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5-aminosalicylic acid

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https://www.readbyqxmd.com/read/27908270/the-importance-of-wireless-capsule-endoscopy-for-research-into-the-intestinal-absorption-window-of-5-aminosalicylic-acid-in-experimental-pigs
#1
Jaroslav Kvetina, Ilja Tacheci, Milan Nobilis, Marcela Kopacova, Martin Kunes, Jan Bures
BACKGROUND: Absorption windows in particular segments of the small intestine can contribute to the development of orally administered drug formulations and can limit the bioavailability of released compounds. OBJECTIVE: The aim of this study was to evaluate use of wireless capsule enteroscopy regarding the disintegration kinetic process of tablets in the small intestine and its comparison with the levels of the model drug (5-aminosalicylic acid; 5-ASA), and its majority metabolite (N-acetyl-5-aminosalicylic acid; N-acetyl-5-ASA) in blood plasma...
December 1, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27906680/chemopreventive-effects-of-5-aminosalicylic-acid-on-inflammatory-bowel-disease-associated-colorectal-cancer-and-dysplasia-a-systematic-review-with-meta-analysis
#2
Xinyun Qiu, Jingjing Ma, Kai Wang, Hongjie Zhang
BACKGROUND AND AIMS: The chemopreventive effect of 5-aminosalicylic acid (5-ASA) in patients with inflammatory bowel disease (IBD) has been widely studied; however, the results remain conflicting. The aim of this study was to systematically review the literature and update evidence concerning effects of 5-ASA on the risk of colorectal cancer (CRC) and dysplasia (Dys) in patients with ulcerative colitis (UC) or Crohn's disease (CD). RESULTS: 5-ASA showed a chemopreventive effect against CRC/Dys in IBD patients (OR = 0...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27851980/co-delivery-of-zinc-and-5-aminosalicylic-acid-from-alginate-n-succinyl-chitosan-blend-microspheres-for-synergistic-therapy-of-colitis
#3
Haogang Duan, Shaoyu Lü, Hongyan Qin, Chunmei Gao, Xiao Bai, Yuhui Wei, Xin'an Wu, Mingzhu Liu, Xinyu Zhang, Zhen Liu
The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis. Physicochemical characterization of blend MS was assessed using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and energy dispersive X-ray spectrometer (EDS). In vitro release studies demonstrated that blend MS has a pH-dependent release property. Both 5-ASA and zinc have lower release in acid medium and higher release in colonic environment...
November 13, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27847525/hydroalcoholic-extract-from-inflorescences-of-achyrocline-satureioides-compositae-ameliorates-dextran-sulphate-sodium-induced-colitis-in-mice-by-attenuation-in-the-production-of-inflammatory-cytokines-and-oxidative-mediators
#4
Luisa Mota da Silva, Jaime Antonio Machado Farias, Thaise Boeing, Lincon Bordignon Somensi, Ana Paula Beber, Benhur Judah Cury, José Roberto Santin, Sérgio Faloni de Andrade
Achyrocline satureioides is a South American herb used to treat inflammatory and gastrointestinal diseases. This study evaluated intestinal anti-inflammatory effects of the hydroalcoholic extract of inflorescences of satureioides (HEAS) in dextran sulfate sodium (DSS) induced colitis in mice. Mice were orally treated with vehicle, 5-aminosalicylic acid (100 mg/kg), or HEAS (1-100 mg/kg). Clinical signs of colitis and colonic histopathological parameters were evaluated, along with the determination of levels of reduced glutathione and lipid hydroperoxide (LOOH), the superoxide dismutase (SOD), and myeloperoxidase (MPO) activity in colon...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27818126/anti-inflammatory-protection-afforded-by-cyanidin-3-glucoside-and-resveratrol-in-human-intestinal-cells-via-nrf2-and-ppar-%C3%AE-comparison-with-5-aminosalicylic-acid
#5
Diana Serra, Leonor M Almeida, Teresa C P Dinis
This study investigated the involvement of nuclear factor erythroid 2 (Nrf2) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathways in the protection afforded by two polyphenols abundant in diet, cyanidin-3-glucoside and resveratrol, against cytokine-induced inflammation and oxidative insult in HT-29 intestinal cells, in comparison with the drug 5-aminosalicylic acid (5-ASA). Our data show for the first time that in cytokine-challenged cells, cyanidin-3-glucoside and resveratrol induced Nrf2 activation, increased hemoxygenase-1 and glutamate cysteine ligase mRNA expression, enhanced reduced glutathione to oxidized glutathione ratio and inhibited reactive species production, at much lower concentrations than 5-ASA...
