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Normobaric hypoxia

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https://www.readbyqxmd.com/read/28432557/proteomic-analysis-of-mitochondrial-proteins-in-the-guinea-pig-heart-following-long-term-normobaric-hyperoxia
#1
Lucia Lichardusova, Zuzana Tatarkova, Andrea Calkovska, Daniela Mokra, Ivan Engler, Peter Racay, Jan Lehotsky, Peter Kaplan
Normobaric hyperoxia is applied for the treatment of a wide variety of diseases and clinical conditions related to ischemia or hypoxia, but it can increase the risk of tissue damage and its efficiency is controversial. In the present study, we analyzed cardiac mitochondrial proteome derived from guinea pigs after 60 h exposure to 100% molecular oxygen (NBO) or O2 enriched with oxygen cation (NBO+). Two-dimensional gel electrophoresis followed by MALDI-TOF/TOF mass spectrometry identified twenty-two different proteins (among them ten nonmitochondrial) that were overexpressed in NBO and/or NBO+ group...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28418725/medex-2015-heart-rate-variability-predicts-development-of-acute-mountain-sickness
#2
Angus Sutherland, Joseph Freer, Laura Evans, Alberto Dolci, Matteo Crotti, Jamie Hugo Macdonald
Sutherland, Angus, Joseph Freer, Laura Evans, Alberto Dolci, Matteo Crotti, and Jamie Hugo Macdonald. MEDEX 2015: Heart rate variability predicts development of acute mountain sickness. High Alt Med Biol 00:000-000, 2017. AIMS: Acute mountain sickness (AMS) develops when the body fails to acclimatize to atmospheric changes at altitude. Preascent prediction of susceptibility to AMS would be a useful tool to prevent subsequent harm. Changes to peripheral oxygen saturation (SpO2) on hypoxic exposure have previously been shown to be of poor predictive value...
April 18, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28386234/high-intensity-interval-training-in-normobaric-hypoxia-improves-cardiorespiratory-fitness-in-overweight-chinese-young-women
#3
Zhaowei Kong, Qingde Shi, Jinlei Nie, Tomas K Tong, Lili Song, Longyan Yi, Yang Hu
Previous studies have investigated the effects of high-intensity interval training (HIIT) on cardiorespiratory fitness and body composition in overweight populations. However, the additive effect of HIIT and hypoxia on health parameters is not clear. This study compared the effects of HIIT under hypoxic conditions on cardiometabolic function with that under normoxia in overweight Chinese young women. Methods: A double-blind randomized controlled experimental design was applied. Twenty-four sedentary overweight Chinese young women (weight: 68...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28370674/reduced-blood-flow-through-intrapulmonary-arteriovenous-anastomoses-during-exercise-in-lowlanders-during-acclimatization-to-high-altitude
#4
Lindsey M Boulet, Andrew T Lovering, Michael M Tymko, Trevor A Day, Mike Stembridge, Trang Anh Nguyen, Philip N Ainslie, Glen E Foster
Blood flow through intrapulmonary arteriovenous anastomoses (Q̇IPAVA ) is elevated during exercise at sea level (SL) and at rest in acute normobaric hypoxia. Following high altitude (HA) acclimatization, resting Q̇IPAVA is similar to SL, but it is unknown if this is true during exercise at HA. We reasoned that exercise at HA (5,050 m) would exacerbate Q̇IPAVA due to heightened pulmonary arterial pressure. Using a supine cycle ergometer, seven healthy adults free from intracardiac shunts underwent an incremental exercise test at SL (25, 50, 75% of SL V̇O2peak ) and at HA (25, 50% of SL V̇O2peak )...
March 30, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28346847/does-acute-normobaric-hypoxia-induce-anapyrexia-in-adult-humans
#5
Yongsuk Seo, Hayden D Gerhart, Jeremiah Vaughan, Jung-Hyun Kim, Ellen L Glickman
Seo, Yongsuk, Hayden D. Gerhart, Jeremiah Vaughan, Jung-Hyun Kim, and Ellen L. Glickman. Does acute normobaric hypoxia induce anapyrexia in adult humans? High Alt Med Biol 00:000-000, 2017.-Exposure to hypoxia is known to induce a reduction in core body temperature as a protective mechanism, which has been shown in both animals and humans. The purpose of this study was to test if acute exposure to normobaric hypoxia (NH) induces anapyrexia in adult humans in association with decreased peripheral oxygen saturation (SpO2)...
