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https://www.readbyqxmd.com/read/29224100/estrogens-and-body-weight-regulation-in-men
#1
Katya B Rubinow
Our understanding of the metabolic roles of sex steroids in men has evolved substantially over recent decades. Whereas testosterone once was believed to contribute to metabolic risk in men, the importance of adequate androgen exposure for the maintenance of metabolic health has been demonstrated unequivocally. A growing body of evidence now also supports a critical role for estrogens in metabolic regulation in men. Recent data from clinical intervention studies indicate that estradiol may be a stronger determinant of adiposity than testosterone in men, and even short-term estradiol deprivation contributes to fat mass accrual...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29223966/advancing-point-of-care-diagnostics-for-the-control-and-prevention-of-stis-the-way-forward
#2
Igor Toskin, Karel Blondeel, Rosanna W Peeling, Carolyn Deal, James Kiarie
WHO recognises the global impact of sexually transmitted infections (STIs) on global public health and individual sexual and reproductive health and well-being. As a component of the WHO Global Health Sector Strategy for the control and prevention of STIs, there has been a growing recognition of the importance of integrating point-of-care tests (POCTs) into overall strategic planning. The process of integrating STI POCTs, in addition to providing a definitive diagnosis and appropriate treatment in a single visit, also includes innovative delivery options, such as on-site delivery, community-based testing (including screening), as well as self-testing at home after purchase of a test online or over-the-counter...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223965/advancing-prevention-of-sexually-transmitted-infections-through-point-of-care-testing-target-product-profiles-and-landscape-analysis
#3
Igor Toskin, Maurine Murtagh, Rosanna W Peeling, Karel Blondeel, Joanna Cordero, James Kiarie
OBJECTIVES: Advancing the field of point-of-care testing (POCT) for STIs can rapidly and substantially improve STI control and prevention by providing targeted, essential STI services (case detection and screening). POCT enables definitive diagnosis and appropriate treatment in a single visit and home and community-based testing. METHODS: Since 2014, the WHO Department of Reproductive Health and Research, in collaboration with technical partners, has completed four landscape analyses of promising diagnostics for use at or near the point of patient care to detect syphilis, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and the human papillomavirus...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223961/a-systematic-review-and-meta-analysis-of-studies-evaluating-the-performance-of-point-of-care-tests-for-human-papillomavirus-screening
#4
REVIEW
Helen Kelly, Philippe Mayaud, Michel Segondy, Nitika Pant Pai, Rosanna W Peeling
BACKGROUND: High-risk human papillomavirus (HPV) is a necessary cause of high-grade cervical intraepithelial neoplasia (grade 2 or higher, CIN2+). Simplified and rapid HPV DNA assays designed for use in resource-limited settings have recently become available. METHODS: We performed a systematic review and meta-analysis by searching Medline, Embase, Global Health and CINAHL databases for studies from 1 January 2004 to 25 February 2017 that reported the performance of careHPV or OncoE6 for the detection of histological CIN2+ in cervical cancer screening...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223934/-hypoglycaemia-in-patients-with-type-1-and-type-2-diabetes-mellitus-on-insulin-therapy-results-of-the-global-hat-study-in-argentina
#5
José E Costa Gil, María A Linari, Natalia Pugnaloni, Fabio G Zambon, Federico Pérez Manghi, Mariana Rezzónico
We describe the results of the HAT study in 433 Argentinean patients with type 1 diabetes (T1D) and 823 with type 2 diabetes (T2D). HAT was an international non-interventional study assessing severe and non-severe hypoglycaemia in patients with T1D and T2D under insulin treatment through a two-part self-assessment questionnaire (retrospective and prospective). The annual incidence of at least one hypoglycaemic episode was 46 episode/patient/year in T1D and 14.2 in T2D (retrospective), 96.5 and 24.6 episode/patient/year in T1D and T2D, respectively (prospective)...
2017: Medicina
https://www.readbyqxmd.com/read/29223902/people-pollution-and-pathogens-global-change-impacts-in-mountain-freshwater-ecosystems
#6
REVIEW
Dirk S Schmeller, Adeline Loyau, Kunshan Bao, Werner Brack, Antonis Chatzinotas, Francois De Vleeschouwer, Jan Friesen, Laure Gandois, Sophia V Hansson, Marilen Haver, Gaël Le Roux, Ji Shen, Roman Teisserenc, Vance T Vredenburg
Mountain catchments provide for the livelihood of more than half of humankind, and have become a key destination for tourist and recreation activities globally. Mountain ecosystems are generally considered to be less complex and less species diverse due to the harsh environmental conditions. As such, they are also more sensitive to the various impacts of the Anthropocene. For this reason, mountain regions may serve as sentinels of change and provide ideal ecosystems for studying climate and global change impacts on biodiversity...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223665/guidelines-and-checklists-for-short-term-missions-in-global-pediatric-surgery-recommendations-from-the-american-academy-of-pediatrics-delivery-of-surgical-care-global-health-subcommittee-american-pediatric-surgical-association-global-pediatric-surgery-committee
#7
REVIEW
Marilyn Butler, Elizabeth Drum, Faye M Evans, Tamara Fitzgerald, Jason Fraser, Ai-Xuan Holterman, Howard Jen, J Matthew Kynes, Jenny Kreiss, Craig D McClain, Mark Newton, Benedict Nwomeh, James O'Neill, Doruk Ozgediz, George Politis, Henry Rice, David Rothstein, Julie Sanchez, Mark Singleton, Francine S Yudkowitz
INTRODUCTION: Pediatric surgeons, anesthesia providers, and nurses from North America and other high-income countries (HICs) are increasingly engaged in resource-limited areas, with short-term missions (STMs) as the most common form of involvement. However, consensus recommendations currently do not exist for STMs in pediatric general surgery and associated perioperative care. METHODS: The American Academy of Pediatrics (AAP) Delivery of Surgical Care Subcommittee and American Pediatric Surgical Association (APSA) Global Pediatric Surgery Committee, with the American Pediatric Surgical Nurses Association, Inc...
