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https://www.readbyqxmd.com/read/28534446/blood-fatty-acid-changes-in-healthy-young-americans-in-response-to-a-10-week-diet-that-increased-n-3-and-reduced-n-6-fatty-acid-consumption-a-randomised-controlled-trial
#1
Andrew J Young, Bernadette P Marriott, Catherine M Champagne, Michael R Hawes, Scott J Montain, Neil M Johannsen, Kevin Berry, Joseph R Hibbeln
Military personnel generally under-consume n-3 fatty acids and overconsume n-6 fatty acids. In a placebo-controlled, double-blinded study, we investigated whether a diet suitable for implementation in military dining facilities and civilian cafeterias could benefit n-3/n-6 fatty acid status of consumers. Three volunteer groups were provided different diets for 10 weeks. Control (CON) participants consumed meals from the US Military's Standard Garrison Dining Facility Menu. Experimental, moderate (EXP-Mod) and experimental-high (EXP-High) participants consumed the same meals, but high n-6 fatty acid and low n-3 fatty acid containing chicken, egg, oils and food ingredients were replaced with products having less n-6 fatty acids and more n-3 fatty acids...
May 23, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28514264/breaks-in-sitting-time-effects-on-continuously-monitored-glucose-and-blood-pressure
#2
Dharini M Bhammar, Brandon J Sawyer, Wesley J Tucker, Glenn A Gaesser
PURPOSE: We examined the effects of interrupting prolonged sitting with multiple 2-min walking breaks or one 30-min continuous walking session on glucose control and ambulatory blood pressure (ABP). METHODS: Ten overweight/obese, physically inactive participants (5 men; 32±5 y, BMI 30.3±4.6 kg·m) participated in this randomized four-trial crossover study, with each trial performed on a separate, simulated workday lasting 9h: 1) 30 min of continuous walking at 71±4% HRmax (30min-MOD); 2) 21x2-min bouts of moderate-intensity walking at 53±5% HRmax (2min-MOD), each performed every 20 min (42 min total); 3) 8x2-min bouts of vigorous-intensity walking at 79±4% HRmax (2min-VIG), each performed every h (16 min total); 4) 9h of prolonged sitting (SIT)...
May 12, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28511384/community-acquired-burkholderia-cepacia-bacteraemia-presenting-as-mods-in-an-immunocompetent-individual-an-unusual-case
#3
Ritesh Ranjan, Priti Chowdhary, Aman Kamra
Burkholderia cepacia has been recognized as a group of highly virulent organisms known as Burkholderia cepacia complex (Bcc). Bcc are ubiquitous in nature and most commonly found in moist environment, on plant roots and soil. Because of its high intrinsic antibiotic resistance, Bcc is a major cause of morbidity and mortality in hospitalized patients. It is reported most commonly in immunocompromised patients especially in patients with cystic fibrosis. Here, we report a rare case report of bacteraemia by Burkholderia cepacia in an immunocompetent male, who presented with fever and Multiple Organ Dysfunction Syndrome (MODS)...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28506672/comparison-of-the-nosocomial-pneumonia-mortality-prediction-npmp-model-with-standard-mortality-prediction-tools
#4
M Srinivasan, N Shetty, S Gadekari, G Thunga, K Rao, V Kunhikatta
BACKGROUND: Severity or mortality prediction of nosocomial pneumonia could aid in the effective triage of patients and assisting physicians. AIM: To compare various severity assessment scoring systems for predicting intensive care unit (ICU) mortality in nosocomial pneumonia patients. METHODS: A prospective cohort study was conducted in a tertiary care university-affiliated hospital in Manipal, India. One hundred patients with nosocomial pneumonia, admitted in the ICUs who developed pneumonia after >48h of admission, were included...
