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https://www.readbyqxmd.com/read/27686726/cannabidiol-a-potential-treatment-for-post-ebola-syndrome
#1
Sandra E Reznik, Eliot L Gardner, Charles R Ashby
Patients recovered from Ebola virus infection may experience short- and long-term physical, neuropsychological and social sequelae, including arthralgia, musculoskeletal pain, ophthalmic inflammation, auditory problems, fatigue, confusion, insomnia, short-term memory impairment, anxiety, depression and anorexia, all lasting from two weeks to more than two years. Currently there are no treatments for post Ebola sequelae. We hypothesize that cannabidiol (CBD) may attenuate some of these post Ebola sequelae, several of which have been postulated to result from inflammation and/or an autoimmune response...
September 26, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27531146/gait-disturbance-as-the-presenting-symptom-in-young-children-with-anti-nmda-receptor-encephalitis
#2
Anusha K Yeshokumar, Lisa R Sun, Jessica L Klein, Kristin W Baranano, Carlos A Pardo
This case series demonstrates a novel clinical phenotype of gait disturbance as an initial symptom in children <3 years old with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Anti-NMDAR encephalitis is one of the most common causes of encephalitis in children, more common than any of the viral encephalitides and the second most common autoimmune cause after acute disseminated encephalomyelitis. Anti-NMDAR encephalitis in children often presents with disrupted speech and sleep patterns followed by progression to motor dysfunction, dyskinesias, and seizures...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27515213/vitamin-d-deficiency-changes-the-intestinal-microbiome-reducing-b-vitamin-production-in-the-gut-the-resulting-lack-of-pantothenic-acid-adversely-affects-the-immune-system-producing-a-pro-inflammatory-state-associated-with-atherosclerosis-and-autoimmunity
#3
S C Gominak
STUDY OBJECTIVES: Vitamin D blood levels of 60-80ng/ml promote normal sleep. The present study was undertaken to explore why this beneficial effect waned after 2years as arthritic pain increased. Pantothenic acid becomes coenzyme A, a cofactor necessary for cortisol and acetylcholine production. 1950s experiments suggested a connection between pantothenic acid deficiency, autoimmune arthritis and insomnia. The B vitamins have been shown to have an intestinal bacterial source and a food source, suggesting that the normal intestinal microbiome may have always been the primary source of B vitamins...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27515199/morvan-s-syndrome-and-the-sustained-absence-of-all-sleep-rhythms-for-months-or-years-an-hypothesis
#4
Claude Touzet
Despite the predation costs, sleep is ubiquitous in the animal realm. Humans spend a third of their life sleeping, and the quality of sleep has been related to co-morbidity, Alzheimer disease, etc. Excessive wakefulness induces rapid changes in cognitive performances, and it is claimed that one could die of sleep deprivation as quickly as by absence of water. In this context, the fact that a few people are able to go without sleep for months, even years, without displaying any cognitive troubles requires explanations...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27259289/capsule-commentary-on-kok-et-al-risk-of-autoimmune-disease-in-adults-with-chronic-insomnia-requiring-sleep-inducing-pills-a-population-based-longitudinal-study
#5
Danya M Qato
No abstract text is available yet for this article.
September 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27253765/familial-kleine-levin-syndrome-a-specific-entity
#6
Quang Tuan Remy Nguyen, Elisabeth Groos, Laurène Leclair-Visonneau, Christelle Monaca-Charley, Tom Rico, Neal Farber, Emmanuel Mignot, Isabelle Arnulf
STUDY OBJECTIVES: Kleine-Levin syndrome (KLS) is a rare, mostly sporadic disorder, characterized by intermittent episodes of hypersomnia plus cognitive and behavior disorders. Although its cause is unknown, multiplex families have been described. We contrasted the clinical and biological features of familial versus sporadic KLS. METHODS: Two samples of patients with KLS from the United States and France (n = 260) were studied using clinical interviews and human leukocyte antigen (HLA) genotyping...
2016: Sleep
https://www.readbyqxmd.com/read/27130621/risk-of-autoimmune-disease-in-adults-with-chronic-insomnia-requiring-sleep-inducing-pills-a-population-based-longitudinal-study
#7
Victor C Kok, Jorng-Tzong Horng, Guo-Dung Hung, Jia-Li Xu, Tzu-Wei Hung, Yu-Ching Chen, Chien-Lung Chen
BACKGROUND: Recent studies indicate that chronic insomnia is associated with the development of certain somatic diseases. Whether it would be associated with the development of an autoimmune disease (AID) was unknown. OBJECTIVE: We aimed to examine the association and quantify the magnitude of risk for AID in individuals suffering from chronic insomnia requiring sleep-inducing pills. DESIGN: This was a population-based, nationwide longitudinal study...
