keyword
MENU ▼
Read by QxMD icon Read
search

Normobaric hypoxia

keyword
https://www.readbyqxmd.com/read/29326416/strategies-to-restore-adenosine-triphosphate-atp-level-after-more-than-20-hours-of-cold-ischemia-time-in-human-marginal-kidney-grafts
#1
Matteo Ravaioli, Maurizio Baldassare, Francesco Vasuri, Gianandrea Pasquinelli, Maristella Laggetta, Sabrina Valente, Vanessa De Pace, Flavia Neri, Antonio Siniscalchi, Chiara Zanfi, Valentina R Bertuzzo, Paolo Caraceni, Davide Trerè, Pasquale Longobardi, Antonio D Pinna
BACKGROUND The persisting organ shortage in the field of transplantation recommends the use of marginal kidneys which poorly tolerate ischemic damage. Adenosine triphosphate (ATP) depletion during cold ischemia time (CIT) is considered crucial for graft function. We tested different strategies of kidney perfusion before transplantation in the attempt to improve the technique. MATERIAL AND METHODS Twenty human discarded kidneys from donors after brain death and with at least 20 hours of CIT were randomized to the following experimental groups (treatment time three-hours at 4°C): a) static cold storage (CS); b) static cold hyperbaric oxygenation (Hyp); c) hypothermic perfusion (PE); d) hypothermic perfusion in hyperbaric oxygenation (PE-Hyp); and e) hypothermic oxygenated perfusion (PE-O2)...
January 12, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29305162/neural-basis-for-reduced-executive-performance-with-hypoxic-exercise
#2
Genta Ochi, Yuhki Yamada, Kazuki Hyodo, Kazuya Suwabe, Takemune Fukuie, Kyeongho Byun, Ippeita Dan, Hideaki Soya
While accumulating evidence suggests positive effects of exercise on executive function, such effects vary with environment. In particular, exercise in a hypoxic environment (hypobaric or normobaric hypoxia), leading to decreased oxygen supply, may dampen or cancel such effects. Thus, we further explore the relation between the effects of hypoxic exercise on executive function and their underlying neural mechanisms by monitoring changes of cortical activation patterns using functional near-infrared spectroscopy (fNIRS)...
January 2, 2018: NeuroImage
https://www.readbyqxmd.com/read/29261343/long-term-hypoxic-tolerance-in-murine-cornea
#3
Kazuhiro Kosaku, Tomonori Harada, Toyoharu Jike, Isao Tsuboi, Shin Aizawa
Kosaku, Kazuhiro, Tomonori Harada, Toyoharu Jike, Isao Tsuboi, and Shin Aizawa. Long-term hypoxic tolerance in murine cornea. High Alt Med Biol 00:000-000, 2017. AIMS: The cornea is believed to be an exceedingly sensitive organ to decreases in atmospheric oxygen concentrations. Previous corneal studies have shown the hypoxic tolerance of the cornea during short-term and local hypoxic exposure. This study investigated the tolerance of the cornea during long-term and systemic hypoxia. METHODS AND RESULTS: Mice were bred under normobaric normoxia or hypoxia (10% oxygen concentration) conditions for 140 days...
December 20, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29247712/effects-of-normobaric-hypoxia-on-upper-body-critical-power-and-anaerobic-working-capacity
#4
Michael B La Monica, David H Fukuda, Tristan M Starling-Smith, Ran Wang, Jay R Hoffman, Jeffrey R Stout
PURPOSE: To evaluate the effects of moderate normobaric hypoxia on the parameters of the work-time relationship in the upper body. METHODS: Twenty-one recreationally active men completed a graded exercise test in both normobaric hypoxia (H) and normoxia (N) to exhaustion on an arm ergometer to determine V̇O2peak and peak power output (PPO). Each participant completed four constant work-rate (CWR) arm-cranking tests at 90-120% PPO in both environmental conditions...
December 13, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29247273/live-high-train-low-guided-by-daily-heart-rate-variability-in-elite-nordic-skiers
#5
Laurent Schmitt, Sarah J Willis, Anthony Fardel, Nicolas Coulmy, Gregoire P Millet
PURPOSE: To analyze if live high-train low (LHTL) effectiveness is improved when daily training is guided by heart rate variability (HRV). METHODS: Twenty-four elite Nordic skiers took part in a 15-day LHTL study and were randomized into a HRV-guided training hypoxic group (H-HRV, n = 9, sleeping in normobaric hypoxia, FiO2 = 15.0%) and two predefined training groups sleeping either in hypoxia (H, n = 9, FiO2 = 15.0%) or normoxia (N, n = 6). HRV and training loads (TL) were recorded daily...
