish Suneja, Mary C Schroeder, Michelle A Fravel, Kathleen M Schneider, June Wilwert, Yi-Jhen Li, Elizabeth A Chrischilles, Douglas W Brenton, Marian Brenton, Jennifer Robinson
BACKGROUND: Our objective is to estimate the effects associated with higher rates of renin-angiotensin system antagonists, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEI/ARBs), in secondary prevention for geriatric (aged >65 years) patients with new ischemic strokes by chronic kidney disease (CKD) status. METHODS AND RESULTS: The effects of ACEI/ARBs on survival and renal risk were estimated by CKD status using an instrumental variable (IV) estimator...
May 30, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29808610/end-stage-renal-disease-patients-using-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-may-reduce-the-risk-of-mortality-a-taiwanese-nationwide-cohort-study
#13
Hsin-Fu Lee, Lai-Chu See, Yi-Hsin Chan, Yung-Hsin Yeh, Lung-Sheng Wu, Jia-Rou Liu, Hui-Tzu Tu, Chun-Li Wang, Chi-Tai Kuo, Shang-Hung Chang
BACKGROUND: The association between angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) use and mortality in end stage renal disease (ESRD) patients lacks sufficient evidence. We aim to investigate the efficacy of ACEIs and ARBs in ESRD patients. METHODS: This nationwide retrospective cohort study using data from the Taiwan National Health Insurance Research Database enrolled ESRD patients from January 1997 to December 2011...
May 29, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29806165/incremental-benefit-of-drug-therapies-for-chronic-heart-failure-with-reduced-ejection-fraction-a-network-meta-analysis
#14
Michel Komajda, Michael Böhm, Jeffrey S Borer, Ian Ford, Luigi Tavazzi, Matthieu Pannaux, Karl Swedberg
AIMS: A network meta-analysis (NMA) of all recommended drug groups for the treatment of heart failure with reduced ejection fraction (HFrEF), including their combinations, was performed to assess the relative efficacy and incremental benefit. METHODS AND RESULTS: A search was made in biomedical databases for randomised controlled trials published between 1987 and 2017 on angiotensin-converting enzyme inhibitors (ACEI), beta-blockers (BB), angiotensin-II receptor blockers (ARB), mineralocorticoid receptor antagonists (MRAs), ivabradine (IVA) or angiotensin receptor/neprilysin inhibitors (ARNI)...
May 27, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29792395/how-are-patients-with-heart-failure-treated-in-primary-care
#15
Hélène Vaillant-Roussel, Bruno Pereira, Sylvaine Gibot-Boeuf, Romain Eschalier, Claude Dubray, Rémy Boussageon, Philippe Vorilhon
OBJECTIVE: The aim of this study was to assess the adherence of general practitioners (GPs) to guidelines in patients with heart failure with reduced ejection fraction (HFrEF) and to describe GPs' prescribing behavior regarding patients with heart failure with preserved ejection fraction (HFpEF). MATERIALS AND METHODS: Cross-sectional study as part of the ETIC trial. Five classes of drugs were described: angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs); β-blockers (BBs); mineralocorticoid receptor antagonists (MRAs); diuretics (thiazide or loop diuretics); and digoxin...
May 24, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29789916/two-dimensional-speckle-tracking-echocardiography-derived-strain-measurements-in-survivors-of-childhood-cancer-on-angiotensin-converting-enzyme-inhibition-or-receptor-blockade
#16
Jamie K Harrington, Marc E Richmond, Arielle W Fein, Serge Kobsa, Prakash Satwani, Amee Shah
Speckle tracking echocardiography (STE)-derived strain indices are believed to detect early cardiac dysfunction in survivors of childhood cancer and have potential to identify patients who may benefit from early heart failure treatment. However, effects of heart failure treatment on STE-derived strain measurements in this population are unknown. The aim of this study was to assess STE-derived strain measurements in survivors of childhood cancer treated with angiotensin converting enzyme inhibition or receptor blockade (ACEi/ARB)...
May 22, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29789100/healthcare-resource-utilisation-by-patients-with-coronary-heart-disease-receiving-a-lifestyle-focused-text-message-support-program-an-analysis-from-the-text-me-study
#17
Jay Thakkar, Julie Redfern, Ehsan Khan, Emily Atkins, Jeffrey Ha, Kha Vo, Aravinda Thiagalingam, Clara K Chow
The 'Tobacco, Exercise and Diet Messages' (TEXT ME) study was a 6-month, single-centre randomised clinical trial (RCT) that found a text message support program improved levels of cardiovascular risk factors in patients with coronary heart disease (CHD). The current analyses examined whether receipt of text messages influenced participants' engagement with conventional healthcare resources. The TEXT ME study database (N=710) was linked with routinely collected health department databases. Number of doctor consultations, investigations and cardiac medication prescriptions in the two study groups were compared...
May 23, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29786638/impact-of-appointment-based-medication-synchronization-on-proportion-of-days-covered-for-chronic-medications
#18
Nancy Dao, Sun Lee, Micah Hata, Lord Sarino
Appointment-based medication synchronization (ABMS) programs have been associated with increased adherence and persistence to chronic medications. Adherence to statin therapy, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and non-insulin antidiabetic medications (NIDM) are used to determine a health plan's Centers for Medicare and Medicaid Services (CMS) Star Rating under a pay-for-performance model. The objective of this study was to evaluate the impact of implementing an ABMS program on overall pharmacy adherence measures for statins, ACEI/ARBs, and NIDM, as presented through the Electronic Quality Improvement Platform for Plans and Pharmacies (EQuIPP©) platform...
May 22, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29781586/treatment-algorithms-for-systemic-sclerosis-according-to-experts
#19
Andreu Fernández-Codina, Kyle M Walker, Janet E Pope
INTRODUCTION: Treatment for many aspects of systemic sclerosis (SSc) lacks agreement. OBJECTIVES: To generate SSc treatment algorithms endorsed by high percentage of SSc experts. METHODS: Experts from the Scleroderma Clinical Trials Consortium and the Canadian Scleroderma Research group (N=170) were asked whether they agreed with SSc algorithms (from 2012). Two consensus rounds refined agreement; 62 (36%), 54 (32%) and 48 (28%) experts completed surveys...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29778133/study-of-acute-kidney-injury-on-309-hypertensive-inpatients-with-acei-arb-diuretic-treatment
#20
Qiaochao Chen, Shaofang Zhu, Jianjun Liao, Wen He
BACKGROUND: The present study investigated risk factors for acute kidney injury (AKI) in patients found to be hypertensive during hospitalization who were prescribed angiotensin converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists (ARB) + diuretic combinations, in order to determine which type of diuretic or combination of diuretics used in ACE/ARB-treated patients leads to a higher risk of acute kidney injury. METHOD: Data on basic information, medical history, diagnostic information and medications prescribed were obtained from the patients' medical records...
June 2018: Journal of the National Medical Association
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