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Microscopic colitis

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https://www.readbyqxmd.com/read/28882823/the-antioxidant-glutathione-protects-against-enteric-neuron-death-in-situ-but-its-depletion-is-protective-during-colitis
#1
Isola Am Brown, Brian D Gulbransen
Enteric glia play an important neuroprotective role in the enteric nervous system (ENS) by producing neuroprotective compounds such as the antioxidant reduced glutathione (GSH). The specific cellular pathways that regulate glial production of GSH, and how these pathways are altered during, or contribute to, neuroinflammation in situ and in vivo are not fully understood. We investigated this issue using immunohistochemistry to localize GSH synthesis enzymes within the myenteric plexus and tested how the inhibition of GSH synthesis with the selective inhibitor L-Buthionine Sulfoximine (BSO) impacts neuronal survival and inflammation...
September 7, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28874961/correlation-of-abnormal-histology-with-endoscopic-findings-among-mycophenolate-mofetil-treated-patients
#2
Mitchell A Izower, Merajur Rahman, Ernesto P Molmenti, Madhu C Bhaskaran, Viren G Amin, Sundas Khan, Keith Sultan
AIM: To describe all abnormal histological findings and their associated endoscopic presentation in patients using mycophenolate mofetil (MMF). METHODS: A retrospective review of all individuals prescribed MMF within 6 mo of a colonoscopy or flexible sigmoidoscopy between 07/2009 and 09/2015 was performed within Northwell Health system. Records were analyzed for age, gender, procedure indication, MMF indication, and both gross and microscopic findings. Only reports with abnormal histology were included...
August 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28871257/reactivation-of-intestinal-inflammation-is-suppressed-by-catestatin-in-a-murine-model-of-colitis-via-m1-macrophages-and-not-the-gut-microbiota
#3
Mohammad F Rabbi, Nour Eissa, Peris M Munyaka, Laëtitia Kermarrec, Omar Elgazzar, Ehsan Khafipour, Charles N Bernstein, Jean Eric Ghia
While there is growing awareness of a relationship between chromogranin-A (CHGA) and susceptibility to inflammatory conditions, the role of human catestatin [(hCTS); CHGA352-67] in the natural history of established inflammatory bowel disease is not known. Recently, using two different experimental models, we demonstrated that hCTS-treated mice develop less severe acute colitis. We have also shown the implication of the macrophages in this effect. The aims of this study were to determine (1) whether hCTS treatment could attenuate the reactivation of inflammation in adult mice with previously established chronic colitis; (2) whether this effect is mediated through macrophages or the gut microbiota...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28868268/effect-of-concentrated-apple-extract-on-experimental-colitis-induced-by-acetic-acid
#4
Maurício Mercaldi Pastrelo, Carla Caroline Dias Ribeiro, Joselmo Willamys Duarte, Andréa Pitelli Bioago Gollücke, Ricardo Artigiani-Neto, Daniel Araki Ribeiro, Sender Jankiel Miszputen, Celina Tizuko Fujiyama Oshima, Ana Paula Ribeiro Paiotti
Reactive oxygen and nitrogen species (ROS/RNS) play a crucial role in inflammatory bowel disease (IBD) exacerbating the chronic inflammatory process. Endogenous and diet antioxidants can neutralize these compounds. The apple is widely consumed, with several antioxidant activity compounds. The present study evaluated the effects of concentrated apple extract (CAE) in acetic acid induced colitis. 29 Wistar male rats were randomized into 5 groups. G1-Sham/saline solution, G2-CAE/control, G3-acetic acid/control, G4-curative- CAE treatment and G5-preventive-CAE treatment...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28855944/anti-inflammatory-effect-of-apigenin-and-hydroalcoholic-extract-of-dracocephalum-kotschyi-on-acetic-acid-induced-colitis-in-rats
#5
Hassan Sadraei, Gholamreza Asghari, Mohammad Khanabadi, Mohsen Minaiyan
Colitis is an inflammatory disease of the intestine with unknown etiology involving multiple immune, genetic, and environmental factors. We were interested to examine the effect of total extract from Dracocephalum kotschyi (D. kotschyi) Boiss. on the experimental colitis. D. kotschyi hydroalcoholic extract (10, 20, and 40 mg/kg) or apigenin (5, 10, and 20 mg/kg) were administered orally 2 h prior to induction of colitis which was induced by intrarectal administration of acetic acid (4%) in rats. Prednisolone (4 m/kg) was used as the standard drug for comparison...
