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Pediatric bipolar illness

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https://www.readbyqxmd.com/read/27871637/comparing-brain-morphometry-across-multiple-childhood-psychiatric-disorders
#1
Andrea L Gold, Melissa A Brotman, Nancy E Adleman, Sara N Lever, Elizabeth R Steuber, Stephen J Fromm, Sven C Mueller, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: In both children and adults, psychiatric illness is associated with structural brain alterations, particularly in the prefrontal cortex (PFC). However, most studies compare gray matter volume (GMV) in healthy volunteers (HVs) to one psychiatric group. We compared GMV among youth with anxiety disorders, bipolar disorder (BD), disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), and HVs. METHOD: 3-Tesla T1-weighted magnetic resonance imaging scans were acquired in 184 youths (39 anxious, 20 BD, 52 DMDD, 20 ADHD, and 53 HV)...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27461426/long-term-safety-of-asenapine-in-pediatric-patients-diagnosed-with-bipolar-i-disorder-a-50-week-open-label-flexible-dose-trial
#2
Robert L Findling, Ronald L Landbloom, Mary Mackle, Xiao Wu, Linda Snow-Adami, Kiki Chang, Suresh Durgam
BACKGROUND: Sublingually administered asenapine was approved in March 2015 by the United States Food and Drug Administration for patients aged 10-17 years with an acute manic or mixed episode associated with bipolar I disorder (BP-1). This is the first long-term safety and tolerability study of asenapine in this population. METHODS: Following the 3-week randomized, double-blind, placebo-controlled trial of patients aged 10-17 years with an acute manic or mixed episode associated with BP-1, patients could enroll in this flexible-dose (2...
October 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27419273/medication-adherence-among-adolescents-with-bipolar-disorder
#3
Tina R Goldstein, Megan Krantz, John Merranko, Matthew Garcia, Loren Sobel, Carlos Rodriguez, Antoine Douaihy, David Axelson, Boris Birmaher
OBJECTIVE: To examine medication adherence and associated factors among adolescents with bipolar disorder (BP) using both objective and subjective methods. METHOD: Participants were 21 adolescents with a primary BP diagnosis recruited from a pediatric specialty clinic. All participants were prescribed at least one psychotropic medication. Self- and parent-reported adherence were assessed monthly over 6 months. Objective data on medication adherence were gathered through an electronic weekly pillbox...
July 15, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27209073/bdnf-val66met-polymorphism-and-peripheral-protein-levels-in-pediatric-bipolar-disorder-and-attention-deficit-hyperactivity-disorder
#4
C P Zeni, S Tramontina, B W Aguiar, A Salatino-Oliveira, G F Pheula, A Sharma, L Stertz, C R Moreira Maia, M Hutz, F P Kapczinski, L A Rohde
OBJECTIVE: Frontiers between pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD) are not well defined. Few studies have addressed potentially different neurobiological factors between the two disorders. Brain-derived neurotrophic factor (BDNF) has been increasingly recognized for its etiologic and prognostic role in adult bipolar disorder (BD) studies. This study aimed to examine the BDNF gene polymorphism and potential alterations in BDNF serum levels in the pediatric ADHD patients with or without comorbid BD illness...
September 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27114896/age-associations-with-neural-processing-of-reward-anticipation-in-adolescents-with-bipolar-disorders
#5
Snežana Urošević, Monica Luciana, Jonathan B Jensen, Eric A Youngstrom, Kathleen M Thomas
Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27028966/efficacy-of-long-acting-injectable-antipsychotics-in-adolescents
#6
Stephanie Pope, Solomon G Zaraa
INTRODUCTION: The number of long-acting injectable antipsychotics (LAIA) has increased in recent years. The safety and efficacy of that treatment are not established in children. This study aims to address this gap of information by studying such treatments in a case series. METHODS: This retrospective chart review of patients identified by the investigators at an academic acute inpatient psychiatric unit included all patients from the past 24 months who required new initial treatment with LAIA...
May 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26963820/hospital-care-for-mental-health-and-substance-abuse-in-children-with-epilepsy
#7
Dylan P Thibault, Adys Mendizabal, Nicholas S Abend, Kathryn A Davis, James Crispo, Allison W Willis
BACKGROUND: Reducing the burden of pediatric mental illness requires greater knowledge of mental health and substance abuse (MHSA) outcomes in children who are at an increased risk of primary psychiatric illness. National data on hospital care for psychiatric illness in children with epilepsy are limited. METHODS: We used the Kids' Inpatient Database (KID), the Healthcare Cost and Utilization Project (HCUP), and the Agency for Healthcare Research and Quality from 2003 to 2009 to examine MHSA hospitalization patterns in children with comorbid epilepsy...
