keyword
MENU ▼
Read by QxMD icon Read
search

Spreading depolarization

keyword
https://www.readbyqxmd.com/read/29063300/delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-beyond-vasospasm-and-towards-a-multifactorial-pathophysiology
#1
REVIEW
Joseph R Geraghty, Fernando D Testai
PURPOSE OF REVIEW: Delayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and animal models have since supported the notion of a multifactorial pathophysiology of DCI. This review summarizes some of the main mechanisms under investigation including cerebral vascular dysregulation, microthrombosis, cortical spreading depolarizations, and neuroinflammation...
October 23, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29046294/local-ca-2-coupling-between-mitochondria-and-sarcoplasmic-reticulum-following-depolarization-in-guinea-pig-urinary-bladder-smooth-muscle-cells
#2
Hisao Yamamura, Keisuke Kawasaki, Sou Inagaki, Yoshiaki Suzuki, Yuji Imaizumi
Spatiotemporal changes in cytosolic Ca(2+) concentration ([Ca(2+)]c) trigger a number of physiological functions in smooth muscle cells (SMCs). We previously imaged Ca(2+)-induced Ca(2+) release following membrane depolarization as local Ca(2+) transients, Ca(2+) hotspots, in subplasmalemmal regions. In this study, the physiological significance of mitochondria on local Ca(2+) signaling was examined. Cytosolic and mitochondrial Ca(2+) images following depolarization or action potentials were recorded in single SMCs from the guinea pig urinary bladder using a fast-scanning confocal fluorescent microscope...
October 18, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29041816/enhanced-susceptibility-to-cortical-spreading-depression-in-two-types-of-na-k-atpase-%C3%AE-2-subunit-deficient-mice-as-a-model-of-familial-hemiplegic-migraine-2
#3
Miyuki Unekawa, Keiko Ikeda, Yutaka Tomita, Kiyoshi Kawakami, Norihiro Suzuki
Background Patients with familial hemiplegic migraine type 2 (FHM2) have a mutated ATP1A2 gene (encoding Na(+),K(+)-ATPase α2 subunit) and show prolonged migraine aura. Cortical spreading depression (CSD), which involves mass depolarization of neurons and astrocytes that propagates slowly through the gray matter, is profoundly related to aura. Methods In two types of Atp1a2-defective heterozygous mice, Atp1a2(tm1Kwk) (C-KO) and Atp1a2(tm2Kwk) (N-KO), the sensitivity and responsiveness to CSD were examined under urethane anesthesia...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29023523/the-role-of-glutamate-in-neuronal-ion-homeostasis-a-case-study-of-spreading-depolarization
#4
Niklas Hübel, Mahshid S Hosseini-Zare, Jokūbas Žiburkus, Ghanim Ullah
Simultaneous changes in ion concentrations, glutamate, and cell volume together with exchange of matter between cell network and vasculature are ubiquitous in numerous brain pathologies. A complete understanding of pathological conditions as well as normal brain function, therefore, hinges on elucidating the molecular and cellular pathways involved in these mostly interdependent variations. In this paper, we develop the first computational framework that combines the Hodgkin-Huxley type spiking dynamics, dynamic ion concentrations and glutamate homeostasis, neuronal and astroglial volume changes, and ion exchange with vasculature into a comprehensive model to elucidate the role of glutamate uptake in the dynamics of spreading depolarization (SD)-the electrophysiological event underlying numerous pathologies including migraine, ischemic stroke, aneurysmal subarachnoid hemorrhage, intracerebral hematoma, and trauma...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28981616/spreading-depression-promotes-astrocytic-calcium-oscillations-and-enhances-gliotransmission-to-hippocampal-neurons
#5
Dong Chuan Wu, Rita Yu-Tzu Chen, Ting-Chun Cheng, Yao-Chang Chiang, Mei-Lin Shen, Li-Ling Hsu, Ning Zhou
Spreading depression (SD) is a pathophysiological phenomenon characterized by propagating waves of profound neuronal and glial depolarization in central nervous system gray matter. Although SD is primarily mediated by neurons with a subsequent astrocytic response, it remains unclear how astrocytic activity is modulated after SD and how altered astrocyte signaling contribute to neuronal excitability. Here, we report that after the concurrent Ca2+ wave, SD enhanced astrocytic activity by promoting a secondary period of Ca2+ oscillations...
August 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28969392/spreading-depolarization-and-acute-ischaemia-in-subarachnoid-haemorrhage-the-role-of-mass-depolarization-waves
#6
Shivani Ghoshal, Jan Claassen
No abstract text is available yet for this article.
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28969382/subarachnoid-blood-acutely-induces-spreading-depolarizations-and-early-cortical-infarction
#7
Jed A Hartings, Jonathan York, Christopher P Carroll, Jason M Hinzman, Eric Mahoney, Bryan Krueger, Maren K L Winkler, Sebastian Major, Viktor Horst, Paul Jahnke, Johannes Woitzik, Vasilis Kola, Yifeng Du, Matthew Hagen, Jianxiong Jiang, Jens P Dreier
No abstract text is available yet for this article.
