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Microscopic colitis

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https://www.readbyqxmd.com/read/28337639/the-impact-of-mangiferin-from-belamcanda-chinensis-on-experimental-colitis-in-rats
#1
Marta Szandruk, Anna Merwid-Ląd, Adam Szeląg
BACKGROUND: Inflammatory bowel disease (IBD) [including Crohn's disease (CD) and ulcerative colitis (UC)] constitutes an important clinical problem. The pathogenesis of IBD remains unclear. It is believed that immune dysfunction, inflammatory mediators and oxidative damage play crucial roles in development of IBD. The condition is clinically associated with symptoms ranging from mild to severe during relapses, depending on the affected segment of the gastrointestinal tract. Bloody diarrhea with mucus, abdominal pain, weight loss and anemia are initial symptoms of both CD and UC...
March 24, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28328627/extended-release-multimatrix-budesonide-for-microscopic-colitis
#2
Amrit K Kamboj, Thomas G Cotter, S Bradley Hicks, William J Tremaine, Edward V Loftus, Darrell S Pardi
No abstract text is available yet for this article.
March 21, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28300788/protective-effect-of-protocatechuic-acid-on-tnbs-induced-colitis-in-mice-is-associated-with-modulation-of-the-sphk-s1p-signaling-pathway
#3
Irene Crespo, Beatriz San-Miguel, José Luis Mauriz, Juan José Ortiz de Urbina, Mar Almar, María Jesús Tuñón, Javier González-Gallego
(1) Background: The present study aimed to investigate whether beneficial effects of protocatechuic acid (PCA) are associated with inhibition of the SphK/S1P axis and related signaling pathways in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of inflammatory bowel disease; (2) Methods: Colitis was induced in male Balb/c mice by intracolonic administration of 2 mg of TNBS. PCA (30 or 60 mg/kg body wt) was given intraperitoneally daily for five days; (3) Results: Administration of PCA prevented the macroscopic and microscopic damage to the colonic mucosa, the decrease in body weight gain and the increase in myeloperoxidase activity induced by TNBS...
March 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28275312/clinical-and-immunologic-effects-of-faecal-microbiota-transplantation-in-a-patient-with-collagenous-colitis
#4
Sezin Günaltay, Lech Rademacher, Elisabeth Hultgren Hörnquist, Johan Bohr
One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation (FMT) in active collagenous colitis (CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT...
February 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28267639/evaluation-of-anti-inflammatory-effect-of-silver-coated-glass-beads-in-mice-with-experimentally-induced-colitis-as-a-new-type-of-treatment-in-inflammatory-bowel-disease
#5
Krzysztof Siczek, Hubert Zatorski, Anna Chmielowiec-Korzeniowska, Radzisław Kordek, Leszek Tymczyna, Jakub Fichna
BACKGROUND: Recent studies point at the anti-inflammatory action of silver through induction of apoptosis of inflammatory cells via oxidative stress, promotion of wound healing as well as antimicrobial effect. Our aim was to design a new formulation based on silver and validate its anti-inflammatory activity in the mouse models of colitis. METHODS: Silver-coated glass beads were prepared using a magnetron sputtering method and a standard magnetron sputtering gun equipped with pure silver target...
January 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28265892/current-approach-to-the-evaluation-and-management-of-microscopic-colitis
#6
REVIEW
Thomas G Cotter, Darrell S Pardi
PURPOSE OF REVIEW: Microscopic colitis is a common cause of chronic watery diarrhea, particularly in the elderly. The accompanying symptoms, which include abdominal pain and fatigue, can markedly impair patients' quality of life. Diagnosis is based upon characteristic histologic findings of the colonic mucosa. This review focuses on the current approach to evaluation and management of patients with microscopic colitis. RECENT FINDINGS: Although the incidence of microscopic colitis has been increasing over time, recent epidemiological studies show stabilization at 21...