September 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27112685/autoimmune-sleep-disorders
#8
Michael H Silber
A number of autoantibodies, some paraneoplastic, are associated with sleep disorders. Morvan syndrome and limbic encephalitis, associated with voltage-gated potassium channel-complex antibodies, principally against CASPR2 and LGI1, can result in profound insomnia and rapid eye movement sleep behavior disorder (RBD). Patients with aquaporin-4 antibodies and neuromyelitis optica may develop narcolepsy in association with other evidence of hypothalamic dysfunction, sometimes as the initial presentation. Central sleep apnea and central neurogenic hypoventilation are found in patients with anti-N-methyl-d-aspartate receptor antibody encephalitis, and obstructive sleep apnea, stridor, and hypoventilation are prominent features of a novel tauopathy associated with IgLON5 antibodies...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27112678/voltage-gated-potassium-channel-complex-autoimmunity-and-associated-clinical-syndromes
#9
Sarosh R Irani, Angela Vincent
Voltage-gated potassium channel (VGKC)-complex antibodies are defined by the radioimmunoprecipitation of Kv1 potassium channel subunits from brain tissue extracts and were initially discovered in patients with peripheral nerve hyperexcitability (PNH). Subsequently, they were found in patients with PNH plus psychosis, insomnia, and dysautonomia, collectively termed Morvan's syndrome (MoS), and in a limbic encephalopathy (LE) with prominent amnesia and frequent seizures. Most recently, they have been described in patients with pure epilepsies, especially in patients with the novel and distinctive semiology termed faciobrachial dystonic seizures (FBDS)...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27070242/nocturnal-arousal-in-a-68-year-old-woman
#10
Romy Hoque, Lourdes M DelRosso
No abstract text is available yet for this article.
2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26943714/a-case-of-recurrent-insomnia-extending-the-spectrum-of-autoimmune-encephalitis
#11
Priyanka Sabharwal, Mandana Mahmoudi, Nisida Berberi, Blanca A Vasquez, Daniel Friedman, Sanjeev V Kothare
Recurrent insomnia is an uncommon manifestation that is encountered rarely in a sleep clinic. We report a woman with recurrent insomnia due to an autoimmune process that resolved after a course of immunotherapy.
May 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26881156/cognitive-impairments-preceding-and-outlasting-autoimmune-limbic-encephalitis
#12
Robert Gross, Jennifer Davis, Julie Roth, Henry Querfurth
Mild cognitive impairment (MCI) can be the initial manifestation of autoimmune limbic encephalitis (ALE), a disorder that at times presents a diagnostic challenge. In addition to memory impairment, clinical features that might suggest this disorder include personality changes, agitation, insomnia, alterations of consciousness, and seizures. Once recognized, ALE typically responds to treatment with immune therapies, but long-term cognitive deficits may remain. We report two cases of patients with MCI who were ultimately diagnosed with ALE with antibodies against the voltage gated potassium channel complex...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/26613326/reliable-disease-biomarkers-characterizing-and-identifying-electrohypersensitivity-and-multiple-chemical-sensitivity-as-two-etiopathogenic-aspects-of-a-unique-pathological-disorder
#13
Dominique Belpomme, Christine Campagnac, Philippe Irigaray
Much of the controversy over the causes of electro-hypersensitivity (EHS) and multiple chemical sensitivity (MCS) lies in the absence of both recognized clinical criteria and objective biomarkers for widely accepted diagnosis. Since 2009, we have prospectively investigated, clinically and biologically, 1216 consecutive EHS and/or MCS-self reporting cases, in an attempt to answer both questions. We report here our preliminary data, based on 727 evaluable of 839 enrolled cases: 521 (71.6%) were diagnosed with EHS, 52 (7...
2015: Reviews on Environmental Health
https://www.readbyqxmd.com/read/26323247/gamma-aminobutyric-acid-receptor-agonists-aquaporin-4-and-neuromyelitis-optica-a-potential-link
#14
S Jarius, O Aktas, B Wildemann
Neuromyelitis optica (NMO; also termed Devic's disease) is a severely disabling autoimmune disorder of the central nervous system (CNS), which predominantly affects the optic nerves and spinal cord. In up to 80% of cases, NMO is associated with antibodies to aquaporin-4 (AQP4-IgG), the most abundant water channel in the CNS. AQP4-IgG have been demonstrated to be directly pathogenic. Gamma-aminobutyric acid A receptor (GABAAR) agonists are frequently used in patients with NMO, e.g., for symptomatic treatment of spasticity or epilepsy or for non-NMO-related indications such as treatment of insomnia...
