Oliver J Liakopoulos, Elmar W Kuhn, Martin Hellmich, Markus Schlömicher, Justus Strauch, Wilko Reents, Anno Diegeler, Matthias Thielmann, Daniel Wendt, Jochen Börgermann, Jan F Gummert, Christian Stoppe, Andreas Goetzenich, Sven Martens, Hermann Reichenspurner, Jens Wippermann, Hannes Reuter, Yeong-Hoon Choi, Thorsten Wahlers
AIMS: Evidence suggests that a high-dose statin loading before a percutaneous coronary revascularization improves outcomes in patients receiving long-term statins. This study aimed to analyse the effects of such an additional statin therapy before surgical revascularization. METHODS AND RESULTS: This investigator-initiated, randomized, double-blind, and placebo-controlled trial was conducted from November 2012 to April 2019 at 14 centres in Germany. Adult patients (n = 2635) with a long-term statin treatment (≥30 days) who were scheduled for isolated coronary artery bypass grafting (CABG) were randomly assigned to receive a statin-loading therapy or placebo at 12 and 2 h prior to surgery using a web-based system...
July 1, 2023: European Heart Journal