keyword
https://read.qxmd.com/read/33418377/longitudinal-course-of-depressive-symptom-severity-among-youths-with-bipolar-disorders-moderating-influences-of-sustained-attention-and-history-of-child-maltreatment
#21
JOURNAL ARTICLE
Rachel A Vaughn-Coaxum, John Merranko, Boris Birmaher, Daniel P Dickstein, Danella Hafeman, Jessica C Levenson, Fangzi Liao, Mary Kay Gill, Heather Hower, Benjamin I Goldstein, Michael Strober, Neal D Ryan, Rasim Diler, Martin B Keller, Shirley Yen, Lauren M Weinstock, David Axelson, Tina R Goldstein
BACKGROUND: Pediatric bipolar disorders are often characterized by disruptions in cognitive functioning, and exposure to child maltreatment (e.g., physical and sexual abuse) is associated with a significantly poorer course of illness. Although clinical and developmental research has shown maltreatment to be robustly associated with poorer cognitive functioning, it is unclear whether maltreatment and cognitive function jointly influence the clinical course of bipolar symptoms. METHODS: This secondary analysis examined moderating effects of lifetime childhood physical and sexual abuse, and cognitive disruptions (sustained attention, affective information processing), on longitudinal ratings of depression symptom severity in youths from the Course and Outcome of Bipolar Youth (COBY) study, examined from intake (M = 12...
March 1, 2021: Journal of Affective Disorders
https://read.qxmd.com/read/33139703/emotional-regulation-neural-circuitry-abnormalities-in-adult-bipolar-disorder-dissociating-effects-of-long-term-depression-history-from-relationships-with-present-symptoms
#22
JOURNAL ARTICLE
Michele A Bertocci, Jeffrey Bergman, Joao Paulo Lima Santos, Satish Iyengar, Lisa Bonar, Mary Kay Gill, Halimah Abdul-Waalee, Genna Bebko, Richelle Stiffler, Jeanette Lockovich, Haris Aslam, Cecile Ladouceur, John Merranko, Rasim Diler, Boris Birmaher, Amelia Versace, Mary L Phillips
Bipolar disorder (BD) is common and debilitating and confounding effects of depression history on neural activity in BD are unknown. We aimed to dissociate neural activity reflecting past depression-load vs. present symptom severity using the Course and Outcome of Bipolar Youth (COBY), a prospective longitudinal cohort study of pediatric-onset BD. In n = 54 COBY (18-32 years), we modeled depression scores over time (up to 17.5 years) using a standardized autoregressive moving average (ARMA) model, followed by k-means cluster analysis...
November 2, 2020: Translational Psychiatry
https://read.qxmd.com/read/33063526/changes-to-the-psychiatric-chatbot-landscape-a-systematic-review-of-conversational-agents-in-serious-mental-illness-changements-du-paysage-psychiatrique-des-chatbots-une-revue-syst%C3%A3-matique-des-agents-conversationnels-dans-la-maladie-mentale-s%C3%A3-rieuse
#23
JOURNAL ARTICLE
Aditya Nrusimha Vaidyam, Danny Linggonegoro, John Torous
OBJECTIVE: The need for digital tools in mental health is clear, with insufficient access to mental health services. Conversational agents, also known as chatbots or voice assistants, are digital tools capable of holding natural language conversations. Since our last review in 2018, many new conversational agents and research have emerged, and we aimed to reassess the conversational agent landscape in this updated systematic review. METHODS: A systematic literature search was conducted in January 2020 using the PubMed, Embase, PsychINFO, and Cochrane databases...
October 16, 2020: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://read.qxmd.com/read/32798619/brain-derived-neurotrophic-factor-in-bipolar-disorder-associations-with-age-at-onset-and-illness-duration
#24
JOURNAL ARTICLE
Burak Baykara, Dogukan Koc, Halil Resmi, Pınar Akan, Zeliha Tunca, Aysegul Ozerdem, Deniz Ceylan, Neslihan Gurz Yalcın, Nagihan Cevher Binici, Sevay Alsen Guney, Esther Mesman, Manon H J Hillegers, Neslihan Inal Emiroglu
Bipolar disorder (BD) is a heterogeneous disorder that contains neurodevelopmental differences. Defining homogeneous subgroups of BD patients by using age at onset (AAO) as a specifier may promote the classification of biomarkers. This study compares peripheral BDNF levels between pediatric and adult BD patients to investigate the associations between BDNF levels, AAO, and illness duration. We enrolled two groups of euthymic patients, those with pediatric BD (n = 39) and those with adult BD (n = 31), as well as a group of healthy controls (HCs) (n = 90)...