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28962806/cortical-spreading-depression-and-ischemia-in-neurocritical-patients
#8
REVIEW
Néstor Wainsztein, Federico Rodríguez Lucci
Spreading depolarization in cerebral cortex is associated with swelling of neurons, distortion of dendritic spines, massive ion translocation with a large change of the slow electrical potential, and silencing of brain electrical activity. The term spreading depression represents a wave of spontaneous activity of the electrocorticogram that propagates through contiguous cerebral gray matter at a characteristic velocity. Spreading depression is a consequence of cortical spreading depolarization. Therefore, spreading depolarization is not always accompanied by spreading depression and the terms are not synonymous...
November 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28951235/intranasally-administered-igf-1-inhibits-spreading-depression-in-vivo
#9
Yelena Y Grinberg, Lois A Zitzow, Richard P Kraig
Spreading depression (SD) is a wave of cellular depolarization that travels slowly through susceptible gray matter brain areas. SD is the most likely cause of migraine aura and perhaps migraine pain, and is a well-accepted animal model of migraine. Identification of therapeutics that can prevent SD may have clinical relevance toward migraine treatment. Here we show that insulin-like growth factor-1 (IGF-1) significantly inhibited neocortical SD in vivo after intranasal delivery to rats. A single dose of IGF-1 inhibited SD within an hour, and continued to protect for at least seven days thereafter...
December 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28948141/simulation-of-spreading-depolarization-trajectories-in-cerebral-cortex-correlation-of-velocity-and-susceptibility-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#10
Denny Milakara, Cristian Grozea, Markus Dahlem, Sebastian Major, Maren K L Winkler, Janos Lückl, Michael Scheel, Vasilis Kola, Karl Schoknecht, Svetlana Lublinsky, Alon Friedman, Peter Martus, Jed A Hartings, Johannes Woitzik, Jens P Dreier
In many cerebral grey matter structures including the neocortex, spreading depolarization (SD) is the principal mechanism of the near-complete breakdown of the transcellular ion gradients with abrupt water influx into neurons. Accordingly, SDs are abundantly recorded in patients with traumatic brain injury, spontaneous intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage (aSAH) and malignant hemispheric stroke using subdural electrode strips. SD is observed as a large slow potential change, spreading in the cortex at velocities between 2 and 9 mm/min...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28941738/spreading-depolarization-is-not-an-epiphenomenon-but-the-principal-mechanism-of-the-cytotoxic-edema-in-various-gray-matter-structures-of-the-brain-during-stroke
#11
REVIEW
Jens P Dreier, Coline L Lemale, Vasilis Kola, Alon Friedman, Karl Schoknecht
Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures that only occurs under pathological conditions. In the present paper, we summarize the evidence from several decades of research that SD and cytotoxic edema in these structures are largely overlapping terms. SD/cytotoxic edema is a toxic state that - albeit initially reversible - leads eventually to cellular death when it is persistent. Both hemorrhagic and ischemic stroke are among the most prominent causes of SD/cytotoxic edema...
September 21, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28928441/effects-of-anti-epileptic-drugs-on-spreading-depolarization-induced-epileptiform-activity-in-mouse-hippocampal-slices
#12
Ching-Huei Lin, Shih-Pin Hsu, Ting-Chun Cheng, Chin-Wei Huang, Yao-Chang Chiang, I-Han Hsiao, Ming-Hsueh Lee, Mei-Lin Shen, Dong Chuan Wu, Ning Zhou
Epilepsy and spreading depolarization (SD) are both episodic brain disorders and often exist together in the same individual. In CA1 pyramidal neurons of mouse hippocampal slices, induction of SD evoked epileptiform activities, including the ictal-like bursts, which occurred during the repolarizing phase of SD, and the subsequent generation of paroxysmal depolarization shifts (PDSs), which are characterized by mild depolarization plateau with overriding spikes. The duration of the ictal-like activity was correlated with both the recovery time and the depolarization potential of SD, whereas the parameters of PDSs were not significantly correlated with the parameters of SD...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28925885/spreading-depolarization-waves-in-neurological-diseases-a-short-review-about-its-pathophysiology-and-clinical-relevance
#13
Yağmur Çetin Taş, İhsan Solaroğlu, Yasemin Gürsoy-Özdemir
Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28916374/amp-activated-protein-kinase-protects-against-anoxia-in-drosophila-melanogaster
#14
Justin J Evans, Chengfeng Xiao, R Meldrum Robertson
During anoxia, proper energy maintenance is essential in order to maintain neural operation. Starvation activates AMP-activated protein kinase (AMPK), an evolutionarily conserved indicator of cellular energy status, in a cascade which modulates ATP production and consumption. We investigated the role of energetic status on anoxia tolerance in Drosophila and discovered that starvation or AMPK activation increases the speed of locomotor recovery from an anoxic coma. Using temporal and spatial genetic targeting we found that AMPK in the fat body contributes to starvation-induced fast locomotor recovery, whereas, under fed conditions, disrupting AMPK in oenocytes prolongs recovery...
