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https://www.readbyqxmd.com/read/28320940/molecular-interactions-and-inhibition-of-the-staphylococcal-biofilm-forming-protein-sdrc
#1
Cécile Feuillie, Cécile Formosa-Dague, Leanne M C Hays, Ophélie Vervaeck, Sylvie Derclaye, Marian P Brennan, Timothy J Foster, Joan A Geoghegan, Yves F Dufrêne
Staphylococcus aureus forms biofilms on indwelling medical devices using a variety of cell-surface proteins. There is growing evidence that specific homophilic interactions between these proteins represent an important mechanism of cell accumulation during biofilm formation, but the underlying molecular mechanisms are still not well-understood. Here we report the direct measurement of homophilic binding forces by the serine-aspartate repeat protein SdrC and their inhibition by a peptide. Using single-cell and single-molecule force measurements, we find that SdrC is engaged in low-affinity homophilic bonds that promote cell-cell adhesion...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28279719/surgical-management-of-perforated-ivc-filters
#2
Miguel Manzur, Christian Ochoa, Sung Wan Ham, William Lee, Trevor Simcox, Vincent Rowe, Fred Weaver
OBJECTIVES: Management of complicated indwelling inferior vena cava (IVC) filters has increased due to low retrieval rates. Filter migration and perforation are infrequent complications and require explantation of the filter. We report our recent experience with endovascular retrieval and surgical explantation of IVC filters after caval perforation. METHODS: This is a retrospective review of patients who had IVC filter explantation between 2014-2015. Patient demographics, indication for filter placement, clinical presentation, surgical indication and technique, and outcomes were noted...
March 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28268952/swallowable-sensing-device-for-long-term-gastrointestinal-tract-monitoring
#3
Ryota Nakamura, Shintaro Izumi, Hiroshi Kawaguchi, Hidetoshi Ohta, Masahiko Yoshimoto
This paper presents a swallowable sensor device that can be ingested orally, later arriving to the stomach, where the device can indwell for a long term and can be egested at any time after it is triggered using wireless communication. This device can inflate a silicone balloon in the gastrointestinal tract using a chemical reaction. The balloon can be deflated later using electrolysis of water at the time of egestion. A motorless chemical-reaction-based egestion method is proposed to minimize the sensor device size...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28261188/marine-sponge-derived-streptomyces-sp-sbt343-extract-inhibits-staphylococcal-biofilm-formation
#4
Srikkanth Balasubramanian, Eman M Othman, Daniel Kampik, Helga Stopper, Ute Hentschel, Wilma Ziebuhr, Tobias A Oelschlaeger, Usama R Abdelmohsen
Staphylococcus epidermidis and Staphylococcus aureus are opportunistic pathogens that cause nosocomial and chronic biofilm-associated infections. Indwelling medical devices and contact lenses are ideal ecological niches for formation of staphylococcal biofilms. Bacteria within biofilms are known to display reduced susceptibilities to antimicrobials and are protected from the host immune system. High rates of acquired antibiotic resistances in staphylococci and other biofilm-forming bacteria further hamper treatment options and highlight the need for new anti-biofilm strategies...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28256471/risk-factors-associated-with-fluoroquinolone-resistant-enterococcal-urinary-tract-infections-in-a-tertiary-care-university-hospital-in-north-india
#5
Tuhina Banerjee, Shampa Anupurba
BACKGROUND & OBJECTIVES: Fluoroquinolone resistance in both Gram-positive and Gram-negative bacteria has increased with the widespread use of fluoroquinolones. Fluoroquinolone resistance in Gram-negative bacilli has been widely studied, though staphylococci and enterococci are also notably resistant. Enterococci being the second most common cause of healthcare-associated urinary tract infections (UTIs) fluoroquinolones are often the drug of choice. This study was undertaken to assess the risk factors associated with fluoroquinolone-resistant enterococcal UTI in a tertiary level health facility in north India...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28251105/carbapenemase-producing-enterobacteriaceae-risk-factors-for-infection-and-impact-of-resistance-on-outcomes
#6
Shanthi Mariappan, Uma Sekar, Arunagiri Kamalanathan
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) have increased in recent years leading to limitations of treatment options. The present study was undertaken to detect CPE, risk factors for acquiring them and their impact on clinical outcomes. METHODS: This retrospective observational study included 111 clinically significant Enterobacteriaceae resistant to cephalosporins subclass III and exhibiting a positive modified Hodge test. Screening for carbapenemase production was done by phenotypic methods, and polymerase chain reaction was performed to detect genes encoding them...
January 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28236355/influence-of-surface-roughness-on-silicone-rubber-voice-prostheses-on-in-vitro-biofilm-formation-and-clinical-lifetime-in-laryngectomized-patients
#7
Kevin J D A Buijssen, Janine J H Oosterhof, Leo Basil, Mark Waters, Mari-Anne Duits, Henk J Busscher, Henny C van der Mei, Bernard F A M van der Laan
OBJECTIVES: Evaluation of the influence of a smooth surface moulding technique of silicone rubber indwelling voice prostheses on in vitro biofilm formation and analysis of the clinical in situ lifetime. DESIGN: Biofilm formation on smooth and Groningen ultra-low resistance (URL) prostheses was studied in an artificial throat model. The clinical lifetime of smooth voice prostheses were compared to the previous lifetime of URL by counting the number of replacements in a consecutive 6 months period in the same patient...
