keyword
https://read.qxmd.com/read/38536998/isoniazid-use-effectiveness-and-safety-for-treatment-of-latent-tuberculosis-infection-a-systematic-review
#1
JOURNAL ARTICLE
Bárbara Manuella Cardoso Sodré-Alves, Melina Mafra Toledo, Ivan Ricardo Zimmermann, Wildo Navegantes de Araújo, Noemia Urruth Leão Tavares
BACKGROUND: The treatment strategy for latent tuberculosis infection is to reduce the number of tuberculosis cases and consequently reduce the transmission of pathogenic bacteria. This study aimed to determine the safety, effectiveness, and adherence of isoniazid use for latent tuberculosis infection treatment. METHODS: To identify studies on isoniazid use for latent tuberculosis infection, five electronic databases were searched. The methods and results are presented in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2024: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/38535878/factors-associated-with-non-adherence-to-tuberculosis-preventive-treatment-among-adult-contacts-of-pulmonary-tuberculosis-cases-with-latent-tuberculosis-infection-in-catalonia-spain-in-2019-2021
#2
JOURNAL ARTICLE
Pedro Plans-Rubió, Sofia Godoy, Diana Toledo, Angela Domínguez, Joan Caylà, Ignasi Parron, Joan Pau Millet, Pere Godoy
The aim of this study was to identify factors associated with non-adherence to tuberculosis (TB) preventive treatment among contacts with latent TB infection for new cases of pulmonary TB cases reported in Catalonia in 2019-2021. All contacts aged 18 years or older with a latent TB infection who received a TB preventive treatment were included in the study. The Chi square test and the odds ratios (OR) were used to assess the association between non-adherence to TB preventive treatment and the study variables; a p < 0...
February 27, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38533017/associations-between-mixed-exposure-to-phthalates-and-latent-tuberculosis-infection-among-the-general-u-s-population-from-nhanes-2011-2012
#3
JOURNAL ARTICLE
Bi Ran, Jiangyue Qin, Yanqiu Wu, Fuqiang Wen
BACKGROUND: People are constantly exposed to phthalates, but few reliable studies have focused on the connection between phthalate exposure and latent tuberculosis infection (LTBI). METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database (2011-2012). The LTBI was assessed by QuantiFERON®-TB Gold-In-Tube (QFT) or tuberculin skin testing (TST). The odds ratios (ORs) and 95% confidence intervals (CIs) per log10 unit change in the concentration of phthalate metabolites were calculated using crude and adjusted logistic regression models...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38531107/tuberculosis-in-united-states-bound-follow-to-join-asylees-2014-2019
#4
JOURNAL ARTICLE
Yecai Liu, Drew L Posey, Michelle S Weinberg, Christina R Phares
Persons may seek asylum in the United States or at a U.S. port of entry. Principal asylees are those who are granted asylum status. Their spouse and unmarried children under 21 years of age may be granted asylum if accompanying, or following to join, the principal asylees. U.S.-bound follow-to-join asylees must undergo an overseas medical examination that includes tuberculosis (TB) screening. Culture-based overseas TB screening in U.S.-bound follow-to-join asylees has not been evaluated. We evaluated data from overseas TB screening in 19,088 arrivals of follow-to-join asylees during 2014-2019 and assessed data from their postarrival evaluation, which is recommended for those at risk for TB...
March 26, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38529772/tuberculosis-in-prison-what-about-after-release-the-example-of-french-guiana
#5
JOURNAL ARTICLE
Moise Niaux, Mathilde Boutrou, Marie Daniel, Vanessa Schiemsky, Evelyn Vierendeels, Félix Djossou, Mathieu Nacher, Florence Huber, Timothée Bonifay
INTRODUCTION: Tuberculosis is a major cause of mortality worldwide. Prisoners in Guiana have multiple risk factors. The primary objective of this study was to describe tuberculosis occurring in prison and after release in French Guiana between 2008 and 2020. Secondary objectives were to identify tuberculosis risk factors and determine annual incidences. METHODS: A retrospective cohort study of tuberculosis cases was carried out at the Guiana prison between 2008 and 2020...