November 3, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27796724/effects-of-methanolic-extract-from-leaves-of-rubus-imperialis-in-dss-induced-colitis-in-mice
#6
Luisa Mota da Silva, Lincon Bordignon Somensi, Thaise Boeing, Cristiane Barp, Valdir Cechinel-Filho, Rivaldo Niero, Sérgio Faloni de Andrade
This study investigated the effects of Rubus imperialis, a berry known as "amora-branca", in colitis dextran sulfate sodium (DSS)-induced in mice. Animals were treated orally with vehicle (water), 5-aminosalicylic acid (100 mg/kg) or methanolic extract from leaves of R. imperialis (MERI, 100 mg/kg), once a day during seven days. The disease activity index (DAI) was observed daily. Colons were collected for histological, histochemical and biochemical analysis. The administration of MERI exacerbated colitis, as indicated by DAI heightened weight loss and increased histological colonic injury...
October 31, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27785086/systematic-review-treatment-pattern-and-clinical-effectiveness-and-safety-of-pharmaceutical-therapies-for-crohn-s-disease-in-europe
#7
REVIEW
Filippo Lelli, Solomon Nuhoho, Xin Ying Lee, Weiwei Xu
BACKGROUND: Although many clinical trials have been conducted in treatments of Crohn's disease (CD), whether the trial results were representative of daily practice needs to be supported by studies conducted in real-world settings. AIM: This study aims to identify how CD is treated and what are the clinical effectiveness and safety of the pharmaceutical therapies of CD in real-world settings. METHODS: A systematic literature review was conducted based on Medline(®), Embase(®), and Cochrane...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27769943/mucoadhesive-chitosan-hydrogels-as-rectal-drug-delivery-vessels-to-treat-ulcerative-colitis
#8
Jinke Xu, Mifong Tam, Sepideh Samaei, Sophie Lerouge, Jake Barralet, Mary M Stevenson, Marta Cerruti
: Mucoadhesive drug delivery systems stick to mucosal tissues and prolong the local retention time of drugs. Since the colon is covered by a mucosal layer, mucoadhesive rectal formulations may improve treatment of such diseases as hypertension or colon cancer. Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation of the colonic mucosa. It is commonly treated with sulfasalazine (SSZ), which is metabolized by the intestinal flora into the therapeutic 5-aminosalicylic acid (5-ASA) and a toxic by-product sulfapyridine (SP)...
October 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27747686/red-brown-urine-discolouration-in-two-patients-taking-mesalamine
#9
Tim Smeets, Florence van Hunsel
A 38-year-old male and a 36-year-old female experienced red-brown urine discolouration after 2 and 3 days, respectively, during the use of mesalamine for inflammatory bowel disease. Both patients mentioned that the urine discoloured after contact with sodium hypochlorite detergent in toilet water. Mesalamine and the inactive metabolite N-acetyl-5-aminosalicylic acid are primarily excreted in the urine. We hypothesised a possible reaction with sodium hypochlorite and/or light. Naranjo assessment scores of 9 and 6 were obtained for the reports, indicating a certain and probable relationship, respectively, between the red-brown urine discolouration and the use of the suspect drug mesalamine...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27718119/successful-colonoscopic-fecal-microbiota-transplantation-for-active-ulcerative-colitis-first-report-from-india
#10
Avnish Kumar Seth, Pawan Rawal, Ruchika Bagga, Priti Jain
Forty-four-year-old male with ulcerative colitis (UC) for 11 years reported frequent relapse despite daily sulfasalazine 4 g, azathioprine 125 mg, and rectal 5-aminosalicylic acid. Repeated use of corticosteroids led to cataract. At enrollment, he was passing eight stools a day with blood with a Mayo score of 9 (3+1+3+2). Stool was negative for ova/cysts/acid fast bacilli and Clostridium difficile toxin assay. Rectal biopsy showed cryptitis, crypt abscess, and crypt distortion with no inclusion bodies, and cytomegalovirus DNA was negative...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27699641/recent-trends-and-future-directions-for-the-medical-treatment-of-ulcerative-colitis
#11
Makoto Naganuma, Shinta Mizuno, Kosaku Nanki, Shinya Sugimoto, Takanori Kanai
Recently, several medical treatments for ulcerative colitis (UC) have been developed, including 5-aminosalicylic acids (5-ASAs), corticosteroids, thiopurine, calcineurin inhibitors, and anti-tumor necrosis factor (TNF) α treatments. Treatment options including calcineurin inhibitors and anti-TNF treatment for refractory UC are discussed in this article. Furthermore, upcoming treatments are introduced, such as golimumab, vedolizumab, AJM300, tofacitinib. Budesonide foamwill be used as one treatment option in patients with distal colitis...
