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docosahexanoic

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https://www.readbyqxmd.com/read/29912604/investigation-of-the-effect-of-dietary-docosahexaenoic-acid-dha-supplementation-on-macular-function-in-subjects-with-autosomal-recessive-stargardt-macular-dystrophy
#1
Ian M MacDonald, Paul A Sieving
PURPOSE: To test the effect of docosahexanoic acid (DHA) dietary supplementation on macular function in patients with Stargardt disease. MATERIALS AND METHODS: A single center, double-masked, randomized placebo-controlled trial of 11 subjects (2 males, 9 females) with Stargardt disease in a crossover design (NCT00060749). Six participants were randomized to two sequences of three month periods of DHA supplementation (2000 mg/day) followed by three months of placebo...
June 18, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29902005/fingerprinting-of-phospholipids-molecular-species-from-human-milk-and-infant-formula-using-hilic-esi-it-tof-ms-and-discriminatory-analysis-by-principal-component-analysis
#2
Chenyu Jiang, Baokai Ma, Shuang Song, Oi-Ming Lai, Ling-Zhi Cheong
Phospholipids composition in the milk fat globule membrane (MFGM) fluctuates during entire lactation period in order to suit the growing needs of newborn infants. Present study elucidated and relatively quantified phospholipids molecular species extracted from human milk (HM), mature human milk (MHM) and infant formulas (with or without MFGM supplementation) using HILIC-ESI-IT-TOF-MS system. Principal component analysis was used to clarify the differences between phospholipids composition in HM, MHM and infant formulas...
June 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29783637/a-phosphatidylserine-source-of-docosahexanoic-acid-improves-neurodevelopment-and-survival-of-preterm-pigs
#3
Randal K Buddington, Victor V Chizhikov, Igor Y Iskusnykh, Helen J Sable, Jeffrey J Sable, Zade R Holloway, Tamar Blumenfeld Katzir, Marie van der Merwe, Taisiya Yakimkova, Karyl K Buddington, Yael Lifshitz, Shoshi Tessler, Ariel Gilbert
The amount, composition, and sources of nutrition support provided to preterm infants is critical for normal growth and development, and particularly for structural and functional neurodevelopment. Although omega-3 long chain polyunsaturated fatty acids (LC-PUFA), and particularly docosahexanoic acid (DHA), are considered of particular importance, results from clinical trials with preterm infants have been inconclusive because of ethical limitations and confounding variables. A translational large animal model is needed to understand the structural and functional responses to DHA...
May 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29725824/a-low-fat-spread-with-added-plant-sterols-and-fish-omega-3-fatty-acids-lowers-serum-triglyceride-and-ldl-cholesterol-concentrations-in-individuals-with-modest-hypercholesterolaemia-and-hypertriglyceridaemia
#4
Wendy A M Blom, Wieneke P Koppenol, Harry Hiemstra, Tatjana Stojakovic, Hubert Scharnagl, Elke A Trautwein
PURPOSE: The primary and secondary objectives were to investigate the triglyceride (TG) and LDL-cholesterol (LDL-C) lowering effects of a spread with added plant sterols (PS) and fish oil as compared to a placebo spread. METHODS: This study had a randomized, double-blind, placebo-controlled, parallel group design with two intervention arms. Following a 2-week placebo run-in period, 260 healthy individuals with modestly elevated blood TG (≥ 1.4 mmol/L) and LDL-C (≥ 3...
May 3, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29710835/eicosahexanoic-acid-epa-and-docosahexanoic-acid-dha-in-muscle-damage-and-function
#5
REVIEW
Eisuke Ochi, Yosuke Tsuchiya
Nutritional supplementation not only helps in improving and maintaining performance in sports and exercise, but also contributes in reducing exercise fatigue and in recovery from exhaustion. Fish oil contains large amounts of omega-3 fatty acids, eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (DHA; 22:6 n-3). It is widely known that omega-3 fatty acids are effective for improving cardiac function, depression, cognitive function, and blood as well as lowering blood pressure. In the relationship between omega-3 fatty acids and exercise performance, previous studies have been predicted improved endurance performance, antioxidant and anti-inflammatory responses, and effectivity against delayed-onset muscle soreness...