February 25, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28227159/swallowable-sensing-device-for-long-term-gastrointestinal-tract-monitoring
#8
Ryota Nakamura, Shintaro Izumi, Hiroshi Kawaguchi, Hidetoshi Ohta, Masahiko Yoshimoto, Ryota Nakamura, Shintaro Izumi, Hiroshi Kawaguchi, Hidetoshi Ohta, Masahiko Yoshimoto, Hidetoshi Ohta, Ryota Nakamura, Hiroshi Kawaguchi, Masahiko Yoshimoto, Shintaro Izumi
This paper presents a swallowable sensor device that can be ingested orally, later arriving to the stomach, where the device can indwell for a long term and can be egested at any time after it is triggered using wireless communication. This device can inflate a silicone balloon in the gastrointestinal tract using a chemical reaction. The balloon can be deflated later using electrolysis of water at the time of egestion. A motorless chemical-reaction-based egestion method is proposed to minimize the sensor device size...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28146021/spinal-tissue-loading-created-by-different-methods-of-spinal-manipulative-therapy-smt-application
#9
Martha Funabashi, François Nougarou, Martin Descarreaux, Narasimha Prasad, Gregory N Kawchuk
STUDY DESIGN: Comparative study using robotic replication of SMT vertebral kinematics together with serial dissection. OBJECTIVE: To quantify loads created in cadaveric spinal tissues arising from three different forms of SMT application. SUMMARY OF BACKGROUND DATA: There exist many distinct methods by which to apply spinal manipulative therapy (SMT). It is not known presently if different forms of SMT application have different effects on spinal tissues...
January 31, 2017: Spine
https://www.readbyqxmd.com/read/28144822/in-vitro-activity-of-berberine-alone-and-in-combination-with-antifungal-drugs-against-planktonic-forms-and-biofilms-of-trichosporon-asahii
#10
Lin Cong, Yong Liao, Suteng Yang, Rongya Yang
Trichosporon asahii (T. asahii) is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients, with high mortality rates up to 80% despite treated with antifungal drugs. The biofilms-forming ability of T. asahii on indwelling medical devices may account for the resistance to antifungal drugs. Berberine (BBR) has been demonstrated to have antifungal activity and synergistic effects in combination with antifungal drugs against pathogenic fungi. In the present study, the in vitro activities of BBR alone or combined with fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), caspofungin (CAS) and amphotericin B (AMB) against planktonic forms and biofilms of 21 clinical T...
January 31, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28144088/outcomes-cost-comparison-and-patient-satisfaction-during-long-term-central-venous-access-in-cancer-patients-experience-from-a-tertiary-care-cancer-institute-in-south-india
#11
K Govind Babu, M C Suresh Babu, D Lokanatha, Gita R Bhat
INTRODUCTION: Prolonged treatment, frequent administration of chemotherapy, antibiotics and blood products in cancer patients requires long term venous access. Central venous catheters (CVC) inserted into the subclavian vein or internal jugular vein, peripherally inserted central venous catheters (PICC) and chemoport (CP) are the commonly used central venous access devices (CVAD). AIM: This study was envisaged to review our experience of CVADs over a one year period and analyze the outcome with regard to catheter life, reasons for removal, complications, patient satisfaction and cost comparison between the CVAD types in the Indian setting...
October 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28142193/staphylococcus-aureus-biofilm-a-complex-developmental-organism
#12
REVIEW
Derek E Moormeier, Kenneth W Bayles
Chronic biofilm-associated infections caused by Staphylococcus aureus often lead to significant increases in morbidity and mortality, particularly when associated with indwelling medical devices. This has triggered a great deal of research attempting to understand the molecular mechanisms that control S. aureus biofilm formation and the basis for the recalcitrance of these multicellular structures to antibiotic therapy. The purpose of this review is to summarize our current understanding of S. aureus biofilm development, focusing on the description of a newly-defined, five-stage model of biofilm development and the mechanisms required for each stage...
January 31, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28123984/inferior-vena-cava-filter-retrievals-standard-and-novel-techniques
#13
REVIEW
Gokhan Kuyumcu, T Gregory Walker
The placement of an inferior vena cava (IVC) filter is a well-established management strategy for patients with venous thromboembolism (VTE) disease in whom anticoagulant therapy is either contraindicated or has failed. IVC filters may also be placed for VTE prophylaxis in certain circumstances. There has been a tremendous growth in placement of retrievable IVC filters in the past decade yet the majority of the devices are not removed. Unretrieved IVC filters have several well-known complications that increase in frequency as the filter dwell time increases...
