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https://www.readbyqxmd.com/read/28935163/optimising-the-diagnosis-of-prostate-cancer-in-the-era-of-multiparametric-magnetic-resonance-imaging-a-cost-effectiveness-analysis-based-on-the-prostate-mr-imaging-study-promis
#1
Rita Faria, Marta O Soares, Eldon Spackman, Hashim U Ahmed, Louise C Brown, Richard Kaplan, Mark Emberton, Mark J Sculpher
BACKGROUND: The current recommendation of using transrectal ultrasound-guided biopsy (TRUSB) to diagnose prostate cancer misses clinically significant (CS) cancers. More sensitive biopsies (eg, template prostate mapping biopsy [TPMB]) are too resource intensive for routine use, and there is little evidence on multiparametric magnetic resonance imaging (MPMRI). OBJECTIVE: To identify the most effective and cost-effective way of using these tests to detect CS prostate cancer...
September 18, 2017: European Urology
https://www.readbyqxmd.com/read/28934299/a-novel-copro-diagnostic-molecular-method-for-qualitative-detection-and-identification-of-parasitic-nematodes-in-amphibians-and-reptiles
#2
Lucas G Huggins, Christopher J Michaels, Sheena M Cruickshank, Richard F Preziosi, Kathryn J Else
Anthropogenic disturbance via resource acquisition, habitat fragmentation and climate change, amongst other factors, has led to catastrophic global biodiversity losses and species extinctions at an accelerating rate. Amphibians are currently one of the worst affected classes with at least a third of species categorised as being threatened with extinction. At the same time, they are also critically important for many habitats and provide man with a powerful proxy for ecosystem health by acting as a bioindicator group...
2017: PloS One
https://www.readbyqxmd.com/read/28926028/achieving-an-optimal-allocation-of-resources-for-animal-health-surveillance-intervention-and-disease-mitigation
#3
B Hasler, A Delabouglise, S Babo Martins
The primary role of animal health economics is to inform decision-making by determining optimal investments for animal health. Animal health surveillance produces information to guide interventions. Consequently, investments in surveillance and intervention must be evaluated together. This article explores the different theoretical frameworks and methods developed to assess and optimise the spending of resources in surveillance and intervention and their technical interdependence. The authors present frameworks that define the relationship between health investment and losses due to disease, and the relationship between surveillance and intervention resources...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28922625/living-and-dying-with-advanced-dementia-a-prospective-cohort-study-of-symptoms-service-use-and-care-at-the-end-of-life
#4
Elizabeth L Sampson, Bridget Candy, Sarah Davis, Anna Buylova Gola, Jane Harrington, Michael King, Nuriye Kupeli, Gerry Leavey, Kirsten Moore, Irwin Nazareth, Rumana Z Omar, Victoria Vickerstaff, Louise Jones
BACKGROUND: Increasing number of people are dying with advanced dementia. Comfort and quality of life are key goals of care. AIMS: To describe (1) physical and psychological symptoms, (2) health and social care service utilisation and (3) care at end of life in people with advanced dementia. DESIGN: 9-month prospective cohort study. SETTING AND PARTICIPANTS: Greater London, England, people with advanced dementia (Functional Assessment Staging Scale 6e and above) from 14 nursing homes or their own homes...
August 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28916581/optimising-impact-and-sustainability-a-qualitative-process-evaluation-of-a-complex-intervention-targeted-at-compassionate-care
#5
Jackie Bridges, Carl May, Alison Fuller, Peter Griffiths, Wendy Wigley, Lisa Gould, Hannah Barker, Paula Libberton
BACKGROUND: Despite concerns about the degree of compassion in contemporary healthcare, there is a dearth of evidence for health service managers about how to promote compassionate healthcare. This paper reports on the implementation of the Creating Learning Environments for Compassionate Care (CLECC) intervention by four hospital ward nursing teams. CLECC is a workplace educational intervention focused on developing sustainable leadership and work-team practices designed to support team relational capacity and compassionate care delivery...
September 15, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28914360/adaptive-variation-in-vein-placement-underpins-diversity-in-a-major-neotropical-plant-radiation
#6
Jamie Males
Vein placement has been hypothesised to control leaf hydraulic properties, but the ecophysiological significance of variation in vein placement in the angiosperms has remained poorly understood. The highly diverse Neotropical Bromeliaceae offers an excellent system for exploring understudied relationships between leaf vein placement, physiological functions, and species ecology. To test key hypotheses regarding the links between vein placement, functional type divergences, and ecological diversity in the Bromeliaceae, I characterised the ratio of interveinal distance (IVD) to vein-epidermis distance (VED) in 376 species, representing all major functional types and 10% of the species diversity in the family, as well as bioclimatic properties and key leaf traits for subsets of species...
