Wafaa S Ramadan, Maha M Saber-Ayad, Ekram Saleh, Hajjaj H M Abdu-Allah, Abdel-Nasser A El-Shorbagi, Varsha Menon, Hamadeh Tarazi, Mohammad H Semreen, Nelson C Soares, Shirin Hafezi, Thenmozhi Venkatakhalam, Samrein Ahmed, Osamu Kanie, Rifat Hamoudi, Raafat El-Awady
The development of hybrid compounds has been widely considered as a promising strategy to circumvent the difficulties that emerge in cancer treatment. The well-established strategy of adding acetyl groups to certain drugs has been demonstrated to enhance their therapeutic efficacy. Based on our previous work, an approach of accommodating two chemical entities into a single structure was implemented to synthesize new acetylated hybrids ( HH32 and HH33 ) from 5-aminosalicylic acid and 4-thiazolinone derivatives...
January 19, 2024: IScience