August 13, 2020: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/32712799/altered-spatiotemporal-consistency-of-corticolimbic-circuitry-in-euthymic-pediatric-bipolar-disorder
#25
JOURNAL ARTICLE
Yongxin Guo, Jinfeng Wang, Qing Jiao, Weifang Cao, Dong Cui, Weijia Gao, Jianfeng Qiu, Linyan Su, Guangming Lu
Bipolar disorder (BD) is a life-threatening illness which clinically defined by an alternating pattern of depressive and manic episodes with a separated period of euthymia. It remains unknown about the consistency of temporal-spatial spontaneous brain activity in euthymic patients, especially in pediatric BD (PBD) patients.Resting-state fMRI signals of sixteen euthymic PBD patients and 16 healthy controls were processed and FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) and functional connectivity were calculated in the present study...
July 25, 2020: Brain Imaging and Behavior
https://read.qxmd.com/read/32447355/clinical-picture-and-treatment-of-bipolar-affective-disorder-in-children-and-adolescents
#26
REVIEW
Lena Cichoń, Małgorzata Janas-Kozik, Andrzej Siwiec, Janusz K Rybakowski
Bipolar disorder (BD) is characterized by pathological changes in mood as well as recurring episodes of mania, hypomania, depression and mixed symptoms. In recent years, the number of BD diagnoses has risen considerably in children and adolescents. Itis believed that anaverage rate of prevalence of bipolar spectrum disorder in the pediatric population is 1.8%, and BD type I - 1.2%, and the prevalence of the disorder increases with the age of patients. Despite the same diagnostic criteria, there are premises that suggest thatthe symptoms of the disorder are present with a different frequency among children and adolescents than in adults...
March 29, 2020: Psychiatria Polska
https://read.qxmd.com/read/32404433/ed-visits-and-readmissions-after-follow-up-for-mental-health-hospitalization
#27
JOURNAL ARTICLE
Naomi S Bardach, Stephanie K Doupnik, Jonathan Rodean, Bonnie T Zima, James C Gay, Carol Nash, Yasas Tanguturi, Tumaini R Coker
OBJECTIVES: A national quality measure in the Child Core Set is used to assess whether pediatric patients hospitalized for a mental illness receive timely follow-up care. In this study, we examine the relationship between adherence to the quality measure and repeat use of the emergency department (ED) or repeat hospitalization for a primary mental health condition. METHODS: We used the Truven MarketScan Medicaid Database 2015-2016, identifying hospitalizations with a primary diagnosis of depression, bipolar disorder, psychosis, or anxiety for patients aged 6 to 17 years...
May 13, 2020: Pediatrics
https://read.qxmd.com/read/32008691/mixed-states-in-early-onset-bipolar-disorder
#28
REVIEW
Kirti Saxena, Sherin Kurian, Johanna Saxena, Adam Goldberg, Eugenia Chen, Alessio Simonetti
Pediatric bipolar disorder (PBD) is a severe and chronic illness. The occurrence of mixed symptoms might add further risk of recurrence of treatment resistance and suicidality. Early recognition and treatment of mixed symptoms might prevent illness progression and development of suicide attempts. This article provides an update on the epidemiology, clinical profile, and treatment of youth with PBD with mixed states. Mixed states in PBD are characterized by higher rates of suicide and more chronic symptoms, and are associated with younger age of onset and greater comorbidity...
March 2020: Psychiatric Clinics of North America
https://read.qxmd.com/read/31922663/metformin-add-on-vs-antipsychotic-switch-vs-continued-antipsychotic-treatment-plus-healthy-lifestyle-education-in-overweight-or-obese-youth-with-severe-mental-illness-results-from-the-impact-trial
#29
JOURNAL ARTICLE
Christoph U Correll, Linmarie Sikich, Gloria Reeves, Jacqueline Johnson, Courtney Keeton, Marina Spanos, Sandeep Kapoor, Kristin Bussell, Leslie Miller, Tara Chandrasekhar, Eva M Sheridan, Sara Pirmohamed, Shauna P Reinblatt, Cheryl Alderman, Abigail Scheer, Irmgard Borner, Terrence C Bethea, Sarah Edwards, Robert M Hamer, Mark A Riddle
Antipsychotics are used for many psychiatric conditions in youth. Although developmentally inappropriate weight gain and metabolic abnormalities, which are risk factors for premature cardiovascular mortality, are especially frequent in youth, optimal strategies to reduce pediatric antipsychotic-induced overweight/obesity are unclear. The Improving Metabolic Parameters in Antipsychotic Child Treatment (IMPACT) was a randomized, parallel group, 24-week clinical trial which enrolled overweight/obese, psychiatrically stable youth, aged 8-19 years, with a DSM-IV diagnosis of severe mental illness (schizophrenia spectrum disorder, bipolar spectrum disorder or psychotic depression), at four US universities...
