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Hong-Jie Li, Dong-Sheng Gao, Yong-Tao Li, Yong-Sheng Wang, Hong-Ying Liu, Jun Zhao
Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, causes acute diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. Severe outbreaks of PEDV variants have re-emerged in Asia and North America since 2010, causing tremendous economic losses to the swine industry. The lack of effective therapeutic treatment promotes the research for new antivirals. Lithium chloride (LiCl) has been reported as a potential antiviral drug for certain viruses. In this study, the antiviral effect of LiCl on PEDV in Vero cells was evaluated...
March 5, 2018: Research in Veterinary Science
Yang Liu, Dandan Sun, Jingjing Zhou, Yingping Qin, Deyu Wang, Bingkun Guo
In this work, we propose a novel electrolyte additive, isophorone diisocyanate(IPDI), to construct the surface protective interlayer. This membrane is produced via nucleophilic addition between the IPDI's diisocyanate groups and the freeradical-onium ion oxidative intermediate of propylene carbonate(PC). In the electrolyte with IPDI added between 10 ~ 20 mM, LiNi0.5Co0.2Mn0.3O2 presents the excellent performance, demonstrating the relative wide operational window to form the optimal protective membrane. This protective membrane ameliorates the cyclic stability...
March 16, 2018: ACS Applied Materials & Interfaces
Sen Xu, Xiaofeng Fan, Jialin Liu, David J Singh, Qing Jiang, Weitao Zheng
We report an investigation of the interactions of Li with silicene. We find silicene to be a promising anode material for high energy density lithium-ion batteries. Based on first-principles calculations, we study the interaction between Li and silicene and explore the microscopic mechanism of Li storage on silicene. We find that Li ion is adsorbed on hollow sites at a very low concentration of less than 1.56%. At a high concentration of Li, the Li chains with up-down pairs on top sites become popular. With the formation of the Li chains, the local structure of silicene is modulated...
March 16, 2018: Physical Chemistry Chemical Physics: PCCP
Lu-Lu Zhang, Ji-Qing Wang, Xue-Lin Yang, Gan Liang, Tao Li, Peng-Lin Yu, Di Ma
Layered LiNi1/3Co1/3Mn1/3O2 (NCM333) is successfully coated by fast ionic conductor LiTi2(PO4)3 (LTP) via wet chemical method. The effects of LTP on the physicochemical properties and electrochemical performance are studied. The results reveal that a highly layered structure of NCM333 can be well maintained with less cation mixing after LTP coating. LTP about 5 nm thickness is coated on the surface of NCM333. Such LTP coating layer can effectively suppress the side reactions between NCM333 and electrolyte but will not hinder the lithium ion transmission...
March 16, 2018: ACS Applied Materials & Interfaces
Wenjiao Ren, Liqiang Xu, Lin Zhu, Xinye Wang, Xiaojian Ma, Debao Wang
Lithium-sulfur (Li-S) battery has attracted increasing attention owning to its high energy density and the abundance of sulfur. However, its commercialization is still restricted owing to the low conductivity of sulfur, large volume expansion and severe polysulfide-shuttle effect. To address these problems, here we reported a simple template-free solvothermal method combined with subsequent calcination method to prepare cobalt-doped VN yolk-shell nanospheres encapsulated in thin layer of nitrogen-doped carbon (Co-VN@C) composite as an ideal sulfur hosts for the first time...
March 16, 2018: ACS Applied Materials & Interfaces
Ze Yang, Xiangyan Shen, Ning Wang, Jianjiang He, Xiaodong Li, Xin Wang, Zhufeng Hou, Kun Wang, Juan Gao, Tonggang Jiu, Changshui Huang
The qualitative and quantitative nitrogen-doping strategy for carbon materials is reported here. Novel porous nanocarbon networks pyrimidine-graphdiyne (PM-GDY) and pyridine-graphdiyne (PY-GDY) films with large areas were successfully prepared. These films are self-supported, uniform, continuous, flexible, transparent, and quantitively doped with merely pyridine-like nitrogen (N) atoms through the facile chemical synthesis route. Theoretical predictions imply these N doped carbonaceous materials are much favorable for storing lithium (Li)-ions since the pyridinic N can enhance the interrelated binding energy...
March 16, 2018: ACS Applied Materials & Interfaces
Haiying Rao, Yuxiang Bai, Qingshu Li, Baimei Zhuang, Yu Yuan, Yamin Liu, Wei Peng, Philip N Baker, Chao Tong, Xin Luo, Hongbo Qi
Preeclampsia (PE) is characterized by abnormal placentation in the early stages of pregnancy. Adequate migration and invasion of trophoblasts into the uterine wall and spiral arteries to form a functional maternal-fetal interface are pivotal for normal placentation, but the exact mechanism remains unclear. Growing evidence has revealed that special AT-rich sequence-binding protein 1 (SATB1) is a tumor promoter that participates in cancer cell migration and invasion. However, the expression and function of SATB1 in trophoblasts is unknown...