January 2024: Global Public Health
https://read.qxmd.com/read/38527485/classification-of-early-tuberculosis-states-to-guide-research-for-improved-care-and-prevention-an-international-delphi-consensus-exercise
#6
REVIEW
Anna K Coussens, Syed M A Zaidi, Brian W Allwood, Puneet K Dewan, Glenda Gray, Mikashmi Kohli, Tamara Kredo, Ben J Marais, Guy B Marks, Leo Martinez, Morten Ruhwald, Thomas J Scriba, James A Seddon, Phumeza Tisile, Digby F Warner, Robert J Wilkinson, Hanif Esmail, Rein M G J Houben
The current active-latent paradigm of tuberculosis largely neglects the documented spectrum of disease. Inconsistency with regard to definitions, terminology, and diagnostic criteria for different tuberculosis states has limited the progress in research and product development that are needed to achieve tuberculosis elimination. We aimed to develop a new framework of classification for tuberculosis that accommodates key disease states but is sufficiently simple to support pragmatic research and implementation...
March 22, 2024: Lancet Respiratory Medicine
https://read.qxmd.com/read/38522174/in-vitro-stimulation-with-nontuberculous-mycobacteria-induced-a-stronger-cytokine-response-in-leukocytes-isolated-from-individuals-with-latent-tuberculosis-compared-to-those-isolated-from-active-tuberculosis-or-cystic-fibrosis-patients
#7
JOURNAL ARTICLE
Hardis Rabe, Elisabeth Lönnermark, Ewa Johansson, Marita Gilljam, Bodil Jönsson
Mycobacterium tuberculosis and opportunistic environmental non-tuberculous mycobacteria (NTM) can cause severe infection. Why latent tuberculosis infection advances to active disease, and why some individuals with cystic fibrosis (CF) develop pulmonary infections with NTM is still poorly understood. The aim of this study was to investigate the effector function of peripheral blood mononuclear cells (PBMC) from individuals with active or latent tuberculosis, individuals with CF with or without pulmonary NTM-infection and healthy controls, by measuring cytokine response to in vitro stimulation with different species of NTMs...
March 20, 2024: Tuberculosis
https://read.qxmd.com/read/38516789/prevalence-estimates-of-tuberculosis-infection-in-adults-in-denmark-a-retrospective-nationwide-register-based-cross-sectional-study-2010-to-2018
#8
JOURNAL ARTICLE
Anne Ahrens Østergaard, Troels Lillebaek, Inge Petersen, Andreas Fløe, Eliza H Worren Bøkan, Ole Hilberg, Inge K Holden, Lone Larsen, Ada Colic, Christian Wejse, Pernille Ravn, Bente Mertz Nørgård, Stephanie Bjerrum, Isik Somuncu Johansen
BackgroundTuberculosis (TB) elimination requires identifying and treating persons with TB infection (TBI).AimWe estimate the prevalence of positive interferon gamma release assay (IGRA) tests (including TB) and TBI (excluding TB) in Denmark based on TBI screening data from patients with inflammatory bowel disease (IBD) or inflammatory rheumatic disease (IRD).MethodsUsing nationwide Danish registries, we included all patients with IBD or IRD with an IGRA test performed between 2010 and 2018. We estimated the prevalence of TBI and positive IGRA with 95% confidence intervals (CI) in adolescents and adults aged 15-64 years after sample weighting adjusting for distortions in the sample from the background population of Denmark for sex, age group and TB incidence rates (IR) in country of birth...
March 2024: Euro Surveillance
https://read.qxmd.com/read/38514601/screening-and-treatment-of-latent-tuberculosis-in-patients-with-solid-tumors-and-systemic-cancer-therapy
#9
REVIEW
Miguel Borregón, David Sánchez, Elia Martínez
INTRODUCTION: Tuberculosis is one of the infectious diseases with greater morbidity and mortality worldwide. Cancer causes an important immunosuppression with increased risk of infections. There is an enlarged bidirectional incidence between tuberculosis and cancer, mainly due to latent tuberculosis. GUIDELINES REVIEW: There is great discrepancy between recommendations for screening and prophylaxis of latent tuberculosis in patients with solid tumors and systemic cancer therapy among different medical societies and guidelines...
March 21, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38511796/rate-of-infection-tuberculosis-in-brazilians-ibd-private-patients-follow-up-15-years
#10
JOURNAL ARTICLE
Didia B Cury, Liana C B Cury, Ana C Micheletti, Rogério A Oliveira, José J S Gonçalves
BACKGROUND: Latent tuberculosis (LTB) is a condition where the patient is infected with Mycobacterium tuberculosis but does not develop active TB. There's a possibility of tuberculosis (TB) activation following the introduction of anti-TNFs. OBJECTIVE: To assess the risk of biological therapy inducing LTB during inflammatory bowel diseases (IBD) treatment over 15 years in a high-risk area in Brazil. METHODS: A retrospective study of an IBD patients' database was carried out in a private reference clinic in Brazil...
