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https://www.readbyqxmd.com/read/29781374/april-and-staci-could-be-predictors-of-severe-multiorgan-dysfunction-syndrome-in-sepsis
#1
Dajana F Lendak, Dunja M Mihajlović, Aleksandra S Novakov-Mikić, Jasmina M Boban, Milan Ubavić, Snežana V Brkić
Although the role of B cells in sepsis immunoregulation has become an interesting topic, there is lack of data on the role of B cell function regulators in prediction of multiorgan dysfunction syndrome (MODS). The aim of this study was to evaluate the prognostic value of A Proliferation Inducing Ligand (APRIL) and soluble Transmembrane Activator and CAML Interactor Protein (sTACI), the main B cell function regulators, in prediction of MODS development within the first 48h after admission to intensive care unit, among septic patients...
May 21, 2018: Virulence
https://www.readbyqxmd.com/read/29767845/final-results-from-a-defibrotide-treatment-ind-study-for-patients-with-hepatic-veno-occlusive-disease-sinusoidal-obstruction-syndrome
#2
Nancy A Kernan, Stephan Grupp, Angela R Smith, Sally Arai, Brandon Triplett, Joseph H Antin, Leslie Lehmann, Tsiporah Shore, Vincent T Ho, Nancy Bunin, Massimo Iacobelli, Wei Liang, Robin Hume, William Tappe, Robert Soiffer, Paul Richardson
Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of haematopoietic stem cell transplant (HSCT) conditioning and chemotherapy. Defibrotide is approved for treatment of hepatic VOD/SOS with pulmonary or renal dysfunction [i.e., multi-organ dysfunction (MOD)] after HSCT in the United States and severe VOD/SOS after HSCT in patients aged older than 1 month in the European Union. Defibrotide was available as an investigational drug by an expanded-access treatment programme (T-IND; NCT00628498)...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29767842/more-than-just-co-2-recycling-corticular-photosynthesis-as-a-mechanism-to-reduce-the-risk-of-an-energy-crisis-induced-by-low-oxygen
#3
Christiane Wittmann, Hardy Pfanz
Reassimilation of internal CO2 via corticular photosynthesis (PScort ) has an important effect on the carbon economy of trees. However, little is known about its role as a source of O2 supply to the stem parenchyma and its implications in consumption and movement of O2 within trees. PScort of young Populus nigra (black poplar) trees was investigated by combining optical micro-optode measurements with monitoring of stem chlorophyll fluorescence. During times of zero sap flow in spring, stem oxygen concentrations (cO2 ) exhibited large temporal changes...
May 16, 2018: New Phytologist
https://www.readbyqxmd.com/read/29766733/-hemophagocytic-lymfohistiocytosis-in-adults-review-and-case-report
#4
Jiří Šrámek, Thomas Karvunidis, Daniel Lysák, Martin Harazim, Michal Karas, Pavel Jindra
Hemophagocytic lymfohistiocytosis (HLH) is rare, life-threatening condition, characterized by excessive activation of immune system with subsequent proinflammatory state resulting in multiorgan failure. Most frequently, it appears in infancy as a primary disorder caused by mutation of immune-regulatory genes. Increasingly, HLH is being diagnosed as a secondary - adult - form, which occurs as a result of aberrant immune response. Viral or bacterial systemic infections, malignancy with a predominance of lymphoproliferative disorders and autoimmune diseases are the most common triggers...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29764551/-predictive-values-of-different-critical-scoring-systems-for-survival-rate-after-discharge-in-critically-ill-patients-supported-by-extracorporeal-membrane-oxygenation
#5
Jinsong Zhang, Wei Li, Xufeng Chen, Yong Mei, Jinru Lyu, Deliang Hu, Gang Zhang, Yongxia Gao, Xihua Huang
OBJECTIVE: To determine the predictive values of different critical scoring systems for survival rate after discharge in critically ill patients supported by extracorporeal membrane oxygenation (ECMO). METHODS: The clinical data of 34 critically ill patients supported by ECMO admitted to Department of Emergency of the First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital) from July 2015 to September 2017 were retrospectively analyzed...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764548/-effects-of-different-core-temperatures-after-heat-strike-on-serum-inflammatory-cytokines-and-multiple-organ-dysfunction-syndrome-in-rats