February 2020: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://read.qxmd.com/read/31825249/cariprazine-in-youth-with-bipolar-and-psychotic-disorders-a-retrospective-chart-review
#30
JOURNAL ARTICLE
Ethan A Poweleit, Michaela Colestock, Eashwar C Kantemneni, Jeffrey R Strawn, Luis R Patino, Melissa P DelBello, Laura B Ramsey
Objective: To examine the potential effectiveness and tolerability of cariprazine in pediatric bipolar and psychotic disorders. Methods: We retrospectively reviewed the electronic health records of patients <21 years of age prescribed cariprazine to treat bipolar and psychotic disorders. Adverse effects, tolerability, therapeutic response (Clinical Global Impression-Improvement [CGI-I]), and severity of illness (Clinical Global Impression-Severity [CGI-S]) were determined through manual chart review. Results: We identified 16 patients aged 6-20 years who were treated with cariprazine (initial dose: 1...
December 11, 2019: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/31468317/dopamine-receptor-partial-agonists-for-the-treatment-of-bipolar-disorder
#31
REVIEW
Jean-Michel Azorin, Nicolas Simon
Bipolar disorder is a chronic, disabling, and costly illness with frequent relapses and recurrences, high rates of co-morbid conditions, and poor adherence to treatment. Mood stabilizers and antipsychotics are the cornerstones of treatment. Dopamine receptor partial agonists are a novel class of antipsychotic agents with original pharmacodynamic properties. Among them, two have been approved by the US Food and Drug Administration for the treatment of bipolar disorder. Aripiprazole (oral formulation) has been approved as monotherapy for the treatment of manic/mixed episodes in adult and pediatric populations and for maintenance treatment in adults, and as adjunctive treatment to mood stabilizers, for the acute treatment of manic/mixed episodes and for maintenance in adults...
October 2019: Drugs
https://read.qxmd.com/read/31123970/altered-regional-homogeneity-in-pediatric-bipolar-disorder-during-manic-and-euthymic-state-a-resting-state-fmri-study
#32
JOURNAL ARTICLE
Qian Xiao, Dong Cui, Qing Jiao, Yuan Zhong, Weifang Cao, Guangming Lu, Linyan Su
Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Little is known about the abnormalities in PBD in resting state, especially comparing manic with euthymic state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. Regional homogeneity (ReHo) was examined with resting-state fMRI on 22 manic PBD patients, 21 euthymic PBD patients and 19 healthy controls...
December 2019: Brain Imaging and Behavior
https://read.qxmd.com/read/31069923/longitudinal-outcomes-in-pediatric-and-adult-onset-bipolar-patients-compared-to-healthy-and-schizophrenia-controls
#33
JOURNAL ARTICLE
Mathilde Frahm Laursen, Jan B Valentin, Rasmus W Licht, Christoph U Correll, René Ernst Nielsen
OBJECTIVES: Comparing outcomes of bipolar disorder (BD) with schizophrenia (SCZ) and psychiatrically healthy controls (PHC), contrasting pediatric-onset with adult-onset disorders. METHODS: A nationwide cohort study, including patients with an incident diagnosis of BD or SCZ registered in the Danish National Patient Registry and corresponding PHCs. Outcomes were 1) duration of hospitalization, 2) psychiatric admissions, 3) psychiatric outpatient contacts, 4) bone-fracture-related healthcare contacts, 5) self-harm-related healthcare contacts (including suicide and non-suicidal self-injuries), and 6) criminal charges...
May 9, 2019: Bipolar Disorders
https://read.qxmd.com/read/30949082/attention-deficits-in-a-comorbidity-free-sample-of-euthymic-pediatric-bipolar-disorder
#34
JOURNAL ARTICLE
Nandini Banerjee, Shi-Kai Liu, Vinod K Sinha, Meera Jayaswal, Pushpal Desarkar
Attention deficits are considered one of the potential endophenotypic markers of Bipolar Disorder (BD). Pediatric bipolar disorder (PBD) likely has stronger genetic underpinnings than adult onset BD; therefore, demonstrating attention deficits in PBD can be both strategic and convincing in attesting their status as one of the potential endophenotypic markers of BD. However, unlike adult literature, uncertainty exists regarding the magnitude of attention deficits in PBD. In this regard, one key unresolved question is the potential impact of attention deficit hyperactivity disorder (ADHD)...
2019: Frontiers in Psychiatry
https://read.qxmd.com/read/30122926/post-hoc-analyses-of-asenapine-treatment-in-pediatric-patients-with-bipolar-i-disorder-efficacy-related-to-mixed-or-manic-episode-stage-of-illness-and-body-weight
#35
JOURNAL ARTICLE
Robert L Findling, Willie Earley, Trisha Suppes, Mehul Patel, Xiao Wu, Cheng-Tao Chang, Roger S McIntyre
Background: Patient characteristics and disease progression may affect response to pharmacologic intervention in bipolar I disorder. Asenapine is approved for acute treatment of manic/mixed episodes of bipolar I disorder in patients 10-17 years old. Post hoc analyses assessed asenapine efficacy in pediatric patients by current manic or mixed episode, number of lifetime episodes, and baseline body mass index (BMI). Patients and methods: Data were obtained from a 3-week, randomized, double-blind, placebo-controlled, parallel-group trial of asenapine 2...
