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https://www.readbyqxmd.com/read/29792114/innovating-urinary-catheter-design-an-introduction-to-the-engineering-challenge
#1
Cathy Murphy
Every day, people around the world rely on intermittent and indwelling urinary catheters to manage bladder dysfunction, but the potential or actual harm caused by these devices is well-recognised. Current catheter designs can cause urinary tract infection and septicaemia, bladder and urethral trauma and indwelling devices frequently become blocked. Furthermore, the devices can severely disrupt users' lives, limiting their daily activities and can be costly to manage for healthcare providers. Despite this, little significant design innovation has taken place in the last 80 years...
May 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29780647/rare-but-not-infrequent-infective-endocarditis-caused-by-abiotrophia-defectiva
#2
Sonia Chowdhury, Matthew L German
Endocarditis (IE) is defined by an infection of a native or prosthetic heart valve, the mural endocardium, or an indwelling cardiac device. Although viridan-group streptococci (VGS) and Staphylococci species have collectively been considered as the most common cause of endocarditis, uncommon pathogens may also lead to the disease with significant morbidity and mortality. Abiotrophia defectiva , a nutritionally variant streptococci (NVS), is a virulent bacterium that preferentially affects endovascular structure and is implicated in many culture-negative endocarditis with dreadful complications such as heart failure, septic embolization, and valve destruction...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29758540/integrated-antibacterial-and-antifouling-surfaces-via-cross-linking-chitosan-g-eugenol-zwitterionic-copolymer-on-electrospun-membranes
#3
Zhenguang Li, Wenhong Hu, Yunhui Zhao, Lixia Ren, Xiaoyan Yuan
Integrated antibacterial and antifouling surfaces in favor of avoiding implant-related infections are necessarily required for biomaterials when they contact with the body fluid. In this work, an antibacterial and antifouling membrane was developed via cross-linking chitosan-g-eugenol and the zwitterionic copolymer poly(sulfobetaine methylacrylate-co-2-aminoethyl methacrylate) on the electrospun polycarbonate urethane substrate using genipin as a cross-linker. Antibacterial assays demonstrated that the prepared membranes had efficient antibacterial activity with 92...
April 27, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29737589/ll-37-fragments-have-antimicrobial-activity-against-staphylococcus-epidermidis-biofilms-and-wound-healing-potential-in-hacat-cell-line
#4
Paola Saporito, Michelle Vang Mouritzen, Anders Løbner-Olesen, Håvard Jenssen
Staphylococcus epidermidis is a common nosocomial pathogen able to form biofilms in indwelling devices, resulting in chronic infections, which are refractory to antibiotics treatment. Staphylococcal biofilms are also associated with the delayed reepithelization and healing of chronic wounds. The human cathelicidin peptide LL-37 has been proven active against S. epidermidis biofilms in vitro and to promote wound healing. As previous studies have demonstrated that fragments of LL-37 could possess an equal antibacterial activity as the parent peptide, we tested whether shorter (12-mer) synthetic fragments of LL-37 maintained the antibiofilm and/or immune modulating activity, aiming at the identification of essential regions within the LL-37 parent sequence...
May 8, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29697045/an-unexpected-case-of-post-operative-superior-caval-vein-syndrome
#5
Lynn Peng, Lisa Wise-Faberowski
Superior caval vein obstruction in children after congenital heart surgery has been more associated with thrombosis formation as result of single-ventricle palliation, infection, indwelling devices/catheters, or external compression. Many of these patients will present to the cardiac catheterisation laboratory for evaluation and possible intervention. We present an unusual case of superior caval vein obstruction in a patient after Tetralogy of Fallot repair.
April 26, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29690925/staphylococcus-epidermidis-meningitis-in-the-absence-of-a-neurosurgical-device-secondary-to-catheter-related-bloodstream-infection-a-case-report-and-review-of-the-literature
#6
Taro Noguchi, Miki Nagao, Masaki Yamamoto, Yasufumi Matsumura, Toshiyuki Kitano, Akifumi Takaori-Kondo, Satoshi Ichiyama
BACKGROUND: Staphylococcus epidermidis can cause nosocomial meningitis in the presence of prosthetic devices. We describe a case of Staphylococcus epidermidis meningitis in a patient with neutropenia who had no intracranial foreign body, and we review the literature on meningitis that is caused by coagulase-negative Staphylococcus spp. without a neurosurgical device. CASE PRESENTATION: A 47-year-old Japanese man with acute myeloid leukemia receiving chemotherapy through a totally implantable central venous catheter developed fever and headache...
April 25, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29624479/in-vivo-and-in-vitro-anti-bacterial-efficacy-of-absorbable-barbed-polydioxanone-monofilament-tissue-control-device-with-triclosan
#7
Shubhangi Bhende, Daniel Burkley, Jesse Nawrocki
BACKGROUND: This study evaluated the in vitro and in vivo anti-bacterial efficacy of STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Devices in comparison with standard absorbable polydioxanone devices lacking triclosan, utilizing challenges by gram-positive and gram-negative bacteria. METHODS: The STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Device was tested for in vitro efficacy against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), S...