April 15, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28487809/the-level-of-oxidative-neutrophil-response-when-determining-endotoxin-activity-assay-a-new-biomarker-for-defining-the-indications-and-effectiveness-of-intensive-care-in-patients-with-sepsis
#5
Michael Yaroustovsky, Ekaterina Rogalskaya, Marina Plyushch, Ludmila Klimovich, Nataliya Samsonova, Marina Abramyan
Background. To analyse the clinical informativity of the neutrophil oxidative response level ("Response") during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with "Response" level, and presepsin...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28482383/-efficacy-of-continuous-blood-purification-in-treatment-of-severe-acute-pancreatitis-in-children
#6
Y Zhu, Y Cui, Y C Zhang, H J Miao, F Wang, R X Chen, Q F Rong
Objective: To explore the therapeutic role of bedside continuous blood purification(CBP) in children with severe acute pancreatitis(SAP). Method: The clinical and laboratory data of 11 children with SAP who were admitted to Pediatric Intensive Care Unit (PICU) of Shanghai Children's Hospital from June 2013 to May 2016 were analyzed, including using pediatric critical illness score (PCIS) and pediatric risk of score mortality (PRISM)-Ⅲ score to assessing the severity of the disease.For those patients with severe organ dysfunction, CBP treatment was used when conventional therapy was not efficient...
May 4, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28477335/2-%C3%AE-fluoro-tricyclo-nucleic-acids-2-f-tc-ana-thermal-duplex-stability-structural-studies-and-rnase-h-activation
#7
Alena Istrate, Adam Katolik, Andrei Istrate, Christian Joerg Leumann
We describe the synthesis, thermal stability and structural and RNase H activation properties of 2'β-fluoro-tricyclo nucleic acids (2'F-tc-ANA). Three 2'F-tc-ANA nucleosides (T, 5MeC and A) were synthesized starting from a previously described fluorinated tricyclo sugar intermediate. NMR analysis and quantum mechanical calculations indicate that 2'F-tc-ANA nucleosides prefer sugar conformations in the East and South regions of the pseudorotational cycle. UV-melting experiments revealed that non-consecutive insertions of 2'F-tc-ANA units in DNA reduce the affinity to DNA and RNA complements...
May 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28471754/ultrasonically-spray-coated-silver-layers-from-designed-precursor-inks-for-flexible-electronics
#8
W Marchal, G Vandevenne, J D'Haen, A Calmont de Andrade Almeida, M A Durand Sola, E J van den Ham, J Drijkoningen, K Elen, W Deferme, M K Van Bael, A Hardy
Integration of electronic circuit components onto flexible materials such as plastic foils, paper and textiles is a key challenge for the development of future smart applications. Therefore, conductive metal features need to be deposited on temperature sensitive substrates in a fast and straightforward way. The feasibility of these emerging (nano-) electronic technologies depends on the availability of well-designed deposition techniques and on novel functional metal inks. As ultrasonic spray coating (USSC) is one of the most promising techniques to meet the above requirements, innovative metal organic decomposition (MOD) inks are designed to deposit silver features on plastic foils...
May 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28467259/in-vitro-evaluation-of-marginal-adaptation-of-direct-class-ii-composite-restorations-made-of-different-low-shrinkage-systems
#9
C Shahidi, I Krejci, D Dietschi
The present study evaluated the influence of various low-shrinkage restorative systems in class II direct composite restorations following simulated occlusal loading. Forty MOD class II cavities were prepared on freshly extracted human lower third molars with proximal margins located mesially 1.0 mm coronal to and distally 1 mm apical to the cementoenamel junction. The samples were randomly distributed into five experimental groups corresponding to the following restorative systems: a conventional resin composite (Tetric) as active control group, a low-shrinkage composite (Extra Low Shrinkage [ELS]) alone or combined with its corresponding flowable version (ELSflow) used as a 1- to 1...
May 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28459835/energy-expenditure-and-affect-responses-to-different-types-of-active-video-game-and-exercise
#10
Javier Monedero, Enda E Murphy, Donal J O'Gorman
BACKGROUND: The purpose of this study was to compare entertainment-themed active video game (AVG) and fitness-themed AVG play with traditional exercise to examine the interaction between physiological and psychological responses. METHODS: Participants (N = 23) were randomly assigned to 30-min of (i) self-selected intensity exercise (SS-EX), (ii) moderate intensity exercise (MOD-EX), (iii) entertainment-themed video game (ET-VG) and (iv) fitness-themed video game (FT-VG)...