November 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/26111291/-psychotic-disorder-and-sheehan-s-syndrome-etiology-or-comorbidity-a-case-report
#15
Baise Tıkır, Erol Göka, Makbule Çiğdem Aydemir, Şahin Gürkan
Sheehan's Syndrome -also called postpartum hypopituitarism- is a syndrome which characterized by lots of bleeding during or after delivery and necrosis of pituitary gland due to hypovolemic shock. It appears with not only agalactorrhea, amenorrhea, hypoythyroidism and hypoglycemia but also psychiatric disorders like psychosis. In this study, we reported a case presented with psychotic disorder and diagnosed as Sheehan's Syndrome at the same time. 44 year-old, female patient, married. She was admitted for withdrawal, irritability, insomnia, hearing voices -especially insult her- thoughts about that her husband was cheating on her and people would do evil...
2015: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/26040501/apigenin-a-natural-flavonoid-attenuates-eae-severity-through-the-modulation-of-dendritic-cell-and-other-immune-cell-functions
#16
Rashida Ginwala, Emily McTish, Chander Raman, Narendra Singh, Mitzi Nagarkatti, Prakash Nagarkatti, Divya Sagar, Pooja Jain, Zafar K Khan
Apigenin, a natural flavonoid, found in several plants, fruits, vegetables, herbs, and spices, is known to have anti-oxidant and anti-inflammatory properties that are evident in the use of these substances for centuries as medicinal approaches to treat asthma, insomnia, Parkinson's disease, neuralgia, and shingles. However, there is a considerable dearth of information regarding its effect on immune cells, especially dendritic cells (DC) that maintain the critical balance between an immunogenic and tolerogenic immune response, in an immunospecialized location like the central nervous system (CNS)...
March 2016: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/25661288/possible-autoimmune-association-between-herpes-simplex-virus-infection-and-subsequent-anti-n-methyl-d-aspartate-receptor-encephalitis-a-pediatric-patient-with-abnormal-movements
#17
Yefim Yushvayev-Cavalier, Charles Nichter, Adolfo Ramirez-Zamora
AIM: We describe a child with severe generalized choreoathetosis and anti-N-methyl-d-aspartate receptor encephalitis after herpes simplex virus type 1 encephalitis. Recent evidence supports an autoimmune trigger for anti-N-methyl-d-aspartate receptor encephalitis following a viral infection. This is emerging as a common and potentially treatable autoimmune condition in the pediatric population. PATIENT DESCRIPTION: A 6-month-old girl presented with fever, diarrhea, and partial seizures and was subsequently treated for proven herpes simplex virus type 1 encephalitis...
April 2015: Pediatric Neurology
https://www.readbyqxmd.com/read/25551844/raltegravir-use-prospectively-assessed-in-a-major-hiv-outpatient-clinic-in-italy-sample-population-virological-immunological-activity-and-tolerability-profile
#18
Roberto Manfredi, Leonardo Calza, Ginevra Marinacci, Alessandra Cascavilla, Vincenzo Colangeli, Caterina Salvadori, Giulia Martelli, Lucia Appolloni, Cristina Puggioli, Pierluigi Viale
Raltegravir, as the first HIV integrase inhibitor, has been used and prospectively monitored since 2010 in our HIV outpatient centre, where over 1,200 patients are monitored. The aim of our report is to perform an interim assessment of the background, the safety profile and the clinical-laboratory monitoring of all patients treated with a combination antiretroviral therapy (cART) including raltegravir, for at least 12 months. In all, 109 pretreated patients started a raltegravir-containing cART when aged 44...
December 2014: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/25486982/the-organization-of-the-stress-system-and-its-dysregulation-in-depressive-illness
#19
REVIEW
P W Gold
Stressors are imminent or perceived challenges to homeostasis. The stress response is an innate, stereotypic, adaptive response to stressors that has evolved in the service of restoring the nonstressed homeostatic set point. It is encoded in specific neuroanatomical sites that activate a specific repertoire of cognitive, behavioral and physiologic phenomena. Adaptive responses, though essential for survival, can become dysregulated and result in disease. A clear example is autoimmune disease. I postulate that depression, like autoimmunity, represents a dysregulated adaptive response: a stress response that has gone awry...
February 2015: Molecular Psychiatry
https://www.readbyqxmd.com/read/25367918/down-syndrome-disintegrative-disorder-new-onset-autistic-regression-dementia-and-insomnia-in-older-children-and-adolescents-with-down-syndrome
#20
Gordon Worley, Blythe G Crissman, Emily Cadogan, Christie Milleson, Deanna W Adkins, Priya S Kishnani
Over a 10-year period in a Down syndrome Clinic, 11 children and adolescents were encountered with a history of new-onset (8) or worsening (3) autistic characteristics. Ten of the 11 (91%) had cognitive decline to a dementia-like state and 9 of the 11 (82%) new-onset insomnia. The mean age at which symptoms developed was 11.4 years (standard deviation = 3.6 years; range 5-14 years), an older age than usual for autistic regression in Down syndrome. Ten of 11 cases (91%) had elevated ("positive") thyroperoxidase antibody titers compared to only 5 of 21 (23%) age-matched control subjects with Down syndrome (P < ...
August 2015: Journal of Child Neurology
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