April 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29609853/risk-factors-for-sepsis-morbidity-in-a-rural-hospital-population-a-case-control-study
#8
Peter D Ahiawodzi, Kimberly Kelly, Alyssa Massengill, Dorothea K Thompson
BACKGROUND: The aim of the study was to identify risk factors for sepsis morbidity in a rural hospital population. METHODS: We used a case-control study design. Patients included adult admissions to a rural health system between January 1, 2012, and December 31, 2015. Case selection was by electronic medical record search for codes of the ICD-9-CM. Cases were validated against Quick Sequential Organ Failure Assessment criteria. Multiple logistic regression modeling was performed to determine which predefined variables were significantly associated with sepsis diagnosis...
March 30, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29603533/aspergillus-flavus-native-valve-endocarditis-following-combined-liver-and-renal-transplantation-case-report-and-review-of-the-literature
#9
Sultan Alsobayeg, Nada Alshehri, Shamayel Mohammed, Bahaa M Fadel, Ali S Omrani, Reem Almaghrabi
Fungal endocarditis is a rare but serious form of infective endocarditis, typically involving prosthetic valves and resulting in high morbidity and mortality[1]. Fungi account for 1.3-6% of all cases of infective endocarditis, out of which Candida species are the most common, followed by Aspergillus species (25-30%)[1-3]. The most frequest risk factors for fungal endocarditis include cardiac surgery, indwelling vascular devices and intravenous drug use. However, fungal endocarditis of the native cardiac valves is extremely unusual[4]...
March 30, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29581679/balloon-inflated-catheters-for-enteral-feeding-a-word-of-caution
#10
Nihar Ranjan Dash, Anand Narayan Singh, Ragini Kilambi
Catheters with inflatable balloons such as a Foley catheter may be used for feeding gastrostomy/jejunostomy. The incorrect or improper use of these catheters can have serious consequences. We report 13 cases of feeding jejunostomy with balloon-inflated catheter's malfunction, some referred to our centre and others operated here over a period of 8 years. The most dramatic consequence of such improper use led to rupture of the small intestine due to inadvertent over-inflation (over 100 ml) of the balloon of the catheter during a contrast study...
February 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29560028/non-retrieval-of-inferior-vena-cava-filters-as-a-patient-safety-concern-evaluation-of-a-new-process-improvement-project-to-increase-retrieval-rates-in-a-vascular-and-interventional-radiology-clinic
#11
Joshua Brown, Jeffery Talbert, Ryan Pennington, Qiong Han, Driss Raissi
Background: Retrieval of inferior vena cava filters (IVCFs) is important to decrease the long-term risk of complications associated with indwelling devices. Our hospital experienced low retrieval rates and implemented a low-cost intervention and evaluation for quality improvement. The working hypothesis was that a simple, mailed letter intervention could increase retrieval rates by increasing patient and primary care provider knowledge of the need for retrieval. Methods: For all prospective patients who received a retrievable IVCF during the intervention period from January 1, 2014 to February 29, 2016, patients and their primary care providers were mailed letters encouraging contact with the clinic for evaluation of eligibility for retrieval...
2018: Patient Safety in Surgery
https://www.readbyqxmd.com/read/29557272/early-abdominal-aortic-graft-infection-due-to-propionibacterium-acnes-a-case-report-and-review-of-the-literature
#12
Carlo Pallotto, Gioele Simonte, Fabio Verzini, Massimo Lenti, Franco Baldelli, Daniela Francisci, Maurizio Fiorio
Propionibacterium acnes is a member of the human microbiota that has been recently associated with late-onset infections of indwelling devices, especially shoulder prosthesis. Aortic graft infection are rare events with significant morbidity and mortality. Here, we describe the case of an abdominal aortic graft infection due to P. acnes with an unusual early onset. A review of the recent English language literature has been added.
May 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29553339/carbapenem-nonsusceptible-acinetobacter-baumannii-8-us-metropolitan-areas-2012-2015
#13
Sandra N Bulens, Sarah H Yi, Maroya S Walters, Jesse T Jacob, Chris Bower, Jessica Reno, Lucy Wilson, Elisabeth Vaeth, Wendy Bamberg, Sarah J Janelle, Ruth Lynfield, Paula Snippes Vagnone, Kristin Shaw, Marion Kainer, Daniel Muleta, Jacqueline Mounsey, Ghinwa Dumyati, Cathleen Concannon, Zintars Beldavs, P Maureen Cassidy, Erin C Phipps, Nicole Kenslow, Emily B Hancock, Alexander J Kallen
In healthcare settings, Acinetobacter spp. bacteria commonly demonstrate antimicrobial resistance, making them a major treatment challenge. Nearly half of Acinetobacter organisms from clinical cultures in the United States are nonsusceptible to carbapenem antimicrobial drugs. During 2012-2015, we conducted laboratory- and population-based surveillance in selected metropolitan areas in Colorado, Georgia, Maryland, Minnesota, New Mexico, New York, Oregon, and Tennessee to determine the incidence of carbapenem-nonsusceptible A...