2018: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/29946107/discrete-patterns-of-cortical-thickness-in-youth-with-bipolar-disorder-differentially-predict-treatment-response-to-quetiapine-but-not-lithium
#36
JOURNAL ARTICLE
Wenjing Zhang, Yuan Xiao, Huaiqiang Sun, L Rodrigo Patino, Maxwell J Tallman, Wade A Weber, Caleb M Adler, Christina Klein, Jeffrey R Strawn, Fabiano G Nery, Qiyong Gong, John A Sweeney, Su Lui, Melissa P DelBello
The need for treatment response predictive biomarkers is being increasingly recognized in children and adolescents with psychiatric disorders. Structural gray matter abnormalities as a predictor of treatment outcome in pediatric bipolar disorder have not been systematically investigated, especially early in the illness course. With a prospective longitudinal study design, the present study enrolled 52 bipolar adolescents with no history of treatment with mood stabilizers or a therapeutic dose of antipsychotic drugs and 31 healthy controls...
October 2018: Neuropsychopharmacology
https://read.qxmd.com/read/29872304/mothers-and-fathers-of-children-with-epilepsy-gender-differences-in-post-traumatic-stress-symptoms-and-correlations-with-mood-spectrum-symptoms
#37
JOURNAL ARTICLE
Claudia Carmassi, Martina Corsi, Carlo Antonio Bertelloni, Barbara Carpita, Camilla Gesi, Virginia Pedrinelli, Gabriele Massimetti, Diego Giampietro Peroni, Alice Bonuccelli, Alessandro Orsini, Liliana Dell'Osso
Background: Post-traumatic stress disorder (PTSD) and post-traumatic stress spectrum have been recently applied to understand the impact of life-threatening disease or injury in one's child; nevertheless, scant data are available on a particular chronic illness such as epilepsy whose phenotypic expression is seizures, which are acute, sudden, and unpredictable manifestations. Subjects with bipolar disorders or with mood spectrum symptoms demonstrated to be more vulnerable to develop PTSD in the aftermath of a trauma...
2018: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/29706155/the-workforce-shortage-of-child-and-adolescent-psychiatrists-is-it-time-for-a-different-approach
#38
EDITORIAL
Robert L Findling, Ekaterina Stepanova
Psychiatric disorders affect a large number of children around the world. Recent data have reported that approximately 10% to 13% of children have a serious emotional disturbance with significant functional impairment, suggesting that at least 1 in 10 children require mental health services.1,2 Approximately half the adults with mental illness received their diagnosis before 15 years of age3 and close to three fourths of mental health disorders start by the mid-20s.4 Mental illnesses are associated with a large disease burden because these conditions lead to increases in morbidity, mortality, and financial costs...
May 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/29651656/using-lithium-in-children-and-adolescents-with-bipolar-disorder-efficacy-tolerability-and-practical-considerations
#39
REVIEW
B Grant, J A Salpekar
Lithium has been an intriguing treatment option in psychiatry for over a century. While seemingly just a simple elemental compound, it has powerful treatment effects for both depression and bipolar disorder. The evidence base for treatment of pediatric bipolar disorder is relatively small, but, in recent years, additional clinical trial data have enabled lithium to re-emerge as a valuable and, in many cases, preferred treatment. Pharmacologically, lithium is complex, with varied effects at both intracellular and extracellular levels...
August 2018: Paediatric Drugs
https://read.qxmd.com/read/29550609/hippocampal-subfield-volumes-in-children-and-adolescents-with-mood-disorders
#40
JOURNAL ARTICLE
Jonika Tannous, Henrique Amaral-Silva, Bo Cao, Mon-Ju Wu, Giovana B Zunta-Soares, Iram Kazimi, Cristian Zeni, Benson Mwangi, Jair C Soares
The hippocampus has been implicated in various mood disorders, with global volume deficits consistently found in patient populations. The hippocampus, however, consists of anatomically distinct subfields, and examination of specific subfield differences may elucidate the possible molecular mechanisms behind psychiatric pathologies. Indeed, adult studies have reported smaller hippocampal subfield volumes in regions within the cornu ammonis (CA1 and CA4), dentate gyrus (DG), and hippocampal tails in both patients with Major Depressive Disorder (MDD) and Bipolar Disorder (BD) compared to healthy controls...
June 2018: Journal of Psychiatric Research
keyword
keyword
35740
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.