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Normobaric hypoxia

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https://www.readbyqxmd.com/read/28103427/repeated-maximal-intensity-hypoxic-exercise-superimposed-to-hypoxic-residence-boosts-skeletal-muscle-transcriptional-responses-in-elite-team-sport-athletes
#1
Franck Brocherie, Grégoire P Millet, Gommaar D'Hulst, Ruud Van Thienen, Louise Deldicque, Olivier Girard
AIM: To determine whether repeated maximal-intensity hypoxic exercise induces larger beneficial adaptations on the hypoxia inducible factor-1α pathway and its target genes than similar normoxic exercise, when combined with chronic hypoxic exposure. METHODS: Lowland elite male team-sport athletes underwent 14 days of passive normobaric hypoxic exposure (≥14 h.day(-1) at Fi O2 14.5-14.2%) with the addition of six maximal-intensity exercise sessions either in normobaric hypoxia (Fi O2 ~14...
January 19, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28090139/the-blood-antioxidant-defence-capacity-during-intermittent-hypoxic-training-in-elite-swimmers
#2
S Poprzęcki, M Czuba, A Zając, J Karpiński, R Wilk, G Bril, A Maszczyk, M Toborek
The main objective of this study was to examine the chronic effect of simulated intermittent normobaric hypoxia on blood antioxidant defence capacity in swimmers. The study included 14 male and 14 female competitive swimmers performing part of land training under simulated intermittent normobaric hypoxia (O2 = 15.5%) or in normoxia. Land interval training took place twice per week, with a total of 8 training units during the study, performed with individualized intensity. The activities of blood antioxidant enzymes did not change significantly during the first and last training unit in the hypoxic and normoxic group...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28069461/is-acute-mountain-sickness-related-to-trait-anxiety-a-normobaric-chamber-study
#3
Martin Niedermeier, Robb Waanders, Verena Menz, Maria Wille, Martin Kopp, Martin Burtscher
INTRODUCTION: Some mountaineers are more prone to the occurrence of acute mountain sickness (AMS) than others. State anxiety during altitude exposure might be associated with AMS development. We hypothesized that trait anxiety might be higher in AMS cases compared to non-AMS cases. The aim of the present study was to study the relationship between AMS development and trait anxiety. METHODS: In an observational study design, AMS incidence during a 12-hour exposure to normobaric hypoxia (FiO2=12...
January 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28065733/amelioration-of-apelin-13-in-chronic-normobaric-hypoxia-induced-anxiety-like-behavior-is-associated-with-an-inhibition-of-nf-%C3%AE%C2%BAb-in-the-hippocampus
#4
Junming Fan, Lu Ding, Dongmei Xia, Danyang Chen, Pu Jiang, Wenhua Ge, Ru Zhao, Jinbin Guo, Xiaofang Fan, Feng Xue, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gong
Apelin, a small bioactive peptide, plays an important role in the pathogenesis of mood disorders through the endogenous ligand APJ. Although the anxiolytic effect of apelin is well established, the mechanisms are poorly understood. In this study, we hypothesized that apelin played an anxiolytic role in chronic normobaric hypoxia (CNH)-induced anxiety like behavior in mice, which might be associated with an inhibition of nuclear factor-κB (NF-κB) activation in the hippocampus. To this end, mice were exposed in a normobaric hypoxic chamber with a fraction of inspired oxygen (FIO2, ∼10%, 23h/d) with or without apelin-13 application (20 nmolkg(-1)d(-1), i...
January 5, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28025662/the-effect-of-a-live-high-train-high-exercise-regimen-on-behavioural-temperature-regulation
#5
Shawnda A Morrison, Urša Ciuha, Daniela Zavec-Pavlinić, Ola Eiken, Igor B Mekjavic
PURPOSE: Acute hypoxia alters the threshold for sensation of cutaneous thermal stimuli. We hypothesised that hypoxia-induced alterations in cutaneous temperature sensation may lead to modulation of the perception of temperature, ultimately influencing behavioural thermoregulation and that the magnitude of this effect could be influenced by daily physical training. METHODS: Fourteen men were confined 10 days to a normobaric hypoxic environment (PIO2 = 88.2 ± 0...
