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EGCG AL Amyloidosis

Angel E Pelaez-Aguilar, Lina Rivillas-Acevedo, Leidys French-Pacheco, Gilberto Valdes-Garcia, Roberto Maya-Martinez, Nina Pastor, Carlos Amero
Light chain amyloidosis (AL) is a deadly disease characterized by the deposition of monoclonal immunoglobulin light chains as insoluble amyloid fibrils in different organs and tissues. Germ line λ VI has been closely related to this condition; moreover, the R24G mutation is present in 25% of the proteins of this germ line in AL patients. In this work, five small molecules were tested as inhibitors of the formation of amyloid fibrils from the 6aJL2-R24G protein. We have found by thioflavin T fluorescence and transmission electron microscopy that EGCG inhibits 6aJL2-R24G fibrillogenesis...
August 18, 2015: Biochemistry
Derliz Mereles, Sebastian J Buss, Stefan E Hardt, Werner Hunstein, Hugo A Katus
BACKGROUND: Amyloid light chain (AL) amyloidosis is a rare disease with poor prognosis and limited therapeutic alternatives. Recently, one clinical case with cardiac involvement, as well as a compelling evidence of green tea polyphenol, epigallocatechin-3-gallate (EGCG), inducing the formation of benign aggregation products that do not polymerize into fibrils were published. This is a report of the cardiac effects of green tea consumption in these patients. METHODS: Patients with known cardiac involvement in AL amyloidosis were examined by routine cardiovascular examinations that took place every 3-6 months...
August 2010: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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