keyword
MENU ▼
Read by QxMD icon Read
search

Normobaric hypoxia

keyword
https://www.readbyqxmd.com/read/29112466/the-effect-of-inspiratory-resistance-on-exercise-performance-and-perception-in-moderate-normobaric-hypoxia
#1
Yongsuk Seo, Jeremiah Vaughan, Tyler D Quinn, Brittany Followay, Raymond Roberge, Ellen L Glickman, Jung-Hyun Kim
Seo, Yongsuk, Jeremiah Vaughan, Tyler D. Quinn, Brittany Followay, Raymond Roberge, Ellen L. Glickman, and Jung-Hyun Kim. The effect of inspiratory resistance on exercise performance and perception in moderate normobaric hypoxia. High Alt Med Biol. 00:000-000, 2017. PURPOSE: Respirators are simple and efficient in protecting workers against toxic airborne substances; however, their use may limit the physical performance of workers. The purpose of this study was to determine the effect of inspiratory resistance on physical performance and breathing perception in normobaric hypoxia...
November 7, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29106947/glial-cell-line-derived-neurotrophic-factor-gdnf-counteracts-hypoxic-damage-to-hippocampal-neural-network-function-in-vitro
#2
Tatiana V Shishkina, Tatiana A Mishchenko, Elena V Mitroshina, Olesya M Shirokova, Alexei S Pimashkin, Innokentiy A Kastalskiy, Irina V Mukhina, Victor B Kazantsev, Maria V Vedunova
Glial cell line-derived neurotrophic factor (GDNF) is regarded as a potent neuroprotector and a corrector of neural network activity in stress conditions. This work aimed to investigate the effect of GDNF on primary hippocampal cultures during acute normobaric hypoxia. Hypoxia induction was performed using day 14 in vitro cultures derived from mouse embryos (E18) with the preventive addition of GDNF (1 ng/ml) to the culture medium 10 minutes before oxygen deprivation. An analysis of spontaneous bioelectrical activity that included defining the internal neural network structure, morphological studies, and viability tests was performed during the post-hypoxic period...
October 26, 2017: Brain Research
https://www.readbyqxmd.com/read/29097771/subclinical-pulmonary-dysfunction-contributes-to-high-altitude-pulmonary-edema-susceptibility-in-healthy-non-mountaineers
#3
Rajinder K Gupta, Poonam Soree, Koundinya Desiraju, Anurag Agrawal, Shashi Bala Singh
HAPE susceptible (HAPE-S, had HAPE episode in past) subjects may have subclinical cardio-pulmonary dysfunction. We compared the results of pulmonary function tests in 25 healthy HAPE-S non-mountaineers and 19 matched HAPE resistant (HAPE-R, no HAPE episode in past). Acute normobaric hypoxia (FIo2 0.12) was administered at sea level to confirm hypoxia intolerance in HAPE-S. Unlike HAPE-R, HAPE-S subjects had elevated baseline and post-hypoxia systolic pulmonary arterial pressures (20.9 ± 3 vs 27.3 ± 5 mm Hg during normoxia and 26...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091934/effects-of-hyperoxia-on-18f-fluoro-misonidazole-brain-uptake-and-tissue-oxygen-tension-following-middle-cerebral-artery-occlusion-in-rodents-pilot-studies
#4
Tim D Fryer, Sohail Ejaz, Ulf Jensen-Kondering, David J Williamson, Sergey Sitnikov, Stephen J Sawiak, Franklin I Aigbirhio, Young T Hong, Jean-Claude Baron
PURPOSE: Mapping brain hypoxia is a major goal for stroke diagnosis, pathophysiology and treatment monitoring. 18F-fluoro-misonidazole (FMISO) positron emission tomography (PET) is the gold standard hypoxia imaging method. Normobaric hyperoxia (NBO) is a promising therapy in acute stroke. In this pilot study, we tested the straightforward hypothesis that NBO would markedly reduce FMISO uptake in ischemic brain in Wistar and spontaneously hypertensive rats (SHRs), two rat strains with distinct vulnerability to brain ischemia, mimicking clinical heterogeneity...
