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Normobaric hypoxia

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https://www.readbyqxmd.com/read/28721516/motor-cognitive-dual-tasking-under-hypoxia
#1
Dennis Hamacher, Marie Brennicke, Tom Behrendt, Prisca Alt, Alexander Törpel, Lutz Schega
Hypoxic conditions diminish motor performance and cognitive functions, especially when the motor task and the cognitive task are conducted simultaneously. Hypoxia does further increase prefrontal cortex activity which provokes a reduced capability of efficient resource utilisation. This, again, might evoke that the capacity of the limited mental resources of a dual task will be reached at an earlier stage of task complexity. The purpose of our study was to examine whether a cognitive task would increase gait variability to a higher extent under hypoxic as compared to normoxic conditions...
July 18, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28705998/is-normobaric-hypoxia-an-effective-treatment-for-sustaining-previously-acquired-altitude-acclimatization
#2
Beth A Beidleman, Charles S Fulco, Bruce S Cadarette, Allen Cymerman, Mark J Buller, Roy M Salgado, Alexander M Posch, Janet E Staab, Ingrid V Sils, Beau R Yurkevicius, Adam J Luippold, Alexander P Welles, Stephen R Muza
This study examined whether normobaric hypoxia (NH) treatment is more efficacious for sustaining high altitude (HA) acclimatization during re-introduction to altitude (RA) than no treatment at all. Seventeen sea level (SL) residents (age=23±6yrs; mean±SE) completed in the following order: 1)4d of SL testing, 2)12d of high altitude (HA) acclimatization at 4300m, 3)12d at SL post HA acclimatization (Post) where each received either NH (n=9;FiO2=0.122) or Sham (n=8;FiO2=0.207) treatment, and 4)24-h re-introduction to 4300m altitude (RA) in a hypobaric chamber...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28699679/one-session-of-remote-ischemic-preconditioning-does-not-improve-vascular-function-in-acute-normobaric-and-chronic-hypobaric-hypoxia
#3
Mathew G Rieger, Ryan L Hoiland, Joshua C Tremblay, Mike Stembridge, Anthony R Bain, Daniela Flück, Prajan Subedi, James D Anholm, Philip N Ainslie
Application of repeated short duration bouts of ischemia to the limbs, termed remote ischemic preconditioning (RIPC), is a novel technique that may have protective effects on vascular function during hypoxic exposures. In separate parallel-design studies, at sea-level (SL; n = 16), and after 8-12 days at high-altitude (HA; n = 12; White Mountain, 3800 m), participants underwent either a sham protocol or one session of 4 × 5 minutes of dual-thigh cuff occlusion with 5 minutes recovery. Brachial artery flow-mediated dilation (FMD; ultrasound), pulmonary artery systolic pressure (PASP; echocardiography), and internal carotid artery flow (ICA; ultrasound) were measured at SL in normoxia and isocapnic hypoxia [end-tidal PO₂ (PETO₂) maintained to 50 mmHg], and during normal breathing at HA...
July 12, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28694491/measuring-the-energy-of-ventilation-and-circulation-during-human-walking-using-induced-hypoxia
#4
Masahiro Horiuchi, Yoshiyuki Fukuoka, Yoko Handa, Daijiro Abe, Herman Pontzer
Energy expenditure (EE) during walking includes energy costs to move and support the body and for respiration and circulation. We measured EE during walking under three different oxygen concentrations. Eleven healthy, young, male lowlanders walked on a treadmill at seven gait speeds (0.67-1.83 m s(-1)) on a level gradient under normobaric normoxia (room air, 21% O2), moderate hypoxia (15% O2), and severe hypoxia (11% O2). By comparing the hypoxia-induced elevation in heart rate (HR [bpm]), ventilation (VE [L min(-1)]) with the change in energy expenditure (EE [W]) at each speed, we were able to determine circulatory and respiratory costs...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28686073/effect-of-hypoxia-on-bold-fmri-response-and-total-cerebral-blood-flow-in-migraine-with-aura-patients
#5
Nanna Arngrim, Anders Hougaard, Henrik W Schytz, Mark B Vestergaard, Josefine Britze, Faisal Mohammad Amin, Karsten S Olsen, Henrik Bw Larsson, Jes Olesen, Messoud Ashina
Experimentally induced hypoxia triggers migraine and aura attacks in patients suffering from migraine with aura (MA). We investigated the blood oxygenation level-dependent (BOLD) signal response to visual stimulation during hypoxia in MA patients and healthy volunteers. In a randomized double-blind crossover study design, 15 MA patients were allocated to 180 min of normobaric poikilocapnic hypoxia (capillary oxygen saturation 70-75%) or sham (normoxia) on two separate days and 14 healthy volunteers were exposed to hypoxia...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28684191/effects-of-oral-sodium-nitrate-on-forearm-blood-flow-oxygenation-and-exercise-performance-during-acute-exposure-to-hypobaric-hypoxia-4300%C3%A2-m
#6
Heath G Gasier, Anthony R Reinhold, Allison R Loiselle, Shawn E Soutiere, David M Fothergill
A reduction in oxygen transport contributes to impaired exercise capacity at high altitude. Since blood flow is mediated, in part, by nitric oxide (NO), we hypothesized that sodium nitrate provided before forearm grip exercise performed at a simulated altitude of 4300 m (hypobaric hypoxia (HH)) would increase forearm blood flow and oxygenation, and decrease the decrement in grip performance. In a double-blind, randomized crossover study, 10 healthy subjects (9 males and 1 female) performed continuous (CGrip) and repeated rhythmic (RGrip) isometric forearm exercise until task failure in normobaric normoxia (NN), 2...