August 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28844038/unrestricted-faecal-calprotectin-testing-performs-poorly-in-the-diagnosis-of-inflammatory-bowel-disease-in-patients-in-primary-care
#6
Samantha Conroy, Melissa F Hale, Simon S Cross, Kirsty Swallow, Reena H Sidhu, Ravishankar Sargur, Alan J Lobo
BACKGROUND: Faecal calprotectin (FC) measurement distinguishes patients with inflammatory bowel disease (IBD) from those with irritable bowel syndrome but evidence of its performance in primary care is limited. AIMS: To assess the yield of IBD from FC testing in primary care. METHODS: Retrospective review of hospital records to assess the outcome following FC testing in primary care. Investigations for all patients undergoing FC testing in a single laboratory for 6 months from 1 October 2013 to 28 February 2014 were reviewed...
August 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28812128/protective-effect-of-cigarette-smoke-on-the-course-of-dextran-sulfate-sodium-induced-colitis-is-accompanied-by-lymphocyte-subpopulation-changes-in-the-blood-and-colon
#7
Jaroslaw Daniluk, Urszula Daniluk, Joanna Reszec, Malgorzata Rusak, Milena Dabrowska, Andrzej Dabrowski
BACKGROUND: Cigarette smoke (CS) exerts protective effect against ulcerative colitis. The mechanism of this phenomenon remains unknown. One of the possible explanation by which CS exerts its anti-inflammatory action is modulation of immune system. Therefore, the aim of the study was to evaluate the effect of CS on the course of inflammation and subpopulations of lymphocytes in the blood and colon in mice with dextran sulfate sodium (DSS)-induced colitis. METHODS: C57BL6/cmdb mice were exposed to CS for 4 weeks...
August 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28811704/gastrointestinal-neuroendocrine-peptides-amines-in-inflammatory-bowel-disease
#8
REVIEW
Magdy El-Salhy, Tefera Solomon, Trygve Hausken, Odd Helge Gilja, Jan Gunnar Hatlebakk
Inflammatory bowel disease (IBD) is a chronic recurrent condition whose etiology is unknown, and it includes ulcerative colitis, Crohn's disease, and microscopic colitis. These three diseases differ in clinical manifestations, courses, and prognoses. IBD reduces the patients' quality of life and is an economic burden to both the patients and society. Interactions between the gastrointestinal (GI) neuroendocrine peptides/amines (NEPA) and the immune system are believed to play an important role in the pathophysiology of IBD...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28807207/effect-of-bevacizumab-on-acetic-acid-induced-ulcerative-colitis-in-rats
#9
Zeki Ozsoy, Seyma Ozsoy, Fikret Gevrek, Emre Demir, Ismail Benli, Emin Daldal, Erdinc Yenidogan
BACKGROUND: The aim of this study was to examine the effect of intraperitoneally administered bevacizumab on colitis induced by acetic acid. METHODS: An experimental model of acetic acid-induced colitis was introduced in rats. After the induction of colitis, bevacizumab was administered intraperitoneally at two different daily doses of low (2.5 mg/kg) or high (5 mg/kg) concentration. Control groups were included for colitis and bevacizumab. After 7 d, the rats were sacrificed, and colonic tissues were harvested for macroscopic and microscopic examination of colonic damage...