April 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29544992/omega-3-fatty-acids-and-non-alcoholic-fatty-liver-disease-evidence-of-efficacy-and-mechanism-of-action
#6
REVIEW
Eleonora Scorletti, Christopher D Byrne
For many years it has been known that high doses of long chain omega-3 fatty acids are beneficial in the treatment of hypertriglyceridaemia. Over the last three decades, there has also been a wealth of in vitro and in vivo data that has accumulated to suggest that long chain omega-3 fatty acid treatment might be beneficial to decrease liver triacylglycerol. Several biological mechanisms have been identified that support this hypothesis; notably, it has been shown that long chain omega-3 fatty acids have a beneficial effect: a) on bioactive metabolites involved in inflammatory pathways, and b) on alteration of nuclear transcription factor activities such as peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), involved in inflammatory pathways and liver lipid metabolism...
March 22, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29525608/beneficial-effects-of-white-wine-polyphenols-enriched-diet-on-alzheimer-s-disease-like-pathology
#7
Daniela Mendes, Maria Manuel Oliveira, Paula I Moreira, João Coutinho, Fernando M Nunes, David M Pereira, Patrícia Valentão, Paula B Andrade, Romeu A Videira
The development of effective medicines to break or delay the progressive brain degeneration underlying cognitive decline and dementia that characterize Alzheimer's disease (AD) is one of the greatest challenges of our time. In the present work, a selective pool of polyphenols, obtained from the white wine by adsorption to polyvinylpyrrolidone polymer (PVPP), was used to prepare a polyphenols-enriched diet, supplementing the drinking water with 100 mg/L (expressed as gallic acid equivalent) of wine polyphenolic extract...
May 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29518202/identification-of-redox-imbalance-as-a-prominent-metabolic-response-elicited-by-rapeseed-feeding-in-swine-metabolome
#8
C Chen, M Pérez de Nanclares, J F Kurtz, M P Trudeau, L Wang, D Yao, M Saqui-Salces, P E Urriola, L T Mydland, G C Shurson, M Overland
Rapeseed (RS) is an abundant and inexpensive source of energy and AA in diets for monogastrics and a sustainable alternative to soybean meal. It also contains diverse bioactive phytochemicals that could have antinutritional effects at high dose. When the RS-derived feed ingredients (RSF) are used in swine diets, the uptake of these nutrients and phytochemicals is expected to affect the metabolic system. In this study, 2 groups of young pigs (17.8 ± 2.7 kg initial BW) were equally fed a soybean meal-based control diet and an RSF-based diet, respectively, for 3 wk...
May 4, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471285/effects-of-docosahexanoic-acid-supplementation-on-inflammatory-and-subcutaneous-adipose-tissue-gene-expression-in-hiv-infected-patients-on-combination-antiretroviral-therapy-cart-a-sub-study-of-a-randomized-double-blind-placebo-controlled-study
#9
Pere Domingo, José Miguel Gallego-Escuredo, Irene Fernández, Joan Villarroya, Ferran Torres, María Del Mar Gutierrez, María Gracia Mateo, Francesc Villarroya, Francesc Vidal, Marta Giralt, Joan Carles Domingo
BACKGROUND: Omega-3 fatty acids have the potential to decrease inflammation and modify gene transcription. Whether docosahexanoic acid (DHA) supplementation can modify systemic inflammatory and subcutaneous adipose tissue (SAT) gene expression in HIV-infected patients is unknown. METHODS: A randomized, double-blind, placebo-controlled trial that enrolled 84 antiretroviral-treated patients who had fasting TG levels from 2.26 to 5.65 mmol/l and received DHA or placebo for 48 weeks was performed (ClinicalTrials...
May 2018: Cytokine
https://www.readbyqxmd.com/read/29182572/aberrant-lipid-metabolism-in-hepatocellular-carcinoma-revealed-by-liver-lipidomics
#10
Zhao Li, Ming Guan, Yu Lin, Xiao Cui, Yangyang Zhang, Zhenwen Zhao, Jiye Zhu
BACKGROUND: The aim of this study was to characterize the disorder of lipid metabolism in hepatocellular carcinoma (HCC). HCC is a worldwide disease. The research into the disorder of lipid metabolism in HCC is very limited. Study of lipid metabolism in liver cancer tissue may have the potential to provide new insight into HCC mechanisms. METHODS: A lipidomics study of HCC based on Ultra high performance liquid chromatography-electronic spray ionization-QTOF mass spectrometer (UPLC-ESI-QTOF MS) and Matrix assisted laser desorption ionization-fourier transform ion cyclotron resonance mass spectrometer (MALDI-FTICR MS) was performed...