July 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28679682/normobaric-hypoxic-conditioning-to-maximise-weight-loss-and-ameliorate-cardio-metabolic-health-in-obese-populations-a-systematic-review
#7
Liam Gray Hobbins, Steve Hunter, Nadia Gaoua, Olivier Girard
Normobaric hypoxic conditioning (HC) denotes exposure to hypoxia at rest (passive) or combined with exercise (active). HC has been applied acutely (single exposure) and chronically (repeated exposure) to obese populations for managing/increasing cardio-metabolic health and weight loss. Cardio-metabolic health and weight loss responses of obese populations in response to passive and active HC are unclear. A systematic search for articles published between 2000-2017 was carried out. Studies investigating the effects of HC for improving cardio-metabolic health and weight loss of obese populations were included...
July 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28657365/acute-hypobaric-hypoxia-augments-rock2-protein-level-and-activity
#8
Priyanka Pandey, Sangeeta Kumari, Zahara Ali, Ma Qadar Pasha
AIM: Rho kinase activation plays an important role in hypoxic pulmonary vasoconstriction and increased vascular resistance. The present study investigated changes in the level and activity of rho kinase isoform 2 (ROCK2) under acute hypobaric hypoxia exposure. For this, Wistar rats were taken as the model organism. MATERIALS AND METHODS: Fifteen male Wistar rats (4-6 week old, 250 grams) were normalized with the surrounding environment by providing a 12/12 hour day and night acclimatization cycle...
June 28, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28649204/effects-of-dietary-nitrate-supplementation-on-physiological-responses-cognitive-function-and-exercise-performance-at-moderate-and-very-high-simulated-altitude
#9
Oliver M Shannon, Lauren Duckworth, Matthew J Barlow, Kevin Deighton, Jamie Matu, Emily L Williams, David Woods, Long Xie, Blossom C M Stephan, Mario Siervo, John P O'Hara
Purpose: Nitric oxide (NO) bioavailability is reduced during acute altitude exposure, contributing toward the decline in physiological and cognitive function in this environment. This study evaluated the effects of nitrate ([Formula: see text]) supplementation on NO bioavailability, physiological and cognitive function, and exercise performance at moderate and very-high simulated altitude. Methods:Ten males (mean (SD): [Formula: see text]: 60.9 (10.1) ml·kg(-1)·min(-1)) rested and performed exercise twice at moderate (~14...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28641679/normobaric-hypoxia-and-submaximal-exercise-effects-on-running-memory-and-mood-state-in-women
#10
Yongsuk Seo, Hayden D Gerhart, Jon Stavres, Curtis Fennell, Shane Draper, Ellen L Glickman
BACKGROUND: An acute bout of exercise can improve cognitive function in normoxic and hypoxic conditions. However, limited research supports the improvement of cognitive function and mood state in women. The purpose of this study was to examine the effects of hypoxia and exercise on working memory and mood state in women. METHODS: There were 15 healthy women (age = 22 ± 2 yr) who completed the Automated Neuropsychological Assessment Metrics-4th Edition (ANAM), including the Running Memory Continuous Performance Task (RMCPT) and Total Mood Disturbance (TMD) in normoxia (21% O2), at rest in normoxia and hypoxia (12...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28625661/resting-limb-muscle-perfusion-during-inspiratory-muscle-loading-in-hypoxia-and-normoxia
#11
Hannes Klenze, Thomas Christian Köhler, Franziska Farquharson, Stephan Walterspacher, Daniel Duerschmied, Kai Roecker, Hans-Joachim Kabitz, David Johannes Walker
INTRODUCTION: Fatiguing of respiratory muscles reduces peripheral muscle perfusion. Further, acute hypoxia enhances respiratory muscle fatigue. This study investigated the effects of inspiratory muscle loading (IML) on resting locomotor muscle perfusion in hypoxia compared to normoxia. METHODS: Ten subjects completed two study days of fatiguing IML (blinded, randomized) in normobaric hypoxia (targeted oxygen saturation 80%) and normoxia, respectively. Contrast-enhanced ultrasound (CEUS) of the gastrocnemius muscle and popliteal doppler ultrasonography were used to monitor muscle perfusion...