August 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28776143/th1-pathway-the-missing-link-between-inflammatory-bowel-disease-and-microscopic-colitis
#10
EDITORIAL
Anna Carrasco, Fernando Fernández-Bañares
No abstract text is available yet for this article.
August 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28761890/microscopic-colitis-after-fecal-microbiota-transplant
#11
Matthew J Fasullo, Yasir Al-Azzawi, Jeffrey Abergel
Microscopic colitis (MC) is an inflammatory condition of the large bowel that is associated with chronic, nonbloody diarrhea. Colonoscopy usually demonstrates normal mucosa, while tissue biopsy reveals intraepithelial lymphocytes or a subepithelial collagen band. Although no specific antibody has been discovered, MC is associated with several autoimmune disorders such as celiac disease, Hashimoto's thyroiditis, and rheumatoid arthritis. There are only a small number of case reports documenting possible hereditary MC cases, but up to 12% of patients with MC have a family history of inflammatory bowel disease...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28752251/a-case-of-kawasaki-disease-presenting-as-sigmoid-colitis
#12
Yasuhiro Ohnishi, Kazuhiro Mori, Miki Inoue, Nobuo Satake, Mitsuyasu Yano
Initial gastrointestinal symptoms might confuse the clinical pictures of some patients with Kawasaki disease (KD) and delay diagnosis and treatment, especially when the patient does not fulfill sufficient diagnostic criteria for KD. Here, we present the case of a 4-year-old boy with KD who complained of severe left abdominal pain and fever alone for the first 6 days. Abdominal ultrasonography showed severe wall thickening localized to the sigmoid colon, and these findings were confirmed by computed tomography and colonoscopy...
July 27, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28717578/in-vivo-analysis-of-mucosal-lipids-reveals-histological-disease-activity-in-ulcerative-colitis-using-endoscope-coupled-raman-spectroscopy
#13
Hao Ding, Andrew W Dupont, Shashideep Singhal, Larry D Scott, Sushovan Guha, Mamoun Younes, Xiaohong Bi
The goal of this study is to evaluate endoscopic Raman spectroscopy as a noninvasive technique to determine histological inflammatory status of colitis. Colon mucosal composition was investigated in vivo from patients with ulcerative colitis (UC) and from age- and body mass index (BMI) matched controls using endoscope-coupled Raman spectroscopy. The results were co-registered with histological assessment of inflammatory status at the same locations. Substantial decreases (50-60%) in the content of phosphotidylcholines (PCs) and total lipids were observed in inflamed colon tissue (histology grade 1, 2 and 3) compared to those from the quiescent (histology grade 0) and from the controls...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28713708/the-healing-effect-of-grape-seed-oil-enema-with-or-without-sesame-oil-in-acetic-acid-induced-ulcerative-colitis-of-rats
#14
Fatemeh Hosseinzadeh, Moosa Salehi, Nader Tanideh, Davood Mehrabani, Azadeh Sayarifard, Anahita Sedighi
BACKGROUND: Inflammatory bowel diseases contain two digestive system diseases, ulcerative colitis (UC) and Crohn's disease with unclear causes. The aim of present study was to investigate the therapeutic effects of administration of the Sesame oil (SO) and grape seed oil (GSO) as enema route in rats suffering from experimental acetic acid induced UC. METHODS: Eighty male rats were randomly allocated into 8 equal groups as health control (HC1) without any disease treated with 1 ml of normal saline as enema; HC2 received SO; HC3 received GSO; negative control (NC) with induced UC receiving 1 ml of normal saline as enema; and positive control (PC) with induced UC treated by asacol...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28706329/effect-of-karanjin-on-2-4-6-trinitrobenzenesulfonic-acid-induced-colitis-in-balb-c-mice
#15
Praful Prakash Patel, Naitikumar Devshankar Trivedi
OBJECTIVES: The objective of this study is to evaluate the beneficial effect of karanjin for the treatment of experimental colitis. METHODS: Colitis was induced in the Balb/c mice by rectal administration of 2% solution of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in 50% methanol. Karanjin (>98% pure) was administered in two different concentrations 100 and 200 mg/kg and sulfasalazine (100 mg/kg) as reference for 7 consecutive days to colitic mice. On the 8 day, mice were euthanized and degree of inflammation was assessed by macroscopic, microscopic, histology and biochemical estimation of myeloperoxidase (MPO), nitric oxide (NO), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and reduced glutathione (GSH) level were measured...