November 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29146112/different-concentrations-of-docosahexanoic-acid-supplement-during-lactation-result-in-different-outcomes-in-preterm-sprague-dawley-rats
#11
Qian Wang, Chunhong Jia, Xiaohua Tan, Fan Wu, Xinqi Zhong, Zhiwen Su, Weiwen Sun, Qiliang Cui
PROPOSE: In this study, we evaluated the effects of different concentrations of docosahexanoic acid (DHA) supplement on preterm Sprague-Dawley rat pups, and in parallel, measured the phosphorylation activity of the mTOR pathway in the hippocampal CA1 area. METHODS: Preterm Sprague-Dawley rat pups were randomly assigned to experimental groups which included; a sufficient DHA group (100 mg/kg/day); an enriched DHA group (300 mg/kg/day); an excess DHA group (800 mg/kg/day); and a deficient DHA group (normal saline gavage 0...
January 1, 2018: Brain Research
https://www.readbyqxmd.com/read/29136094/effects-of-multidomain-lifestyle-intervention-omega-3-supplementation-or-their-combination-on-physical-activity-levels-in-older-adults-secondary-analysis-of-the-multidomain-alzheimer-preventive-trial-mapt-randomised-controlled-trial
#12
Philipe de Souto Barreto, Yves Rolland, Matteo Cesari, Charlotte Dupuy, Sandrine Andrieu, Bruno Vellas
Background/objectives: to investigate the effects of a 3-year multidomain lifestyle intervention, omega-3 supplementation or both on physical activity (PA) in older adults with subjective memory complaints. Design/settings/subjects: the Multidomain Alzheimer Preventive Trial was a 3-year randomised controlled trial that enroled 1,680 community-dwelling adults aged 70 years or over, with subjective memory complaints. Participants were randomised to omega-3 supplementation (total daily dose of 800 mg docosahexanoic acid and up to 225 mg eicosapentanoic acid), multidomain intervention (nutritional and exercise counselling and cognitive training), omega-3 plus multidomain intervention or placebo with usual care...
March 1, 2018: Age and Ageing
https://www.readbyqxmd.com/read/28861453/data-on-the-effect-of-oral-feeding-of-arachidonic-acid-or-docosahexanoic-acid-on-haematopoiesis-in-mice
#13
Kedar Limbkar, Ankita Dhenge, Dipesh D Jadhav, Hirekodathakallu V Thulasiram, Vaijayanti Kale, Lalita Limaye
Stem cells have peculiar property to self-renew and differentiate. It is important to control their fate in safe and effective ways for their therapeutic use. The mediators of essential polyunsaturated fatty acids (PUFAs) namely Arachidonic acid (AA) and Docosahexanoic acid (DHA) are known to play a role in haematopoiesis via various metabolic pathways [1]. However the direct effect of purified AA or DHA on haematopoiesis has not been well investigated yet. We have reported that oral administration of PUFAs enhanced haematopoiesis in mice [2]...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28719669/a-whey-protein-based-multi-ingredient-nutritional-supplement-stimulates-gains-in-lean-body-mass-and-strength-in-healthy-older-men-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Kirsten E Bell, Tim Snijders, Michael Zulyniak, Dinesh Kumbhare, Gianni Parise, Adrian Chabowski, Stuart M Phillips
Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 ± 1 years [mean ± SEM]; BMI: 28.5 ± 1.5 kg/m2) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2...
2017: PloS One
https://www.readbyqxmd.com/read/28648475/effects-of-docosahexanoic-acid-on-metabolic-and-fat-parameters-in-hiv-infected-patients-on-cart-a-randomized-double-blind-placebo-controlled-study
#15
Pere Domingo, Irene Fernández, José Miguel Gallego-Escuredo, Ferran Torres, Ma Del Mar Gutierrez, Ma Gracia Mateo, Joan Villarroya, Marta Giralt, Francesc Vidal, Francesc Villarroya, Joan Carles Domingo
BACKGROUND: Hypertriglyceridemia is common in HIV-infected patients. Polyunsaturated fatty acids reduce fasting serum triglyceride (TG) levels in HIV-infected patients. It is not known whether docosahexanoic acid (DHA) supplementation can reduce hypertriglyceridemia and modify fat distribution in HIV-infected patients. METHODS: We conducted a randomized, double-blind, placebo-controlled trial with 84 antiretroviral-treated patients who had fasting TG levels from 2...