2017: PloS One
https://www.readbyqxmd.com/read/29069356/glucocorticoid-receptor-signaling-impairs-protein-turnover-regulation-in-hypoxia-induced-muscle-atrophy-in-male-mice
#5
Chiel C de Theije, Annemie M W J Schols, Wouter H Lamers, Judith J M Ceelen, Rick H van Gorp, J J Rob Hermans, S Elonore Köhler, Ramon C J Langen
Hypoxemia may contribute to muscle wasting in conditions such as Chronic Obstructive Pulmonary Disease. Muscle wasting develops when muscle proteolysis exceeds protein synthesis. Hypoxia induces skeletal muscle atrophy in mice, which can in part be attributed to reduced food intake. We hypothesized that hypoxia elevates circulating corticosterone concentrations by reduced food intake and enhances GR signaling in muscle, which causes elevated protein degradation signaling and dysregulates protein synthesis signaling during hypoxia-induced muscle atrophy...
October 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/28966706/the-effect-of-psychomotor-performance-cerebral-and-arterial-blood-saturation-between-african-american-and-caucasian-males-before-during-and-after-normobaric-hypoxic-exercise
#6
Matthew R Feeback, Yongsuk Seo, Matthew Dancy, Ellen L Glickman
To further elucidate physiological and cognitive performance differences between African-American (AA) and Caucasian individuals (CAU) before, during or after hypoxic and normoxic exercise. Twelve college aged (18-25) apparently healthy African-American (six volunteers) and Caucasian (six subjects) males took part in two trials consisting of normobaric normoxia and normobaric hypoxia (12% oxygen). Each subject cycled at 50% of their altitude adjusted VO2max (-26% of normoxia VO2max) for one hour after a two-hour baseline...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28956166/acute-and-chronic-changes-in-baroreflex-sensitivity-in-hypobaric-vs-normobaric-hypoxia
#7
Nicolas Bourdillon, Jonas Saugy, Laurent Schmitt, Thomas Rupp, Sasan Yazdani, Jean-Marc Vesin, Grégoire P Millet
Normobaric hypoxia (NH) is used as a surrogate for hypobaric hypoxia (HH). Recent studies reported physiological differences between NH and HH. Baroreflex sensitivity (BRS) decreases at altitude or following intense training. However, until now no study compared the acute and chronic changes of BRS in NH vs. HH. First, BRS was assessed in 13 healthy male subjects prior and after 20 h of exposure at 3450 m (study 1), and second in 15 well-trained athletes prior and after 18 days of "live-high train-low" (LHTL) at 2250 m (study 2) in NH vs...
September 27, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28923140/working-memory-capacity-and-surgical-performance-while-exposed-to-mild-hypoxic-hypoxemia
#8
Paul J Parker, Andrew J Manley, Ross Shand, John P O'Hara, Adrian Mellor
INTRODUCTION: Medical Emergency Response Team (MERT) helicopters fly at altitudes of 3000 m in Afghanistan (9843 ft). Civilian hospitals and disaster-relief surgical teams may have to operate at such altitudes or even higher. Mild hypoxia has been seen to affect the performance of novel tasks at flight levels as low as 5000 ft. Aeromedical teams frequently work in unpressurized environments; it is important to understand the implications of this mild hypoxia and investigate whether supplementary oxygen systems are required for some or all of the team members...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28923139/cerebral-hemodynamics-and-executive-function-during-exercise-and-recovery-in-normobaric-hypoxia
#9
Jon Stavres, Hayden D Gerhart, Jung-Hyun Kim, Ellen L Glickman, Yongsuk Seo
BACKGROUND: Hypoxia and exercise each exhibit opposing effects on executive function, and the mechanisms for this are not entirely clear. This study examined the influence of cerebral oxygenation and perfusion on executive function during exercise and recovery in normobaric hypoxia (NH) and normoxia (N). METHODS: There were 18 subjects who completed cycling trials in NH (12.5% FIo2) and N (20.93% FIo2). Right prefrontal cortex (PFC) oxyhemoglobin (O2Hb) and middle cerebral artery blood velocity (MCAbv) were collected during executive function challenges [mathematical processing and running memory continuous performance task (RMCPT)] at baseline, following 30 min of acclimation, during 20 min of cycling (60% Vo2max), and at 1, 15, 30, and 45 min following exercise...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28914359/changes-in-acid-base-and-ion-balance-during-exercise-in-normoxia-and-normobaric-hypoxia
#10
Olaf Lühker, Marc Moritz Berger, Alexander Pohlmann, Lorenz Hotz, Tilmann Gruhlke, Marcel Hochreiter
PURPOSE: Both exercise and hypoxia cause complex changes in acid-base homeostasis. The aim of the present study was to investigate whether during intense physical exercise in normoxia and hypoxia, the modified physicochemical approach offers a better understanding of the changes in acid-base homeostasis than the traditional Henderson-Hasselbalch approach. METHODS: In this prospective, randomized, crossover trial, 19 healthy males completed an exercise test until voluntary fatigue on a bicycle ergometer on two different study days, once during normoxia and once during normobaric hypoxia (12% oxygen, equivalent to an altitude of 4500 m)...