October 3, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27681657/oral-5-aminosalicylic-acid-for-maintenance-of-medically-induced-remission-in-crohn-s-disease
#12
Anthony K Akobeng, Dongni Zhang, Morris Gordon, John K MacDonald
BACKGROUND: The prevention of relapse is a major issue in the management of Crohn's disease. Corticosteroids, the mainstay of treatment of acute exacerbations, are not effective for maintenance of remission and its chronic use is limited by numerous adverse events. Randomised controlled trials assessing the efficacy of oral 5-aminosalicylic acid (5-ASA) agents for maintenance of medically-induced remission in Crohn's disease have produced conflicting results. OBJECTIVES: To conduct a systematic review to evaluate the efficacy and safety of oral 5-ASA agents for the maintenance of medically-induced remission in Crohn's disease...
September 28, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27648296/usefulness-of-sulfasalazine-for-patients-with-refractory-ulcerative-colits
#13
Takuya Yoshino, Makoto Sono, Shujiro Yazumi
BACKGROUND: Patients with refractory-ulcerative colitis (UC) require therapy escalation. Sulfasalazine (SASP) could deliver a high concentration of 5-aminosalicylic acid to the colon. The usefulness of SASP for refractory-UC patients, however, is unclear. AIM: The aim was to evaluate the usefulness of SASP for refractory-UC patients. METHOD: We retrospectively analysed 36 (11.4%) of 316 patients with refractory-UC who had been treated with SASP...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27631599/trends-in-pharmacologic-interventions-for-preventing-recurrence-of-crohn-s-disease-after-ileocolonic-surgery
#14
Mei-Sing Ong, Richard J Grand, Kenneth D Mandl
BACKGROUND: Prophylactic treatment of postoperative Crohn's disease (CD) plays a critical role in maintaining clinical remission. We performed the first study in the last decade to examine secular trends in the use of pharmacologic interventions after ileocolonic resection in the United States, to understand whether clinical practice converges with recent advances in scientific knowledge. METHODS: A retrospective study of a U.S. national claims database was performed...
October 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27617928/magnetic-molecularly-imprinted-composite-for-the-selective-solid-phase-extraction-of-p-aminosalicylic-acid-followed-by-high-performance-liquid-chromatography-with-ultraviolet-detection
#15
Hasan Bagheri, Karam Molaei, Ali Akbar Asgharinezhad, Homeira Ebrahimzadeh, Mojtaba Shamsipur
A new method for the selective extraction of p-aminosalicylic acid from aqueous and urine samples has been developed using magnetic molecularly imprinted polymer nanoparticles before determination by high-performance liquid chromatography. The Fe3 O4 nanoparticles were first prepared through the chemical coprecipitation of Fe(2+) and Fe(3+) and then coated with a vinyl shell. Subsequently, a layer of molecularly imprinted polymers was grafted onto the vinyl-modified magnetic nanoparticles by precipitation polymerization...
