keyword
MENU ▼
Read by QxMD icon Read
search

resource optimisation

keyword
https://www.readbyqxmd.com/read/27908503/cobalt-60-machines-and-medical-linear-accelerators-competing-technologies-for-external-beam-radiotherapy
#1
B J Healy, D van der Merwe, K E Christaki, A Meghzifene
Medical linear accelerators (linacs) and cobalt-60 machines are both mature technologies for external beam radiotherapy. A comparison is made between these two technologies in terms of infrastructure and maintenance, dosimetry, shielding requirements, staffing, costs, security, patient throughput and clinical use. Infrastructure and maintenance are more demanding for linacs due to the complex electric componentry. In dosimetry, a higher beam energy, modulated dose rate and smaller focal spot size mean that it is easier to create an optimised treatment with a linac for conformal dose coverage of the tumour while sparing healthy organs at risk...
November 28, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27905893/computational-prediction-of-multidisciplinary-team-decision-making-for-adjuvant-breast-cancer-drug-therapies-a-machine-learning-approach
#2
Frank P Y Lin, Adrian Pokorny, Christina Teng, Rachel Dear, Richard J Epstein
BACKGROUND: Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision-making, we developed a machine learning model designed to predict MDT decisions about adjuvant breast cancer treatments. METHODS: We analysed MDT decisions regarding adjuvant systemic therapy for 1065 breast cancer cases over eight years. Machine learning classifiers with and without bootstrap aggregation were correlated with MDT decisions (recommended, not recommended, or discussable) regarding adjuvant cytotoxic, endocrine and biologic/targeted therapies, then tested for predictability using stratified ten-fold cross-validations...
December 1, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27899574/uniclust-databases-of-clustered-and-deeply-annotated-protein-sequences-and-alignments
#3
Milot Mirdita, Lars von den Driesch, Clovis Galiez, Maria J Martin, Johannes Söding, Martin Steinegger
We present three clustered protein sequence databases, Uniclust90, Uniclust50, Uniclust30 and three databases of multiple sequence alignments (MSAs), Uniboost10, Uniboost20 and Uniboost30, as a resource for protein sequence analysis, function prediction and sequence searches. The Uniclust databases cluster UniProtKB sequences at the level of 90%, 50% and 30% pairwise sequence identity. Uniclust90 and Uniclust50 clusters showed better consistency of functional annotation than those of UniRef90 and UniRef50, owing to an optimised clustering pipeline that runs with our MMseqs2 software for fast and sensitive protein sequence searching and clustering...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27897734/how-to-insert-a-peripheral-cannula
#4
Sally Jane Shaw
Rationale and key points This article aims to assist practitioners to undertake the safe and effective insertion of a peripheral cannula. It provides information on best practice related to peripheral cannulation with an open-ported safety cannula. The same principles for practice apply to non-ported open safety cannulae. » Peripheral cannulation enables venous access, the administration of intravenous medication, infusion therapy and total parenteral nutrition. It also enables blood samples to be obtained...
November 16, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27893999/ebola-virus-disease-an-update-on-current-prevention-and-management-strategies
#5
REVIEW
M A Trad, W Naughton, A Yeung, L Mazlin, M O'sullivan, N Gilroy, D A Fisher, R L Stuart
Ebola virus disease (EVD) is characterised by systemic viral replication, immuno-suppression, abnormal inflammatory responses, large volume fluid and electrolyte losses, and high mortality in under-resourced settings. There are various therapeutic strategies targeting EVD including vaccines utilizing different antigen delivery methods, antibody-based therapies and antiviral drugs. These therapies remain experimental, but received attention following their use particularly in cases treated outside West Africa during the 2014-15 outbreak, in which 20 (80%) out of 25 patients survived...
November 11, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27886946/building-multidisciplinary-health-workforce-capacity-to-support-the-implementation-of-integrated-people-centred-models-of-care-for-musculoskeletal-health
#6
REVIEW
M J Chehade, T K Gill, D Kopansky-Giles, L Schuwirth, J Karnon, P McLiesh, J Alleyne, A D Woolf
To address the burden of musculoskeletal (MSK) conditions, a competent health workforce is required to support the implementation of MSK models of care. Funding is required to create employment positions with resources for service delivery and training a fit-for-purpose workforce. Training should be aligned to define "entrustable professional activities", and include collaborative skills appropriate to integrated and people-centred care and supported by shared education resources. Greater emphasis on educating MSK healthcare workers as effective trainers of peers, students and patients is required...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27871193/physiotherapist-delivered-cognitive-behavioural-interventions-are-effective-for-low-back-pain-but-can-they-be-replicated-in-clinical-practice-a-systematic-review
#7
Amanda Hall, Helen Richmond, Bethan Copsey, Zara Hansen, Esther Williamson, Gillian Jones, Beth Fordham, Zafra Cooper, Sarah Lamb
PURPOSE: To determine if physiotherapist-led cognitive-behavioural (CB) interventions are effective for low back pain (LBP) and described sufficiently for replication. METHOD: Randomised controlled trials (RCTs) of patients with LBP treated by physiotherapists using a CB intervention were included. Outcomes of disability, pain, and quality of life were assessed using the GRADE approach. Intervention reporting was assessed using the Template for Intervention Description and Replication...