April 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26646031/a-randomized-clinical-trial-of-high-eicosapentaenoic-acid-omega-3-fatty-acids-and-inositol-as-monotherapy-and-in-combination-in-the-treatment-of-pediatric-bipolar-spectrum-disorders-a-pilot-study
#8
RANDOMIZED CONTROLLED TRIAL
Janet Wozniak, Stephen V Faraone, James Chan, Laura Tarko, Mariely Hernandez, Jacqueline Davis, K Yvonne Woodworth, Joseph Biederman
OBJECTIVE: We conducted a 12-week, randomized, double-blind, controlled clinical trial to evaluate the effectiveness and tolerability of high eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) omega-3 fatty acids and inositol as monotherapy and in combination in children with bipolar spectrum disorders. METHOD: Participants were children 5-12 years of age meeting DSM-IV diagnostic criteria for bipolar spectrum disorders (bipolar I or II disorder or bipolar disorder not otherwise specified [NOS]) and displaying mixed, manic, or hypomanic symptoms...
November 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26604770/early-stages-of-pediatric-bipolar-disorder-retrospective-analysis-of-a-czech-inpatient-sample
#9
Michal Goetz, Tomas Novak, Marie Vesela, Zdenek Hlavka, Martin Brunovsky, Michal Povazan, Radek Ptacek, Antonin Sebela
BACKGROUND: Approximately 30%-60% of adults diagnosed with bipolar disorder (BD) report onset between the ages 15 and 19 years; however, a correct diagnosis is often delayed by several years. Therefore, investigations of the early features of BD are important for adequately understanding the prodromal stages of the illness. METHODS: A complete review of the medical records of 46 children and adolescents who were hospitalized for BD at two psychiatric teaching centers in Prague, Czech Republic was performed...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/26600584/the-establishment-of-a-mother-baby-inpatient-psychiatry-unit-in-india-adaptation-of-a-western-model-to-meet-local-cultural-and-resource-needs
#10
Prabha S Chandra, Geetha Desai, Dharma Reddy, Harish Thippeswamy, Gayatri Saraf
BACKGROUND: Several Western countries have established mother-baby psychiatric units for women with mental illness in the postpartum; similar facilities are however not available in most low and medium income countries owing to the high costs of such units and the need for specially trained personnel. MATERIALS AND METHODS: The first dedicated inpatient mother-baby unit (MBU) was started in Bengaluru, India, in 2009 at the National Institute of Mental Health and Neurosciences in response to the growing needs of mothers with severe mental illness and their infants...
July 2015: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/26598477/adjunctive-maintenance-lamotrigine-for-pediatric-bipolar-i-disorder-a-placebo-controlled-randomized-withdrawal-study
#11
RANDOMIZED CONTROLLED TRIAL
Robert L Findling, Kiki Chang, Adelaide Robb, Vicki J Foster, Joseph Horrigan, Alok Krishen, Art Wamil, John E Kraus, Melissa DelBello
OBJECTIVE: This study aimed to compare the efficacy of lamotrigine versus placebo in 10- to 17-year-olds with bipolar I disorder (BP-I) who were receiving conventional bipolar disorder treatment. METHOD: In this randomized withdrawal trial, patients with BP-I of at least moderate severity received lamotrigine during an ≤18-week open-label phase. Patients who maintained a stable lamotrigine dose for ≥2 weeks and Clinical Global Impression-Bipolar Severity of Illness (CGI-BP[S]) score of ≤3 for ≥6 consecutive weeks were randomized to double-blind lamotrigine or placebo for ≤36 weeks...
December 2015: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/26590512/associations-of-age-with-reward-delay-discounting-and-response-inhibition-in-adolescents-with-bipolar-disorders
#12
Snežana Urošević, Eric A Youngstrom, Paul Collins, Jonathan B Jensen, Monica Luciana
OBJECTIVES: Bipolar disorders' (BD) onset before age 18 is a potential marker for a more severe illness course. Adolescence is also a period of significant normative maturation of inhibitory control and reward-relevant decision-making processes, such as decreased delay discounting (i.e., decreased preference for smaller, immediate versus larger, delayed rewards). Adults with BD exhibit elevated delay discounting rates. Very little is known about developmental changes in delay discounting in adolescents with BD, or about associations between inhibitory control and delay discounting in BD...
January 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26164411/reasons-for-readmissions-what-are-the-reasons-for-90-day-readmissions-of-psychiatric-patients-from-the-ed
#13
La Vonne A Downey, Leslie S Zun
BACKGROUND: Frequent users of the emergency department (ED) contribute to the problem of overcrowding and are more likely to have psychiatric problems and a higher than average 90-day readmission rate. In addition, ED visits due to mental health problems have increased in recent years, thus driving up 90-day readmission rates. OBJECTIVES: The objective of the study is to determine the reasons for readmissions of psychiatric patients who have previously presented to the ED...
October 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26135596/cognitive-remediation-potential-novel-brain-based-treatment-for-bipolar-disorder-in-children-and-adolescents
#14
REVIEW
Daniel P Dickstein, Grace K Cushman, Kerri L Kim, Alexandra B Weissman, Ezra Wegbreit
Bipolar disorder (BD) is among the most impairing psychiatric disorders affecting children and adolescents, despite our best psychopharmacological and psychotherapeutic treatments. Cognitive remediation, defined as a behavioral intervention designed to improve cognitive functions so as to reduce psychiatric illness, is an emerging brain-based treatment approach that has thus far not been studied in pediatric BD. The present article reviews the basic principles of cognitive remediation, describes what is known about cognitive remediation in psychiatric disorders, and delineates potential brain/behavior alterations implicated in pediatric BD that might be targets for cognitive remediation...