2017: PloS One
https://www.readbyqxmd.com/read/28456113/the-enhancement-mechanism-of-wine-processed-radix-scutellaria-on-ntg-induced-migraine-rats
#11
Cheng-Long Cui, Xin He, Cui-Lan Dong, Zi-Jing Song, Jun Ji, Xue Wang, Ling Wang, Jiao-Ying Wang, Wen-Juan Du, Chong-Zhi Wang, Chun-Su Yuan, Chang-Run Guo, Chun-Feng Zhang
To elucidate the increasing dissolution and enhancement mechanism of wine-processed Radix Scutellaria (RS) by fractal theory in nitroglycerin (NTG)-induced migraine rats. We prepared three RS from the process with 10% (S1), 15% (S2), 20% (S3) (v/m) rice wine. Mercury intrusion porosimetry and scanning electron microscope were employed to explore the internal structure of RS and the components dissolution of RS was analyzed by HPLC. Rats were randomly allocated into following groups and orally given different solutions for 10days: normal group (NOR, normal saline), model group (MOD, normal saline), Tianshu capsule group (TSC, 0...
April 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28447715/correlation-of-the-expression-of-yy1-and-fas-cell-surface-death-receptor-with-apoptosis-of-peripheral-blood-mononuclear-cells-and-the-development-of-multiple-organ-dysfunction-in-children-with-sepsis
#12
Judith Reséndiz-Martínez, Juan Asbun-Bojalil, Sara Huerta-Yepez, Mario Vega
Multiple organ dysfunction (MOD) is a lethal complication in children with sepsis. Apoptosis of several cell types is involved in this process, and it is associated with increased Fas cell surface death receptor (Fas) expression. As YY1 transcription factor (YY1) negatively regulates the expression of Fas in cancer models, and is associated with the clinical outcome, it may be important in MOD. The present study aimed to determine the association between the expression of Fas, YY1 and apoptosis in children with sepsis, and its association with MOD, these factors were analyzed in 30 pediatric patients that had been diagnosed with sepsis...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28438201/relation-of-antioxidant-status-at-admission-and-disease-severity-and-outcome-in-dogs-naturally-infected-with-babesia-canis-canis
#13
Martina Crnogaj, José Joaquin Cerón, Iva Šmit, Ivana Kiš, Jelena Gotić, Mirna Brkljačić, Vesna Matijatko, Camila Peres Rubio, Nada Kučer, Vladimir Mrljak
BACKGROUND: Canine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors' knowledge there are no reports in which antioxidants have been analyzed in different presentations of canine babesiosis or in which the prognostic value of antioxidants has been studied. The aim of this study was to evaluate whether oxidative stress could be related to the severity and outcome of canine babesiosis. For this purpose a profile consisting of four antioxidant biomarkers (superoxide dismutase - SOD, glutathione peroxidase - GPx, catalase, total antioxidant status - TAS) and malondialdehyde - MDA as an oxidant biomarker (previously evaluated, here studied for comparative purposes) were evaluated in dogs with canine babesiosis of different clinical severity and outcomes...
April 24, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28420477/-metabolism-of-high-density-lipoprotein-and-the-research-progress-of-its-effects-on-sepsis
#14
Meiyun Liu, Huanping Zhou, Xin Lyu
Sepsis is a high-risk factor for the death of critical patients. High density lipoprotein (HDL) are the major protective serum proteins, and the serum levels of HDL are closely related to the severity of sepsis. The anti-inflammatory and anti-oxidation properties of HDL, may be able to play an important role in the innate immune response. Thereby it may reduce the damage of septic shock and multiple organ dysfunction syndrome (MODS) in animals or human beings, and improve the prognosis. In order to unveil the metabolism of HDL in septic patients and its effects on both progression and prognosis of sepsis, this review not only focuses on the composition and structure of HDL, but also analyzes its pivotal role in inflammatory immune response and anti-oxidation...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28420460/-bone-marrow-mesenchymal-stem-cells-modulated-the-inflammatory-response-by-regulating-the-expression-of-il-4-and-rage-products-in-the-rats-with-mods
#15
Xia Zhou, Guanghui Xiu, Yichao Zhu, Xiaolei Chen, Wei Xiong, Xinghua Pan, Jie Sun, Bin Ling
OBJECTIVE: To investigate the underlying mechanism of bone marrow mesenchymal stem cells (BMSC) modulating the inflammatory response during the multiple organ dysfunction syndrome (MODS), especially the expression of inflammatory cytokines, which will provide new theoretical and experimental basis of MODS in clinic. METHODS: BMSC of Sprague-Dawley (SD) rat (female, 4 weeks) was extracted and cultivated, and the 4th passage were used in experimental study. According to the random number table, 60 female SD rats were divided into three groups (n = 20 per group): sham group, MODS group, BMSC group...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28414569/elevated-levels-of-plasma-mitochondrial-dna-are-associated-with-clinical-outcome-in-intra-abdominal-infections-caused-by-severe-trauma
#16
Qiongyuan Hu, Jianan Ren, Jie Wu, Guanwei Li, Xiuwen Wu, Song Liu, Gefei Wang, Guosheng Gu, Jieshou Li
BACKGROUND: The purpose of our study was to determine prospectively relationships between plasma mitochondrial deoxyribonucleic acid (mtDNA) concentration and clinical outcome in patients with intra-abdominal infections (IAIs) induced by severe abdominal trauma. PATIENTS AND METHODS: The DNA was isolated from serum samples taken from patients with IAIs at hospital days zero, one, and two. Plasma mtDNA concentration was assessed by real-time polymerase chain reaction (PCR)...