#6
Qinghua Li, Rongqing Sun, Hongdi Lyu, Dexin Shen, Qing Hu, Haiwei Wang, Nannan Wang, Jin Yan, Jing Wang
OBJECTIVE: To observe the effect of different core temperatures (Tc) after heat strike on serum inflammatory cytokines and multiple organ dysfunction syndrome (MODS) in rat. METHODS: 120 male Sprague-Dawley (SD) rats were randomly divided into normal control group (n = 30) and heat strike group (n = 90). The rats in heat strike group were put into simulated thermal climate animal module after adaptive training. The module temperature was raised to 39 centigrade in 30 minutes with 65% humidity...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29756642/reference-values-and-correlates-of-right-atrial-volume-in-healthy-adults-by-two-dimensional-echocardiography
#7
Francesco Ferrara, Luna Gargani, Saku Ruohonen, Olga Vriz, Marco Scalese, Valentina Russo, Alberto M Marra, Anna Agnese Stanziola, Antonio Cittadini, Antonello D'Andrea, Robert Naeije, Eduardo Bossone
BACKGROUND: Right atrial (RA) volume is an important parameter in the evaluation of patients with pulmonary hypertension. Aim of this study was to define reference ranges for RA volume by two-dimensional echocardiography (2DE) in healthy adults. METHODS: A total of 596 healthy subjects [mean age 45.7 ± 14.6 years, range 18-88 years; 60.1% women] underwent a transthoracic echocardiography. In addition, a meta-analysis was performed of published studies measuring RA volume in healthy subjects, using 2DE single plane area-length (A-L) and/or method of disks (MOD) at end-systole in apical four-chamber view...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29750094/effect-of-cusp-coverage-and-water-storage-on-compressive-strength-of-composite-restorations-of-premolars
#8
Shila Emamieh, Parvaneh Hojati, Amir Ghasemi, Hasan Torabzadeh
Background: The aim of this study was to assess the effect of cusp coverage and water storage on compressive strength of composite restorations. Material and Methods: This in vitro experimental study was conducted on 40 extracted human maxillary premolar teeth, which were randomly divided into four groups of 10. Mesio-occluso-distal (MOD) cavities were prepared in all teeth. The thickness of composite for cusp coverage was 1.5 mm in groups 1 and 3 and 2.5 mm in groups 2 and 4...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29749505/identification-of-genes-and-pathways-associated-with-multiple-organ-dysfunction-syndrome-by-microarray-analysis
#9
Changwei Gu, Wanhai Qiao, Lina Wang, Minmin Li, Kang Song
Multiple organ dysfunction syndrome (MODS) is characterized by the development of progressive physiological dysfunction of ≥2 organs or organ systems and is responsible for the majority of the morbidity and mortality among patients in intensive care units. The aim of the present study was to investigate the potential genes and pathways associated with MODS. The microarray dataset GSE60088 was downloaded from the Gene Expression Omnibus and used to identify differentially expressed genes (DEGs) between organ tissues (lung, liver and kidney) obtained from a murine model of MODS and healthy controls...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29738820/classification-of-forensic-autopsy-reports-through-conceptual-graph-based-document-representation-model
#10
Ghulam Mujtaba, Liyana Shuib, Ram Gopal Raj, Retnagowri Rajandram, Khairunisa Shaikh, Mohammed Ali Al-Garadi
Text categorization has been used extensively in recent years to classify plain-text clinical reports. This study employs text categorization techniques for the classification of open narrative forensic autopsy reports. One of the key steps in text classification is document representation. In document representation, a clinical report is transformed into a format that is suitable for classification. The traditional document representation technique for text categorization is the bag-of-words (BoW) technique...
