Philippe-Henri Secretan, Victoire Vieillard, Olivier Thirion, Maxime Annereau, Hassane Sadou Yayé, Alain Astier, Muriel Paul, Thibaud Damy, Bernard Do
In vitro studies have shown that epigallocatechin gallate (EGCG), the most potent antioxidant of the green tea polyphenol catechins, is able to effectively prevent the formation of amyloid plaques and induce their clearance. However, its high chemical reactivity promotes high chemical instability, which represents a major obstacle for the development of pharmaceutical forms containing solubilized EGCG, an essential condition for a better systemic passage via the oral route. After discovering that EGCG forms a deep eutectic with choline chloride, we exploited this property to formulate and patent liquid-filled capsules containing 200-800 mg of soluble EGCG in easy-to-administer sizes...
February 9, 2023: Antioxidants (Basel, Switzerland)