keyword
https://read.qxmd.com/read/38268224/integrative-bioinformatics-and-experimental-validation-of-hub-genetic-markers-in-acne-vulgaris-toward-personalized-diagnostic-and-therapeutic-strategies
#21
JOURNAL ARTICLE
Qian Lin, Beichen Cai, Ruonan Ke, Lu Chen, Xuejun Ni, Hekun Liu, Xinjian Lin, Biao Wang, Xiuying Shan
BACKGROUND: Acne vulgaris is a widespread chronic inflammatory dermatological condition. The precise molecular and genetic mechanisms of its pathogenesis remain incompletely understood. This research synthesizes existing databases, targeting a comprehensive exploration of core genetic markers. METHODS: Gene expression datasets (GSE6475, GSE108110, and GSE53795) were retrieved from the GEO. Differentially expressed genes (DEGs) were identified using the limma package...
January 24, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38250727/gsdmd-suppresses-keratinocyte-differentiation-by-inhibiting-flg-expression-and-attenuating-kctd6-mediated-hdac1-degradation-in-atopic-dermatitis
#22
JOURNAL ARTICLE
Yi Zhong, Taoyuan Huang, Xiaoli Li, Peiyi Luo, Bingjun Zhang
BACKGROUND: Recent studies have shown that activated pyroptosis in atopic dermatitis (AD) switches inflammatory processes and causes abnormal cornification and epidermal barrier dysfunction. Little research has focused on the interaction mechanism between pyroptosis-related genes and human keratinocyte differentiation. METHODS: The AD dataset from the Gene Expression Omnibus (GEO) was used to identify differently expressed pyroptosis-related genes (DEPRGs). Hub genes were identified and an enrichment analysis was performed to select epithelial development-related genes...
2024: PeerJ
https://read.qxmd.com/read/38248716/expression-profiles-of-hypoxia-related-genes-of-cancers-originating-from-anatomically-similar-locations-using-tcga-database-analysis
#23
JOURNAL ARTICLE
Hye Lim Bae, Kyeonghun Jeong, Suna Yang, Hyeji Jun, Kwangsoo Kim, Young Jun Chai
Background: Hypoxia is a well-recognized characteristic of the tumor microenvironment of solid cancers. This study aimed to analyze hypoxia-related genes shared by groups based on tumor location. Methods: A total of 9 hypoxia-related pathways from the Kyoto Encyclopedia of Genes and Genomes database or the Reactome database were selected, and 850 hypoxia-related genes were analyzed. Based on their anatomical locations, 14 tumor types were categorized into 6 groups. The group-specific genetic risk score was classified as high- or low-risk based on mRNA expression, and survival outcomes were evaluated...
December 31, 2023: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/38231049/screening-for-biomarkers-related-to-pigmentation-and-formation-in-vitiligo
#24
JOURNAL ARTICLE
Ying Shi, Mengyun Su
BACKGROUND: Vitiligo is an autoimmune skin disorder primarily characterized by the absence of melanocytes, leading to the development of white patches on the patient's skin. Narrowband Ultraviolet B (NB-UVB) therapy is among the most effective approaches for stimulating the reformation of hyperpigmentation. This treatment utilizes a narrow spectrum of NBUVB wavelengths ranging from 311 to 313 nm to irradiate the affected area, thereby preventing the destruction of migrating and proliferating melanocytes...
January 12, 2024: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38230305/integrated-bioinformatics-analysis-reveals-diagnostic-biomarkers-and-immune-cell-infiltration-characteristics-of-solar-lentigines
#25
JOURNAL ARTICLE
Xin Yang, Zhikuan Xia, Yunlong Fan, Yitong Xie, Ge Ge, Dexiu Lang, Junhong Ao, Danxia Yue, Jiamin Wu, Tong Chen, Yuekun Zou, Mingwang Zhang, Rongya Yang
BACKGROUND: Solar lentigines (SLs), serving as a prevalent characteristic of skin photoaging, present as cutaneous aberrant pigmentation. However, the underlying pathogenesis remains unclear and there is a dearth of reliable diagnostic biomarkers. OBJECTIVE: The aim of this study was to identify diagnostic biomarkers for SLs and reveal its immunological features. METHODS: In this study, gene expression profiling datasets (GSE192564 and GSE192565) of SLs were obtained from the GEO database...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38200904/transcriptome-and-weighted-gene-co-expression-network-analysis-for-feather-follicle-density-in-a-chinese-indigenous-breed
#26
JOURNAL ARTICLE
Jiangxian Wang, Wei Wei, Chaohui Xing, Hao Wang, Meng Liu, Jinmei Xu, Xinxin He, Yanan Liu, Xing Guo, Runshen Jiang
Feather follicle density plays an important role in appealing to consumers' first impressions when making purchasing decisions. However, the molecular network that contributes to this trait remains largely unknown. The aim of this study was to perform transcriptome and weighted gene co-expression network analyses to determine the candidate genes relating to feather follicle density in Wannan male chickens. In total, five hundred one-day-old Wannan male chickens were kept in a conventional cage system. Feather follicle density was recorded for each bird at 12 weeks of age...