December 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28868043/metabolomics-profiling-as-a-diagnostic-tool-in-severe-traumatic-brain-injury
#15
REVIEW
Jussi P Posti, Alex M Dickens, Matej Orešič, Tuulia Hyötyläinen, Olli Tenovuo
Traumatic brain injury (TBI) is a complex disease with a multifaceted pathophysiology. Impairment of energy metabolism is a key component of secondary insults. This phenomenon is a consequence of multiple potential mechanisms including diffusion hypoxia, mitochondrial failure, and increased energy needs due to systemic trauma responses, seizures, or spreading depolarization. The degree of disturbance in brain metabolism is affected by treatment interventions and reflected in clinical patient outcome. Hence, monitoring of these secondary events in peripheral blood will provide a window into the pathophysiological course of severe TBI...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28864364/role-of-astrocyte-connexin-hemichannels-in-cortical-spreading-depression
#16
REVIEW
Maximiliano Rovegno, Juan C Sáez
Cortical spreading depression (CSD) is an intriguing phenomenon consisting of massive slow brain depolarizations that affects neurons and glial cells. It has been recognized since 1944, but its pathogenesis has only been uncovered during the last decade. Acute brain injuries can be further complicated by CSD in >50% of severe cases. This phenomenon is repetitive and produces a metabolic overload that increments secondary damage. Propagation of CSD is known to be linked to excitotoxicity, but the mechanisms associated with its initiation remain less understood...
August 31, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28860653/chill-coma-in-the-locust-locusta-migratoria-is-initiated-by-spreading-depolarization-in-the-central-nervous-system
#17
R Meldrum Robertson, Kristin E Spong, Phinyaphat Srithiphaphirom
The ability of chill-sensitive insects to function at low temperatures limits their geographic ranges. They have species-specific temperatures below which movements become uncoordinated prior to entering a reversible state of neuromuscular paralysis. In spite of decades of research, which in recent years has focused on muscle function, the role of neural mechanisms in determining chill coma is unknown. Spreading depolarization (SD) is a phenomenon that causes a shutdown of neural function in the integrating centres of the central nervous system...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842982/novel-therapeutic-targets-against-spreading-depression
#18
REVIEW
Shih-Pin Chen, Cenk Ayata
Migraine is among the most prevalent and disabling neurological diseases in the world. Cortical spreading depression (SD) is an intense wave of neuronal and glial depolarization underlying migraine aura, and a headache trigger, which has been used as an experimental platform for drug screening in migraine. Here, we provide an overview of novel therapeutic targets that show promise to suppress SD, such as acid-sensing ion channels, casein kinase Iδ, P2X7-pannexin 1 complex, and neuromodulation, and outline the experimental models and essential quality measures for rigorous and reproducible efficacy testing...
October 2017: Headache
https://www.readbyqxmd.com/read/28842440/age-related-impairment-of-metabo-vascular-coupling-during-cortical-spreading-depolarization
#19
Stéphane Marinesco, Zoltán Ungvári, Veronica Galvan
Cortical spreading depolarizations (SDs) may lead to long-lasting alterations in cerebral blood flow (CBF), which contribute to neuronal dysfunction and hypoxic tissue injury. There is growing evidence to suggest that age-related structural and functional alterations of the neurovascular unit significantly increase both the incidence of SDs and aggravate their functional consequences. Recent studies suggest that metabolic signaling plays a major role in modulating cerebral blood flow responses evoked by SDs and provide critical evidence that aging considerably weakens metabovascular coupling with SD...
August 25, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28820571/comparison-of-spreading-depolarizations-in-the-motor-cortex-and-nucleus-accumbens-similar-patterns-of-oxygen-responses-and-the-role-of-dopamine
#20
Caddy N Hobbs, Gordon Holzberg, Akira S Min, R Mark Wightman
Spreading depolarizations (SD) are pathophysiological phenomena that spontaneously arise in traumatized neural tissue and can promote cellular death. Most investigations of SD are performed in the cortex, a brain region that is susceptible to these depolarizing waves and accessible via a variety of monitoring techniques. Here, we describe SD responses in the cortex and the deep brain region of the nucleus accumbens (NAc) of the anesthetized rat with a minimally invasive, implantable sensor. With high temporal resolution, we characterize the time course of oxygen responses to SD in relation to the electrophysiological depolarization signal...
September 5, 2017: ACS Chemical Neuroscience
keyword
keyword
35762
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"