2024: Arquivos de Gastroenterologia
https://read.qxmd.com/read/38510248/antigen-specific-chemokine-profiles-as-biomarkers-for-detecting-mycobacterium-tuberculosis-infection
#11
JOURNAL ARTICLE
Weicong Ren, Zichun Ma, Qiang Li, Rongmei Liu, Liping Ma, Cong Yao, Yuanyuan Shang, Xuxia Zhang, Mengqiu Gao, Shanshan Li, Yu Pang
BACKGROUND: Latent tuberculosis (TB) infection can progress to active TB, which perpetuates community transmission that undermines global TB control efforts. Clinically, interferon-γ release assays (IGRAs) are commonly used for active TB case detection. However, low IGRA sensitivity rates lead to false-negative results for a high proportion of active TB cases, thus highlighting IGRA ineffectiveness in differentiating MTB-infected individuals from healthy individuals. METHODS: Participants enrolled at Beijing Chest Hospital from May 2020-April 2022 were assigned to healthy control (HC), LTBI, IGRA-positive TB, and IGRA-negative TB groups...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38507431/association-between-smoking-and-lack-of-hiv-virological-suppression-in-a-cross-sectional-study-of-persons-with-hiv-on-antiretroviral-therapy-in-uganda
#12
JOURNAL ARTICLE
Adah Tumwegamire, Robin Fatch, Nneka I Emenyonu, Sara Lodi, Winnie R Muyindike, Allen Kekibiina, Julian Adong, Christine Ngabirano, Brian Beesiga, Kara Marson, Nakisa Golabi, Moses Kamya, Gabriel Chamie, Judith A Hahn
BACKGROUND: Smoking and alcohol use frequently co-occur and are the leading causes of preventable death in sub-Saharan Africa (SSA) and are common among people living with HIV (PLWH). While alcohol use has been shown to be associated with reduced adherence to antiretroviral treatment (ART), which may affect HIV viral suppression, the independent effect of smoking on HIV outcomes in SSA is unknown. We aimed to 1) describe the prevalence of current smoking and correlates of smoking; 2) assess the association of smoking with viral suppression, adjusting for level of alcohol use; 3) explore the relationship between smoking and CD4 cell count <350 cells/mm3, among participants who are virally suppressed...
2024: PloS One
https://read.qxmd.com/read/38502454/infection-of-fetal-membranes-with-mycobacterium-tuberculosis-and-tissue-processing-to-isolate-rna-for-expression-analysis
#13
JOURNAL ARTICLE
Samantha Yong-Mendoza, Mónica Selena Fonseca-Pérez, Oscar Villavicencio-Carrisoza, Sandra Rivera-Gutiérrez, Addy Cecilia Helguera-Repetto
This chapter outlines the methodology employed to infect the chorionic and amniotic membranes with Mycobacterium tuberculosis during pregnancy. Particularly, congenital tuberculosis, a rare and serious condition associated with cases in neonates and reactivation of latent tuberculosis in pregnant mothers, is interesting to study. Understanding the mechanisms of infection and the response of fetal membranes is crucial for developing effective treatments in these cases, which will promote better neonatal and maternal health in situations of tuberculosis during pregnancy...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38502387/the-applications-of-elispot-in-the-identification-and-treatment-of-various-forms-of-tuberculosis-and-in-the-cancer-immunotherapies
#14
JOURNAL ARTICLE
Hemant K Mishra
ELISpot (enzyme-linked immunospot) is a powerful immunological tool for the detection of cytokine-secreting cells at a single-cell resolution. It is widely used for the diagnosis of various infectious diseases, e.g., tuberculosis and sarcoidosis, and it is also widely used in cancer immunotherapy research. Its ability to distinguish between active and latent forms of tuberculosis makes it an extremely powerful tool for epidemiological studies and contact tracing. In addition to that, it is a very useful tool for the research and development of cancer immunotherapies...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38499946/adapted-generative-latent-diffusion-models-for-accurate-pathological-analysis-in-chest-x-ray-images
#15
JOURNAL ARTICLE
Daniel I Morís, Joaquim de Moura, Jorge Novo, Marcos Ortega
Respiratory diseases have a significant global impact, and assessing these conditions is crucial for improving patient outcomes. Chest X-ray is widely used for diagnosis, but expert evaluation can be challenging. Automatic computer-aided diagnosis methods can provide support for clinicians in these tasks. Deep learning has emerged as a set of algorithms with exceptional potential in such tasks. However, these algorithms require a vast amount of data, often scarce in medical imaging domains. In this work, a new data augmentation methodology based on adapted generative latent diffusion models is proposed to improve the performance of an automatic pathological screening in two high-impact scenarios: tuberculosis and lung nodules...