January 4, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38195709/biomarkers-of-uvb-radiation-related-senescent-fibroblasts
#27
JOURNAL ARTICLE
Mingyue Qiang, Zijia Dai
Excessive exposure to ultraviolet (UV) light is known to induce photoaging in the skin, necessitating the development of effective anti-photoaging strategies to mitigate the adverse effects of UV radiation. Understanding the biofunctional characteristics of diverse skin cell types and unraveling the molecular modifications implicated in the aging process are pivotal in comprehending the intricacies of photoaging in human skin. Such insights are essential for paving the way for innovative interventions to counteract the deleterious impact of UV radiation on the skin...
January 9, 2024: Scientific Reports
https://read.qxmd.com/read/38172590/whole-transcriptome-sequencing-for-revealing-the-pathogenesis-of-sporotrichosis-caused-by-sporothrix-globosa
#28
JOURNAL ARTICLE
Zhe Liu, Su-Shan Li, Gui-Yun Zhang, Sha Lv, Shuang Wang, Fu-Qiu Li
This study aimed to investigate the molecular mechanism of sporotrichosis and identify possible novel therapeutic targets. Total RNA was extracted from skin lesion samples from sporotrichosis patients and used to construct a long-chain RNA transcriptome library and miRNA transcriptome library for whole transcriptome sequencing. The differentially expressed genes (DEGs) between the groups were identified, and then Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis enrichment analyses were performed based on the DEGs...
January 3, 2024: Scientific Reports
https://read.qxmd.com/read/38172207/systems-based-identification-of-the-hippo-pathway-for-promoting-fibrotic-mesenchymal-differentiation-in-systemic-sclerosis
#29
JOURNAL ARTICLE
Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A Hile, Paul W Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L Modlin, John Varga, Lam C Tsoi, Robert Lafyatis, J Michelle Kahlenberg, Allison C Billi, Dinesh Khanna, Johann E Gudjonsson
Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis of skin and other internal organs. However, the main cellular participants in SSc skin fibrosis remain incompletely understood. Here using differentiation trajectories at a single cell level, we demonstrate a dual source of extracellular matrix deposition in SSc skin from both myofibroblasts and endothelial-to-mesenchymal-transitioning cells (EndoMT)...
January 3, 2024: Nature Communications
https://read.qxmd.com/read/38156909/identification-of-irf1-as-a-novel-pyroptosis-related-prognostic-biomarker-of-atopic-dermatitis
#30
JOURNAL ARTICLE
Xin Liu, Yi Wang, Ruofan Xi, Dongjie Guo, Wanjun Guo, Linyan Cheng, Ting Du, Hanzhi Lu, Peiyao Wang, Yanjuan Duan, Jianyong Zhu, Fulun Li
Purpose: The aim of this study was to characterize key biomarkers associated with pyroptosis in atopic dermatitis (AD). Materials and methods: To identify the differentially expressed pyroptosis-related genes (DEPRGs), the gene expression profiles GSE16161 and GSE32924 from the Gene Expression Omnibus (GEO) database were utilized. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to determine the potential biological functions and involved pathways...
December 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38151761/exploring-the-impact-of-tgf-%C3%AE-family-gene-mutations-and-expression-on-skin-wound-healing-and-tissue-repair
#31
JOURNAL ARTICLE
Kai Cui, Sunxin Gong, Junfeng Bai, Liangliang Xue, Xue Li, Xiaodong Wang
Transforming Growth Factor-Beta (TGF-β) signalling pathway is of paramount importance in the processes of wound healing, epidermal integrity maintenance and development of skin cancer. The objective of this research endeavour was to clarify the impact of gene mutations and variations in expression within TGF-β family on mechanisms of tissue repair, as well as to identify potential targets for therapeutic purposes in non-melanoma skin cancer (NMSC). The methods utilized in this study involved obtaining RNA-seq data from 224 NMSC patients and paired normal skin tissues from the PRJNA320473 and PRJEB27606 databases...
