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https://www.readbyqxmd.com/read/28337813/health-care-experiences-among-women-diagnosed-with-gestational-breast-cancer
#1
K Hammarberg, E Sullivan, N Javid, G Duncombe, L Halliday, F Boyle, C Saunders, A Ives, J E Dickinson, J Fisher
Gestational breast cancer (GBC) presents many challenges for women and the clinicians who care for them. The aim of this study was to explore the health care experiences of women diagnosed with GBC to inform and improve clinical care of women in this predicament. Semi-structured interviews were conducted with 17 women who had been diagnosed with GBC in the previous 5 years. The overarching themes for perceived quality of care were "communication" and "comprehensive care." "Communication" had two sub themes: "interdisciplinary communication" (the way health professionals from different disciplines communicated with each other about the management of the woman's care) and "patient communication" (how they communicated this to the woman)...
March 24, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28318522/prognostic-stratification-and-healthcare-approach-in-patients-with-multiple-pathologies
#2
M Bernabeu-Wittel, B Barón-Franco, D Nieto-Martín, L Moreno-Gaviño, N Ramírez-Duque, M Ollero-Baturone
Polypathological patients constitute a prevalent, fairly homogeneous population, which is characterised by high clinical complexity, substantial vulnerability and significant resource consumption, in addition to high mortality and the need for comprehensive, coordinated care. It is particularly important to establish a reliable prognosis in these patients. It is also extremely useful for professionals involved in the decision-making process for patients and their families in vital planning and their preferences, for strategic health planning in management fields, and for clinical research, by facilitating their incorporation into clinical trials and other intervention studies...
March 16, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28304127/molecular-regulation-of-sucrose-catabolism-and-sugar-transport-for-development-defence-and-phloem-function
#3
REVIEW
Jun Li, Limin Wu, Ryan Foster, Yong-Ling Ruan
Sucrose (Suc) is the major end product of photosynthesis in mesophyll cells of most vascular plants. It is loaded into phloem of mature leaves for long-distance translocation to non-photosynthetic organs where it is unloaded for diverse uses. Clearly, Suc transport and metabolism is central to plant growth and development and the functionality of the entire vascular system. Despite of vast information in the literature about the physiological roles of individual sugar metabolic enzymes and transporters, there is a lack of systematic evaluation about their molecular regulation from transcriptional to post-translational levels...
March 17, 2017: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/28300343/medical-student-use-of-digital-learning-resources
#4
Karen Scott, Anne Morris, Ben Marais
BACKGROUND: University students expect to use technology as part of their studies, yet health professional teachers can struggle with the change in student learning habits fuelled by technology. Our research aimed to document the learning habits of contemporary medical students during a clinical rotation by exploring the use of locally and externally developed digital and print self-directed learning resources, and study groups. METHODS: We investigated the learning habits of final-stage medical students during their clinical paediatric rotation using mixed methods, involving learning analytics and a student questionnaire...
March 16, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28298238/biofed-federated-query-processing-over-life-sciences-linked-open-data
#5
Ali Hasnain, Qaiser Mehmood, Syeda Sana E Zainab, Muhammad Saleem, Claude Warren, Durre Zehra, Stefan Decker, Dietrich Rebholz-Schuhmann
BACKGROUND: Biomedical data, e.g. from knowledge bases and ontologies, is increasingly made available following open linked data principles, at best as RDF triple data. This is a necessary step towards unified access to biological data sets, but this still requires solutions to query multiple endpoints for their heterogeneous data to eventually retrieve all the meaningful information. Suggested solutions are based on query federation approaches, which require the submission of SPARQL queries to endpoints...