September 15, 2017: Oecologia
https://www.readbyqxmd.com/read/28913887/the-equity-of-access-to-primary-dental-care-in-s%C3%A3-o-paulo-brazil-a-geospatial-analysis
#7
Aidan Yuen, Carla Martins Rocha, Estie Kruger, Marc Tennant
OBJECTIVES: Brazil is one of the largest countries in the world, in terms of geography and population. Most Brazilians reside in the south and south-eastern regions, with notable numbers in the regions' megacities, such as São Paulo city. Healthcare provision in such a complex environment is difficult. Thus, a clear understanding of the distribution - or rather, the maldistribution - of these services is fundamental for optimising the allocation of human and financial resources to areas of greatest privation...
September 15, 2017: International Dental Journal
https://www.readbyqxmd.com/read/28910500/is-systems-pharmacology-ready-to-impact-upon-therapy-development-a-study-on-the-cholesterol-biosynthesis-pathway
#8
Helen Benson, Steven Watterson, Joanna Sharman, Chido Mpamhanga, Andrew Parton, Christopher Southan, Anthony Harmar, Peter Ghazal
BACKGROUND AND PURPOSE: An ever-growing wealth of information on current drugs and their pharmacological effects is available from online databases. As our understanding of systems biology increases, we have the opportunity to predict, model and quantify how drug combinations can be introduced that outperform conventional single-drug therapies. Here, we explore the feasibility of such systems pharmacology approaches with an analysis of the mevalonate branch of the cholesterol biosynthesis pathway...
September 14, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28898665/shaping-3d-root-system-architecture
#9
REVIEW
Emily C Morris, Marcus Griffiths, Agata Golebiowska, Stefan Mairhofer, Jasmine Burr-Hersey, Tatsuaki Goh, Daniel von Wangenheim, Brian Atkinson, Craig J Sturrock, Jonathan P Lynch, Kris Vissenberg, Karl Ritz, Darren M Wells, Sacha J Mooney, Malcolm J Bennett
Plants are sessile organisms rooted in one place. The soil resources that plants require are often distributed in a highly heterogeneous pattern. To aid foraging, plants have evolved roots whose growth and development are highly responsive to soil signals. As a result, 3D root architecture is shaped by myriad environmental signals to ensure resource capture is optimised and unfavourable environments are avoided. The first signals sensed by newly germinating seeds - gravity and light - direct root growth into the soil to aid seedling establishment...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28893672/a-situational-analysis-of-current-antimicrobial-governance-regulation-and-utilisation-in-south-africa
#10
Natalie Schellack, Deon Benjamin, Adrian Brink, Adriano Duse, Kim Faure, Debra Goff, Marc Mendelson, Johanna Meyer, Jacqui Miot, Olga Perovic, Troy Pople, Fatima Suleman, Moritza van Vuuren, Sabiha Essack
The Global Action Plan (GAP) on AMR calls for optimising the use of antimicrobial medicines in human and animal health, in tandem with strengthening of the knowledge and evidence base through surveillance and research. However, there is a paucity of consumption data in African countries such as South Africa. Determining antimicrobial consumption data in low resource settings remains a challenge. This paper describes alternative mechanisms of assessing antimicrobial consumption data such as Intercontinental Marketing Services (IMS), and contract data arising from tenders (an open Request for Proposal, RFP) as opposed to the international norms of daily defined doses per 100 patient days, or per 1000 of the population...
September 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28886740/sustainability-in-health-care-by-allocating-resources-effectively-share-10-operationalising-disinvestment-in-a-conceptual-framework-for-resource-allocation
#11
Claire Harris, Sally Green, Adam G Elshaug
BACKGROUND: This is the tenth in a series of papers reporting a program of Sustainability in Health care by Allocating Resources Effectively (SHARE) in a local healthcare setting. After more than a decade of research, there is little published evidence of active and successful disinvestment. The paucity of frameworks, methods and tools is reported to be a factor in the lack of success. However there are clear and consistent messages in the literature that can be used to inform development of a framework for operationalising disinvestment...
September 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28886735/sustainability-in-health-care-by-allocating-resources-effectively-share-9-conceptualising-disinvestment-in-the-local-healthcare-setting
#12
Claire Harris, Sally Green, Wayne Ramsey, Kelly Allen, Richard King
BACKGROUND: This is the ninth in a series of papers reporting a program of Sustainability in Health care by Allocating Resources Effectively (SHARE) in a local healthcare setting. The disinvestment literature has broadened considerably over the past decade; however there is a significant gap regarding systematic, integrated, organisation-wide approaches. This debate paper presents a discussion of the conceptual aspects of disinvestment from the local perspective. DISCUSSION: Four themes are discussed: Terminology and concepts, Motivation and purpose, Relationships with other healthcare improvement paradigms, and Challenges to disinvestment...
September 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28882917/effects-of-cerebral-near-infrared-spectroscopy-on-the-outcome-of-patients-undergoing-cardiac-surgery-a-systematic-review-of-randomised-trials
#13
Giuseppe Filiberto Serraino, Gavin J Murphy
OBJECTIVES: Goal-directed optimisation of cerebral oxygenation using near-infrared spectroscopy (NIRS) during cardiopulmonary bypass is widely used. We tested the hypotheses that the use of NIRS cerebral oximetry results in reductions in cerebral injury (neurocognitive function, serum biomarkers), injury to other organs including the heart and brain, transfusion rates, mortality and resource use. DESIGN: Systematic review and meta-analysis. SETTING: Tertiary cardiac surgery centres in North America, Europe and Asia...