June 15, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28620311/physiological-adaptations-to-hypoxic-vs-normoxic-training-during-intermittent-living-high
#12
Stefan De Smet, Paul van Herpt, Gommaar D'Hulst, Ruud Van Thienen, Marc Van Leemputte, Peter Hespel
In the setting of "living high," it is unclear whether high-intensity interval training (HIIT) should be performed "low" or "high" to stimulate muscular and performance adaptations. Therefore, 10 physically active males participated in a 5-week "live high-train low or high" program (TR), whilst eight subjects were not engaged in any altitude or training intervention (CON). Five days per week (~15.5 h per day), TR was exposed to normobaric hypoxia simulating progressively increasing altitude of ~2,000-3,250 m...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28592459/the-effects-of-10-days-of-separate-heat-and-hypoxic-exposure-on-heat-acclimation-and-temperate-exercise-performance
#13
Rebecca A Neal, Jamie Prout, Joseph Costello, Heather C Massey, Michael J Tipton, John S Young, Jo Corbett
Adaptations to heat and hypoxia are typically studied in isolation, but are often encountered in combination. Whether the adaptive response to multiple stressors affords the same response as when examined in isolation is unclear. We examined: i) the influence of overnight moderate normobaric hypoxia on the time course and magnitude of adaption to daily heat exposure; ii) whether heat acclimation (HA) was ergogenic and if this was influenced by an additional hypoxic-stimulus. Eight males (V̇O2max=58.5[8.3] mL·kg(-1)·min(-1)) undertook two 11-day HA programmes (balanced-crossover design), once with overnight normobaric hypoxia (8[1] h per night; 10 nights; FIO2=0...
June 7, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28583927/the-effects-of-moderate-intensity-training-in-a-hypoxic-environment-on-transcriptional-responses-in-thoroughbred-horses
#14
Allan J Davie, Li Wen, Andrew R E Cust, Rosalind Beavers, Tom Fyfe, Shi Zhou
This study investigated the effects of six weeks of normobaric hypoxic training on transcriptional expression of the genes associated with mitochondrial and glycolytic activities in Thoroughbred horses. Eight horses were divided into two groups of four. They completed an identical incremental, moderate intensity training program, except that one group trained in a hypoxic chamber with 15% oxygen for 30 min on alternate days except Sundays (HT), while the other group trained in normal air (NC). Prior to and post training, heart rate and blood lactate were measured during an incremental treadmill test...
July 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28577088/role-of-atp-sensitive-k-channels-in-myocardial-infarct-size-limiting-effect-of-chronic-continuous-normobaric-hypoxia
#15
Yu B Lishmanov, N V Naryzhnaya, S Yu Tsibul'nikov, H Wang, L N Maslov
The role of KATP channels in myocardial infarct size-limiting effect of chronic continuous normobaric hypoxia was examined in a rat model based on a 20-min coronary occlusion and subsequent 3-h reperfusion. Rats were adapted to normobaric hypoxia (12% O2) for 21 days. This hypoxia produced a pronounced infarct size-limiting effect, which had been prevented by 0.3 mg/kg glibenclamide, a non-selective inhibitor of entire pool of KATP channels, or 5 mg/kg 5-hydroxydecanoate, an inhibitor of mitochondrial KATP channels...
