Dingjiacheng Jia, Qiwen Wang, Yadong Qi, Yao Jiang, Jiamin He, Yifeng Lin, Yong Sun, Jilei Xu, Wenwen Chen, Lina Fan, Ruochen Yan, Wang Zhang, Guohong Ren, Chaochao Xu, Qiwei Ge, Lan Wang, Wei Liu, Fei Xu, Pin Wu, Yuhao Wang, Shujie Chen, Liangjing Wang
The immune checkpoint blockade (ICB) response in human cancers is closely linked to the gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is positively correlated with the responsiveness of ICB. Supplementation with Lactobacillus johnsonii or tryptophan-derived metabolite indole-3-propionic acid (IPA) enhances the efficacy of CD8+ T cell-mediated αPD-1 immunotherapy. Mechanistically, Lactobacillus johnsonii collaborates with Clostridium sporogenes to produce IPA...
March 11, 2024: Cell