December 26, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27959667/bench-evaluation-of-four-portable-oxygen-concentrators-under-different-conditions-representing-altitudes-of-2438-4200-and-8000%C3%A2-m
#6
Vincent Bunel, Amr Shoukri, Frederic Choin, Serge Roblin, Cindy Smith, Thomas Similowski, Capucine Morélot-Panzini, Jesus Gonzalez
Bunel, Vincent, Amr Shoukri, Frederic Choin, Serge Roblin, Cindy Smith, Thomas Similowski, Capucine Morélot-Panzini, and Jésus Gonzalez. Bench evaluation of four portable oxygen concentrators under different conditions representing altitudes of 2438, 4200, and 8000 m. High Alt Med Biol. 17:370-374, 2016.-Air travel is responsible for a reduction of the partial pressure of oxygen (O2) as a result of the decreased barometric pressure. This hypobaric hypoxia can be dangerous for passengers with respiratory diseases, requiring initiation or intensification of oxygen therapy during the flight...
December 2016: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27864638/effects-of-caffeine-on-neuromuscular-fatigue-and-performance-during-high-intensity-cycling%C3%A2-exercise-in-moderate-hypoxia
#7
Bruno P C Smirmaul, Antonio Carlos de Moraes, Luca Angius, Samuele M Marcora
PURPOSE: To investigate the effects of caffeine on performance, neuromuscular fatigue and perception of effort during high-intensity cycling exercise in moderate hypoxia. METHODS: Seven adult male participants firstly underwent an incremental exercise test on a cycle ergometer in conditions of acute normobaric hypoxia (fraction inspired oxygen = 0.15) to establish peak power output (PPO). In the following two visits, they performed a time to exhaustion test (78 ± 3% PPO) in the same hypoxic conditions after caffeine ingestion (4 mg kg(-1)) and one after placebo ingestion in a double-blind, randomized, counterbalanced cross-over design...
November 18, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27856711/pulmonary-vascular-collagen-content-not-cross-linking-contributes-to-right-ventricular-pulsatile-afterload-and-overload-in-early-pulmonary-hypertension
#8
Zhijie Wang, David A Schreier, Hinnah Abid, Timothy A Hacker, Naomi C Chesler
Hypoxic pulmonary hypertension (HPH) is associated with pulmonary artery (PA) remodeling and right ventricular (RV) overload. We have previously uncovered collagen-mediated mechanisms of proximal PA stiffening in early HPH by manipulating collagen degradation and crosslinking using a transgenic mouse strain and a potent collagen cross-link inhibitor β-aminopropionitrile (BAPN). However, the roles of collagen in distal PA remodeling, overall RV afterload and RV hypertrophy in HPH remain unknown. Here, we used the same experimental strategy to investigate the impact of pulmonary vascular collagen content and cross-linking on steady and pulsatile RV afterload as well as RV hypertrophy in early HPH...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27847819/acute-mountain-sickness-symptoms-depend-on-normobaric-versus-hypobaric-hypoxia
#9
Dana M DiPasquale, Gary E Strangman, N Stuart Harris, Stephen R Muza
Acute mountain sickness (AMS), characterized by headache, nausea, fatigue, and dizziness when unacclimatized individuals rapidly ascend to high altitude, is exacerbated by exercise and can be disabling. Although AMS is observed in both normobaric (NH) and hypobaric hypoxia (HH), recent evidence suggests that NH and HH produce different physiological responses. We evaluated whether AMS symptoms were different in NH and HH during the initial stages of exposure and if the assessment tool mattered. Seventy-two 8 h exposures to normobaric normoxia (NN), NH, or HH were experienced by 36 subjects...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27800505/fifteen-days-of-3-200-m-simulated-hypoxia-marginally-regulates-markers-for-protein-synthesis-and-degradation-in-human-skeletal-muscle
#10
Gommaar D'Hulst, Alessandra Ferri, Damien Naslain, Luc Bertrand, Sandrine Horman, Marc Francaux, David J Bishop, Louise Deldicque
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon are not well defined in vivo. We sought to determine how chronic hypoxia regulates molecular markers of protein synthesis and degradation in human skeletal muscle and whether these regulations were related to the regulation of the hypoxia-inducible factor (HIF) pathway. Eight young male subjects lived in a normobaric hypoxic hotel (FiO2 14.1%, 3,200 m) for 15 days in well-controlled conditions for nutrition and physical activity...