November 21, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27871192/specialised-dental-care-for-children-with-complex-disabilities-focusing-on-child-s-functioning-and-need-for-general-anaesthesia
#8
Johanna Norderyd, Gunilla Klingberg, Denise Faulks, Mats Granlund
PURPOSE: To describe and analyse dental care and treatment modalities for children with complex disabilities from a biopsychosocial perspective, with special focus on dental treatment under general anaesthesia (GA) and its relationship to child's functioning. METHOD: An ICF-CY Checklist for Oral Health was completed using structured interview, direct observations, and dental records for patients attending a specialist paediatric dentistry clinic. Descriptive and comparative data analysis was performed...
November 22, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27867506/independent-validation-of-the-pain-management-plan-in-a-multi-disciplinary-pain-team-setting
#9
Joanna Quinlan, Richard Hughes, David Laird
CONTEXT/BACKGROUND: The Pain Management Plan (PP) is a brief cognitive behavioural therapy (CBT) self-management programme for people living with persistent pain that can be individually facilitated or provided in a group setting. Evidence of PP efficacy has been reported previously by the pain centres involved in its development. OBJECTIVES: To provide a fully independent evaluation of the PP and compare these with the findings reported by Cole et al. METHODS: The PP programme was delivered by the County Durham Pain Team (Co...
November 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27836039/an-elaborated-sir-model-for-haemonchosis-in-sheep-in-south-africa-under-a-targeted-selective-anthelmintic-treatment-regime
#10
Nlingisisi D Babayani, Jan A van Wyk, Eric R Morgan
Infection with the abomasal nematode Haemonchus contortus is responsible for considerable production loss in small ruminants globally, and especially in warm, summer-rainfall regions. Previous attempts to predict infection levels have followed the traditional framework for macroparasite models, i.e. tracking parasite population sizes as a function of host and climatic factors. Targeted treatment strategies, in which patho-physiological indices are used to identify the individuals most affected by parasites, could provide a foundation for alternative, incidence-based epidemiological models...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27832436/screening-of-heavy-metal-containing-waste-types-for-use-as-raw-material-in-arctic-clay-based-bricks
#11
Louise Josefine Belmonte, Lisbeth M Ottosen, Gunvor Marie Kirkelund, Pernille Erland Jensen, Andreas Peter Vestbø
In the vulnerable Arctic environment, the impact of especially hazardous wastes can have severe consequences and the reduction and safe handling of these waste types are therefore an important issue. In this study, two groups of heavy metal containing particulate waste materials, municipal solid waste incineration (MSWI) fly and bottom ashes and mine tailings (i.e., residues from the mineral resource industry) from Greenland were screened in order to determine their suitability as secondary resources in clay-based brick production...
November 10, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27829667/novel-ph-sensing-semiconductor-for-point-of-care-detection-of-hiv-1-viremia
#12
R Gurrala, Z Lang, L Shepherd, D Davidson, E Harrison, M McClure, S Kaye, C Toumazou, G S Cooke
The timely detection of viremia in HIV-infected patients receiving antiviral treatment is key to ensuring effective therapy and preventing the emergence of drug resistance. In high HIV burden settings, the cost and complexity of diagnostics limit their availability. We have developed a novel complementary metal-oxide semiconductor (CMOS) chip based, pH-mediated, point-of-care HIV-1 viral load monitoring assay that simultaneously amplifies and detects HIV-1 RNA. A novel low-buffer HIV-1 pH-LAMP (loop-mediated isothermal amplification) assay was optimised and incorporated into a pH sensitive CMOS chip...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822968/towards-interprofessional-networking-in-medication-management-of-the-aged-current-challenges-and-potential-solutions-in-finland
#13
Sonja Kallio, Anne Kumpusalo-Vauhkonen, Timo Järvensivu, Antti Mäntylä, Marika Pohjanoksa-Mäntylä, Marja Airaksinen
OBJECTIVE: The Finnish Medicines Agency (Fimea) initiated a programme in 2012 for enhancing interprofessional networking in the medication management of the aged. The goal is to develop national guidelines for interprofessional collaboration with respect to medication management. This study aims to explore the challenges and potential solutions experienced by existing health care teams in managing medication of the aged: (1) at the individual and team level (micro level), (2) organisational level (meso level) and (3) structural level (macro level)...