November 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27610010/endoscopic-and-non-endoscopic-approaches-for-the-management-of-radiation-induced-rectal-bleeding
#16
REVIEW
Joseph Paul Weiner, Andrew Thomas Wong, David Schwartz, Manuel Martinez, Ayse Aytaman, David Schreiber
Pelvic radiation is a commonly utilized treatment for malignancy of the genitourinary and lower gastrointestinal tract. Radiation proctitis and the resultant clinical picture varies from asymptomatic to potentially life threatening. Similarly, treatment options also vary greatly, from medical therapy to surgical intervention. Commonly utilized medical therapy includes sucralfate enemas, antibiotics, 5-aminosalicylic acid derivatives, probiotics, antioxidants, short-chain fatty acids, formalin instillation and fractionated hyperbaric oxygen...
August 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27597248/in-vitro-and-in-vivo-inhibitory-activity-of-6-amino-2-4-5-trimethylpyridin-3-ols-against-inflammatory-bowel-disease
#17
Suhrid Banskota, Han-Eol Kang, Dong-Guk Kim, Sang Won Park, Hyeonjin Jang, Ujjwala Karmacharya, Byeong-Seon Jeong, Jung-Ae Kim, Tae-Gyu Nam
Although the pathogenesis of inflammatory bowel disease (IBD) is complex, attachment and infiltration of leukocytes to gut epithelium induced by pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) represents the initial step of inflammation in IBD. Previously, we have reported that some 6-amino-2,4,5-trimethylpyridin-3-ols have significant levels of antiangiogenic activity via PI3K inhibition. Based on the reports that angiogenesis is involved in the aggravation of IBD and that PI3K is a potential target for IBD therapy, we investigated whether the scaffold has inhibitory activity against in vitro and in vivo models of colitis...
October 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27587080/pre-clinical-toxicity-of-a-combination-of-berberine-and%C3%A2-5-aminosalicylic-acid-in-mice
#18
Yan-Hong Li, Man Zhang, Hai-Bo Fu, Hai-Tao Xiao, Zhao-Xiang Bian
Our previous study demonstrated that a combination of alternative medicine berberine and conventional 5-aminosalicylic acid (5-ASA) showed promise to be a novel therapeutic strategy for ulcerative colitis (UC). This present study aims to sketch the pre-clinical toxicity profile of this combination (1:10 dose ratio) on mice. In acute toxicity test, the determined median lethal dose (LD50) was 278.7 mg/kg berberine plus 2787 mg/kg 5-ASA. The results from subacute toxicity test demonstrated that no toxic signs of clinical symptoms, no significant changes in hematological or biochemical parameters were detected in mice treated with 14 + 140, 28 + 280 or 56 + 560 mg/kg of berberine plus 5-ASA treatment...
August 30, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27582588/effect-of-cyperus-rotundus-on-cytokine-gene-expression-in-experimental-inflammatory-bowel-disease
#19
Sarika Johari, Chaitanya Joshi, Tejal Gandhi
BACKGROUND: The protective effect of the chloroform extract of Cyperus rotundus (CHCR) is attributed to its anti-inflammatory and antioxidant activities. Cytokines, important regulators of inflammation and repair, play a key role in the pathogenesis of inflammatory bowel disease (IBD). Targeting these cytokines can effectively ameliorate the symptoms of IBD. The aim of the present study was to unravel the molecular mechanism through cytokine regulation in rats in experimental IBD. METHODS: Sprague Dawley rats were randomly allocated to 5 groups (n=6)...
September 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27554385/hemangioma-of-the-rectum-how-misleading-can-hematochezia-be
#20
Sofia Vitor, Alexandre Oliveira Ferreira, João Lopes, José Velosa
We present the case of an 18-year-old male patient that was referred to our gastrenterology department with history of intermittent painless hematochezia since childhood. During such instances, he was diagnosed with bowel intussusception, eosinophilic gastroenteritis and inflammatory bowel disease at 4, 6 and 8 years old, respectively. He underwent treatment with 5-aminosalicylic acid for two years, without improvement of symptoms. He was then lost to follow-up until our observation. His physical examination was unremarkable except for digital rectal examination which found a nodular compressible mass by the palpating finger...
August 2016: Revista Española de Enfermedades Digestivas
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