March 27, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28338405/physiological-responses-to-treadmill-running-with-body-weight-support-in-hypoxia-compared-to-normoxia
#6
Ben J Lee, Charles Douglas Thake
CONTEXT: Anecdotal reports suggest elite sports clubs combine lower body positive pressure (LBPP) rehabilitation with a hypoxic stimulus in order to maintain or increase physiological and metabolic strain, which are reduced during LBPP. However the effects of hypoxia on cardiovascular and metabolic response during LBPP rehabilitation is unknown. OBJECTIVE: Evaluate the use of normobaric hypoxia as a means to increase physiological strain during body weight supported (BWS) running...
March 24, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28335733/effects-of-short-term-hyperoxia-on-erythropoietin-levels-and-microcirculation-in-critically-ill-patients-a-prospective-observational-pilot-study
#7
Abele Donati, Elisa Damiani, Samuele Zuccari, Roberta Domizi, Claudia Scorcella, Massimo Girardis, Alessia Giulietti, Arianna Vignini, Erica Adrario, Rocco Romano, Laura Mazzanti, Paolo Pelaia, Mervyn Singer
BACKGROUND: The normobaric oxygen paradox states that a short exposure to normobaric hyperoxia followed by rapid return to normoxia creates a condition of 'relative hypoxia' which stimulates erythropoietin (EPO) production. Alterations in glutathione and reactive oxygen species (ROS) may be involved in this process. We tested the effects of short-term hyperoxia on EPO levels and the microcirculation in critically ill patients. METHODS: In this prospective, observational study, 20 hemodynamically stable, mechanically ventilated patients with inspired oxygen concentration (FiO2) ≤0...
March 23, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28332025/endurance-aerobic-high-intensity-and-repeated-sprint-cycling-performance-is-unaffected-by-normobaric-live-high-train-low-a-double-blind-placebo-controlled-cross-over-study
#8
Jacob Bejder, Andreas Breenfeldt Andersen, Rie Buchardt, Tanja Hultengren Larsson, Niels Vidiendal Olsen, Nikolai Baastrup Nordsborg
The aim was to investigate whether 6 weeks of normobaric "Live High-Train Low" (LHTL) using altitude tents affect highly trained athletes incremental peak power, 26-km time-trial cycling performance, 3-min all-out performance, and 30-s repeated sprint ability. In a double-blinded, placebo-controlled cross-over design, seven highly trained triathletes were exposed to 6 weeks of normobaric hypoxia (LHTL) and normoxia (placebo) for 8 h/day. LHTL exposure consisted of 2 weeks at 2500 m, 2 weeks at 3000 m, and 2 weeks at 3500 m...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28323585/feasibility-of-hypoxic-challenge-testing-in-children-and-adolescents-with-congenital-heart-and-lung-disease
#9
Mandy E Spoorenberg, Erik H J Hulzebos, Tim Takken
BACKGROUND: This is a cross-sectional observational study to investigate the safety and feasibility of integrating changing body positions and physical activity in a hypoxic challenge test (HCT). The secondary objective was to compare oxygen saturation (Spo2) in two different locations (forehead and finger). METHODS: Included were 12 pediatric to young adult patients with congenital heart (N = 7) or lung disease (N = 5). An HCT was performed using breathing room air (21% oxygen) while sitting and breathing a normobaric hypoxic gas mixture (15% oxygen) through a facemask while seated, lying supine, standing, walking 3 km/h, and walking 5 km/h in a nonrandomized order...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28323448/effects-of-chronic-ghrelin-treatment-on-hypoxia-induced-brain-oxidative-stress-and-inflammation-in-a-rat-normobaric-chronic-hypoxia-model
#10
Hasan Omrani, Mohammad Reza Alipour, Fereshteh Farajdokht, Hadi Ebrahimi, Mehran Mesgari Abbasi, Gisou Mohaddes
AIM: This study aimed to evaluate the probable antioxidant effects of ghrelin in the brain and serum and its effect on tumor necrosis factor-alpha (TNF-α) levels in the brain in a model of chronic systemic hypoxia in rats. METHODS: Systemic hypoxia was induced by a normobaric hypoxic chamber (O2 11%) for ten days. Adult male Wistar rats were divided into control (C), chronic ghrelin (80 μg/kg/10 days) (Ghr), chronic hypoxia (CH), and CH and ghrelin (80 μg/kg/ip/10 days) (CH + Gh) groups...