June 8, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28570944/oral-feeding-with-polyunsaturated-fatty-acids-fosters-hematopoiesis-and-thrombopoiesis-in-healthy-and-bone-marrow-transplanted-mice
#16
Kedar Limbkar, Ankita Dhenge, Dipesh D Jadhav, Hirekodathakallu V Thulasiram, Vaijayanti Kale, Lalita Limaye
Hematopoietic stem cells play the vital role of maintaining appropriate levels of cells in blood. Therefore, regulation of their fate is essential for their effective therapeutic use. Here we report the role of polyunsaturated fatty acids (PUFAs) in regulating hematopoiesis which has not been explored well so far. Mice were fed daily for 10 days with n-6/n-3 PUFAs, viz. linoleic acid (LA), arachidonic acid (AA), alpha-linolenic acid and docosahexanoic acid (DHA) in four separate test groups with phosphate-buffered saline fed mice as control set...
May 17, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28569164/omega-3-fatty-acids-phenolic-compounds-and-antioxidant-characteristics-of-chia-oil-supplemented-margarine
#17
Muhammad Nadeem, Muhammad Imran, Imran Taj, Muhammad Ajmal, Muhammad Junaid
BACKGROUND: Chia (Salvia hispanica L.) is known as power house of omega fatty acids which has great health benefits. It contains up to 78% linolenic acid (ω-3) and 18% linoleic acid (ω-6), which could be a great source of omega-3 fatty acids for functional foods. Therefore, in this study, margarines were prepared with supplementation of different concentrations of chia oil to enhance omega-3 fatty acids, antioxidant characteristics and oxidative stability of the product. METHODS: Margarines were formulated from non-hydrogenated palm oil, palm kernel and butter...
May 31, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28558948/ultrasonic-assisted-incorporation-of-nano-encapsulated-omega-3-fatty-acids-to-enhance-the-fatty-acid-profile-of-pork-meat
#18
K Shikha Ojha, Camila A Perussello, Carlos Álvarez García, Joseph P Kerry, Daniel Pando, Brijesh K Tiwari
In this study, ultrasound was employed to enhance the diffusion of microencapsulated fatty acids into pork meat. Nanovesicles of fish oil composed of 42% EPA (eicosapentanoic acid) and 16% DHA (docosahexanoic acid) were prepared using two different commercial Pronanosome preparations (Lipo-N and Lipo-CAT; which yield cationic and non-cationic nanovesicles, respectively). The thin film hydration (TFH) methodology was employed for encapsulation. Pork meat (Musculus semitendinosus) was submerged in the nanovesicles suspension and subjected to ultrasound (US) treatment at 25kHz for either 30 or 60min...
October 2017: Meat Science
https://www.readbyqxmd.com/read/28511406/effect-of-sodium-valproate-and-docosahexaenoic-acid-on-pain-in-rats
#19
REVIEW
Sushil Kiran Kunder, Laxminarayana Kurady Bairy, Avinash Arivazhahan
INTRODUCTION: Analgesics are commonly prescribed medications used to alleviate pain of various aetiologies without affecting the patient's consciousness. They interfere with the transmission of pain signals. A commonly used antiepileptic drug, sodium valproate has been used in various non-epileptic conditions like migraine prophylaxis and in the treatment of bipolar disorder because of the multiple mechanisms by which it acts. Docosahexanoic Acid (DHA), an omega 3 fatty acid, is known to possess analgesic activity...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28442061/effect-of-docosahexanoic-acid-on-quality-of-frozen-thawed-bull-semen-in-bioxcell-extender
#20
Asmatullah Kaka, Wahid Haron, Rosnina Yusoff, Nurhusien Yimer, A M Khumran, Kazhal Sarsaifi, Atique Ahmed Behan, Ubedullah Kaka, Akeel Ahmed Memon, Mahdi Ebrahimi
This study was conducted to investigate the effect of docosahexanoic acid (DHA) supplementation in BioXcell extender on the quality of frozen-thawed bull semen. Twenty-four ejaculates were collected from three bulls (eight from each bull). Ejaculates with motility ≥70% and normal morphology ≥80% were extended into BioXcell extender to which 0 (control), 3, 5, 10 or 15ngmL-1 DHA was added. The supplemented semen samples were incubated at 37°C for 15min for DHA uptake by spermatozoa. Later, samples were cooled for 2h at 5°C and packaged into 0...
March 2017: Reproduction, Fertility, and Development
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