December 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28081148/characterization-of-multi-drug-resistant-enterococcus-faecalis-isolated-from-cephalic-recording-chambers-in-research-macaques-macaca-spp
#14
Stephanie E Woods, Mia T Lieberman, Francois Lebreton, Elise Trowel, César de la Fuente-Núñez, Joanne Dzink-Fox, Michael S Gilmore, James G Fox
Nonhuman primates are commonly used for cognitive neuroscience research and often surgically implanted with cephalic recording chambers for electrophysiological recording. Aerobic bacterial cultures from 25 macaques identified 72 bacterial isolates, including 15 Enterococcus faecalis isolates. The E. faecalis isolates displayed multi-drug resistant phenotypes, with resistance to ciprofloxacin, enrofloxacin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, bacitracin, and erythromycin, as well as high-level aminoglycoside resistance...
2017: PloS One
https://www.readbyqxmd.com/read/28076593/brachial-insertion-of-fully-implantable-venous-catheters-for-chemotherapy-complications-and-quality-of-life-assessment-in-35-patients
#15
Igor Yoshio Imagawa Fonseca, Mariana Krutman, Kenji Nishinari, Guilherme Yazbek, Marcelo Passos Teivelis, Guilherme André Zottele Bomfim, Rafael Noronha Cavalcante, Nelson Wolosker
Objective: To prospectively evaluate the perioperative safety, early complications and satisfaction of patients who underwent the implantation of central catheters peripherally inserted via basilic vein. Methods: Thirty-five consecutive patients with active oncologic disease requiring chemotherapy were prospectively followed up after undergoing peripheral implantation of indwelling venous catheters, between November 2013 and June 2014. The procedures were performed in the operating room by the same team of three vascular surgeons...
October 2016: Einstein
https://www.readbyqxmd.com/read/28069496/probiotic-e-coli-nissle-1917-biofilms-on-silicone-substrates-for-bacterial-interference-against-pathogen-colonization
#16
Quan Chen, Zhiling Zhu, Jun Wang, Analette I Lopez, Siheng Li, Amit Kumar, Fei Yu, Haoqing Chen, Chengzhi Cai, Lijuan Zhang
Bacterial interference is an alternative strategy to fight against device-associated bacterial infections. Pursuing this strategy, a non-pathogenic bacterial biofilm is used as a live, protective barrier to fence off pathogen colonization. In this work, biofilms formed by probiotic Escherichia coli strain Nissle 1917 (EcN) are investigated for their potential for long-term bacterial interference against infections associated with silicone-based urinary catheters and indwelling catheters used in the digestive system, such as feeding tubes and voice prostheses...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28068356/mrsa-prevalence-and-risk-factors-among-health-personnel-and-residents-in-nursing-homes-in-hamburg-germany-a-cross-sectional-study
#17
Claudia Peters, Madeleine Dulon, Olaf Kleinmüller, Albert Nienhaus, Anja Schablon
INTRODUCTION: The increase of multidrug-resistant organisms in hospitals causes problems in nursing homes. Staff in geriatric nursing homes are at greater risk of MRSA colonisation. The aim of the study was to describe the occupational exposure to MRSA among health personnel in geriatric nursing. METHODS: A point prevalence survey was conducted among health personnel and residents of geriatric nursing homes within the greater Hamburg district. Nasal swabs and, where relevant, wound swabs were collected for the screening survey...
2017: PloS One
https://www.readbyqxmd.com/read/28056743/antimicrobial-peptides-for-the-control-of-biofilm-formation
#18
Mercedes González Moreno, Lisa Lombardi, Mariagrazia Di Luca
Antimicrobial peptides (AMPs) are an abundant and varied group of molecules recognized as the most ancient components of the innate immune system. They are found in a wide group of organisms including bacteria, plants and animals as a defense mechanism against different kinds of infectious pathogens. Over the past two decades, a fast-growing number of AMPs have been identified/designed and their wide-spectrum antimicrobial activity has been deeply investigated. In recent years, there has been an increasing interest in the use of AMPs as alternative anti-biofilm molecules for the control of biofilm-related infections...
January 5, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28045921/peripheral-venous-catheter-related-adverse-events-evaluation-from-a-multicentre-epidemiological-study-in-france-the-catheval-project
#19
Katiuska Miliani, Raphaël Taravella, Denis Thillard, Valérie Chauvin, Emmanuelle Martin, Stéphanie Edouard, Pascal Astagneau
INTRODUCTION: Peripheral venous catheters (PVC) are medical devices most frequently used during hospital care. Although the frequency of specific PVC-related adverse events (PVCAEs) has been reported, the global risk related to the insertion of this device is poorly estimated. The aim of this study is to determine the incidence of PVCAEs during the indwell time, after catheter removal, and to identify practice-mirroring risk factors. METHODS: A prospective observational study was conducted as a part of a research project, called CATHEVAL, in one surgery ward and four medicine wards from three public general tertiary care hospitals in Northern France that were invited to participate between June-2013 and June-2014...
2017: PloS One
https://www.readbyqxmd.com/read/28003353/this-article-has-been-temporarily-withdrawn-and-will-be-reposted-within-a-supplement-in-2017-the-press-apologizes-for-any-inconvenience-caused
#20
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 21, 2016: Journal of Infectious Diseases
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