keyword
https://read.qxmd.com/read/38530702/clinical-trial-inclusion-and-impact-on-early-adoption-of-medical-innovation-in%C3%A2-diverse-populations
#21
JOURNAL ARTICLE
Philip B Adamson, Melvin Echols, Ersilia M DeFilippis, Alanna A Morris, Mosi Bennett, William T Abraham, JoAnn Lindenfeld, John R Teerlink, Christopher M O'Connor, Allison T Connolly, Huanan Li, Mona Fiuzat, Muthiah Vaduganathan, Orly Vardeny, Wayne Batchelor, Kelly C McCants
BACKGROUND: Inadequate inclusion in clinical trial enrollment may contribute to health inequities by evaluating interventions in cohorts that do not fully represent target populations. OBJECTIVES: The aim of this study was to determine if characteristics of patients with heart failure (HF) enrolled in a pivotal trial are associated with who receives an intervention after approval. METHODS: Demographics from 2,017,107 Medicare patients hospitalized for HF were compared with those of the first 10,631 Medicare beneficiaries who received implantable pulmonary artery pressure sensors...
March 21, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38530131/precision-delivery-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-the-pancreas-via-intra-arterial-injection-prevents-the-onset-of-diabetes
#22
JOURNAL ARTICLE
Rosita Primavera, Shobha Regmi, Reza Yarani, Steven Levitte, Jing Wang, Abantika Ganguly, Shashank Chetty, Michele Guindani, Camillo Ricordi, Everett Meyer, Avnesh S Thakor
Mesenchymal stem cells (MSCs) are a promising therapy to potentially treat diabetes given their potent anti-inflammatory and immune-modulatory properties. While these regenerative cells have shown considerable promise in cell culture, their clinical translation has been challenging. In part, this can be attributed to these cells not reaching the pancreas to exert their regenerative effects following conventional intravenous (IV) injection, with the majority of cells being trapped in the lungs in the pulmonary first-pass effect...
March 26, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38530061/covid-19-severity-and-mortality-in-veterans-with-chronic-lung-disease
#23
JOURNAL ARTICLE
Kristina Crothers, Scott V Adams, Aaron P Turner, Lisa Batten, Reyhaneh Nikzad, John R Kundzins, Vincent S Fan
INTRODUCTION: Chronic lung disease (CLD) has been associated with risk for more severe manifestations and death with COVID-19. However, few studies have evaluated the risk overall and by type of CLD for severity of COVID-19 outcomes in a US national cohort. METHODS: Using data from the Veterans Health Administration, we determined the risk associated with CLDs including COPD (mild/severe), asthma (mild/active/severe), idiopathic pulmonary fibrosis (IPF), sarcoidosis and other interstitial lung diseases (ILDs) for outcomes among veterans with SARS-CoV-2 positive tests between 3/1/2020-4/30/2021...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38530051/vessel-and-airway-characteristics-in-one-year-ct-defined-rapid-emphysema-progression-spiromics
#24
JOURNAL ARTICLE
Sarah E Gerard, Timothy M Dougherty, Prashant Nagpal, Dakai Jin, MeiLan K Han, John D Newell, Punam K Saha, Alejandro P Comellas, Christopher B Cooper, David Couper, Spyridon Fortis, Junfeng Guo, Nadia N Hansel, Richard E Kanner, Ella A Kazeroni, Fernando J Martinez, Amin Motahari, Robert Paine Iii, Stephen Rennard, Joyce D Schroeder, Prescott G Woodruff, R Graham Barr, Benjamin M Smith, Eric A Hoffman
Rationale: Rates of emphysema progression vary in chronic obstructive pulmonary disease (COPD), and the relationship with vascular and airway pathophysiology remain unclear. Objective: We sought to determine if indices of peripheral (segmental and beyond) pulmonary arterial (PA) dilation measured via computed tomography (CT) are associated with a 1-year index of emphysema (EI: %voxels<-950HU) progression. Methods: 599 GOLD 0-3 former and never-smokers were evaluated from the SubPopulations and InterMediate Outcome Measures in COPD Study (SPIROMICS) cohort: rapid-emphysema-progressors (RP, n=188; 1-year ΔEI>1%), non-progressors (NP, n=301; 1-year ΔEI±0...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38529899/correction-of-absent-pulmonary-valve-syndrome-using-hilum-to-hilum-internal-pulmonary-artery-plication-plasty
#25
Fabian A Kari, Sebastian Michel, Jürgen Hörer
A 12-month-old girl (8.4 kg) with absent pulmonary valve syndrome and enlarged bilateral pulmonary arteries underwent trans-tricuspid ventricular septal defect closure, placement of a right ventricular-to-pulmonary artery conduit and hilum-to-hilum internal pulmonary artery plication plasty.