2016: Hypoxia
https://www.readbyqxmd.com/read/27765844/intermittent-hypobaric-hypoxia-combined-with-aerobic-exercise-improves-muscle-morphofunctional-recovery-after-eccentric-exercise-to-exhaustion-in-trained-rats
#11
David Rizo-Roca, Juan Gabriel Ríos-Kristjánsson, Cristian Núñez-Espinosa, Estela Santos-Alves, Ines O Goncalves, Jose Magalhaes, Antonio A Ascensao, Teresa Pagès, Ginés Viscor, Joan Ramon Torrella
Unaccustomed eccentric exercise leads to muscle morphological and functional alterations, including microvasculature damage, the repair of which is modulated by hypoxia. Here we present the effects of intermittent hypobaric hypoxia and exercise on recovery from eccentric-induced muscle damage (EEIMD). Soleus muscles from trained rats were excised pre- (CTRL) and 1, 3, 7 and 14 days after a double session of EEIMD protocol. A recovery treatment consisting of one of the following protocols was applied one day after the EEIMD: passive normobaric recovery (PNR), a 4-hour daily exposure to passive hypobaric hypoxia at 4000m (PHR) or hypobaric hypoxia exposure followed by aerobic exercise (AHR)...
October 20, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27765746/heart-lung-interaction-in-a-model-of-copd-importance-of-lung-volume-and-direct-ventricular-interaction
#12
William S Cheyne, Alexandra M Williams, Megan I Harper, Neil D Eves
Chronic obstructive pulmonary disease (COPD) is associated with dynamic lung hyperinflation (DH), increased pulmonary vascular resistance (PVR), and large increases in negative intrathoracic pressure (nITP). The individual and interactive effect of these stressors on left ventricular (LV) filling, emptying, and geometry and the role of direct ventricular interaction (DVI) in mediating these interactions have not been fully elucidated. Twenty healthy subjects were exposed to the following stressors alone and in combination: 1) inspiratory resistive loading of -20 cmH2O (nITP), 2) expiratory resistive loading to cause dynamic hyperinflation (DH), and 3) normobaric-hypoxia to increase PVR (hPVR)...
December 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27750391/clarification-on-altitude-training
#13
LETTER
Grégoire P Millet, Franck Brocherie, Raphael Faiss, Olivier Girard
No abstract text is available yet for this article.
January 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/27744292/walking-economy-at-simulated-high-altitude-in-human-healthy-young-male-lowlanders
#14
Masahiro Horiuchi, Yoko Handa, Daijiro Abe, Yoshiyuki Fukuoka
We measured oxygen consumption during walking per unit distance (Cw) values for 12 human healthy young males at six speeds from 0.667 to 1.639 m s(-1) (four min per stage) on a level gradient under normobaric normoxia, moderate hypoxia (15% O2), and severe hypoxia (11% O2). Muscle deoxygenation (HHb) was measured at the vastus lateralis muscle using near-infrared spectroscopy. Economical speed which can minimize the Cw in each individual was calculated from a U-shaped relationship. We found a significantly slower economical speed (ES) under severe hypoxia [1...