November 15, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29223583/the-global-burden-of-tuberculosis-results-from-the-global-burden-of-disease-study-2015
#8
(no author information available yet)
BACKGROUND: An understanding of the trends in tuberculosis incidence, prevalence, and mortality is crucial to tracking of the success of tuberculosis control programmes and identification of remaining challenges. We assessed trends in the fatal and non-fatal burden of tuberculosis over the past 25 years for 195 countries and territories. METHODS: We analysed 10 691 site-years of vital registration data, 768 site-years of verbal autopsy data, and 361 site-years of mortality surveillance data using the Cause of Death Ensemble model to estimate tuberculosis mortality rates...
December 6, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29223486/cost-effectiveness-of-rotavirus-vaccination-in-ghana-examining-impacts-from-2012-to-2031
#9
Justice Nonvignon, Deborah Atherly, Clint Pecenka, Moses Aikins, Lauren Gazley, Devin Groman, Clement T Narh, George Armah
BACKGROUND: Diarrhea causes about 10% of all deaths in children under five years globally, with rotavirus causing about 40% of all diarrhea deaths. Ghana introduced rotavirus vaccination as part of routine immunization in 2012 and it has been shown to be effective in reducing disease burden in children under five years. Ghana's transition from low to lower-middle income status in 2010 implies fewer resources from Gavi as well as other major global financing mechanisms. Ghana will soon bear the full cost of vaccines...
December 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29223299/burden-of-skin-pain-in-atopic-dermatitis
#10
Paras P Vakharia, Rishi Chopra, Ryan Sacotte, Kevin R Patel, Vivek Singam, Neha Patel, Supriya Immaneni, Takeshia White, Robert Kantor, Derek Y Hsu, Jonathan I Silverberg
BACKGROUND: Atopic dermatitis (AD) is associated with itch, skin inflammation and barrier disruption, and scratching, all of which may be associated with skin pain. OBJECTIVE: To characterize the patient burden of skin pain in AD. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist. RESULTS: Overall, 305 patients (age range, 13-97 years) were included in the study, with 564 encounters...
December 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29223087/oxidative-stress-in-birds-along-a-nox-and-urbanisation-gradient-an-interspecific-approach
#11
Pablo Salmón, Emilie Stroh, Amparo Herrera-Dueñas, Maria von Post, Caroline Isaksson
Urbanisation is regarded as one of the most threatening global issues for wildlife, however, measuring its impact is not always straight forward. Oxidative stress physiology has been suggested to be a useful biomarker of health and therefore, a potentially important indicator of the impact that urban environmental stressors, especially air pollution, can have on wildlife. For example, nitrogen oxides (NOx), released during incomplete combustion of fossil fuels, are highly potent pro-oxidants, thus predicted to affect either the protective antioxidants and/or cause oxidative damage to bio-molecules...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29222597/incongruence-in-treatment-decision-making-is-associated-with-lower-health-related-quality-of-life-among-prostate-cancer-survivors-results-from-the-picture-study
#12
Frances J Drummond, Anna T Gavin, Linda Sharp
PURPOSE: We investigated associations between treatment decision making (TDM) and global health-related-quality-of-life (gHRQoL) among prostate cancer (PCa) survivors. METHODS: Postal questionnaires were sent to 6559 PCa survivors 2-18 years post-diagnosis, identified through population-based cancer registries in Ireland. The Control Preference Scale was used to investigate respondents' 'actual' and 'preferred' role in TDM. The TDM experience was considered 'congruent' when actual and preferred roles matched and 'incongruent' otherwise...
