Christoph U Correll, Linmarie Sikich, Gloria Reeves, Jacqueline Johnson, Courtney Keeton, Marina Spanos, Sandeep Kapoor, Kristin Bussell, Leslie Miller, Tara Chandrasekhar, Eva M Sheridan, Sara Pirmohamed, Shauna P Reinblatt, Cheryl Alderman, Abigail Scheer, Irmgard Borner, Terrence C Bethea, Sarah Edwards, Robert M Hamer, Mark A Riddle
Antipsychotics are used for many psychiatric conditions in youth. Although developmentally inappropriate weight gain and metabolic abnormalities, which are risk factors for premature cardiovascular mortality, are especially frequent in youth, optimal strategies to reduce pediatric antipsychotic-induced overweight/obesity are unclear. The Improving Metabolic Parameters in Antipsychotic Child Treatment (IMPACT) was a randomized, parallel group, 24-week clinical trial which enrolled overweight/obese, psychiatrically stable youth, aged 8-19 years, with a DSM-IV diagnosis of severe mental illness (schizophrenia spectrum disorder, bipolar spectrum disorder or psychotic depression), at four US universities...
February 2020: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)