Xu Zhou, Xiaohan Kong, Jun Lu, Heng Wang, Meng Liu, Shuchao Zhao, Zhaozhi Xia, Qinggong Liu, Hongrui Sun, Xin Gao, Chaoqun Ma, Zheyu Niu, Faji Yang, Xie Song, Hengjun Gao, Shizhe Zhang, Huaqiang Zhu
BACKGROUND: Exosomes assume a pivotal role as essential mediators of intercellular communication within tumor microenvironments. Within this context, long noncoding RNAs (LncRNAs) have been observed to be preferentially sorted into exosomes, thus exerting regulatory control over the initiation and progression of cancer through diverse mechanisms. RESULTS: Exosomes were successfully isolated from cholangiocarcinoma (CCA) CTCs organoid and healthy human serum. Notably, the LncRNA titin-antisense RNA1 (TTN-AS1) exhibited a conspicuous up-regulation within CCA CTCs organoid derived exosomes...
April 18, 2024: Journal of Nanobiotechnology