November 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28912649/does-live-high-train-low-and-high-hypoxic-training-alter-running-mechanics-in-elite-team-sport-players
#11
Olivier Girard, Grégoire P Millet, Jean-Benoit Morin, Franck Brocherie
This study aimed to investigate if "Live High-Train Low (and High)" hypoxic training alters constant-velocity running mechanics. While residing under normobaric hypoxia (≥14 h·d(-1); FiO2 14.5-14.2%) for 14 days, twenty field hockey players performed, in addition to their usual training in normoxia, six sessions (4 × 5 × 5-s maximal sprints; 25 s passive recovery; 5 min rest) under either normobaric hypoxia (FiO2 ~14.5%, n = 9) or normoxia (FiO2 20.9%, n = 11). Before and immediately after the intervention, their running pattern was assessed at 10 and 15 km·h(-1) as well as during six 30-s runs at ~20 km·h(-1) with 30-s passive recovery on an instrumented motorised treadmill...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28901662/acute-hypoxemia-and-vascular-function-in-healthy-humans
#12
N C S Lewis, A R Bain, K W Wildfong, D J Green, P N Ainslie
Endothelium-dependent flow mediated dilation (FMD) and endothelium-independent dilation (GTN) are impaired at high altitude (5050 m), and FMD is impaired following acute exposure (<60-minutes) to normobaric hypoxia equivalent to ∼5050 m (∼FI O2  = 0.11). Whether glyceryl trinitrate (GTN)-induced dilation is impaired acutely, and whether FMD is impaired during milder hypoxia is unknown. Therefore, we assessed brachial FMD at baseline and following 30-minutes of mild (74 ± 2 mmHg PET O₂) and moderate (50 ± 3 mmHg PET O₂) normobaric hypoxia (n = 12) or normoxia (time-control trial; n = 10)...
September 13, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28879713/impact-of-moderate-altitude-on-pro-inflammatory-cytokines-in-healthy-volunteers
#13
Christoph Edlinger, Catharina Schreiber, Bjoern Goebel, Rudin Pistulli, Vera Paar, Christiana Schernthaner, Ilonka Rohm, Hans-Reiner Figulla, Uta C Hoppe, Marcus Franz, Christian Jung, Michael Lichtenauer
BACKGROUND: The induction of microvascular inflammation and the effects on cytokine production in blood due to hypoxia has been shown in the past. We have previously reported a statistically significant increase of the pro-inflammatory cytokine interleukin-8 (IL-8) in normobaric hypoxia in the setting of a hypoxia-chamber. In the present study, we sought to analyze plasma levels of inflammatory cytokines in a real-life stetting in order to foster our knowledge on hypoxia induced microvascular inflammation at moderate altitude...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28876128/influence-of-inhaled-amiloride-on-lung-fluid-clearance-in-response-to-normobaric-hypoxia-in-healthy-individuals
#14
Courtney M Wheatley, Sarah E Baker, Bryan J Taylor, Manda L Keller-Ross, Steven C Chase, Alex R Carlson, Robert J Wentz, Eric M Snyder, Bruce D Johnson
Wheatley, Courtney M., Sarah E. Baker, Bryan J. Taylor, Manda L. Keller-Ross, Steven C. Chase, Alex R. Carlson, Robert J. Wentz, Eric M. Snyder, and Bruce D. Johnson. Influence of inhaled amiloride on lung fluid clearance in response to normobaric hypoxia in healthy individuals. High Alt Med Biol 00:000-000, 2017. AIM: To investigate the role of epithelial sodium channels (ENaC) on lung fluid clearance in response to normobaric hypoxia, 20 healthy subjects were exposed to 15 hours of hypoxia (fraction of inspired oxygen [FiO2] = 12...
September 6, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28873460/perfluorocarbon-emulsions-radiosensitise-brain-tumors-in-carbogen-breathing-mice-with-orthotopic-gl261-gliomas
#15
Lisa A Feldman, Marie-Sophie Fabre, Carole Grasso, Dana Reid, William C Broaddus, Gregory M Lanza, Bruce D Spiess, Joel R Garbow, Melanie J McConnell, Patries M Herst
BACKGROUND: Tumour hypoxia limits the effectiveness of radiation therapy. Delivering normobaric or hyperbaric oxygen therapy elevates pO2 in both tumour and normal brain tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy. AIM: To investigate the effect of perfluorocarbon (PFC) emulsions on hypoxia in subcutaneous and intracranial mouse gliomas and their radiosensitising effect in orthotopic gliomas in mice breathing carbogen (95%O2 and 5%CO2)...