December 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29178051/behavior-disorders-caused-by-perinatal-hypoxia-in-juvenile-rats-and-their-correction-with-gaba-derivative
#6
N E Ordyan, V K Akulova, V I Mironova, V A Otellin
We studied the effects of acute normobaric hypoxia on postnatal day 2 (model of preterm pregnancy) on reflex activity and behavior of juvenile male Wistar rats and the possibility of correction of behavioral deficit by administration of GABA derivative Salifen after hypoxia. It is shown, that perinatal hypoxia impaired righting reflex and forelimb grip strength and increased motor activity in juvenile male rats. Administration of Salifen for 14 days in a dose of 15 mg/kg improved reflex activity and behavior of rats, which indicates the prospect of further study of the therapeutic efficacy of this drug on models of neonatal encephalopathy...
November 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29163193/changes-in-muscle-and-cerebral-deoxygenation-and-perfusion-during-repeated-sprints-in-hypoxia-to-exhaustion
#7
Sarah J Willis, Laurent Alvarez, Grégoire P Millet, Fabio Borrani
During supramaximal exercise, exacerbated at exhaustion and in hypoxia, the circulatory system is challenged to facilitate oxygen delivery to working tissues through cerebral autoregulation which influences fatigue development and muscle performance. The aim of the study was to evaluate the effects of different levels of normobaric hypoxia on the changes in peripheral and cerebral oxygenation and performance during repeated sprints to exhaustion. Eleven recreationally active participants (six men and five women; 26...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29153259/reduction-of-olfactory-sensitivity-during-normobaric-hypoxia
#8
Tilman Huppertz, Jessica Freiherr, Bernhard Olzowy, Ulrich Kisser, Jutta Stephan, Gunther Fesl, Kathrin Haegler, Berend Feddersen, Rainald Fischer, Klaus Mees, Sven Becker
OBJECTIVE: Acute mountain sickness (AMS) is caused by a low partial pressure of oxygen and may occur above 2500m. The aim of this research was to evaluate olfactory and gustatory abilities of healthy subjects during baseline conditions and after seven hours of normobaric hypoxia. METHODS: Sixteen healthy subjects were assessed using the Sniffin' Sticks, as well as intensity and pleasantness ratings. Gustatory function was evaluated utilizing the Taste Strips. Experiments were carried out under baseline conditions (518m altitude) followed by a second testing session after seven hours of normobaric hypoxia exposure (comparable to 4000m altitude)...
November 15, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29112466/the-effect-of-inspiratory-resistance-on-exercise-performance-and-perception-in-moderate-normobaric-hypoxia
#9
Yongsuk Seo, Jeremiah Vaughan, Tyler D Quinn, Brittany Followay, Raymond Roberge, Ellen L Glickman, Jung-Hyun Kim
Seo, Yongsuk, Jeremiah Vaughan, Tyler D. Quinn, Brittany Followay, Raymond Roberge, Ellen L. Glickman, and Jung-Hyun Kim. The effect of inspiratory resistance on exercise performance and perception in moderate normobaric hypoxia. High Alt Med Biol. 00:000-000, 2017. PURPOSE: Respirators are simple and efficient in protecting workers against toxic airborne substances; however, their use may limit the physical performance of workers. The purpose of this study was to determine the effect of inspiratory resistance on physical performance and breathing perception in normobaric hypoxia...
November 7, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29106947/glial-cell-line-derived-neurotrophic-factor-gdnf-counteracts-hypoxic-damage-to-hippocampal-neural-network-function-in-vitro
#10
Tatiana V Shishkina, Tatiana A Mishchenko, Elena V Mitroshina, Olesya M Shirokova, Alexei S Pimashkin, Innokentiy A Kastalskiy, Irina V Mukhina, Victor B Kazantsev, Maria V Vedunova
Glial cell line-derived neurotrophic factor (GDNF) is regarded as a potent neuroprotector and a corrector of neural network activity in stress conditions. This work aimed to investigate the effect of GDNF on primary hippocampal cultures during acute normobaric hypoxia. Hypoxia induction was performed using day 14 in vitro cultures derived from mouse embryos (E18) with the preventive addition of GDNF (1 ng/ml) to the culture medium 10 minutes before oxygen deprivation. An analysis of spontaneous bioelectrical activity that included defining the internal neural network structure, morphological studies, and viability tests was performed during the post-hypoxic period...