December 8, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29222426/surveillance-of-antibiotic-resistance-among-common-clostridium-difficile-ribotypes-in-hong-kong
#13
Viola C Y Chow, Thomas N Y Kwong, Erica W M So, Yolanda I I Ho, Sunny H Wong, Raymond W M Lai, Raphael C Y Chan
Incidence of Clostridium difficile infection (CDI) is rapidly increasing and it poses a major health burden globally. However, data regarding the epidemiology of CDI in Asia are limited. We aimed to characterize the antimicrobial susceptibility patterns of common ribotypes of toxigenic C. difficile in Hong Kong. Fifty-three PCR ribotypes were identified among 284 toxigenic C. difficile clinical isolates. The five most prevalent ribotypes were 002 (13%), 017 (12%), 014 (10%), 012 (9.2%), and 020 (9.5%). All tested C...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222349/inequity-in-biological-dmard-prescription-for-spondyloarthritis-across-the-globe-results-from-the-asas-comospa-study
#14
Elena Nikiphorou, Désirée van der Heijde, Sam Norton, Robert Bm Landewé, Anna Molto, Maxime Dougados, Filip E Van den Bosch, Sofia Ramiro
OBJECTIVES: The value of biological disease-modifying antirheumatic drugs (bDMARDs) in spondyloarthritis (SpA) is well recognised, but global access to these treatments can be limited due to high costs and other factors. This study explores country variation in the use of bDMARDs in SpA in relation to country-level socioeconomic factors. METHODS: Patients fulfilling the Assessment in SpondyloArthritis International Society (ASAS) SpA criteria in the multinational, cross-sectional ASAS Comorbidities in Spondyloarthritis study were studied...
December 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29222091/waste-management-informal-recycling-environmental-pollution-and-public-health
#15
Hong Yang, Mingguo Ma, Julian R Thompson, Roger J Flower
With rapid population growth, especially in low-income and middle-income countries, the generation of waste is increasing at an unprecedented rate. For example, annual global waste arising from waste electrical and electronic equipment alone will have increased from 33.8 to 49.8 million tonnes between 2010 and 2018. Despite incineration and other waste treatment techniques, landfill still dominates waste disposal in low-income and middle-income countries. There is usually insufficient funding for adequate waste management in these countries and uptake of more advanced waste treatment technologies is poor...
December 8, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29222078/texting-condolences-adapting-mhealth-programs-after-unexpected-pregnancy-and-infant-outcomes
#16
Jennifer A Unger, John Kinuthia, Grace John-Stewart
Mobile health (mHealth) short message system (SMS) interventions for maternal and child health (MCH) are being implemented globally. In many low- and middle-income settings in which these mHealth interventions are being rolled out, stillbirths and neonatal and infant deaths are common. It is important that mHealth solutions do not exacerbate emotional stress and pain by continuing with routine messaging for pregnancy or infant care when someone has experienced loss. In this brief viewpoint paper, we argue that SMS programs for maternal and child health need to adapt and make available messaging for miscarriage, stillbirth, and infant loss...
December 8, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29222005/does-involvement-in-global-health-reduce-perceived-radiologist-burnout
#17
Aaron D Kline, Joshua S Harford, Melissa P Culp
No abstract text is available yet for this article.
December 5, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29221895/report-on-eighth-who-meeting-on-development-of-influenza-vaccines-that-induce-broadly-protective-and-long-lasting-immune-responses-chicago-usa-23-24-august-2016
#18
Justin R Ortiz, Julian Hickling, Rebecca Jones, Armen Donabedian, Othmar G Engelhardt, Jacqueline M Katz, Shabir A Madhi, Kathleen M Neuzil, Guus F Rimmelzwaan, James Southern, David J Spiro, Joachim Hombach
In August 2016, the World Health Organization (WHO) convened the "Eighth meeting on development of influenza vaccines that induce broadly protective and long-lasting immune responses" to discuss the regulatory requirements and pathways for licensure of next-generation influenza vaccines, and to identify areas where WHO can promote the development of such vaccines. Participants included approximately 120 representatives of academia, the vaccine industry, research and development funders, and regulatory and public health agencies...
December 5, 2017: Vaccine
https://www.readbyqxmd.com/read/29221890/22nd-international-conference-on-medical-physics-2016-bangkok-thailand-medical-physics-propelling-global-health
#19
EDITORIAL
Virginia Tsapaki, Geoff Ibbott, Anchali Krisanachinda, Kwan-Hoong Ng, Tae-Suk Suh, Slavik Tabakov, John Damilakis
As medical technology evolves and patient needs increase, the need for well-trained and highly professional medical physicists (MPs) becomes even more urgent. The roles and responsibilities of MPs in various departments within the hospital are diverse and demanding. It is obvious that training, continuing education and professional development of MPs have become essential. One of the ways for an MP to advance his or her knowledge is to participate in conferences and congresses. Last year, the 22nd International Conference of Medical Physics (ICMP 2016) took place in Bangkok, Thailand...
December 6, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29221643/respiratory-and-cardiovascular-responses-to-walking-down-a-traffic-polluted-road-compared-with-walking-in-a-traffic-free-area-in-participants-aged-60-years-and-older-with-chronic-lung-or-heart-disease-and-age-matched-healthy-controls-a-randomised-crossover
#20
Rudy Sinharay, Jicheng Gong, Benjamin Barratt, Pamela Ohman-Strickland, Sabine Ernst, Frank Kelly, Junfeng Jim Zhang, Peter Collins, Paul Cullinan, Kian Fan Chung
BACKGROUND: Long-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from ischaemic heart disease and exacerbations of COPD. We aimed to assess the effects on respiratory and cardiovascular responses of walking down a busy street with high levels of pollution compared with walking in a traffic-free area with lower pollution levels in older adults...
December 5, 2017: Lancet
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