February 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28246536/effects-of-herb-partitioned-moxibustion-on-the-mirna-expression-profiles-in-colon-from-rats-with-dss-induced-ulcerative-colitis
#7
Yan Huang, Zhe Ma, Yun-Hua Cui, Hong-Sheng Dong, Ji-Meng Zhao, Chuan-Zi Dou, Hui-Rong Liu, Jing Li, Huan-Gan Wu
Objective. This study explored the mechanism of herb-partitioned moxibustion (HM) on dextran sulfate sodium- (DSS-) induced ulcerative colitis (UC) from the miRNA perspective. Methods. Rats were randomly divided into 3 groups [normal control (NC) group, UC model (UC) group, and herb-partitioned moxibustion (UCHM) group]. The UC and UCHM groups were administered 4% DSS for 7 days. The UCHM group received HM at the Tianshu (bilateral, ST25). The effect of HM on UC was observed and the miRNA expression profile in the colon tissues was analyzed...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28244237/usefulness-of-confocal-laser-endomicroscopy-to-diagnose-ulcerative-colitis-associated-neoplasia
#8
Naoki Ohmiya, Noriyuki Horiguchi, Tomomitsu Tahara, Dai Yoshida, Hyuga Yamada, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Makoto Kuroda
Chromoendoscopy, narrow-band imaging (NBI), and confocal laser endomicroscopy (CLE) have been introduced in ulcerative colitis (UC)-associated neoplasia surveillance. We aimed to determine the ability of CLE to differentiate among UC-associated neoplasia (differentiated type or undifferentiated type), sporadic adenoma, and circumscribed regenerative lesions. Of 665 patients with UC, we performed probe-based CLE (pCLE) on 12 patients with suspected UC-associated neoplasia in addition to magnifying chromoendoscopy with crystal violet and NBI...
February 28, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28215538/over-90-of-cases-of-microscopic-colitis-can-be-diagnosed-by-performing-a-short-colonoscopy
#9
Gilles Macaigne, Pierre Lahmek, Christophe Locher, Jean François Boivin, Bruno Lesgourgues, Mathieu Yver, Laurent Costes, I Abd Alsamad, Joel Cucherousset, Claire Charpignon, Hélène Guyot, Bénédicte Lambaré, Jean-Michel Ghilain, Valérie Calès, Stéphanie de Montigny-Lenhardt, Guy Bellaïche, Alexandre Pariente, Stéphane Nahon
AIMS: To determinate the topographical distribution of key diagnostic histological features of lymphocytic colitis (LC) and collagenous colitis (CC) and to establish what correlations may exist between the histological findings and the causes and severity of MC. PATIENTS AND METHODS: Patients with MC were included in a prospective multicentre French study from September 2010 to October 2012. MC was diagnosed by performing total colonoscopy with multiple biopsies of the rectum and colon collected in separate jars and analyzed separately for each site (descending and sigmoid colon, transverse colon, ascending colon)...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28175211/p720-use-of-proton-pump-inhibitors-associated-with-a-markedly-increased-risk-of-microscopic-colitis
#10
O Bonderup, G Lauge Nielsen, M Dall, A Pottegård, J Hallas
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175032/p234-recent-trends-in-microscopic-colitis-demographics-clinical-features-and-outcomes-in-a-portuguese-cohort
#11
M Silva, A Peixoto, S Lopes, A C-R Nunes, F Magro, G Macedo
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173087/p696-ambient-air-quality-as-risk-factor-for-microscopic-colitis-a-geographic-information-system-study
#12
B P M Verhaegh, E M Beijnens, T R A van den Heuvel, D Goudkade, M P Zeegers, T S Nawrot, A A M Masclee, D M A E Jonkers, M J Pierik
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172765/p737-early-life-microbial-exposure-lifestyle-and-comorbidity-as-risk-factors-for-microscopic-colitis-a%C3%A2-case-control-study
#13
B P M Verhaegh, D M A E Jonkers, M J Pierik, A A M Masclee, D Goudkade
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172750/op016-potential-role-of-bile-acid-receptor-fxr-in-microscopic-colitis
#14
C Palmela, J Torres, P Gomes de Sena, M P Costa Santos, C Gouveia, M H Oliveira, C M P Rodrigues, M Cravo, P Borralho
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172605/p713-possible-explanations-of-the-marked-differences-in-the-incidence-of-microscopic-colitis-between-denmark-and-sweden
#15
S Davidson, L Munck, L Vigren, P Engel, K Sjöberg
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28168580/the-incidence-of-microscopic-colitis-microscopic-no-more
#16
EDITORIAL
Nicole M Gentile, Eugene F Yen
No abstract text is available yet for this article.