May 5, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29722564/long-term-culture-and-cloning-of-primary-human-bronchial-basal-cells-that-maintain-multipotent-differentiation-capacity-and-cftr-channel-function
#11
Jennifer Ruth Peters-Hall, Melissa L Coquelin, Michael J Torres, Ryan LaRanger, Busola Ruth Alabi, Sei Sho, Jose Francisco Calva-Moreno, Philip J Thomas, Jerry William Shay
While primary cystic fibrosis (CF) and non-CF human bronchial epithelial basal cells (HBECs) accurately represent in vivo phenotypes, one barrier to their wider use has been a limited ability to clone and expand cells in sufficient numbers to produce rare genotypes using genome editing tools. Recently, conditional reprogramming of cells (CRC) with a ROCK inhibitor and culture on an irradiated fibroblast feeder layer resulted in extension of the lifespan of HBECs, but differentiation capacity and CF transmembrane conductance regulator (CFTR) function decreased as a function of passage...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29716369/the-flush-mounted-rail-langmuir-probe-array-designed-for-the-alcator-c-mod-vertical-target-plate-divertor
#12
A Q Kuang, D Brunner, B LaBombard, R Leccacorvi, R Vieira
An array of flush-mounted and toroidally elongated Langmuir probes (henceforth called rail probes) have been specifically designed for the Alcator C-Mod's vertical target plate divertor and operated over multiple campaigns. The "flush" geometry enables the tungsten electrodes to survive high heat flux conditions in which traditional "proud" tungsten electrodes suffer damage from melting. The toroidally elongated rail-like geometry reduces the influence of sheath expansion, which is an important effect to consider in the design and interpretation of flush-mounted Langmuir probes...
April 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29715794/mo-detector-mod-a-dual-function-optical-modulator-detector-for-on-chip-communication
#13
Shuai Sun, Ruoyu Zhang, Jiaxin Peng, Vikram K Narayana, Hamed Dalir, Tarek El-Ghazawi, Volker J Sorger
While augmenting network on chips (NoC) with photonic links enables high-bandwidth communication, the overhead for photonics is rather large, mainly driven by bulky footprints and the multi-functionality of transceivers. The latter requires, in addition to a photon source, signal modulation and detection. If the NoC were photonically augmented at every network point to enable all-to-all connectivity, the resulting photonic overhead would be excessive. Besides, the high bandwidth of a single optical bus may be sufficient to supply the data-sharing demand of a network...
April 2, 2018: Optics Express
https://www.readbyqxmd.com/read/29707014/thermal-scanning-of-dental-pulp-chamber-by-thermocouple-system-and-infrared-camera-during-photo-curing-of-resin-composites
#14
Faeze Hamze, Seyed Abdolreza Ganjalikhan Nasab, Ali Eskandarizadeh, Arash Shahravan, Fatemeh Akhavan Fard, Neda Sinaee
Introduction: Due to thermal hazard during composite restorations, this study was designed to scan the pulp temperature by thermocouple and infrared camera during photo polymerizing different composites. Methods and Materials: A mesio-occlso-distal (MOD) cavity was prepared in an extracted tooth and the K-type thermocouple was fixed in its pulp chamber. Subsequently, 1 mm increment of each composites were inserted (four composite types were incorporated) and photo polymerized employing either LED or QTH systems for 60 sec while the temperature was recorded with 10 sec intervals...