April 17, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28413061/mechanical-behavior-of-bulk-direct-composite-versus-block-composite-and-lithium-disilicate-indirect-class-ii-restorations-by-cad-fem-modeling
#17
Pietro Ausiello, Stefano Ciaramella, Andrea Fabianelli, Antonio Gloria, Massimo Martorelli, Antonio Lanzotti, David C Watts
OBJECTIVES: To study the influence of resin based and lithium disilicate materials on the stress and strain distributions in adhesive class II mesio-occlusal-distal (MOD) restorations using numerical finite element analysis (FEA). To investigate the materials combinations in the restored teeth during mastication and their ability to relieve stresses. METHODS: One 3D model of a sound lower molar and three 3D class II MOD cavity models with 95° cavity-margin-angle shapes were modelled...
April 13, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28410931/a-model-of-recovery-from-inhalation-injury-and-cutaneous-burn-in-ambulatory-swine
#18
David M Burmeister, Matthew K McIntyre, Brendan Beely, Bryan Jordan, Kerfoot P Walker, James K Aden, Andriy Batchinsky, Kevin K Chung, Leopoldo C Cancio, Robert J Christy
Inhalation injury commonly accompanies thermal injury, increasing the likelihood of mortality and multiple organ dysfunction (MOD). Large animal models have given important insight into the pathophysiology of this injury; however recapitulating late MOD has remained difficult. The current report describes experiments using a smoke inhalation and burn model, with follow-up of ambulatory swine for 14days with bronchoscopy, CT scanning, and bronchoalveolar lavage fluid (BALF)/blood collection. Clinically, animals cleared airway damage in the first several days after-injury...
April 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28402737/comparison-of-polymerization-shrinkage-physical-properties-and-marginal-adaptation-of-flowable-and-restorative-bulk-fill-resin-based-composites
#19
J H Jung, S H Park
PURPOSE: The purpose of this study was to compare the marginal adaptation of two flowable bulk fill resin-based composites (FB-RBCs), two restorative bulk fill resin-based composites (RB-RBCs), and one regular incremental-fill RBC in MOD cavities in vitro. Additionally, the influence of linear polymerization shrinkage, shrinkage force, flexural modulus, and bottom/top surface hardness ratio on the marginal adaptation was evaluated. METHODS: A Class II MOD cavity was prepared in 40 extracted sound lower molars...
April 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28399519/pharmacokinetic-and-pharmacodynamic-modeling-of-mod-4023-a-long-acting-human-growth-hormone-in-growth-hormone-deficiency-children
#20
Dennis M Fisher, Ron G Rosenfeld, Michal Jaron-Mendelson, Leanne Amitzi, Ronit Koren, Gili Hart
BACKGROUND/AIMS: MOD-4023 is a long-acting human growth hormone (hGH) in clinical trials for the treatment of growth hormone deficiency (GHD). A key goal is maintenance of serum concentrations of insulin-like growth factor (IGF) 1 within normal range throughout GH dosing. The study aimed to develop a pharmacokinetic model for MOD-4023 and a pharmacodynamic model for the effect of MOD-4023 on IGF-1 to allow estimation of peak and mean IGF-1 and to identify the optimal IGF-1 sampling day...
April 11, 2017: Hormone Research in Pædiatrics
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