October 26, 2017: Brain Research
https://www.readbyqxmd.com/read/29097771/subclinical-pulmonary-dysfunction-contributes-to-high-altitude-pulmonary-edema-susceptibility-in-healthy-non-mountaineers
#11
Rajinder K Gupta, Poonam Soree, Koundinya Desiraju, Anurag Agrawal, Shashi Bala Singh
HAPE susceptible (HAPE-S, had HAPE episode in past) subjects may have subclinical cardio-pulmonary dysfunction. We compared the results of pulmonary function tests in 25 healthy HAPE-S non-mountaineers and 19 matched HAPE resistant (HAPE-R, no HAPE episode in past). Acute normobaric hypoxia (FIo2 0.12) was administered at sea level to confirm hypoxia intolerance in HAPE-S. Unlike HAPE-R, HAPE-S subjects had elevated baseline and post-hypoxia systolic pulmonary arterial pressures (20.9 ± 3 vs 27.3 ± 5 mm Hg during normoxia and 26...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091934/effects-of-hyperoxia-on-18f-fluoro-misonidazole-brain-uptake-and-tissue-oxygen-tension-following-middle-cerebral-artery-occlusion-in-rodents-pilot-studies
#12
Tim D Fryer, Sohail Ejaz, Ulf Jensen-Kondering, David J Williamson, Sergey Sitnikov, Stephen J Sawiak, Franklin I Aigbirhio, Young T Hong, Jean-Claude Baron
PURPOSE: Mapping brain hypoxia is a major goal for stroke diagnosis, pathophysiology and treatment monitoring. 18F-fluoro-misonidazole (FMISO) positron emission tomography (PET) is the gold standard hypoxia imaging method. Normobaric hyperoxia (NBO) is a promising therapy in acute stroke. In this pilot study, we tested the straightforward hypothesis that NBO would markedly reduce FMISO uptake in ischemic brain in Wistar and spontaneously hypertensive rats (SHRs), two rat strains with distinct vulnerability to brain ischemia, mimicking clinical heterogeneity...
2017: PloS One
https://www.readbyqxmd.com/read/29069356/glucocorticoid-receptor-signaling-impairs-protein-turnover-regulation-in-hypoxia-induced-muscle-atrophy-in-male-mice
#13
Chiel C de Theije, Annemie M W J Schols, Wouter H Lamers, Judith J M Ceelen, Rick H van Gorp, J J Rob Hermans, S Elonore Köhler, Ramon C J Langen
Hypoxemia may contribute to muscle wasting in conditions such as Chronic Obstructive Pulmonary Disease. Muscle wasting develops when muscle proteolysis exceeds protein synthesis. Hypoxia induces skeletal muscle atrophy in mice, which can in part be attributed to reduced food intake. We hypothesized that hypoxia elevates circulating corticosterone concentrations by reduced food intake and enhances GR signaling in muscle, which causes elevated protein degradation signaling and dysregulates protein synthesis signaling during hypoxia-induced muscle atrophy...
October 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/28966706/the-effect-of-psychomotor-performance-cerebral-and-arterial-blood-saturation-between-african-american-and-caucasian-males-before-during-and-after-normobaric-hypoxic-exercise
#14
Matthew R Feeback, Yongsuk Seo, Matthew Dancy, Ellen L Glickman
To further elucidate physiological and cognitive performance differences between African-American (AA) and Caucasian individuals (CAU) before, during or after hypoxic and normoxic exercise. Twelve college aged (18-25) apparently healthy African-American (six volunteers) and Caucasian (six subjects) males took part in two trials consisting of normobaric normoxia and normobaric hypoxia (12% oxygen). Each subject cycled at 50% of their altitude adjusted VO2max (-26% of normoxia VO2max) for one hour after a two-hour baseline...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28956166/acute-and-chronic-changes-in-baroreflex-sensitivity-in-hypobaric-vs-normobaric-hypoxia
#15
Nicolas Bourdillon, Jonas Saugy, Laurent Schmitt, Thomas Rupp, Sasan Yazdani, Jean-Marc Vesin, Grégoire P Millet
Normobaric hypoxia (NH) is used as a surrogate for hypobaric hypoxia (HH). Recent studies reported physiological differences between NH and HH. Baroreflex sensitivity (BRS) decreases at altitude or following intense training. However, until now no study compared the acute and chronic changes of BRS in NH vs. HH. First, BRS was assessed in 13 healthy male subjects prior and after 20 h of exposure at 3450 m (study 1), and second in 15 well-trained athletes prior and after 18 days of "live-high train-low" (LHTL) at 2250 m (study 2) in NH vs...