November 8, 2016: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/27801359/bed-utilisation-in-an-irish-regional-paediatric-unit-a-cross-sectional-study-using-the-paediatric-appropriateness-evaluation-protocol-paep
#14
Coilín ÓhAiseadha, Mai Mannix, Jean Saunders, Roy K Philip
BACKGROUND: Increasing demand for limited healthcare resources raises questions about appropriate use of inpatient beds. In the first paediatric bed utilisation study at a regional university centre in Ireland, we conducted a cross-sectional study to audit the utilisation of inpatient beds at the Regional Paediatric Unit (RPU) in University Hospital Limerick (UHL), Limerick, Ireland and also examined hospital activity data, to make recommendations for optimal use of inpatient resources...
May 10, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/27798064/a-critical-evaluation-of-ecological-indices-for-the-comparative-analysis-of-microbial-communities-based-on-molecular-datasets
#15
Rico Lucas, Jürgen Groeneveld, Hauke Harms, Karin Johst, Karin Frank, Sabine Kleinsteuber
In times of global change and intensified resource exploitation, advanced knowledge of ecophysiological processes in natural and engineered systems driven by complex microbial communities is crucial for both safeguarding environmental processes and optimising rational control of biotechnological processes. To gain such knowledge, high-throughput molecular techniques are routinely employed to investigate microbial community composition and dynamics within a wide range of natural or engineered environments. However, for molecular dataset analyses no consensus about a generally applicable alpha diversity concept and no appropriate benchmarking of corresponding statistical indices exist yet...
January 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27776143/defining-priorities-for-future-research-results-of-the-uk-kidney-transplant-priority-setting-partnership
#16
Simon R Knight, Leanne Metcalfe, Katriona O'Donoghue, Simon T Ball, Angela Beale, William Beale, Rachel Hilton, Keith Hodkinson, Graham W Lipkin, Fiona Loud, Lorna P Marson, Peter J Morris
BACKGROUND: It has been suggested that the research priorities of those funding and performing research in transplantation may differ from those of end service users such as patients, carers and healthcare professionals involved in day-to-day care. The Kidney Transplant Priority Setting Partnership (PSP) was established with the aim of involving all stakeholders in prioritising future research in the field. METHODS: The PSP methodology is as outlined by the James Lind Alliance...
2016: PloS One
https://www.readbyqxmd.com/read/27773076/pathology-use-stewardship-pre-analytical-review-of-tissue-specimens-previously-processed-by-default-for-mycobacterial-culture-maintains-the-quality-of-laboratory-diagnosis-and-optimises-the-use-of-laboratory-resources
#17
Jeremy Brown, Jason Patterson, Briony Hazelton, Mitchell Brown, Peter Jelfs, Vitali Sintchenko, Sharon C-A Chen
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27726916/waste-or-substrate-for-metal-hyperaccumulating-plants-the-potential-of-phytomining-on-waste-incineration-bottom-ash
#18
Theresa Rosenkranz, Johannes Kisser, Walter W Wenzel, Markus Puschenreiter
Phytomining could represent an innovative low-cost technology for the selective recovery of valuable trace elements from secondary resources. In this context the potential of phytomining from waste incineration bottom ash was tested in a pot experiment. Fresh bottom ash was acidified, leached to reduce salinity and amended with organic material to obtain a suitable substrate for plant growth. Two hyperaccumulator species, Alyssum serpyllifolium subsp. lusitanicum and Sedum plumbizincicola as well as three metal tolerant species, Brassica napus, B...
October 7, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27725014/cost-considerations-in-determining-the-affordability-of-adjuvant-trastuzumab-in-breast-cancer
#19
R P Abratt
The drug cost of adjuvant trastuzumab to benefit one patient with localised human epidermal growth factor receptor 2 (HER2)-positive breast cancer depends on the baseline survival rate (BLSR) of the prognostic group of the patient. This varies from ZAR13 752 900 (BLSR 90%) to ZAR4 006 100 (BLSR 60%). All treated patients are exposed to potential toxicity. The value and affordability of treatments need to be considered, as there are finite resources available in our healthcare system. All patients must have access to cost-effective treatments...
September 23, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27725009/passing-the-baton-to-pharmacists-and-nurses-new-models-of-antibiotic-stewardship-for-south-africa
#20
A Brink, D Van den Bergh, M Mendelson, G A Richards
The optimisation of antibiotic use to maximise patient care and safety through antibiotic stewardship forms one of the cornerstones of the global response to antibiotic resistance. Stewardship efforts in low- and middle-income countries are challenged by lack of healthcare professionals trained in infection. Therefore, in resource-poor settings, the traditional model of infection specialist-led stewardship may be impractical, requiring new models to be developed. A recent South African study across 47 Netcare hospitals nationally highlighted the role of pharmacists in this regard, proving that non-specialised pharmacists can drive a prospective audit, feedback collaborative strategy and a range of improvement science principles to reduce antibiotic consumption by the same levels as that documented in high-resource, infection specialist-led stewardship programmes...
September 6, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
keyword
keyword
35724
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"