March 26, 2024: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://read.qxmd.com/read/38529652/diagnostic-strategy-for-suspected-unilateral-absence-of-the-pulmonary-artery
#26
JOURNAL ARTICLE
Van Luong Hoang, Viet Anh Lam, Thanh Nguyen Pham
UNLABELLED: <p>Background: Unilateral absence of the pulmonary artery (UAPA) is a very rare congenital anomaly. OBJECTIVE: To analyze the diagnostic strategy applied to seven patients with UAPA who were examined and subsequently treated at the National Lung Hospital, Hanoi, Vietnam. METHODS: All seven patients, including three pediatric cases (1, 2, and 14 years old) and four adult cases (21, 26, 44, and 53 years old), had a history of recurrent pneumonia, and the clinical symptoms on admission included cough, progressive dyspnea, chest pain, and fatigue...
March 19, 2024: Current medical imaging
https://read.qxmd.com/read/38529483/a-computational-study-of-right-ventricular-mechanics-in-a-rat-model-of-pulmonary-arterial-hypertension
#27
JOURNAL ARTICLE
Oscar O Odeigah, Ethan D Kwan, Kristen M Garcia, Henrik Finsberg, Daniela Valdez-Jasso, Joakim Sundnes
Pulmonary arterial hypertension (PAH) presents a significant challenge to right ventricular (RV) function due to progressive pressure overload, necessitating adaptive remodeling in the form of increased wall thickness, enhanced myocardial contractility and stiffness to maintain cardiac performance. However, the impact of these remodeling mechanisms on RV mechanics in not clearly understood. In addition, there is a lack of quantitative understanding of how each mechanism individually influences RV mechanics...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38528794/bicuspidisation-of-unicuspid-stenotic-pulmonary-valve-in-a-nine-year-old-male
#28
JOURNAL ARTICLE
Florin Anghel, Catalin Constantin Badiu, Alain J Poncelet
We report the case of a 9-year-old male with severe congenital pulmonary valve stenosis referred to our centre for percutaneous valvotomy. On admission, trans-thoracic echocardiogram confirmed a unicuspid pulmonary valve with a peak/mean pulmonary valve gradient of 91/53 mmHg and a pulmonary annulus of 13.8 mm (-0.8 Z Score). It also showed an enlarged RV (RV/LV ratio 0,9). During cardiac catheterisation, an additional atrial septal defect (secundum) with significant left to right shunt (Qp/Qs > 2) was diagnosed, which was not amenable to percutaneous closure...
March 26, 2024: Cardiology in the Young
https://read.qxmd.com/read/38528047/identification-of-the-shared-hub-gene-signatures-and-molecular-mechanisms-between-hiv-1-and-pulmonary-arterial-hypertension
#29
JOURNAL ARTICLE
Huanzhuo Mai, Xing Yang, Yulan Xie, Jie Zhou, Yiru Wei, Tingyan Luo, Jing Yang, Ping Cui, Li Ye, Hao Liang, Jiegang Huang
The close link between HIV-1 infection and the occurrence of pulmonary arterial hypertension (PAH). However, the underlying molecular mechanisms of their interrelation remain unclear. The microarray data of HIV-1 and PAH were downloaded from GEO database. We utilized WGCNA to identify shared genes between HIV-1 and PAH, followed by conducting GO and pathway enrichment analyses. Subsequently, differentially genes analysis was performed using external validation datasets to further filter hub genes. Immunoinfiltration analysis was performed using CIBERSORT...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527563/formulation-and-evaluation-of-inhaled-sildenafil-loaded-plga-microparticles-for-treatment-of-pulmonary-arterial-hypertension-pah-a-novel-high-drug-loaded-formulation-and-scalable-process-via-hot-melt-extrusion-technology-part-%C3%A2
#30
JOURNAL ARTICLE
Mashan Almutairi, Amr Hefnawy, Ahmed Almotairy, Ahmed Alobaida, Mohammed Alyahya, Abdulmajeed Althobaiti, Ahmed Adel Ali Youssef, Rasha M Elkanayati, Eman A Ashour, Hugh D C Smyth, Michael A Repka
In recent years, several techniques were employed to develop a local sustained pulmonary delivery of sildenafil citrate (SC) as an alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). Most of these methods, however, need to be improved due to limitations of scalability, low yield production, low drug loading, and stability issues. In this study, we report the use of hot-melt extrusion (HME) as a scalable process for making Poly (lactic-co-glycolic acid) (PLGA) microparticles with high SC load...