March 15, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28290273/from-the-ebm-pyramid-to-the-greek-temple-a-new-conceptual-approach-to-guidelines-as-implementation-tools-in-mental-health
#6
L Salvador-Carulla, S Lukersmith, W Sullivan
Guideline methods to develop recommendations dedicate most effort around organising discovery and corroboration knowledge following the evidence-based medicine (EBM) framework. Guidelines typically use a single dimension of information, and generally discard contextual evidence and formal expert knowledge and consumer's experiences in the process. In recognition of the limitations of guidelines in complex cases, complex interventions and systems research, there has been significant effort to develop new tools, guides, resources and structures to use alongside EBM methods of guideline development...
April 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28286357/pastoralists-as-optimal-foragers-reoccupation-and-site-selection-in-the-deserts-of-post-soviet-kazakhstan
#7
S Robinson, C Kerven, R Behnke, K Kushenov, E J Milner-Gulland
This study explores the drivers of site selection amongst livestock owners under conditions of increasing animal numbers following a low point in the 1990s. Our major goal was to understand whether livestock owners are acting as 'optimal foragers,' targeting areas of highest forage availability as they colonise previously empty areas. The results presented here suggest that they do not. Initially, distance from home settlement was the dominant determinant of site occupancy, with closer sites occupied earlier regardless of other characteristics...
2017: Human Ecology: An Interdisciplinary Journal
https://www.readbyqxmd.com/read/28283293/linking-energy-sanitation-agriculture-intersectional-resource-management-in-smallholder-households-in-tanzania
#8
Ariane Krause, Vera Susanne Rotter
In order to create sustainable systems for resource management, residues from cooking and ecological sanitation (EcoSan) can be employed in recycling-driven soil fertility management. However, the link between energy, sanitation, and agricultural productivity is often neglected. Hence, the potential self-sufficient nature of many smallholdings in sub-Saharan Africa is underexploited. OBJECTIVE: To compare those cooking and sanitation technologies most commonly used in north-western Tanzania with locally developed alternatives, with respect to (i) resource consumption, (ii) potential to recover resources, and (iii) environmental emissions...
March 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28263059/postexposure-recovery-and-analysis-of-biological-agent-in-a-simulated-biothreat-scenario-using-tandem-mass-spectrometry
#9
Sakshi Rajoria, Ravi Bhushan Kumar, Pallavi Gupta, Syed Imteyaz Alam
Some pathogens and toxins have the potential to be used as weapons of mass destruction and instigate population-based fear. Rapid, sensitive, and unambiguous identification of biothreat agents is of paramount importance for confirmation of the event and to mitigate the direct and indirect damages to public health and resources. Although there are several potential dissemination scenarios to describe an attack with a biological weapon, artificially generated bioaerosol is of the greatest concern from a bioterrorism or warfare perspective, potentially capable of causing mass destruction to a civilian or military population by inhalation of toxic bioaerosol...
March 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28253883/systematic-development-and-implementation-of-interventions-to-optimise-health-literacy-and-access-ophelia
#10
Alison Beauchamp, Roy W Batterham, Sarity Dodson, Brad Astbury, Gerald R Elsworth, Crystal McPhee, Jeanine Jacobson, Rachelle Buchbinder, Richard H Osborne
BACKGROUND: The need for healthcare strengthening to enhance equity is critical, requiring systematic approaches that focus on those experiencing lesser access and outcomes. This project developed and tested the Ophelia (OPtimising HEalth LIteracy and Access) approach for co-design of interventions to improve health literacy and equity of access. Eight principles guided this development: Outcomes focused; Equity driven, Needs diagnosis, Co-design, Driven by local wisdom, Sustainable, Responsive and Systematically applied...
March 3, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28249568/by-more-ways-than-one-rapid-convergence-at-hydrothermal-vents-shown-by-3d-anatomical-reconstruction-of-gigantopelta-mollusca-neomphalina
#11
Chong Chen, Katsuyuki Uematsu, Katrin Linse, Julia D Sigwart
BACKGROUND: Extreme environments prompt the evolution of characteristic adaptations. Yet questions remain about whether radiations in extreme environments originate from a single lineage that masters a key adaptive pathway, or if the same features can arise in parallel through convergence. Species endemic to deep-sea hydrothermal vents must accommodate high temperature and low pH. The most successful vent species share a constrained pathway to successful energy exploitation: hosting symbionts...