October 15, 2016: Biology Open
https://www.readbyqxmd.com/read/27721912/effect-of-high-intensity-training-in-normobaric-hypoxia-on-thoroughbred-skeletal-muscle
#15
Hiroshi Nagahisa, Kazutaka Mukai, Hajime Ohmura, Toshiyuki Takahashi, Hirofumi Miyata
Hypoxic training is believed to increase endurance capacity in association with hypoxia inducible factor-1α (HIF-1α), a modulator of vascular endothelial growth factor-A (VEGF-A), and to influence activation of satellite cells (SCs). However, the effect of hypoxic training on SC activation and its relation to angiogenesis has not been thoroughly investigated. Eight Thoroughbred horses were subjected to normoxic (FIO2 = 21%) or hypoxic (FIO2 = 15%) training for 3 days/week (100%  [Formula: see text]) for 4 weeks...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27708611/a-history-of-mild-traumatic-brain-injury-affects-peripheral-pulse-oximetry-during-normobaric-hypoxia
#16
Leonard A Temme, Paul St Onge, Joseph Bleiberg
INTRODUCTION: Physiological and emotional stressors increase symptoms of concussion in recently injured individuals and both forms of stress-induced symptoms in people recovering from mild traumatic brain injury (mTBI), but who are asymptomatic when not stressed or are at rest. METHODS: Healthy asymptomatic adults (25.0 ± 5.1 years) with a history of mTBI (n = 36) and matched healthy controls (HC) (n = 36) with no mTBI history were exposed to three levels of normobaric hypoxic stress generated with the Reduced Oxygen Breathing Device (ROBD) (Environics, Inc...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27694473/simvastatin-prevents-and-reverses-chronic-pulmonary-hypertension-in-newborn-rats-via-pleiotropic-inhibition-of-rhoa-signaling
#17
Mathew J Wong, Crystal Kantores, Julijana Ivanovska, Amish Jain, Robert P Jankov
Chronic neonatal pulmonary hypertension (PHT) frequently results in early death. Systemically administered Rho-kinase (ROCK) inhibitors prevent and reverse chronic PHT in neonatal rats, but at the cost of severe adverse effects, including systemic hypotension and growth restriction. Simvastatin has pleiotropic inhibitory effects on isoprenoid intermediates that may limit activity of RhoA, which signals upstream of ROCK. We therefore hypothesized that statin treatment would safely limit pulmonary vascular RhoA activity and prevent and reverse experimental chronic neonatal PHT via downstream inhibitory effects on pathological ROCK activity...
September 30, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27689470/normobaric-hypoxia-effects-on-balance-measured-by-computerized-dynamic-posturography
#18
Dale R Wagner, Skyler Saunders, Brady Robertson, John E Davis
: Wagner, Dale R., Skyler Saunders, Brady Robertson, and John E. Davis. Normobaric hypoxia effects on balance measured by computerized dynamic posturography. High Alt Med Biol. 17:222-227, 2016.-Background/Aim: Equilibrium was measured by computerized dynamic posturography at varying levels of normobaric hypoxia before and after exercise. METHODS: Following a familiarization trial, 12 males (27.3 ± 7.1 years) completed three sessions in random order on a NeuroCom SMART Balance Master: a sham trial at the ambient altitude of 1500 m and simulated altitudes of 3000 and 5000 m created by a hypoxic generator...
September 2016: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27672589/a-novel-model-of-retinopathy-of-prematurity-in-normobaric-hyperoxic-conditions
#19
Taner Ozgurtas, Sercan Tekin, Fatih Yesildal, Umut Karaca, Fevzi Nuri Aydin, Muhammed Talha Ugurlu, Mehmet Ozler, Hakan Durukan
AIM: To examine changes in retinal vasculature after treatment with different oxygen concentrations from common retinopathy of prematurity (ROP) models and to determine a novel and practical ROP model. METHODS: A sample of 14 newborn Sprague-Dawley rats was used. The study group (n=7) was exposed to 95% oxygen for 4h per day followed by normoxic laboratory conditions for 20h. This cycle was repeated for 14d. The control group (n=7) was subjected to normobaric normoxic conditions...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27642493/protection-of-pentoxifylline-against-testis-injury-induced-by-intermittent-hypobaric-hypoxia
#20
Chen Yao, Gang Li, Yeyong Qian, Ming Cai, Hong Yin, Li Xiao, Wei Tang, Fengjie Guo, Bingyi Shi
To investigate the effect of pentoxifylline (PTX) on spermatogenesis dysfunction induced by intermittent hypobaric hypoxia (IHH) and unveil the underlying mechanism, experimental animals were assigned to Control, IHH+Vehicle, and IHH+PTX groups and exposed to 4 cycles of 96 h of hypobaric hypoxia followed by 96 h of normobaric normoxia for 32 days. PTX was administered for 32 days. Blood and tissue samples were collected 7 days thereafter. Serum malondialdehyde levels were used to assess lipid peroxidation; ferric-reducing antioxidant power (FRAP), superoxide dismutase, and catalase and glutathione peroxidase enzyme activities were assessed to determine antioxidant capacity in various samples...
2016: Oxidative Medicine and Cellular Longevity
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