March 19, 2024: Medical & Biological Engineering & Computing
https://read.qxmd.com/read/38498488/tuberculin-skin-test-and-interferon-gamma-release-assay-agreement-and-associated-factors-with-latent-tuberculosis-infection-in-medical-and-nursing-students-in-bandung-indonesia
#16
JOURNAL ARTICLE
Lika Apriani, Susan McAllister, Katrina Sharples, Isni Nurul Aini, Hanifah Nurhasanah, Dwi Febni Ratnaningsih, Agnes Rengga Indrati, Rovina Ruslami, Bachti Alisjahbana, Reinout van Crevel, Philip C Hill
BACKGROUND: No gold standard diagnostic test exists for latent tuberculosis infection (LTBI). The intra-dermal tuberculin skin test (TST) has known limitations and Interferon-gamma release assays (IGRA) have been developed as an alternative. We aimed to assess agreement between IGRA and TST, and risk factors for test positivity, in Indonesian healthcare students. METHODS: Medical and nursing students starting their clinical training were screened using IGRA and TST...
2024: PloS One
https://read.qxmd.com/read/38495623/incidence-and-risk-factors-of-active-tuberculosis-among-hospitalized-patients-with-latent-tuberculosis-infection-in-china-a-cohort-study
#17
JOURNAL ARTICLE
Ye Liu, Lifan Zhang, Yan Chen, Guiren Ruan, Yuchen Liu, Shi Chen, Lantian Xie, Fengying Wu, Xiaochun Shi, Xiaoqing Liu
BACKGROUND: The population with latent tuberculosis infection (LTBI) represents a potential pool of patients with active tuberculosis (ATB). T-SPOT.TB is an important test tool for screening LTBI. Owing to the large population of LTBI patients in China, it is necessary to identify a high-risk group for LTBI and enlarge tuberculosis preventive treatment (TPT) to reduce the incidence of ATB. METHODS: Hospitalized patients with positive T-SPOT.TB results were recruited from January 2013 to December 2016...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38494532/important-role-of-dna-methylation-hints-at-significant-potential-in-tuberculosis
#18
REVIEW
Yuexuan Qin, Tianyue Li, Peiyan An, Zhi Ren, Jun Xi, Bikui Tang
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, has persisted as a major global public health threat for millennia. Until now, TB continues to challenge efforts aimed at controlling it, with drug resistance and latent infections being the two main factors hindering treatment efficacy. The scientific community is still striving to understand the underlying mechanisms behind Mtb's drug resistance and latent infection. DNA methylation, a critical epigenetic modification occurring throughout an individual's growth and development, has gained attention following advances in high-throughput sequencing technologies...
March 18, 2024: Archives of Microbiology
https://read.qxmd.com/read/38488508/mycobacterium-tuberculosis-latent-infection-in-healthcare-students-systematic-review-of-prevalence
#19
JOURNAL ARTICLE
Renata Silva de Lima, Rodrigo Nogueira da Silva, Suzana Rosa André, Ana Kedma Correa Pinheiro, Ana Inês Sousa, Ingrid Fabiane Santos da Silva, Juliano Dos Santos, Laura Maria Vidal Nogueira, Regina Célia Gollner Zeitoune
OBJECTIVE: The aim of this study was to synthesize the evidence on the prevalence of latent Mycobacterium tuberculosis infection (LTBI) among undergraduate health care students. METHODS: A systematic review of prevalence with meta-analysis was conducted. Prospective and retrospective cohorts and cross-sectional studies involving probable exposure to M. tuberculosis during undergraduate education, along with the tuberculin skin test (TST) or interferon-γ release assay (IGRA) for investigation of latent tuberculosis were searched...
2024: Revista da Escola de Enfermagem da U S P
https://read.qxmd.com/read/38486698/the-changes-and-its-significance-of-peripheral-blood-nk-cells-in-patients-with-tuberculous-meningitis
#20
JOURNAL ARTICLE
Jie Mi, Yinping Liu, Yong Xue, Wenna Sun, Yan Liang, Jianqin Liang, Huiru An, Xueqiong Wu
OBJECTIVE: Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB). The purpose of this study was to explore the relationship between the number of natural killer (NK) cells and adaptive immune status, and disease severity in TBM patients. METHODS: We conducted a retrospective study on 244 TB patients and 146 healthy control subjects in the 8th Medical Center of the PLA General Hospital from March 2018 and August 2023. RESULTS: The absolute count of NK cells in the peripheral blood of TBM patients was significantly lower than that in normal controls (NC), latent tuberculosis infection (LTBI), and non-severe TB (NSTB) patients ( p  < 0...
2024: Frontiers in Microbiology
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