March 13, 2018: Biology of Reproduction
Yijun Pan, Jennifer L Short, Stephanie A Newman, Kwok H C Choy, Durgesh Tiwari, Christopher Yap, Danielle Senyschyn, William A Banks, Joseph A Nicolazzo
Epidemiological evidence suggests that people with bipolar disorder prescribed lithium exhibit a lower risk of Alzheimer's disease (AD) relative to those prescribed other mood-stabilizing medicines. Lithium chloride (LiCl) reduces brain β-amyloid (Aβ) levels, and the brain clearance of Aβ is reduced in AD. Therefore, the purpose of this study was to assess whether the cognitive benefits of LiCl are associated with enhanced brain clearance of exogenously-administered Aβ. The brain clearance of intracerebroventricularly (icv) administered125 I-Aβ42 was assessed in male Swiss outbred mice administered daily oral NaCl or LiCl (300 mg/kg for 21 days)...
March 12, 2018: Brain, Behavior, and Immunity
Heike Bittersohl, Björn Schniedewind, Uwe Christians, Peter B Luppa
Therapeutic drug monitoring (TDM) of the immunosuppressive drug tacrolimus is essential to avoid side effects and rejection of the allograft after transplantation. In the blood circulation, tacrolimus is largely located inside erythrocytes or bound to plasma proteins and less than 0.1% is protein-unbound (free). One basic principle of clinical pharmacology is that only free drug is pharmacologically active and monitoring this portion has the potential to better reflect the drug effect than conventional measurements of total tacrolimus in whole blood...
March 7, 2018: Journal of Chromatography. A
Shan Xing, Gregory S Calip, Alex D Leow, Shiyun Kim, Glen T Schumock, Daniel R Touchette, Todd A Lee
AIMS: To compare adherence and persistence to oral antidiabetic drugs (OAD) between patients who are new users of second generation antipsychotics (SGA) versus new users of other depression therapies in adults with type 2 diabetes mellitus (T2DM) and major depressive disorder (MDD). METHODS: Adults 18-64 years with previously-treated T2DM and MDD (past OAD and SSRI/SNRI use) who are new users of SGA or non-SGA therapies (bupropion, lithium, mirtazapine, thyroid hormone, tricyclic antidepressant) were identified in the 2009-2015 MarketScan® Commercial Claims and Encounters database...
December 27, 2017: Journal of Diabetes and its Complications
Ali Sahraian, Zahra Ehsaei, Arash Mowla
BACKGROUND AND OBJECTIVE: Our Objective is to study the effects of aripiprazole as an adjuvant treatment for obsessive and compulsive (OC) symptoms in patients with bipolar disorder (BD) type I, manic phase. PATIENTS AND METHODS: In this 8-week, double-blind, placebo-controlled randomized clinical trial, 56 patients with BD who had OC symptoms were randomly allocated to receive aripiprazole or placebo plus their routine medication regimen (lithium + clonazepam)...
March 12, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
S N Beznosov, M G Pyatibratov, O V Fedorov
At the end of 1980s, regions of the polypeptide chain of bacterial flagella subunits (flagellins) responsible for different properties of these protein polymers were identified by structural studies. It was found that the N- and C-terminal regions are responsible for the polymerization properties of subunits, and the central region is responsible for antigenic properties of the flagellum. Soon after that, it was proposed to use variability of the central flagellin domain for directed modification to impart new properties to the flagellum surface...
January 2018: Biochemistry. Biokhimii︠a︡
Teng-Sing Wei, Bok Yeop Ahn, Julia Grotto, Jennifer A Lewis
The growing demand for rechargeable lithium-ion batteries (LIBs) with higher capacity in customized geometries underscores the need for new battery materials, architectures, and assembly strategies. Here, the design, fabrication, and electrochemical performance of fully 3D printed LIBs composed of thick semisolid electrodes that exhibit high areal capacity are reported. Specifically, semisolid cathode and anode inks, as well as UV curable packaging and separator inks for direct writing of LIBs in arbitrary geometries are created...
