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Stem cell in sport medicine

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https://www.readbyqxmd.com/read/29772932/recent-advances-in-kartogenin-for-cartilage-regeneration
#1
Gaorui Cai, Wei Liu, Yong He, Jianghong Huang, Li Duan, Jianyi Xiong, Lijun Liu, Daping Wang
Either osteoarthritisor sports-related injuries can lead to cartilage defects,whereas both chondrocyte self-renewal and conventional treatments face limitations. In cartilage regenerative medicine, growth factors are commonly used to induce chondrogenic differentiation of stem cells. However, application of growth factors is confined by some drawbacks. Emerging small molecules are regarded as an alternative for cartilage regeneration. A recently discovered small-molecule compound, kartogenin (KGN), has been proven to be a chondrogenic and chondroprotective agent and is more effective in inducing cartilage regeneration when compared with growth factors...
May 18, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29554460/reporting-of-mesenchymal-stem-cell-preparation-protocols-and-composition-a-systematic-review-of-the-clinical-orthopaedic-literature
#2
Patrick G Robinson, Iain R Murray, Christopher C West, Ewan B Goudie, Li Y Yong, Timothy O White, Robert F LaPrade
BACKGROUND: Mesenchymal stem cells (MSCs) are increasingly being used in the treatment of a wide variety of sports-related conditions. Despite this enthusiasm, the biological properties of MSCs and their effects on musculoskeletal tissue healing remain poorly understood. MSC-based strategies encompass cell populations with heterogeneous phenotypes isolated from multiple tissues and using different methods. Therefore, comprehensive reporting of the source, preparation methods, and characteristics of MSC strategies is essential to enable interpretation of results...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29497876/characterisation-and-immunosuppressive-activity-of-human-cartilage-derived-mesenchymal-stem-cells
#3
Pratheep Sandrasaigaran, Satar Jabbar Rahi Algraittee, Azfar Rizal Ahmad, Sharmili Vidyadaran, Rajesh Ramasamy
Mesenchymal stem cells (MSCs) exert potent immuno-regulatory activities on various immune cells and also differentiate into various mesodermal lineages besides retaining a distinct self-renewal ability. Such exclusive characteristics had enabled MSCs to be recognised as an ideal source for cell-based treatment in regenerative medicine and immunotherapy. Thus, considering MSCs for treating degenerative disease of organs with limited regenerative potential such as cartilage would serve as an ideal therapy. This study explored the feasibility of generating human cartilage-derived MSCs (hC-MSCs) from sports injured patients and characterised based on multipotent differentiation and immunosuppressive activities...
March 1, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29395555/reporting-standards-in-clinical-studies-evaluating-bone-marrow-aspirate-concentrate-a-systematic-review
#4
REVIEW
Iain R Murray, Patrick G Robinson, Christopher C West, Ewan B Goudie, Li Y Yong, Timothy O White, Robert F LaPrade
PURPOSE: To perform a systematic review of clinical studies evaluating bone marrow aspirate concentrate (BMAC) in the treatment of musculoskeletal pathology to compare levels of reporting with recently published minimum standards. METHODS: A systematic review of the clinical literature from August 2002 to August 2017 was performed. Human clinical studies published in English and involving the administration of BMAC for musculoskeletal applications were included...
April 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28919510/magnesium-mg-based-interference-screws-developed-for-promoting-tendon-graft-incorporation-in-bone-tunnel-in-rabbits
#5
Jiali Wang, Jiankun Xu, Bin Song, Dick Hokiu Chow, Patrick Shu-Hang Yung, Ling Qin
How to enhance tendon graft incorporation into bone tunnels for achieving satisfactory healing outcomes in patients with anterior cruciate ligament reconstruction (ACLR) is one of the most challenging clinical problems in orthopaedic sports medicine. Several studies have recently reported the beneficial effects of Mg implants in bone fracture healing, indicating the use potential of Mg devices in promoting the tendon graft osteointegration. Here, we developed an innovative Mg-based interference screws for fixation of the tendon graft in rabbits underwent ACLR and investigated the biological role of Mg-based implants in the graft healing...