March 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28702956/interventions-for-treating-lymphocytic-colitis
#16
REVIEW
Nilesh Chande, Noor Al Yatama, Tania Bhanji, Tran M Nguyen, John Wd McDonald, John K MacDonald
BACKGROUND: Lymphocytic colitis is a cause of chronic diarrhea. It is a subtype of microscopic colitis characterized by chronic, watery, non-bloody diarrhea and normal endoscopic and radiologic findings. The etiology of this disorder is unknown.Therapy is based mainly on case series and uncontrolled trials, or by extrapolation of data for treating collagenous colitis, a related disorder. This review is an update of a previously published Cochrane review. OBJECTIVES: To evaluate the efficacy and safety of treatments for clinically active lymphocytic colitis...
July 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28694747/evaluation-of-central-and-peripheral-effects-of-doxepin-on-acetic-acid-induced-colitis-in-rat-and-the-involved-mechanisms
#17
Mohsen Zabihi, Valiollah Hajhashemi, Ardeshir Talebi, Mohsen Minaiyan
Anti-colitis effect of antidepressants has been demonstrated recently. Doxepin, a tricyclic antidepressant drug (TCA), with potent H1, H2, alpha1 adrenergic and muscarinic receptor blocking effects could be a good candidate for investigation for its anti-colitis activity. Moreover high prevalence of depression in patients who suffer from IBD (inflammatory bowel disease), defends this idea that adjuvant therapy with an antidepressant drug which has anti-inflammatory effect, may exert favorable effects in the control of the disease...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28692320/the-probiotic-vsl-3-modulates-colonic-macrophages-inflammation-and-microflora-in-acute-trinitrobenzene-sulfonic-acid-colitis
#18
Raymond A Isidro, Abdon Lopez, Myrella L Cruz, Mayra I Gonzalez Torres, Gladys Chompre, Angel A Isidro, Caroline B Appleyard
The probiotic mixture VSL#3 attenuates colitis in patients with Inflammatory Bowel Disease (IBD) and in animal models of this condition, but the mechanisms involved are incompletely understood. VSL#3 alters macrophage morphology and secretory profile in vitro in a polarization-dependent manner. We examined the effect of VSL#3 on macrophages in acute trinitrobenzene sulfonic acid-induced colitis. Rats were randomized to normal, colitis, or colitis+VSL#3 groups. After sacrifice, the colons were evaluated for macroscopic and microscopic damage...
August 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28682012/collagenous-colitis-presenting-with-skip-lesions-mimicking-crohn-s-disease-and-complicated-by-intestinal-obstruction
#19
Chee K Hui, N Kit Hui
Microscopic colitis is a chronic inflammatory disease that traditionally affects the large intestine. It is characterized by frequent episodic non-bloody watery diarrhea. Occasionally, microscopic colitis may present with abdominal pain, fecal incontinence and weight loss.
July 6, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28669150/prevalence-pathogenesis-diagnosis-and-management-of-microscopic-colitis
#20
REVIEW
Nicole Gentile, Eugene F Yen
Microscopic colitis (MC), which is comprised of lymphocytic colitis and collagenous colitis, is a clinicopathological diagnosis that is commonly encountered in clinical practice during the evaluation and management of chronic diarrhea. With an incidence approaching the incidence of inflammatory bowel disease, physician awareness is necessary, as diagnostic delays result in a poor quality of life and increased health care costs. The physician faces multiple challenges in the diagnosis and management of MC, as these patients frequently relapse after successful treatment...
July 4, 2017: Gut and Liver
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