March 21, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28323322/adaptations-following-an-intermittent-hypoxia-hyperoxia-training-in-coronary-artery-disease-patients-a-controlled-study
#11
Oleg Glazachev, Phylipp Kopylov, Davide Susta, Elena Dudnik, Elena Zagaynaya
BACKGROUND: Repeated exposure to intermittent normobaric hypoxia improves exercise tolerance in cardiac patients. Little is known on the effects of intermittent normobaric hypoxia-hyperoxia exposure in coronary artery disease (CAD) patients (New York Heart Association II-III). HYPOTHESIS: IHHT improves exercise tolerance, cardiometabolic profile, and quality of life in CAD patients. METHODS: The study design was a nonrandomized, controlled, before-and-after trial...
March 21, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28301525/muscle-activities-during-walking-and-running-at-energetically-optimal-transition-speed-under-normobaric-hypoxia-on-gradient-slopes
#12
Daijiro Abe, Yoshiyuki Fukuoka, Masahiro Horiuchi
Energy cost of transport per unit distance (CoT; J·kg-1·km-1) displays a U-shaped fashion in walking and a linear fashion in running as a function of gait speed (v; km·h-1). There exists an intersection between U-shaped and linear CoT-v relationships, being termed energetically optimal transition speed (EOTS; km·h-1). Combined effects of gradient and moderate normobaric hypoxia (15.0% O2) were investigated when walking and running at the EOTS in fifteen young males. The CoT values were determined at eight walking speeds (2...
2017: PloS One
https://www.readbyqxmd.com/read/28299447/markers-of-physiological-stress-during-exercise-under-conditions-of-normoxia-normobaric-hypoxia-hypobaric-hypoxia-and-genuine-high-altitude
#13
David Richard Woods, John Paul O'Hara, Christopher John Boos, Peter David Hodkinson, Costas Tsakirides, Neil Edward Hill, Darren Jose, Amanda Hawkins, Kelly Phillipson, Antonia Hazlerigg, Nicola Arjomandkhah, Liam Gallagher, David Holdsworth, Mark Cooke, Nicholas Donald Charles Green, Adrian Mellor
PURPOSE: To investigate whether there is a differential response at rest and following exercise to conditions of genuine high altitude (GHA), normobaric hypoxia (NH), hypobaric hypoxia (HH), and normobaric normoxia (NN). METHOD: Markers of sympathoadrenal and adrenocortical function [plasma normetanephrine (PNORMET), metanephrine (PMET), cortisol], myocardial injury [highly sensitive cardiac troponin T (hscTnT)], and function [N-terminal brain natriuretic peptide (NT-proBNP)] were evaluated at rest and with exercise under NN, at 3375 m in the Alps (GHA) and at equivalent simulated altitude under NH and HH...
March 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28292971/selective-replacement-of-mitochondrial-dna-increases-the-cardioprotective-effect-of-chronic-continuous-hypoxia-in-spontaneously-hypertensive-rats
#14
Jan Neckář, Anna Svatoňová, Romana Weissová, Zdeněk Drahota, Pavlína Zajíčková, Iveta Brabcová, David Kolář, Petra Alánová, Jana Vašinová, Jan Šilhavý, Markéta Hlaváčková, Kateřina Tauchmannová, Marie Milerová, Bohuslav Ošťádal, Luděk Červenka, Jitka Žurmanová, Martin Kalous, Olga Nováková, Jiří Novotný, Michal Pravenec, František Kolář
Mitochondria play an essential role in improved cardiac ischaemic tolerance conferred by adaptation to chronic hypoxia. In the present study, we analysed the effects of continuous normobaric hypoxia (CNH) on mitochondrial functions, including the sensitivity of the mitochondrial permeability transition pore (MPTP) to opening, and infarct size (IS) in hearts of spontaneously hypertensive rats (SHR) and the conplastic SHR-mt(BN) strain, characterized by the selective replacement of the mitochondrial genome of SHR with that of the more ischaemia-resistant brown Norway (BN) strain...