November 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28577782/orthobiologics-in-pediatric-sports-medicine
#6
REVIEW
Christopher C Bray, Clark M Walker, David D Spence
Orthobiologics are biological substances that allow injured muscles, tendons, ligaments, and bone to heal more quickly. They are found naturally in the body; at higher concentrations they can aid in the healing process. These substances include autograft bone, allograft bone, demineralized bone matrix, bone morphogenic proteins, growth factors, stem cells, plasma-rich protein, and ceramic grafts. Their use in sports medicine has exploded in efforts to increase graft incorporation, stimulate healing, and get athletes back to sport with problems including anterior cruciate ligament ruptures, tendon ruptures, cartilage injuries, and fractures...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28509821/minimum-information-for-studies-evaluating-biologics-in-orthopaedics-mibo-platelet-rich-plasma-and-mesenchymal-stem-cells
#7
Iain R Murray, Andrew G Geeslin, Ewan B Goudie, Frank A Petrigliano, Robert F LaPrade
BACKGROUND: A comprehensive approach to the evaluation of biologic therapies for musculoskeletal conditions is required to guide appropriate future use. Clinical studies evaluating platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) are limited by inadequate reporting of scientific details critical to outcome. We developed minimum reporting requirements for clinical studies evaluating PRP and MSCs using Delphi consensus methods. METHODS: The need for consensus on the minimum reporting requirements for studies evaluating biologics was identified at the American Academy of Orthopaedic Surgeons/Orthopaedic Research Society (AAOS/ORS) Biologic Treatments for Orthopaedic Injuries Symposium in 2015 and the American Orthopaedic Society for Sports Medicine (AOSSM) Biologic Treatments for Sports Injuries II Think Tank in 2015...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28375638/the-placenta-applications-in-orthopaedic-sports-medicine
#8
James Alexander McIntyre, Ian A Jones, Alla Danilkovich, C Thomas Vangsness
BACKGROUND: Placenta has a long history of use for treating burns and wounds. It is a rich source of collagen and other extracellular matrix proteins, tissue reparative growth factors, and stem cells, including mesenchymal stem cells (MSCs). Recent data show its therapeutic potential for orthopaedic sports medicine indications. PURPOSE: To provide orthopaedic surgeons with an anatomic description of the placenta, to characterize its cellular composition, and to review the literature reporting the use of placenta-derived cells and placental tissue allografts for orthopaedic sports medicine indications in animal models and in humans...
January 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27729913/utility-of-a-mouse-model-of-osteoarthritis-to-demonstrate-cartilage-protection-by-ifn%C3%AE-primed-equine-mesenchymal-stem-cells
#9
Marie Maumus, Gautier Roussignol, Karine Toupet, Geraldine Penarier, Isabelle Bentz, Sandrine Teixeira, Didier Oustric, Mireille Jung, Olivier Lepage, Regis Steinberg, Christian Jorgensen, Danièle Noel
OBJECTIVE: Mesenchymal stem cells isolated from adipose tissue (ASC) have been shown to influence the course of osteoarthritis (OA) in different animal models and are promising in veterinary medicine for horses involved in competitive sport. The aim of this study was to characterize equine ASCs (eASCs) and investigate the role of interferon-gamma (IFNγ)-priming on their therapeutic effect in a murine model of OA, which could be relevant to equine OA. METHODS: ASC were isolated from subcutaneous fat...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27694102/change-to-australasian-college-of-sport-and-exercise-physicians-position-statement-the-place-of-mesenchymal-stem-stromal-cell-therapies-in-sport-and-exercise-medicine
#10
EDITORIAL
Hamish Osborne, Adam Castricum
No abstract text is available yet for this article.
October 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27677916/biological-therapies-in-regenerative-sports-medicine
#11
REVIEW
Isabel Andia, Nicola Maffulli
Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action...
May 2017: Sports Medicine
https://www.readbyqxmd.com/read/27552450/current-and-future-stem-cell-regulation-a-call-to-action
#12
REVIEW
Adam Anz
The orthopedic sports medicine profession experienced a pivotal shift with the acceptance and application of the arthroscope. The next leap forward will hinge on the acceptance, application, and regulation of biologic therapies, and a sentinel event will be the US Food and Drug Administration approval of a stem cell technology. While the arthroscope was developed in the hands of our sports medicine mentors, the current history of biologics has been mostly written by basic scientists. The baby steps of these technologies have involved benchtop laboratory studies and preclinical animal trials, clearly illustrating great potential...
July 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27535248/tendon-stem-cells-mechanobiology-and-development-of-tendinopathy
#13
REVIEW
James H-C Wang, Issei Komatsu
Millions of people suffer from tendon injuries in both occupational and athletic settings. However, the restoration of normal structure and function to injured tendons still remains as one of the greatest challenges in orthopaedics and sports medicine. In recent years, a remarkable advancement in tendon research field has been the discovery of tendon stem/progenitor cells (TSCs). Unlike tenocytes, the predominant resident cell in tendons, TSCs have the ability to self-renew and multi-differentiate. Because of these distinct properties, TSCs may play a critical role in tendon physiology as well as pathology such as tendinopathy, which is a prevalent chronic tendon injury...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27329787/the-effect-of-tendon-stem-progenitor-cell-tsc-sheet-on-the-early-tendon-healing-in-a-rat-achilles-tendon-injury-model
#14
Issei Komatsu, James H-C Wang, Kiyotaka Iwasaki, Tatsuya Shimizu, Teruo Okano
UNLABELLED: Tissue-engineering approaches have a great potential to improve the treatment of tendon injuries that affect millions of people. The present study tested the hypothesis that introduction of a tendon derived stem/progenitor cell (TSC) sheet accelerates tendon healing and tendon regeneration in a rat model. TSC sheets were produced on temperature-responsive culture dishes. Then, they were grafted on unwounded Achilles tendons and at sites of a 3mm of Achilles tendon defect. At 2 and 4weeks after implantation tendons were examined by histology, immunohistochemistry, transmission electron microscopy (TEM) and mechanical testing...