2017: PloS One
https://www.readbyqxmd.com/read/28852828/exercise-related-sensations-contribute-to-decrease-power-during-repeated-cycle-sprints-with-limited-influence-on-neural-drive
#16
Olivier Girard, François Billaut, Ryan J Christian, Paul S Bradley, David J Bishop
PURPOSES: We manipulated the inspired oxygen fraction (FiO2) to examine the effects of physiological perturbations on exercise-related sensations and the neural drive of the quadriceps during repeated, brief, maximal cycle sprints. METHODS: Nine active males completed a repeated sprint cycle protocol (10 × 4-s maximal sprints with 30 s of passive recovery) in normoxia (NM; FiO2 0.21) and severe normobaric hypoxia (HY; FiO2 0.13). Peak power, quadriceps Root Mean Squared electromyography (RMS EMG), physiological (heart rate, arterial oxygen saturation, blood lactate concentration) and perceptual responses were recorded...
November 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28846046/the-use-of-simulated-altitude-techniques-for-beneficial-cardiovascular-health-outcomes-in-nonathletic-sedentary-and-clinical-populations-a-literature-review
#17
Catherine A Lizamore, Michael J Hamlin
Lizamore, Catherine A., and Michael J. Hamlin. The use of simulated altitude techniques for beneficial cardiovascular health outcomes in nonathletic, sedentary, and clinical populations: A literature review. High Alt Med Biol 00:000-000, 2017. BACKGROUND: The reportedly beneficial improvements in an athlete's physical performance following altitude training may have merit for individuals struggling to meet physical activity guidelines. AIM: To review the effectiveness of simulated altitude training methodologies at improving cardiovascular health in sedentary and clinical cohorts...
August 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28818999/short-term-arrival-strategies-for-endurance-exercise-performance-at-moderate-altitude
#18
Joshua L Foss, Keren Constantini, Timothy D Mickleborough, Robert F Chapman
For sea level-based endurance athletes who compete at moderate and high altitudes, many are not logistically able to arrive at altitude weeks prior to the event to fully acclimatize. For those who can only arrive at altitude the night before competition, we asked if there is a physiological and performance advantage in reducing altitude exposure time to two hours prior to competition. On three separate visits, ten cyclists completed overnight laboratory exposures of: 1) a 14-hour exposure to normobaric hypoxia (16...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28782598/physiological-and-performance-effects-of-nitrate-supplementation-during-roller-skiing-in-normoxia-and-normobaric-hypoxia
#19
Linn Nybäck, Caroline Glännerud, Gustav Larsson, Eddie Weitzberg, Oliver Michael Shannon, Kerry McGawley
The present study examined the effects of acute nitrate (NO3(-)) supplementation ingested in the form of concentrated beetroot juice on cross-country roller-ski performance in normoxia (N) and normobaric hypoxia (H). Eight competitive cross-country skiers (five males: age 22 ± 3 years, V·O2max 71.5 ± 4.7 mL kg(-1)·min(-1); three females: age 21 ± 1 years, V·O2max 58.4 ± 2.5 mL kg(-1)·min(-1)) were supplemented with a single dose of NO3(-)-rich beetroot juice (BRJ, ∼13 mmol NO3(-)) or a NO3(-)-depleted placebo (PL, ∼0 mmol NO3(-)) and performed 2 x 6-min submaximal exercise bouts and a 1000-m time-trial (TT) on a treadmill in N (20...
August 4, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28775065/effect-of-hypoxia-and-hyperoxia-on-exercise-performance-in-healthy-individuals-and-in-patients-with-pulmonary-hypertension-a-systematic-review
#20
Silvia Ulrich, Simon Raphael Schneider, Konrad E Bloch
Exercise performance is determined by oxygen supply to working muscles and vital organs. In healthy individuals, exercise performance is limited in the hypoxic environment at altitude, when oxygen delivery is diminished due to the reduced alveolar and arterial oxygen partial pressures. In patients with pulmonary hypertension, exercise performance is already reduced near sea level due to impairments of the pulmonary circulation and gas exchange and, presumably, these limitations are more pronounced at altitude...
August 3, 2017: Journal of Applied Physiology
keyword
keyword
35789
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"