May 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28291475/a-novel-inexpensive-method-to-monitor-record-and-analyze-breathing-behavior-during-normobaric-hypoxia-generated-by-the-reduced-oxygen-breathing-device
#15
Leonard A Temme, Paul St Onge, Mark Adams, David L Still, Jonathan K Statz, Steven T Williams
OBJECTIVES: Since hypoxia remains one of the most important physiological hazards the aviation environment poses, military aviators are trained to recognize symptoms of hypoxia in order to implement appropriate safety procedures and countermeasures when hypoxia occurs. A widely used commercial instrument for hypoxia training, demonstration, and research is the Reduced Oxygen Breathing Device (ROBD). Here we describe a novel, inexpensive method to use the ROBD's breathing loop pressure (BLP) to measure respiration rate, a critically important response parameter for hypoxia...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290047/adaptation-to-chronic-continuous-hypoxia-potentiates-akt-hk2-anti-apoptotic-pathway-during-brief-myocardial-ischemia-reperfusion-insult
#16
David Kolar, Milada Gresikova, Petra Waskova-Arnostova, Barbara Elsnicova, Jana Kohutova, Daniela Hornikova, Pavel Vebr, Jan Neckar, Tereza Blahova, Dita Kasparova, Jiri Novotny, Frantisek Kolar, Olga Novakova, Jitka M Zurmanova
Adaptation to chronic hypoxia represents a potential cardioprotective intervention reducing the extent of acute ischemia/reperfusion (I/R) injury, which is a major cause of death worldwide. The main objective of this study was to investigate the anti-apoptotic Akt/hexokinase 2 (HK2) pathway in hypoxic hearts subjected to I/R insult. Hearts isolated from male Wistar rats exposed either to continuous normobaric hypoxia (CNH; 10% O2) or to room air for 3 weeks were perfused according to Langendorff and subjected to 10 min of no-flow ischemia and 10 min of reperfusion...
March 13, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28282350/moving-the-debate-forward-are-normobaric-and-hypobaric-hypoxia-interchangeable-in-the-study-of-altitude
#17
Dana M DiPasquale
No abstract text is available yet for this article.
March 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28280973/determinants-of-curvature-constant-w-of-the-power-duration-relationship-under-normoxia-and-hypoxia-the-effect-of-pre-exercise-alkalosis
#18
Sanjoy K Deb, Lewis A Gough, S Andy Sparks, Lars R McNaughton
PURPOSE: This study investigated the effect of induced alkalosis on the curvature constant (W') of the power-duration relationship under normoxic and hypoxic conditions. METHODS: Eleven trained cyclists (mean ± SD) Age: 32 ± 7.2 years; body mass (bm): 77.0 ± 9.2 kg; VO2peak: 59.2 ± 6.8 ml·kg(-1)·min(-1) completed seven laboratory visits which involved the determination of individual time to peak alkalosis following sodium bicarbonate (NaHCO3) ingestion, an environment specific ramp test (e...
March 9, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28259102/oxidative-stress-and-apoptosis-after-acute-respiratory-hypoxia-and-reoxygenation-in-rat-brain
#19
Debora Coimbra-Costa, Norma Alva, Mónica Duran, Teresa Carbonell, Ramón Rama
Acute hypoxia increases the formation of reactive oxygen species (ROS) in the brain. However, the effect of reoxygenation, unavoidable to achieve full recovery of the hypoxic organ, has not been clearly established. The aim of the present study was to evaluate the effects of exposition to acute severe respiratory hypoxia followed by reoxygenation on the evolution of oxidative stress and apoptosis in the brain. We investigated the effect of in vivo acute severe normobaric hypoxia (rats exposed to 7% O2 for 6h) and reoxygenation in normoxia (21% O2 for 24h or 48h) on oxidative stress markers, the antioxidant system and apoptosis in the brain...
February 24, 2017: Redox Biology
https://www.readbyqxmd.com/read/28248531/baseline-values-of-cardiovascular-and-respiratory-parameters-predict-response-to-acute-hypoxia-in-young-healthy-men
#20
V N Melnikov, S G Krivoschekov, V E Divert, T G Komlyagina, N S Consedine
The majority of the available works have studied distinct hypoxic responses of respiratory and cardiovascular systems. This study examines how these systems interact while responding to hypoxia and whether baseline metrics moderate reactions to a hypoxic challenge. Central hemodynamic, aortic wave reflection, and gas exchange parameters were measured in 27 trained young men before and after 10-min normobaric isocapnic hypoxia (10 % O2). Associations were assessed by correlation and multiple regression analyses...
February 28, 2017: Physiological Research
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