December 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28923140/working-memory-capacity-and-surgical-performance-while-exposed-to-mild-hypoxic-hypoxemia
#16
Paul J Parker, Andrew J Manley, Ross Shand, John P O'Hara, Adrian Mellor
INTRODUCTION: Medical Emergency Response Team (MERT) helicopters fly at altitudes of 3000 m in Afghanistan (9843 ft). Civilian hospitals and disaster-relief surgical teams may have to operate at such altitudes or even higher. Mild hypoxia has been seen to affect the performance of novel tasks at flight levels as low as 5000 ft. Aeromedical teams frequently work in unpressurized environments; it is important to understand the implications of this mild hypoxia and investigate whether supplementary oxygen systems are required for some or all of the team members...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28923139/cerebral-hemodynamics-and-executive-function-during-exercise-and-recovery-in-normobaric-hypoxia
#17
Jon Stavres, Hayden D Gerhart, Jung-Hyun Kim, Ellen L Glickman, Yongsuk Seo
BACKGROUND: Hypoxia and exercise each exhibit opposing effects on executive function, and the mechanisms for this are not entirely clear. This study examined the influence of cerebral oxygenation and perfusion on executive function during exercise and recovery in normobaric hypoxia (NH) and normoxia (N). METHODS: There were 18 subjects who completed cycling trials in NH (12.5% FIo2) and N (20.93% FIo2). Right prefrontal cortex (PFC) oxyhemoglobin (O2Hb) and middle cerebral artery blood velocity (MCAbv) were collected during executive function challenges [mathematical processing and running memory continuous performance task (RMCPT)] at baseline, following 30 min of acclimation, during 20 min of cycling (60% Vo2max), and at 1, 15, 30, and 45 min following exercise...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28914359/changes-in-acid-base-and-ion-balance-during-exercise-in-normoxia-and-normobaric-hypoxia
#18
Olaf Lühker, Marc Moritz Berger, Alexander Pohlmann, Lorenz Hotz, Tilmann Gruhlke, Marcel Hochreiter
PURPOSE: Both exercise and hypoxia cause complex changes in acid-base homeostasis. The aim of the present study was to investigate whether during intense physical exercise in normoxia and hypoxia, the modified physicochemical approach offers a better understanding of the changes in acid-base homeostasis than the traditional Henderson-Hasselbalch approach. METHODS: In this prospective, randomized, crossover trial, 19 healthy males completed an exercise test until voluntary fatigue on a bicycle ergometer on two different study days, once during normoxia and once during normobaric hypoxia (12% oxygen, equivalent to an altitude of 4500 m)...
November 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28912649/does-live-high-train-low-and-high-hypoxic-training-alter-running-mechanics-in-elite-team-sport-players
#19
Olivier Girard, Grégoire P Millet, Jean-Benoit Morin, Franck Brocherie
This study aimed to investigate if "Live High-Train Low (and High)" hypoxic training alters constant-velocity running mechanics. While residing under normobaric hypoxia (≥14 h·d(-1); FiO2 14.5-14.2%) for 14 days, twenty field hockey players performed, in addition to their usual training in normoxia, six sessions (4 × 5 × 5-s maximal sprints; 25 s passive recovery; 5 min rest) under either normobaric hypoxia (FiO2 ~14.5%, n = 9) or normoxia (FiO2 20.9%, n = 11). Before and immediately after the intervention, their running pattern was assessed at 10 and 15 km·h(-1) as well as during six 30-s runs at ~20 km·h(-1) with 30-s passive recovery on an instrumented motorised treadmill...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28901662/acute-hypoxemia-and-vascular-function-in-healthy-humans
#20
N C S Lewis, A R Bain, K W Wildfong, D J Green, P N Ainslie
Endothelium-dependent flow mediated dilation (FMD) and endothelium-independent dilation (GTN) are impaired at high altitude (5050 m), and FMD is impaired following acute exposure (<60-minutes) to normobaric hypoxia equivalent to ∼5050 m (∼FI O2  = 0.11). Whether glyceryl trinitrate (GTN)-induced dilation is impaired acutely, and whether FMD is impaired during milder hypoxia is unknown. Therefore, we assessed brachial FMD at baseline and following 30-minutes of mild (74 ± 2 mmHg PET O₂) and moderate (50 ± 3 mmHg PET O₂) normobaric hypoxia (n = 12) or normoxia (time-control trial; n = 10)...
September 13, 2017: Experimental Physiology
keyword
keyword
35789
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"