March 23, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38527273/a-65-year-old-man-with-refractory-hemoptysis-associated-with-chronic-progressive-pulmonary-aspergillosis-who-failed-to-respond-to-combined-endobronchial-occlusion-and-bronchial-artery-embolization-a-case-report-and-literature-review
#31
REVIEW
Ryotaro Yoneoka, Kenichiro Takeda, Hajime Kasai, Toshihiko Sugiura, Kohei Shikano, Mitsuhiro Abe, Takuji Suzuki
BACKGROUND Hemoptysis due to airway hemorrhage is treated with hemostatic agents, bronchial artery embolization (BAE), or surgical resection. We present the case of a 65-year-old man with refractory hemoptysis associated with chronic progressive pulmonary aspergillosis (CPPA) who failed to respond to combined endobronchial occlusion (EBO) with endobronchial Watanabe spigot (EWS) and BAE. CASE REPORT A 63-year-old man was diagnosed with CPPA in the right upper lung and presented to our hospital 2 years later for hemoptysis at age 65...
March 13, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38527024/omentin-1-ameliorates-pulmonary-arterial-hypertension-by-inhibiting-endoplasmic-reticulum-stress-through-ampk%C3%AE-signaling
#32
JOURNAL ARTICLE
Xinyu Deng, Hao Luo, Jing He, Wang Deng, Daoxin Wang
BACKGROUND: Endothelial dysfunction of the pulmonary artery contributes to hypoxia-induced pulmonary arterial hypertension (PAH). Omentin-1, as a novel adipocytokine, plays an important protective role against cardiovascular diseases. However, the effect and underlying mechanisms of omentin-1 against PAH remain unclear. METHODS: PAH was induced in SD (Sprague & Dawley) rats via a low-oxygen chamber for 4 weeks. Hemodynamic evaluation was undertaken using a PowerLab data acquisition system, and histopathological analysis was stained with hematoxylin and eosin (H&E)...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38526489/physiologic-effects-of-ecmo-in-patients-with-severe-acute-respiratory-distress-syndrome
#33
JOURNAL ARTICLE
Elena Spinelli, Marco Giani, Douglas Slobod, Bertrand Pavlovsky, Michela di Pierro, Stefania Crotti, Alfredo Lissoni, Giuseppe Foti, Giacomo Grasselli, Tommaso Mauri
RATIONALE: Blood flow rate affects mixed venous oxygenation (SvO2 ) during venovenous extracorporeal membrane oxygenation (ECMO), with possible effects on the pulmonary circulation and the right heart function. OBJECTIVES: We aimed at describing the physiologic effects of different levels of SvO2 obtained by changing ECMO blood flow, in patients with severe ARDS receiving ECMO and controlled mechanical ventilation. METHODS: Low (SvO2 target 70-75%), intermediate (SvO2 target 75-80%) and high (SvO2 target > 80%) ECMO blood flows were applied for 30 minutes in random order in 20 patients...
March 25, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38526363/-a-case-of-right-heart-failure-when-it-is-not-pulmonary-embolism
#34
JOURNAL ARTICLE
Enrico Tadiello, Emma Zimelli, Giulia Urbani, Tommaso Hinna Danesi, Daniela Reghellin, Claudio Bilato
A 66-year-old patient with recent instrumental findings (echocardiogram, cardiac magnetic resonance imaging) of right ventricular failure was hospitalized due to worsening signs and symptoms of right heart failure, while waiting for diagnostic definition. Pulmonary computed tomography angiography revealed findings compatible with bilateral pulmonary thromboembolism involving the main pulmonary artery. Anticoagulant therapy was initiated with initial benefit, partial relief of symptoms, and moderate improvement in right ventricular function...