August 2015: CNS Spectrums
https://www.readbyqxmd.com/read/26084666/bipolar-disorder-and-adhd-comorbidity-and-diagnostic-distinctions
#15
REVIEW
Ciro Marangoni, Lavinia De Chiara, Gianni L Faedda
Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) are neurodevelopmental disorders with onset in childhood and early adolescence, and common persistence in adulthood. Both disorders are often undiagnosed, misdiagnosed, and sometimes over diagnosed, leading to high rates of morbidity and disability. The differentiation of these conditions is based on their clinical features, comorbidity, psychiatric family history course of illness, and response to treatment. We review recent relevant findings and highlight epidemiological, clinical, family history, course, and treatment-response differences that can aid the differential diagnosis of these conditions in an outpatient pediatric setting...
August 2015: Current Psychiatry Reports
https://www.readbyqxmd.com/read/26072345/sleep-in-children-with-psychiatric-disorders
#16
REVIEW
Ujjwal Ramtekkar, Anna Ivanenko
Sleep disturbances are common in pediatric psychiatric disorders and constitute key elements in diagnostic symptomatology of various primary psychiatric disorders including bipolar disorder, depression, and anxiety disorder. Although sleep is not included in key defining criteria of some impairing illnesses such as obsessive-compulsive disorder and schizophrenia, these disorders present with a very high prevalence of sleep disturbances. The interaction between sleep and psychopathology is very complex with significant interrelationship in development, severity, and prognosis of psychiatric disorders and comorbid sleep disturbances...
June 2015: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/25911091/the-health-status-of-adults-on-the-autism-spectrum
#17
Lisa A Croen, Ousseny Zerbo, Yinge Qian, Maria L Massolo, Steve Rich, Stephen Sidney, Clarissa Kripke
Compared to the general pediatric population, children with autism have higher rates of co-occurring medical and psychiatric illnesses, yet very little is known about the general health status of adults with autism. The objective of this study was to describe the frequency of psychiatric and medical conditions among a large, diverse, insured population of adults with autism in the United States. Participants were adult members of Kaiser Permanente Northern California enrolled from 2008 to 2012. Autism spectrum disorder cases (N = 1507) were adults with autism spectrum disorder diagnoses (International Classification of Diseases-9-Clinical Modification codes 299...
October 2015: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/25865120/borderline-personality-disorder-in-transition-age-youth-with-bipolar-disorder
#18
S Yen, E Frazier, H Hower, L M Weinstock, D R Topor, J Hunt, T R Goldstein, B I Goldstein, M K Gill, N D Ryan, M Strober, B Birmaher, M B Keller
OBJECTIVE: To determine the longitudinal impact of borderline personality disorder (BPD) on the course and outcome of bipolar disorder (BP) in a pediatric BP sample. METHOD: Participants (N = 271) and parents from the Course and Outcome of Bipolar Youth (COBY) study were administered structured clinical interviews and self-reports on average every 8.7 months over a mean of 93 months starting at age 13.0 ± 3.1 years. The structured interview for DSM-IV personality disorders (SIDP-IV) was administered at the first follow-up after age 18 to assess for symptoms of BPD...
October 2015: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/25646309/mood-and-affect-disorders
#19
Michael H Tang, Elizabeth G Pinsky
Depressive disorders are common in children and adolescents, with estimates for depressive episodes as high as 18.2% for girls and 7.7% for boys by age 17 years, and are a major cause of morbidity and even mortality. The primary care pediatrician should be able to (1) diagnose depressive disorders and use standardized instruments; (2) ask about suicide, self-harm, homicide, substance use, mania, and psychosis; (3) triage the severity of illness; (4) be aware of the differential diagnosis, including normal development, other depressive disorders, bipolar disorders, and comorbid disorders, such as anxiety and substance use; (5) refer to evidenced-based psychotherapies; (6) prescribe first-line medications; and (7) provide ongoing coordination in a medical home...
February 2015: Pediatrics in Review
https://www.readbyqxmd.com/read/25473324/profile-of-aripiprazole-in-the-treatment-of-bipolar-disorder-in-children-and-adolescents
#20
REVIEW
Eiji Kirino
Bipolar disorder is a pernicious illness. Compared with the later-onset form, early onset bipolar disorder is associated with worse psychosocial outcomes, and is characterized by rapid cycling and increased risks of substance abuse and suicide attempts. Controlling mood episodes and preventing relapse in this group of pediatric patients requires careful treatment. Here, we review the effectiveness of aripiprazole for bipolar disorder in children and adolescents, with discussion of this drug's unique pharmacological profile and various clinical study outcomes...
2014: Adolescent Health, Medicine and Therapeutics
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