December 27, 2023: International Wound Journal
https://read.qxmd.com/read/38149621/best-clinical-practice-in-the-treatment-of-juvenile-systemic-sclerosis-expert-panel-guidance-the-result-of-the-international-hamburg-consensus-meeting-december-2022
#32
REVIEW
Ivan Foeldvari, Kathryn S Torok, Jordi Antón, Michael Blakley, Tamás Constantin, Maurizio Cutolo, Christopher P Denton, Kim Fligelstone, Bernd Hinrichs, Suzanne C Li, Susan Maillard, Edoardo Marrani, Pia Moinzadeh, Catherine H Orteu, Clare E Pain, John D Pauling, Clarissa Pilkington, Franziska Rosser, Vanessa Smith, Daniel F Furst
INTRODUCTION: Juvenile systemic sclerosis (jSSc) is an orphan disease with a prevalence of 3 in 1,000,000 children. Currently there is only one consensus treatment guideline concerning skin, pulmonary and vascular involvement for jSSc, the jSSc SHARE (Single Hub and Access point for pediatric Rheumatology in Europe) initiative, which was based on data procured up to 2014. Therefore, an update of these guidelines, with a more recent literature and expert experience, and extension of the guidance to more aspects of the disease is needed...
December 27, 2023: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38149569/rutin-attenuates-inflammation-by-downregulating-age-rage-signaling-pathway-in-psoriasis-network-pharmacology-analysis-and-experimental-evidence
#33
JOURNAL ARTICLE
Mingxia Wang, Xiaoxuan Ma, Chunjie Gao, Yue Luo, Xiaoya Fei, Qi Zheng, Xin Ma, Le Kuai, Bin Li, Ruiping Wang, Jiankun Song
BACKGROUND: Jueyin granules (JYG) is effective against psoriasis, but its utility components are not clear. Rutin is the main monomer of JYG, its therapeutic effect and mechanism on psoriasis need to be further clarified. PURPOSE: To explore the potential mechanisms of rutin on psoriasis through network pharmacology and experiments. METHODS: In vitro, cell viability was determined using the CCK8 assay, and inflammatory factors were identified using RT-qPCR...
December 2023: International Immunopharmacology
https://read.qxmd.com/read/38144308/decoding-the-role-of-m-6-a-regulators-in-identifying-and-characterizing-molecular-subtypes-of-rosacea
#34
JOURNAL ARTICLE
Shuping Zhang, Meng Wu, Wenbo Xue
Rosacea is a common skin disease that predominantly affects individuals aged between 30 and 50 years. While the exact cause of the disease remains unclear, various factors have been shown to trigger or exacerbate its symptoms. N6-methyladenosine (m6 A) modification is one of the most abundant epigenetic methylation modification in messenger RNA (mRNA) and non-coding RNA (ncRNA), plays a crucial role in RNA splicing, export, stability, and translation. In this study, we aimed to characterize m6 A genes in rosacea, identify molecular subtypes based on m6 A gene expression, characterize the immune features among subtypes, explore key molecules based on co-expression analysis, and identify potential targets and drugs...
December 2023: Heliyon
https://read.qxmd.com/read/38115636/exploration-of-the-biomarkers-of-comorbidity-of-psoriasis-with-inflammatory-bowel-disease-and-their-association-with-immune-infiltration
#35
JOURNAL ARTICLE
Rui-Lian Ding, Yu Zheng, Jin Bu
BACKGROUND: There was evidence that significant bidirectional associations between psoriasis and inflammatory bowel diseases (IBDs), which influences management strategy of the patients, so the investigation on the mechanisms by which these two diseases co-occur is important. METHODS: The Gene Expression Omnibus (GEO) database was used to download gene expression profiles of psoriasis and IBD. The differentially expressed genes (DEGs) between disease and health control groups for each data set were calculated, and Venn diagram was used to obtain for intersection...
December 2023: Skin Research and Technology
https://read.qxmd.com/read/38112978/understanding-the-charismatic-potential-of-nanotechnology-to-treat-skin-carcinoma
#36
REVIEW
Aamravi Sathe, Bhupendra G Prajapati, Sankha Bhattacharya
Carcinoma is a condition that continues to pose a significant challenge, despite current medical advances. Skin carcinoma is the leading cause of cancer, and it has seen a massive increase all over the world. The challenges with current treatment are due to toxicity that leads to many more skin complications. Due to this to avoid such complications by designing diverse nanoparticles as delivery carriers, nanomedicine is employed as a hub for diagnostics and therapy. Liposomes, gold nanoparticles, transferases, nanofibers, etc...