June 2, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28567570/%C3%AE-adrenergic-signaling-monoamine-oxidase-a-and-antioxidant-defence-in-the-myocardium-of-shr-and-shr-mtbn-conplastic-rat-strains-the-effect-of-chronic-hypoxia
#16
Klara Hahnova, Iveta Brabcova, Jan Neckar, Romana Weissova, Anna Svatonova, Olga Novakova, Jitka Zurmanova, Martin Kalous, Jan Silhavy, Michal Pravenec, Frantisek Kolar, Jiri Novotny
The β-adrenergic signaling pathways and antioxidant defence mechanisms play important roles in maintaining proper heart function. Here, we examined the effect of chronic normobaric hypoxia (CNH, 10% O2, 3 weeks) on myocardial β-adrenergic signaling and selected components of the antioxidant system in spontaneously hypertensive rats (SHR) and in a conplastic SHR-mtBN strain characterized by the selective replacement of the mitochondrial genome of SHR with that of the more ischemia-resistant Brown Norway strain...
May 31, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28567018/acute-normobaric-hypoxia-increases-post-exercise-lipid-oxidation-in-healthy-males
#17
Liam P Kelly, Fabien A Basset
The primary objective of the current study was to determine the effect of moderate normobaric hypoxia exposure during constant load cycling on post-exercise energy metabolism recorded in normoxia. Indirect calorimetry was used to examine whole body substrate oxidation before, during, 40-60 min post, and 22 h after performing 60 min of cycling exercise at two different fractions of inspired oxygen (FIO2): (i) FIO2 = 0.2091 (normoxia) and (ii) FIO2 = 0.15 (hypoxia). Seven active healthy male participants (26 ± 4 years of age) completed both experimental trials in randomized order with a 7-day washout period to avoid carryover effects between conditions...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28564745/cardiorespiratory-responses-of-adults-and-children-during-normoxic-and-hypoxic-exercise
#18
Jernej Kapus, Igor B Mekjavic, Adam C McDonnell, Anton Ušaj, Janez Vodičar, Peter Najdenov, Miroljub Jakovljević, Polona Jaki Mekjavić, Milan Žvan, Tadej Debevec
We aimed to elucidate potential differential effects of hypoxia on cardiorespiratory responses during submaximal cycling and simulated skiing exercise between adults and pre-pubertal children. Healthy, low-altitude residents (adults, N=13, Age=40±4yrs.; children, N=13, age=8±2yrs.) were tested in normoxia (Nor: PiO2=134±0.4 mmHg; 940 m) and normobaric hypoxia (Hyp: PiO2=105±0.6 mmHg; ~3 000 m) following an overnight hypoxic acclimation (≥12-hrs). On both days, the participants underwent a graded cycling test and a simulated skiing protocol...
July 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28533889/effects-of-low-dose-acetazolamide-on-exercise-performance-in-simulated-altitude
#19
Ernst Elisabeth, Gatterer Hannes, Burtscher Johannes, Faulhaber Martin, Pocecco Elena, Burtscher Martin
Preventive effects of acetazolamide (ACZ) on acute mountain sickness (AMS) are well established but effects on exercise performance at high altitude or in hypoxia have been less considered and are still inconsistent. We hypothesized that low-dose ACZ would not impair exercise performance at simulated high altitude. Thus, the aim of this study was to evaluate the interaction between low-dose ACZ and exercise performance in normobaric hypoxia. Sixteen subjects (8 males and 8 females) were randomly assigned either to receive low-dose ACZ (3×125 mg in 36 hours) or placebo...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28522767/individual-hemoglobin-mass-response-to-normobaric-and-hypobaric-live-high-train-low-a-one-year-crossover-study
#20
Anna Hauser, Severin Troesch, Jonas J Saugy, Laurent Schmitt, Roberto Cejuela-Anta, Raphael Faiss, Thomas Steiner, Neil Robinson, Grégoire P Millet, Jon Peter Wehrlin
PURPOSE: To compare individual hemoglobin mass (Hbmass) changes following a live high-train low (LHTL) altitude training camp under either normobaric hypoxia (NH) or hypobaric hypoxia (HH) conditions in endurance athletes. METHODS: In a crossover design with a one-year washout, 15 male triathletes randomly performed two 18-d LHTL training camps in either HH or NH. All athletes slept at 2250 m and trained at altitudes < 1200 m. Hbmass was measured in duplicate with the optimized carbon monoxide rebreathing method before (pre-) and immediately after (post-) each 18 d training camp...
May 18, 2017: Journal of Applied Physiology
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