September 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27159318/biologic-treatments-for-sports-injuries-ii-think-tank-current-concepts-future-research-and-barriers-to-advancement-part-1-biologics-overview-ligament-injury-tendinopathy
#15
Robert F LaPrade, Andrew G Geeslin, Iain R Murray, Volker Musahl, Jason P Zlotnicki, Frank Petrigliano, Barton J Mann
Biologic therapies, including stem cells, platelet-rich plasma, growth factors, and other biologically active adjuncts, have recently received increased attention in the basic science and clinical literature. At the 2015 AOSSM Biologics II Think Tank held in Colorado Springs, Colorado, a group of orthopaedic surgeons, basic scientists, veterinarians, and other investigators gathered to review the state of the science for biologics and barriers to implementation of biologics for the treatment of sports medicine injuries...
December 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27135289/platelet-rich-plasma-and-bone-marrow-derived-mesenchymal-stem-cells-in-sports-medicine
#16
REVIEW
Alberto Gobbi, Matthew Fishman
Regenerative medicine is a fast-growing field in orthopedic sports medicine. Platelet-rich plasma contains multiple factors that have been shown to augment healing, thereby stimulating its use in multiple areas of acute and chronic injuries. Mesenchymal stem cells have pluripotent potential to form into tissues pertinent to orthopedics, such as cartilage and bone. As such, there is been a surge in the research directed toward steering those stem cells into a particular lineage as part of treatment for a variety of soft-tissue, cartilage, and bone pathologies...
June 2016: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/26784119/australasian-college-of-sports-physicians-position-statement-the-place-of-mesenchymal-stem-stromal-cell-therapies-in-sport-and-exercise-medicine
#17
Hamish Osborne, Lynley Anderson, Peter Burt, Mark Young, David Gerrard
No abstract text is available yet for this article.
March 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/26701927/australasian-college-of-sports-physicians-position-statement-the-place-of-mesenchymal-stem-stromal-cell-therapies-in-sport-and-exercise-medicine
#18
Hamish Osborne, Lynley Anderson, Peter Burt, Mark Young, David Gerrard
This Position Statement has been written expressly for members of the Australasian College of Sports Physicians (ACSP); however, it may also be of interest to the wider medical community, sporting organisations, athletes and the general community. It has been informed by a comprehensive review of the scientific literature and the opinions of kindred organisations. This statement outlines the use of mesenchymal stem cell (MSC) therapies in the broad context of Sport and Exercise Medicine, recognising that every medical practitioner should respect: (1) the evidence for the therapeutic use of MSCs and (2) the priority for patient health and welfare...
October 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26585668/human-amniotic-membrane-derived-products-in-sports-medicine-basic-science-early-results-and-potential-clinical-applications
#19
REVIEW
Jonathan C Riboh, Bryan M Saltzman, Adam B Yanke, Brian J Cole
BACKGROUND: Amniotic membrane (AM)-derived products have been successfully used in ophthalmology, plastic surgery, and wound care, but little is known about their potential applications in orthopaedic sports medicine. PURPOSE: To provide an updated review of the basic science and preclinical and clinical data supporting the use of AM-derived products and to review their current applications in sports medicine. STUDY DESIGN: Systematic review...
September 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/25864663/the-role-of-physiatry-in-regenerative-medicine-the-past-the-present-and-future-challenges
#20
REVIEW
Fernando Sepúlveda, Luis Baerga, William Micheo
Historically, the foundation of physical medicine and rehabilitation training has provided the capabilities to optimize nonoperative treatments of a variety of musculoskeletal conditions, including acute and chronic muscle, tendon, ligament, and cartilage disorders. Such treatments include the use of nonsteroidal anti-inflammatory drugs (NSAIDs), therapeutic modalities (eg, thermal and manual therapies), and corticosteroid injections in conjunction with specific rehabilitation exercises. Although NSAIDs, modalities, and corticosteroids may be helpful for short-term pain reduction and early recovery of function, they do not typically reverse the structural changes associated with degenerative conditions and may contribute to worse long-term outcomes by potentially interfering with tissue healing...
April 2015: PM & R: the Journal of Injury, Function, and Rehabilitation
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