March 15, 2018: Advanced Materials
Min Xu, Shulai Lei, Jing Qi, Qingyun Dou, Lingyang Liu, Yulan Lu, Qing Huang, Siqi Shi, Xingbin Yan
Two-dimensional (2D) Ti3C2 MXene has attracted great attention in electrochemical energy storage devices (supercapacitors, lithium-ion and sodium-ion batteries) due to its excellent electrical conductivity as well as high volumetric capacity. Nevertheless, existing study showed that multivalent Mg2+ ions cannot reversibly insert into MXene, resulting in a negligible capacity. Here we demonstrate a simple strategy to achieve high magnesium storage capability for Ti3C2 MXene by pre-intercalating a cationic surfactant cetyltrimethylammonium bromide (CTAB)...
March 15, 2018: ACS Nano
Eunji Kim, Hyeri Kim, Byung-Jun Park, Young-Hee Han, Jong Hyuk Park, Jinhan Cho, Sang-Soo Lee, Jeong Gon Son
From graphene oxide wrapped iron oxide particles with etching/reduction process, high-performance anode and cathode materials of lithium-ion hybrid supercapacitors are obtained in the same process with different etching conditions, which consist of partially etched crumpled graphene (CG) wrapped spiky iron oxide particles (CG@SF) for a battery-type anode, and fully etched CG for a capacitive-type cathode. The CG is formed along the shape of spikily etched particles, resulting in high specific surface area and electrical conductivity, thus the CG-based cathode exhibits remarkable capacitive performance of 210 F g-1 and excellent rate capabilities...
March 15, 2018: Small
Nika Mahne, Sara E Renfrew, Bryan D McCloskey, Stefan A Freunberger
Solid alkaline carbonates are universal passivation layer components of intercalation battery materials, common side products in metal-O₂ batteries, and are believed to form and decompose reversibly in metal-O₂/CO₂ cells. In all of these cathode chemistries, Li₂CO₃ decomposes to CO₂ when exposed to potentials >3.8 V vs. Li/Li+. Notably, though, O₂ evolution is not detected, as is expected according to the decomposition reaction 2 Li₂CO₃ → 4 Li+ + 4 e- + 2 CO₂ + O₂. O-moieties were therefore previously considered unaccounted for in unidentified parasitic reactions...
March 15, 2018: Angewandte Chemie
Samuel B Penwell, Lukas Whaley-Mayda, Andrei Tokmakoff
We present the design and characterization of a tunable mid-IR optical parametric amplifier (OPA) with a 1 MHz 1033 nm fiber laser pump source. The OPA generates >10  nJ/pulse tunable from 3-7.5 μm with 85-165  cm-1 bandwidth and 140-540 fs pulse durations. The design utilizes a single stage of collinear, Type I amplification in lithium gallium sulfide (LGS) seeded by the near-IR portion of a super-continuum (SC) generated in yttrium aluminum garnet (YAG). The resulting mid-IR idler beam is isolated as the output...
March 15, 2018: Optics Letters
Duong Tung Pham, Joseph Paul Baboo, Jinju Song, Sungjin Kim, Jeonggeun Jo, Vinod Mathew, Muhammad Hilmy Alfaruqi, Balaji Sambandam, Jaekook Kim
Pyrite (FeS2 ) is a promising electrode material for lithium ion batteries (LIBs) because of its high natural availability, low toxicity, cost-effectiveness, high theoretical capacity (894 mA h g-1 ) and high theoretical specific energy density (1270 W h kg-1 , 4e- /FeS2 ). Nevertheless, the use of FeS2 in electrochemical capacitors was restricted due to fast capacity fading as a result of polysulfide (S/Sn 2- ) formation during the initial electrochemical cycling. In order to avoid the formation of polysulfides, we employed the strategy of utilizing an ether based electrolyte (1...
March 15, 2018: Nanoscale
Bingwen Zhang, Qinfang Zhang, Yujie Bai
A new monolayer MnC<sub>2</sub> was predicted as a stable 2D material associated with the
 result of phonon and AIMD calculations. The in-plane young's modulus is 73.6 N/m,
 which is about 20% of graphene. The monolayer MnC<sub>2</sub> is antiferromagnetic with a
 Neil temperature around 280K and from the dirac point of the electronic band we got
 the fermi velocity of 5.37×10<sup>5</sup> m/s showing excellent electronic transport property...
March 15, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Meng-Ting Li, Ning Kong, Ya-Qian Lan, Zhong-Min Su
We utilise the dual synthesis strategy in terms of bimetallic inorganic building blocks and sulfur containing organic ligand. A novel sulfur-containing bimetallic metal organic framework (Fe2 Co-TPDC) with two types of 4-fold meso-helical structures has been successfully synthesized. Benefitting from the uniform distribution of active sulfur sites and the structural stability of the mixed-metallic method, Fe2 Co-TPDC can efficiently prevent a shuttle behavior of sulfur and endow a commendable specific capacity...
March 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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