December 19, 2023: Medical Oncology
https://read.qxmd.com/read/38107964/monkeypox-virus-crosstalk-with-hiv-an-integrated-skin-transcriptome-and-machine-learning-study
#37
JOURNAL ARTICLE
Xueyao Cai, Tianyi Zhou, Wenjun Shi, Yuchen Cai, Jianda Zhou
The emergence of the monkeypox virus (MPXV) outbreak presents a formidable challenge to human health. Emerging evidence suggests that individuals with HIV have been disproportionately affected by MPXV, with adverse clinical outcomes and higher mortality rates. However, the shared molecular mechanisms underlying MPXV and HIV remain elusive. We identified differentially expressed genes (DEGs) from two public data sets, GSE219036 and GSE184320, and extracted common DEGs between MPXV and HIV. We further performed gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein-protein interactions (PPI), candidate drug assessment, and immune correlation of hub genes analysis...
December 12, 2023: ACS Omega
https://read.qxmd.com/read/38094092/apaaaci-clinical-pathway-on-direct-provocation-testing-for-penicillin-allergy-delabeling
#38
JOURNAL ARTICLE
Philip Hei Li, Bernard Yu-Hor Thong, Ruby Pawankar, Chandima Jeewandara, Rommel Crisenio M Lobo, Hye-Ryun Kang, Padukudru Anand Mahesh, Juan Meng, Sonomjamts Munkhbayarlakh, Duy Le Pham, Ticha Rerkpattanapipat, Min-Moon Tang, Masao Yamaguchi, Amir Hamzah Abdul Latiff, Iris Rengganis, Jiu-Yao Wang, Luo Zhang, Michaela Lucas
BACKGROUND: Allergy to penicillin is commonly reported in many countries and is an overwhelming global public health concern. Penicillin allergy labels can lead to the use of less effective antibiotics and can be associated with antimicrobial resistance. Appropriate assessment of suspected penicillin allergy (often including skin testing, followed by drug provocation testing [DPT] performed by allergists) can prevent the unnecessary restriction of penicillin or delabelling. Many countries in the Asia Pacific (AP) have very limited access to allergy services, and there are significant disparities in the methods of evaluating penicillin allergy...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38089052/fangji-dihuang-formulation-ameliorated-dncb-induced-atopic-dermatitis-like-skin-lesions-by-il-17-signaling-pathway-integrating-network-analysis-and-experimental-validation
#39
JOURNAL ARTICLE
Wenting Zhao, Honghong Jiang, Yunfan Gu, Weiming Zhang, Shijie Bao, Ming Dai, Bilin Dong, Ya Yang, Ke Li, Li Qin, Xianyu Zeng
Background: The Fangji Dihuang formulation (FJDHF) is a widely recognized Traditional Chinese Medicine (TCM) formula that consists of five plant drugs: Stephaniae Tetrandrae Radix, Cinnamomi Ramulus, Rehmanniae Radix, Saposhnikoviae Radix, and Glycyrrhiza Urensis Fisch. This formulation has been known to exhibit clinical therapeutic effects in the treatment of inflammatory skin diseases. However, there is a lack of pharmacological research on its anti-atopic dermatitis (AD) activity. Methods: To investigate the potential anti-AD activity of FJDHF, DNCB was used to induce AD-like skin inflammation in the back of mice...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38085347/transcriptome-sequencing-promotes-insights-on-the-molecular-mechanism-of-skp-sc-evs-mitigating-denervation-induced-muscle-atrophy
#40
JOURNAL ARTICLE
Junfei Lin, Yong Cai, Jian Wang, Ruiqi Liu, Chong Qiu, Yan Huang, Boya Liu, Xiaoming Yang, Songlin Zhou, Yuntian Shen, Wei Wang, Jianwei Zhu
BACKGROUND: Complex pathophysiological changes accompany denervation-induced skeletal muscle atrophy, but no effective treatment strategies exist. Our previous study indicated that extracellular vesicles derived from skin-derived precursors-derived Schwann cells (SKP-SC-EVs) can effectively mitigate denervation-induced muscle atrophy. However, the specific molecular mechanism remains unclear. METHODS AND RESULTS: In this study, we used bioinformatics methods to scrutinize the impact of SKP-SC-EVs on gene expression in denervation-induced skeletal muscle atrophy...
December 12, 2023: Molecular Biology Reports
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