February 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28159515/local-enema-treatment-to-inhibit-folh1-gcpii-as-a-novel-therapy-for-inflammatory-bowel-disease
#17
Abhijit A Date, Rana Rais, Taarika Babu, Jairo Ortiz, Pranjali Kanvinde, Ajit G Thomas, Sarah C Zimmermann, Alexandra J Gadiano, Gilad Halpert, Barbara S Slusher, Laura M Ensign
Here we evaluate the potential for local administration of a small molecule FOLH1/GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) as a novel treatment for inflammatory bowel disease (IBD). We found that FOLH1/GCPII enzyme activity was increased in the colorectal tissues of mice with TNBS-induced colitis, and confirmed that 2-PMPA inhibited FOLH1/GCPII enzyme activity ex vivo. In order to maximize local enema delivery of 2-PMPA, we studied the effect of vehicle tonicity on the absorption of 2-PMPA in the colon...
January 31, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28138449/budesonide-related-iatrogenic-cushing-s-syndrome-in-microscopic-colitis
#18
Kartikeya Tripathi, Thomas Dunzendorfer
Budesonide is the treatment of choice for microscopic colitis because of its excellent risk to benefit ratio. It is a potent, well-absorbed corticosteroid, but because of a high rate of first-pass metabolism in the liver, its systemic bioavailability is low. It has fewer corticosteroid-related adverse effects than prednisone, and adrenal suppression is considered to be rare. We present a middle-aged woman with lymphocytic colitis whose symptoms responded to budesonide but developed budesonide-related iatrogenic Cushing's syndrome...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28128877/endoscopic-findings-of-ipilimumab-induced-colitis
#19
Tatsunori Satoh, Kazuya Ohno, Takafumi Kurokami
Ipilimumab is a fully humanized monoclonal antibody targeting inhibitory cytotoxic T-lymphocyte-associated antigen-4 on T cells, thereby enhancing antitumor immunity.(1) While ipilimumab has significant therapeutic benefit, it induces hypersensitivity reactions in some targeted organs. Ipilimumab-induced colitis (IiC) is one such hypersensitivity reaction, clinically manifesting as colitis.(2) Colonoscopy is helpful in diagnosing IiC. The macroscopic and microscopic features of IiC include friable erythematous mucosa and ulcers with an absent vascular pattern...
January 27, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28121001/anti-inflammatory-effects-of-dioscorea-alata-l-anthocyanins-in-a-tnbs-induced-colitis-model
#20
Tao Chen, Shihui Hu, Haiwen Zhang, Qingfeng Guan, Yuhui Yang, Xuemei Wang
The purple yam, Dioscorea alata L., is an important source of starch, vitamins and polyphenols. Five different pigments from the purple tubers of this plant were separated by high-performance liquid chromatography-mass spectrometry, and the anthocyanin fraction (DACN) was collected. The anti-inflammatory effects of DACNs were investigated at different concentrations and compared with the standard colitis treatment, 5-aminosalicylic acid, in a trinitrobenzenesulfonic acid (TNBS)-induced colitis mouse model. Macro- and microscopic parameters including body weight change, disease activity index (DAI) and intestinal histology were used for the determination of the anti-inflammatory effects of DACNs...
January 25, 2017: Food & Function
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