April 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29541449/the-infection-risk-scan-iris-standardization-and-transparency-in-infection-control-and-antimicrobial-use
#14
Ina Willemsen, Jan Kluytmans
Background: Infection control needs user-friendly standardized instruments to measure the compliance to guidelines and to implement targeted improvement actions. This abstract describes a tool to measure the quality of infection control and antimicrobial use, the Infection Risk Scan (IRIS). It has been applied in a hospital, several nursing homes and a rehabilitation clinic in the Netherlands. Method: The IRIS consists of a set of objective reproducible measurements, combining patient- and healthcare related variables, such as: hand hygiene compliance, environmental contamination using ATP measurements, prevalence of resistant microorganisms by active screening, availability of infection control preconditions, personal hygiene of healthcare workers, appropriate use of indwelling medical devices and appropriate use of antimicrobials...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29526448/s-aureus-endocarditis-clinical-aspects-and-experimental-approaches
#15
REVIEW
V Hoerr, M Franz, M W Pletz, M Diab, S Niemann, C Faber, T Doenst, P C Schulze, S Deinhardt-Emmer, B Löffler
Infective endocarditis (IE) is a life-threatening disease, caused by septic vegetations and inflammatory foci on the surface of the endothelium and the valves. Due to its complex and often indecisive presentation the mortality rate is still about 30%. Most frequently bacterial microorganisms entering the bloodstream are the underlying origin of the intracardiac infection. While the disease was primarily restricted to younger patients suffering from rheumatic heart streptococci infections, new at risk categories for Staphylococcus (S...
February 21, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29502119/use-of-urinary-collection-devices-in-community-and-nursing-homes-in-istria-county
#16
Branimir Lodeta, Dino Lovrinic, Maja Lodeta, Tina Zavidic, Hrvoje Baric
INTRODUCTION: This study is aimed at assessing the use of various types of urinary catheters, appropriateness of catheter placement and factors associated with antibiotic use in a population of chronically catheterized patients in Istria County. MATERIALS AND METHODS: This cross-sectional study, conducted between March and June 2017 in Istria County, Croatia, was initiated through a network of general family medicine offices. Data were collected from general practitioners (GPs) and from medical managers in nursing homes...
2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29491185/mechanical-circulatory-support-device-heart-hysteretic-interaction-can-predict-left-ventricular-end-diastolic-pressure
#17
Brian Y Chang, Steven P Keller, Sonya S Bhavsar, Noam Josephy, Elazer R Edelman
The full potential of mechanical circulatory systems in the treatment of cardiogenic shock is impeded by the lack of accurate measures of cardiac function to guide clinicians in determining when to initiate and how to optimally titrate support. The left ventricular end diastolic pressure (LVEDP) is an established metric of cardiac function that refers to the pressure in the left ventricle at the end of ventricular filling and immediately before ventricular contraction. In clinical practice, LVEDP is typically only inferred from, and poorly correlates with, the pulmonary capillary wedge pressure (PCWP)...
February 28, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29488406/intraperitoneal-chemotherapy-for-ovarian-cancer-using-sustained-release-implantable-devices
#18
Smrithi Padmakumar, Neha Parayath, Fraser Leslie, Shantikumar V Nair, Deepthy Menon, Mansoor M Amiji
Epithelial ovarian cancer (EOC) remains to be the most lethal of all gynecological malignancies mainly due to its asymptomatic nature. The late stages are manifested with predominant metastases confined to the peritoneal cavity. Although there has been a substantial progress in the treatment avenue with different therapeutic interventions, the overall survival rate of patients remain poor due to relapse and drug resistance. Areas covered: The pharmacokinetic advantages offered by intraperitoneal (IP) chemotherapy due to peritoneal-plasma barrier can be potentially exploited for EOC relapse treatment...
May 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29461278/home-inotropes-in-patients-supported-with-left-ventricular-assist-devices
#19
Emeka C Anyanwu, Viktoriya Kagan, Ankit Bhatia, David M Tehrani, Sirtaz Adatya, Gene Kim, Nitasha Sarswat, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
There is little data outlining the use of outpatient inotropic medications in patients with existing left ventricular assist devices (LVADs). This case series explores this patient population and seeks to define the indications, complications, and safety of dual support. A retrospective chart review was conducted for all patients on LVAD and then subsequently started on home inotropes post device implant. Eight patients met inclusion criteria. The indications for inotropes were right ventricular failure, aortic insufficiency with biventricular failure, LVAD thrombosis with contraindication to device exchange, and cannula malposition with elevated pulmonary vascular resistance...
February 15, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29458204/a-review-of-implantable-biosensors-for-closed-loop-glucose-control-and-other-drug-delivery-applications
#20
Kee Scholten, Ellis Meng
Closed-loop drug delivery promises autonomous control of pharmacotherapy through the continuous monitoring of biomarker levels. For decades, researchers have strived for portable closed-loop systems capable of treating ambulatory patients with chronic conditions such as diabetes mellitus. After years of development, the first of these systems have left the laboratory and entered commercial use. This long-awaited advance reflects recent development of chronically stable implantable biosensors able to accurately measure biomarker levels in vivo...
February 16, 2018: International Journal of Pharmaceutics
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