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JOURNAL ARTICLE
E Pleasance, A Bohm, L M Williamson, J M T Nelson, Y Shen, M Bonakdar, E Titmuss, V Csizmok, K Wee, S Hosseinzadeh, C J Grisdale, C Reisle, G A Taylor, E Lewis, M R Jones, D Bleile, S Sadeghi, W Zhang, A Davies, B Pellegrini, T Wong, R Bowlby, S K Chan, K L Mungall, E Chuah, A J Mungall, R A Moore, Y Zhao, B Deol, A Fisic, A Fok, D A Regier, D Weymann, D F Schaeffer, S Young, S Yip, K Schrader, N Levasseur, S K Taylor, X Feng, A Tinker, K J Savage, S Chia, K Gelmon, S Sun, H Lim, D J Renouf, S J M Jones, M A Marra, J Laskin
BACKGROUND: Recent advances are enabling delivery of precision genomic medicine to cancer clinics. While the majority of approaches profile panels of selected genes or hotspot regions, comprehensive data provided by whole-genome and transcriptome sequencing and analysis (WGTA) present an opportunity to align a much larger proportion of patients to therapies. PATIENTS AND METHODS: Samples from 570 patients with advanced or metastatic cancer of diverse types enrolled in the Personalized OncoGenomics (POG) program underwent WGTA...
September 2022: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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JOURNAL ARTICLE
Katherine Dixon, Sean Young, Yaoqing Shen, My Linh Thibodeau, Alexandra Fok, Erin Pleasance, Eric Zhao, Martin Jones, Geraldine Aubert, Linlea Armstrong, Alice Virani, Dean Regier, Karen Gelmon, Dan Renouf, Stephen Chia, Ian Bosdet, S Rod Rassekh, Rebecca J Deyell, Stephen Yip, Ana Fisic, Emma Titmuss, Shirin Abadi, Steven J M Jones, Sophie Sun, Aly Karsan, Marco Marra, Janessa Laskin, Howard Lim, Kasmintan A Schrader
Inherited genetic variation has important implications for cancer screening, early diagnosis, and disease prognosis. A role for germline variation has also been described in shaping the molecular landscape, immune response, microenvironment, and treatment response of individual tumors. However, there is a lack of consensus on the handling and analysis of germline information that extends beyond known or suspected cancer susceptibility in large-scale cancer genomics initiatives. As part of the Personalized OncoGenomics program in British Columbia, we performed whole-genome and transcriptome sequencing in paired tumor and normal tissues from advanced cancer patients to characterize the molecular tumor landscape and identify putative targets for therapy...
October 2020: JNCI Cancer Spectrum
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COMMENT
Antica Duletić-Načinović, Vedrana Gačić, Toni Valković, Ksenija Lučin, Elizabeta Fišić, Marta Žuvić-Butorac, Irena Seili-Bekafigo, Nives Jonjić
BACKGROUND: Diffuse large B-cell lymphomas (DLBCL) are heterogeneous diseases, and the identification of additional DLBCL risk factors is especially important. METHODS: In this pilot study, we determined pretreatment serum levels of vascular endothelial growth factor (VEGF), osteopontin (OPN) and macrophage chemotactic protein-1 (MCP-1) in 67 newly diagnosed DLBCL patients before treatment with standard chemoimmunotherapy and in 30 healthy persons. RESULTS: Serum levels of all three cytokines were significantly elevated in untreated patients compared to controls...
2016: Acta Haematologica
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