2018: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29706799/recent-advances-in-the-molecular-mechanisms-underlying-pyroptosis-in-sepsis
#15
REVIEW
Yu-Lei Gao, Jian-Hua Zhai, Yan-Fen Chai
Sepsis is recognized as a life-threatening organ dysfunctional disease that is caused by dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause of multiple organ dysfunction syndrome (MODS) and death among severe condition patients. Pyroptosis, originally named after the Greek words " pyro " and " ptosis " in 2001, has been defined as a specific programmed cell death characterized by release of inflammatory cytokines. During sepsis, pyroptosis is required for defense against bacterial infection because appropriate pyroptosis can minimize tissue damage...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29699435/fetal-cerebral-and-cardiac-hemodynamics-in-postdate-pregnancy
#16
Aysegul Ozel, Ebru Alici Davutoglu, Sule Yildirim, Riza Madazli
OBJECTIVE: We aimed to determine the fetal cerebro-placental Doppler indices and modified myocardial performance index (Mod-myocardial performance index (MPI)) in this homogenous group of postdated pregnancies. METHODS: A total of 92 singleton pregnant women were included in this prospective study. The study involved three groups; full term control (Group 1, n = 42, 39 0/7 to 40 6/7 week' gestation), late term (Group 2, n = 34, 41 0/7 to 41 6/7 week' gestation) and post term (Group 3, n = 16, ≥ 42 0/7 weeks' gestation)...
April 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29695671/marginal-sealing-of-relocated-cervical-margins-of-mesio-occluso-distal-overlays
#17
Serhat Köken, Jelena Juloski, Roberto Sorrentino, Simone Grandini, Marco Ferrari
We investigated the effect of cervical marginal relocation (CMR) on marginal sealing with two different viscosity resin composites, before adhesive cementation of composite computer-aided design/computer-assisted manufacture mesio-occluso-distal (MOD) overlays. Standardized MOD cavities prepared in 39 human molars were randomly assigned to three groups. The proximal margins on the mesial side were located 1 mm below the cementoenamel junction. On the distal side of the tooth, the margins were located 1 mm above the cementoenamel junction...
April 25, 2018: Journal of Oral Science
https://www.readbyqxmd.com/read/29682261/cement-layer-thickness-and-shear-stress-resistance-in-cylindrical-dowel-spaces-pull-out-test
#18
M Andreasi Bassi, D Lauritano, M Brizzi, C Andrisani, S Lico, V Candotto
Purpose: This study evaluated the effects of different dowel space (DS) diameters on pull-out bond strength of a cylindrical post, of threaded steel, to dentin. Materials and methods: Forty-five extracted human teeth were divided in 3 groups with DSs, with the same depth (6 mm), differing for the diameter (i.e. 1.5 mm, Group 1; 1.75 mm, Group 2; 2.00 mm, Group 3). Both the diameter of the post (1.3 mm) and the composite resin cement (Panavia 21) were the same for all the samples...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29671035/-prognostic-relevance-of-tissue-oxygen-saturation-in-patients-in-the-early-stage-of-multiple-organ-dysfunction-syndrome
#19
D Huster, F Härtel, S Nuding, J Schroeder, Y Zhang, K Werdan, H Ebelt
BACKGROUND: Patients in circulatory shock exhibit insufficient peripheral perfusion to ensure adequate oxygenation of vital organs such as the heart and brain. Early detection of reduced tissue oxygen saturation (St O2 ) could be used for rapid therapeutic intervention and thus improve the prognosis of patients in the early stage of multiple organ dysfunction syndrome (MODS). MATERIALS AND METHODS: A total of 60 patients in the early stage of MODS (APACHE [Acute Physiology and Chronic Health Evaluation] II score ≥20) were investigated in a monocentric, prospective, randomized phase II study...
April 18, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29670661/effect-of-zishen-jiangtang-pill-a-chinese-herbal-product-on-rats-with-diabetic-osteoporosis
#20
Huilin Li, Shufang Chu, Hengxia Zhao, Deliang Liu, Xuemei Liu, Xi Qu, Jianpin Chen, Zengyin Li, Jinhua Li
Diabetic osteoporosis (DO) is a complication of diabetes. Zishen Jiangtang Pill (ZJP) is a Chinese herbal product which has been used in clinic to maintain blood glucose level and bone density for decades. However, the evidence about its mechanism on diabetes and osteoporosis is still unknown. The aim of this study is to investigate therapeutic effect of ZJP on DO in streptozotocin- (STZ-) induced rats. Rats were randomly assigned to 4 groups: one control group (CON), one model group (MOD), and two ZJP treatment groups (1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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