September 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28881327/solving-multi-objective-water-management-problems-using-evolutionary-computation
#14
A Lewis, M Randall
Water as a resource is becoming increasingly more valuable given the changes in global climate. In an agricultural sense, the role of water is vital to ensuring food security. Therefore the management of it has become a subject of increasing attention and the development of effective tools to support participative decision-making in water management will be a valuable contribution. In this paper, evolutionary computation techniques and Pareto optimisation are incorporated in a model-based system for water management...
September 4, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28874706/synthesis-of-arbitrary-quantum-circuits-to-topological-assembly-systematic-online-and-compact
#15
Alexandru Paler, Austin G Fowler, Robert Wille
It is challenging to transform an arbitrary quantum circuit into a form protected by surface code quantum error correcting codes (a variant of topological quantum error correction), especially if the goal is to minimise overhead. One of the issues is the efficient placement of magic state distillation sub circuits, so-called distillation boxes, in the space-time volume that abstracts the computation's required resources. This work presents a general, systematic, online method for the synthesis of such circuits...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870379/esource-for-clinical-trials-implementation-and-evaluation-of-a-standards-based-approach-in-a-real-world-trial
#16
Jean-Francois Ethier, Vasa Curcin, Mark M McGilchrist, Sarah N Lim Choi Keung, Lei Zhao, Anna Andreasson, Piotr Bródka, Radoslaw Michalski, Theodoros N Arvanitis, Nikolaos Mastellos, Anita Burgun, Brendan C Delaney
OBJECTIVE: The Learning Health System (LHS) requires integration of research into routine practice. 'eSource' or embedding clinical trial functionalities into routine electronic health record (EHR) systems has long been put forward as a solution to the rising costs of research. We aimed to create and validate an eSource solution that would be readily extensible as part of a LHS. MATERIALS AND METHODS: The EU FP7 TRANSFoRm project's approach is based on dual modelling, using the Clinical Research Information Model (CRIM) and the Clinical Data Integration Model of meaning (CDIM) to bridge the gap between clinical and research data structures, using the CDISC Operational Data Model (ODM) standard...
October 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28868148/automatic-disease-diagnosis-using-optimised-weightless-neural-networks-for-low-power-wearable-devices
#17
Ramalingaswamy Cheruku, Damodar Reddy Edla, Venkatanareshbabu Kuppili, Ramesh Dharavath, Nareshkumar Reddy Beechu
Low-power wearable devices for disease diagnosis are used at anytime and anywhere. These are non-invasive and pain-free for the better quality of life. However, these devices are resource constrained in terms of memory and processing capability. Memory constraint allows these devices to store a limited number of patterns and processing constraint provides delayed response. It is a challenging task to design a robust classification system under above constraints with high accuracy. In this Letter, to resolve this problem, a novel architecture for weightless neural networks (WNNs) has been proposed...
August 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28867964/weights-and-importance-in-composite-indicators-closing-the-gap
#18
William Becker, Michaela Saisana, Paolo Paruolo, Ine Vandecasteele
Composite indicators are very popular tools for assessing and ranking countries and institutions in terms of environmental performance, sustainability, and other complex concepts that are not directly measurable. Because of the stakes that come with the media attention of these tools, a word of caution is warranted. One common misconception relates to the effect of the weights assigned to indicators during the aggregation process. This work presents a novel series of tools that allow developers and users of composite indicators to explore effects of these weights...
September 2017: Ecological Indicators
https://www.readbyqxmd.com/read/28866610/seasonality-in-oestrus-and-litter-size-in-an-assistance-dog-breeding-colony-in-the-united-kingdom
#19
Eleanor E Wigham, Rachel S Moxon, Gary C W England, James L N Wood, Michelle K Morters
Evidence of seasonality in oestrus in bitches within specialist breeding programmes, such as those for assistance dogs, may support colony management through tailoring the distribution of resources required for breeding throughout the year. However, at present there are conflicting data regarding seasonality in oestrus (and litter size) in domestic dogs. The primary objective of this study was to investigate seasonal variations in oestrus and litter size in a large assistance dog breeding colony in the UK in order to optimise colony management...
September 2, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28830090/practical-considerations-for-large-scale-gut-microbiome-studies
#20
Doris Vandeputte, Raul Y Tito, Rianne Vanleeuwen, Gwen Falony, Jeroen Raes
First insights on the human gut microbiome have been gained from medium-sized, cross-sectional studies. However, given the modest portion of explained variance of currently identified covariates and the small effect size of gut microbiota modulation strategies, upscaling seems essential for further discovery and characterisation of the multiple influencing factors and their relative contribution. In order to guide future research projects and standardisation efforts, we here review currently applied collection and preservation methods for gut microbiome research...
August 1, 2017: FEMS Microbiology Reviews
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