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Do bugs need drugs

Liao Y Chen
BACKGROUND: Plasmodium falciparum is the parasite that causes the most severe form of malaria responsible for nearly a million deaths a year. Currently, science has been established about its cellular structures, its metabolic processes, and even the molecular structures of its intrinsic membrane proteins responsible for transporting water, nutrient, and waste molecules across the parasite plasma membrane (PPM). PRESENTATION OF THE HYPOTHESIS: I hypothesize that Plasmodium falciparum has an Achilles' heel that can be attacked with erythritol, the well-known sweetener that is classified as generally safe...
April 5, 2014: Malaria Chemotherapy, Control & Elimination
John M Conly
UNLABELLED: HASH(0x4033258) BACKGROUND: In Canada, systematic efforts for controlling antibiotic resistance began in 1997 following a national Consensus Conference. The Canadian strategy produced 27 recommendations, one of which was the formation of the Canadian Committee on Antibiotic Resistance (CCAR). In addition several other organizations began working on a national or provincial basis over the ensuing years on one or more of the 3 identified core areas of the strategy...
2012: Antimicrobial Resistance and Infection Control
Rachel M McKay, Linda Vrbova, Elaine Fuertes, Mei Chong, Samara David, Kim Dreher, Dale Purych, Edith Blondel-Hill, Bonnie Henry, Fawziah Marra, Perry Rw Kendall, David M Patrick
OBJECTIVE: Antibiotic resistance is accelerated by the overuse of antibiotics. Do Bugs Need Drugs? is an educational program adapted in British Columbia to target both the public and health care professionals, with the aim of reducing unnecessary prescribing. The current article presents a descriptive evaluation of the impact of the program over the first four years. METHOD: Program implementation was measured by the amount of educational material distributed and the level of participation in educational sessions...
2011: Canadian Journal of Infectious Diseases & Medical Microbiology
George R Golding, Brian Quinn, Kirsten Bergstrom, Donna Stockdale, Shirley Woods, Mandiangu Nsungu, Barb Brooke, Paul N Levett, Greg Horsman, Ryan McDonald, Brian Szklarczuk, Steve Silcox, Shirley Paton, Mary Carson, Michael R Mulvey, James Irvine
BACKGROUND: Surveillance examining the incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was conducted over 8 years beginning in 2001 in three health regions covering the northern half of Saskatchewan. The annual rate of individuals reported with CA-MRSA infection in these regions dramatically increased from 8.2 per 10,000 population in 2001 (range to 4.4-10.1 per 10,000) to 168.1 per 10,000 in 2006 (range 43.4-230.9 per 10,000). To address this issue, a team of community members, healthcare professionals, educators and research scientists formed a team called "the Northern Antibiotic Resistance Partnership" (NARP) to develop physician, patient, community, and school based educational materials in an attempt to limit the spread of CA-MRSA...
2012: BMC Public Health
Elaine Isabelle Fuertes, Bonnie Henry, Fawziah Marra, Hubert Wong, David M Patrick
OBJECTIVE: "Do Bugs Need Drugs" (DBND) is a community education program that was implemented in British Columbia (BC) in September 2005 to decrease inappropriate antibiotic use. This study conducted descriptive analyses of the association between DBND and changes in overall, pediatric, drug-specific, and indication-specific antibiotic utilization rates in Vancouver, BC. METHODS: Utilization data on all oral solid and liquid antibiotics classified as "antibacterials for systemic use" were obtained from BC PharmaNet for the years 1996 to 2008...
July 2010: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
Deirdre M Murphy, Vasily V Ivanenkov, Terence L Kirley
A newly discovered human analogue of a bed bug apyrase, which we named hSCAN-1 for human soluble calcium-activated nucleotidase-1, was expressed in bacteria, refolded from inclusion bodies, purified, and characterized. This apyrase, which is distinct from the eNTPDases exemplified by the endothelial CD39 (NTPDase1) apyrase, is a 38 kDa monomeric enzyme capable of hydrolyzing a variety of nucleoside di- and triphosphates, but not monophosphates. Preferred substrates include GDP, UDP, and IDP, with a pH optimum for activity between 6 and 7...
March 4, 2003: Biochemistry
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