April 2024: Giornale Italiano di Cardiologia
https://read.qxmd.com/read/38526074/a-porcine-model-of-acute-respiratory-failure-with-a-continuous-infusion-of-oleic-acid
#35
JOURNAL ARTICLE
Bret D Alvis, Colleen Brophy, Joyce Cheung-Flynn, Marisa Case, Kyle Hocking
This protocol outlines an acute respiratory distress model utilizing centrally administered oleic acid infusion in Yorkshire pigs. Prior to experimentation, each pig underwent general anesthesia, endotracheal intubation, and mechanical ventilation, and was equipped with bilateral jugular vein central vascular access catheters. Oleic acid was administered through a dedicated pulmonary artery catheter at a rate of 0.2 mL/kg/h. The infusion lasted for 60-120 min, inducing respiratory distress. Throughout the experiment, various parameters including heart rate, respiratory rate, arterial blood pressure, central venous pressure, pulmonary artery pressure, pulmonary capillary wedge pressure, end-tidal carbon dioxide, peak airway pressures, and plateau pressures were monitored...
March 8, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38525938/impact-of-aspirin-use-on-rates-of-metastasis-in-patients-with-esophageal-cancer-insights-from-the-national-inpatient-sample
#36
JOURNAL ARTICLE
Jay Patel, Tejasvini Khanna, Aalam Sohal, Armaan Dhaliwal, Hunza Chaudhry, Shivam Kalra, Ishandeep Singh, Dino Dukovic, Kanwal Bains
Despite advancing treatment methods, esophageal cancer (EC) maintains a high mortality rate and poor prognosis. Through various mechanisms, aspirin has been suggested to have a chemopreventive effect on EC. However, the long-term impact, particularly regarding the rate of metastasis, needs to be further elucidated. NIS 2016-2020 was used to identify adult patients (age > 18 years) with EC using ICD-10 codes. Patients with missing demographics and mortality were excluded. Patients were stratified into two groups based on aspirin use...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38524984/anomalous-left-coronary-artery-originating-from-the-pulmonary-artery-diagnosed-in-an-adult
#37
Lindsey Croll, Michael Ellerman, Muhammad J Ahsan, Manik Veer
• ALCAPA presenting in adulthood is a rare cause of ischemic cardiomyopathy. • An unexplained dilated RCA should raise concern for ALCAPA. • Multimodality imaging is helpful for diagnosis, but often echo alone can be diagnostic. • Treatment is reimplantation of the LMCA.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524981/delayed-diagnosis-of-unilateral-absence-of-pulmonary-artery-presenting-with-recurrent-bronchopneumonia
#38
Raja Ezman Raja Shariff, Mohd Rahal Yusoff, Khairul Shafiq Ibrahim, Sazzli Kasim
• Unilateral absence of the pulmonary artery (UAPA) is a rare congenital condition. • Patients with UAPA may present initially following recurrent bouts of pneumonia. • Echocardiography remains a useful tool for diagnosis in resource-limited settings.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524978/multimodality-imaging-in-management-of-adults-with-dextro-transposition-of-the-great-arteries-post-arterial-switch-operation
#39
Desireé R Conrad, Jennifer P Woo, George K Lui, Daniel E Clark
• Echo is an essential tool for monitoring long-term complications of D-TGA with ASO. • Multimodality imaging is complementary to echo in the assessment of complications. • 4D flow CMR can assess supravalvular PS post ASO. • Branch pulmonary arteries after LeCompte maneuver can be challenging to image.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524975/multimodality-imaging-of-patent-ductus-arteriosus-complicated-by-severe-pulmonary-arterial-hypertension-in-a-pregnant-patient
#40
Offdan D Narvaez-Guerra, Karela B Herrera-Enriquez, Gerard P Aurigemma, Dennis A Tighe, Bryon A Gentile
• Large uncorrected PDA may first be diagnosed during pregnancy. • Multimodality imaging may be safely utilized in these patients. • Multimodality imaging is safely utilized in these patients. • Multidisciplinary team approach is key for percutaneous closure of PDA in pregnancy.
March 2024: CASE: Cardiovascular Imaging Case Reports
keyword
keyword
35809
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.