March 1, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28238038/bluegenics-bioactive-natural-products-of-medicinal-relevance-and-approaches-to-their-diversification
#12
Joseph S Zarins-Tutt, Emily R Abraham, Christopher S Bailey, Rebecca J M Goss
Nature provides a valuable resource of medicinally relevant compounds, with many antimicrobial and antitumor agents entering clinical trials being derived from natural products. The generation of analogues of these bioactive natural products is important in order to gain a greater understanding of structure activity relationships; probing the mechanism of action, as well as to optimise the natural product's bioactivity and bioavailability. This chapter critically examines different approaches to generating natural products and their analogues, exploring the way in which synthetic and biosynthetic approaches may be blended together to enable expeditious access to new designer natural products...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28220745/is-it-possible-to-differentiate-tuberculous-and-cryptococcal-meningitis-in-hiv-infected-patients-using-only-clinical-and-basic-cerebrospinal-fluid-characteristics
#13
J E Vidal, E J F Peixoto de Miranda, J Gerhardt, M Croda, D R Boulware
BACKGROUND: Tuberculous and cryptococcal meningitis (TBM and CM) are the most common causes of opportunistic meningitis in HIVinfected patients from resource-limited settings, and the differential diagnosis is challenging. OBJECTIVE: To compare clinical and basic cerebrospinal fluid (CSF) characteristics between TBM and CM in HIV-infected patients. METHODS: A retrospective analysis was conducted of clinical, radiological and laboratory records of 108 and 98 HIV-infected patients with culture-proven diagnosis of TBM and CM, respectively...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28207841/barriers-and-enablers-to-the-implementation-of-the-6-pack-falls-prevention-program-a-pre-implementation-study-in-hospitals-participating-in-a-cluster-randomised-controlled-trial
#14
Darshini R Ayton, Anna L Barker, Renata T Morello, Caroline A Brand, Jason Talevski, Fiona S Landgren, Mayer M Melhem, Evelyn Bian, Sandra G Brauer, Keith D Hill, Patricia M Livingston, Mari Botti
Evidence for effective falls prevention interventions in acute wards is limited. One reason for this may be suboptimal program implementation. This study aimed to identify perceived barriers and enablers of the implementation of the 6-PACK falls prevention program to inform the implementation in a randomised controlled trial. Strategies to optimise successful implementation of 6-PACK were also sought. A mixed-methods approach was applied in 24 acute wards from 6 Australian hospitals. Participants were nurses working on participating wards and senior hospital staff including Nurse Unit Managers; senior physicians; Directors of Nursing; and senior personnel involved in quality and safety or falls prevention...
2017: PloS One
https://www.readbyqxmd.com/read/28169021/supplemental-parenteral-nutrition-in-intensive-care-patients-a-cost-saving-strategy
#15
Lorenzo Pradelli, Séverine Graf, Claude Pichard, Mette M Berger
BACKGROUND & AIMS: The Swiss supplemental parenteral nutrition (SPN) study demonstrated that optimised energy provision combining enteral nutrition (EN) and SPN reduces nosocomial infections in critically ill adults who fail to achieve targeted energy delivery with EN alone. To assess the economic impact of this strategy, we performed a cost-effectiveness analysis using data from the SPN study. METHODS: Multivariable regression analyses were performed to characterise the relationships between SPN, cumulative energy deficit, nosocomial infection, and resource consumption...
January 25, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28148277/safe-sparql-federation-over-rdf-data-cubes-with-access-control
#16
Yasar Khan, Muhammad Saleem, Muntazir Mehdi, Aidan Hogan, Qaiser Mehmood, Dietrich Rebholz-Schuhmann, Ratnesh Sahay
BACKGROUND: Several query federation engines have been proposed for accessing public Linked Open Data sources. However, in many domains, resources are sensitive and access to these resources is tightly controlled by stakeholders; consequently, privacy is a major concern when federating queries over such datasets. In the Healthcare and Life Sciences (HCLS) domain real-world datasets contain sensitive statistical information: strict ownership is granted to individuals working in hospitals, research labs, clinical trial organisers, etc...
February 1, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28145220/the-clinical-effectiveness-of-individual-behaviour-change-interventions-to-reduce-risky-sexual-behaviour-after-a-negative-human-immunodeficiency-virus-test-in-men-who-have-sex-with-men-systematic-and-realist-reviews-and-intervention-development
#17
Paul Flowers, Olivia Wu, Karen Lorimer, Bipasha Ahmed, Hannah Hesselgreaves, Jennifer MacDonald, Sandi Cayless, Sharon Hutchinson, Lawrie Elliott, Ann Sullivan, Dan Clutterbuck, Michael Rayment, Lisa McDaid
BACKGROUND: Men who have sex with men (MSM) experience significant inequalities in health and well-being. They are the group in the UK at the highest risk of acquiring a human immunodeficiency virus (HIV) infection. Guidance relating to both HIV infection prevention, in general, and individual-level behaviour change interventions, in particular, is very limited. OBJECTIVES: To conduct an evidence synthesis of the clinical effectiveness of behaviour change interventions to reduce risky sexual behaviour among MSM after a negative HIV infection test...
January 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28139367/critical-review-of-real-time-methods-for-solid-waste-characterisation-informing-material-recovery-and-fuel-production
#18
REVIEW
C Vrancken, P J Longhurst, S T Wagland
Waste management processes generally represent a significant loss of material, energy and economic resources, so legislation and financial incentives are being implemented to improve the recovery of these valuable resources whilst reducing contamination levels. Material recovery and waste derived fuels are potentially valuable options being pursued by industry, using mechanical and biological processes incorporating sensor and sorting technologies developed and optimised for recycling plants. In its current state, waste management presents similarities to other industries that could improve their efficiencies using process analytical technology tools...
January 27, 2017: Waste Management
https://www.readbyqxmd.com/read/28129748/the-speed-of-increasing-milk-feeds-a-randomised-controlled-trial
#19
Jane Abbott, Janet Berrington, Ursula Bowler, Elaine Boyle, Jon Dorling, Nicholas Embleton, Edmund Juszczak, Alison Leaf, Louise Linsell, Samantha Johnson, Kenny McCormick, William McGuire, Tracy Roberts, Ben Stenson
BACKGROUND: In the UK, 1-2% of infants are born very preterm (<32 weeks of gestation) or have very low birth weight (<1500 g). Very preterm infants are initially unable to be fed nutritional volumes of milk and therefore require intravenous nutrition. Milk feeding strategies influence several long and short term health outcomes including growth, survival, infection (associated with intravenous nutrition) and necrotising enterocolitis (NEC); with both infection and NEC being key predictive factors of long term disability...
January 28, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28118967/pharmacists-perceptions-and-communication-of-risk-for-alertness-impairing-medications
#20
Ibrahim Jomaa, Mariam Odisho, Janet M Y Cheung, Keith Wong, Jason G Ellis, Tanya Smyth, Bandana Saini
BACKGROUND: A core role of the pharmacist is to ensure safe and effective medication use. Therapeutic classes that impair alertness (e.g. sedatives or hypnotics) can pose safety concerns for the consumer when undertaking activities requiring psychomotor vigilance (e.g. driving). OBJECTIVE: To explore pharmacists' perceptions and communication strategy of the risks related to alertness impairing medications in clinical practice. METHODS: In-depth semi-structured interviews explored community pharmacists' perceptions of medication-related risks, current medication provision and the feasibility of new practice tools...
January 10, 2017: Research in Social & Administrative Pharmacy: RSAP
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