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https://www.readbyqxmd.com/read/28858069/comparison-of-health-care-utilization-and-costs-between-patients-with-perianal-fistulizing-crohn-s-disease-treated-with-biologics-with-or-without-previous-seton-placement
#1
David A Schwartz, Anthony Wang, Burak Ozbay, Martha Skup, Samantha F Eichner, Jay Lin, Jingdong Chao
BACKGROUND: Fistulas are a common and often debilitating complication of Crohn's disease (CD). Tumor necrosis factor inhibitors and/or seton drainage are effective treatment options. We compared health care utilization and costs for patients with perianal CD who had setons placed before treatment with biologics versus those who did not. METHODS: Patients with CD (≥18 yr) were identified from the Truven Health MarketScan Database by ICD-9 code 555.x (January 1, 2006-March 31, 2015); those with external fistulas were identified by ICD-9 codes 565...
August 29, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28837846/synthesis-of-aloevera-acrylonitrile-based-nanoparticles-for-targeted-drug-delivery-of-5-aminosalicylic-acid
#2
Tulika Malviya, Sneha Joshi, Lalit Mohan Dwivedi, Kirti Baranwal, Shehala, Arvind Kumar Pandey, Vandana Singh
Aloevera (AV) polysaccharide/acrylonitrile (AN) nanoparticles (AVANp4 of ∼50nm size have been crafted via free radical polymerization method using persulfate/ascorbic acid (KPS/AA) and methylenebisacrylamide (MBA) as the redox initiator and crosslinker respectively. AVANp4 was extensively characterized using FTIR, SEM, TEM, XRD, and Thermal analysis (TGA & DTG). Inclusion of AN in AV polysaccharide has been evidenced by nitrile stretching peak at 2244cm(-1) in FTIR spectrum of AVANp4. Colon specific targeted in-vitro release of 5-Aminosalicylic acid from AVANp4 has been studied in pH 1...
August 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28774843/self-assembling-polymeric-nanocarriers-to-target-inflammatory-lesions-in-ulcerative-colitis
#3
Herve Courthion, Thibault Mugnier, Christel Rousseaux, Michael Möller, Robert Gurny, Doris Gabriel
We have developed a self-assembling polymeric nanocarrier to deliver the potent immunosuppressive drug Cyclosporine A (CsA) to inflammatory lesions in ulcerative colitis (UC) patients. Our nanocarrier has a high drug loading capacity and efficiently targets its CsA payload to the diseased tissue after local administration. Tissue drug levels were several orders of magnitude higher in animals suffering from a trinitrobenzene-sulfonic acid (TNBS) - induced colitis, compared to healthy control animals; no drug was detectable in the plasma, underlining the localized delivery strategy...
July 31, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28765693/jianpi-qingchang-decoction-regulates-intestinal-motility-of-dextran-sulfate-sodium-induced-colitis-through-reducing-autophagy-of-interstitial-cells-of-cajal
#4
Yan-Cheng Dai, Lie Zheng, Ya-Li Zhang, Xuan Chen, De-Liang Chen, Li-Juan Wang, Zhi-Peng Tang
AIM: To investigate the underlying effect of Jianpi Qingchang decoction (JQD) regulating intestinal motility of dextran sulfate sodium (DSS)-induced colitis in mice. METHODS: C57BL/6 mice were randomly divided into four groups: the control group, the DSS group, the JQD group, and the 5-aminosalicylic acid group. Except for the control group, colitis was induced in other groups by giving distilled water containing 5% DSS. Seven days after modeling, the mice were administered corresponding drugs intragastrically...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28708248/oral-and-upper-gastrointestinal-crohn-s-disease
#5
REVIEW
Robyn Laube, Ken Liu, Mark Schifter, Jessica L Yang, Michael K Suen, Rupert W Leong
Crohn's disease is a heterogeneous, inflammatory condition that can affect any location of the gastrointestinal tract. Proximal gastrointestinal involvement occurs in 0.5-16% of patients, and it is usually diagnosed after recognition of intestinal disease. Symptoms are often mild and non-specific, however upper gastrointestinal disease predicts a more severe Crohn's phenotype with a greater frequency of complications such as obstruction and perforation. Gastroscopy and biopsy is the most sensitive diagnostic investigation...
July 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28670228/treatment-and-outcomes-medical-and-surgical-treatment-for-intestinal-beh%C3%A3-et-s-disease
#6
REVIEW
Tadakazu Hisamatsu, Mari Hayashida
Behçet's disease (BD) is a chronic relapsing disease involving multiple organ systems. BD is characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. It is widely recognized that the presence of intestinal lesions may be a poor prognostic factor in intestinal BD, increasing the risk of surgery and decreasing the quality of life. Despite this, the management of intestinal BD has not been standardized. Empirical therapies including 5-aminosalicylic acid and corticosteroids have been used anecdotally to treat intestinal BD, but recent studies have provided evidence for the efficacy of anti-tumor necrosis factor α monoclonal antibodies...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28669550/sulfasalazine-induced-crystalluria-causing-severe-acute%C3%A2-kidney%C3%A2-injury
#7
Michael Durando, Hannah Tiu, James Soo Kim
Sulfasalazine is an anti-inflammatory agent commonly used in the treatment of autoimmune conditions such as inflammatory bowel disease and rheumatoid arthritis. Sulfasalazine is converted by gut bacteria into sulfapyridine and the clinically active metabolite 5-aminosalicylic acid (5-ASA), and its efficacy is proportional to the 5-ASA concentration within the intestinal lumen. Renal complications are commonly reported for the chemically similar 5-ASA derivative mesalamine, but are not well-known side effects of sulfasalazine therapy...
June 29, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28654307/mangosteen-extract-prevents-dextran-sulfate-sodium-induced-colitis-in-mice-by-suppressing-nf-%C3%AE%C2%BAb-activation-and-inflammation
#8
Hee-Sung Chae, Byoung Hoon You, Jieun Song, Hyuk Wan Ko, Young Hee Choi, Young-Won Chin
In this study, the anti-inflammatory effects of mangosteen extract (MGE) on dextran sulfate sodium (DSS)-induced colitis in mice and nuclear factor (NF)-κB pathway modulation were investigated. Acute colitis was induced by administering 3% DSS in drinking water for 7 days, and three groups of Institute of Cancer Research mice were treated with 30 and 120 mg/kg MGE or 5-aminosalicylic acid for 7 days; an additional two groups of mice served as healthy and disease controls. The results indicated that MGE significantly prevented weight loss, reduced disease activity index scores, and preserved colon length compared with the findings in the untreated colitis group...
August 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28644308/the-use-of-5-aminosalicylic-acid-in-children-and-adolescents-with-inflammatory-bowel-disease
#9
Christiane Sokollik, Nicolas Fournier, David Rizzuti, Christian P Braegger, Andreas Nydegger, Susanne Schibli, Johannes Spalinger
BACKGROUND: In ulcerative colitis (UC) 5-aminosalicylic acid (5-ASA) is recommended as primary therapy for mild to moderate disease. Topical 5-ASA has been proven especially effective. In Crohn's disease (CD) the evidence for a beneficial role of 5-ASA is weak. We investigated the use of topical and systemic 5-ASA therapy in children and adolescents with inflammatory bowel disease. MATERIALS AND METHODS: Data of patients younger than 18 years, registered between April 2008 and December 2015 in the Swiss Inflammatory Bowel Disease Cohort, were analyzed...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28623877/5-aminosalicylic-acid-agents-for-prevention-of-recurrent-diverticulitis-a-systematic-review-and-meta-analysis
#10
Seigo Urushidani, Akira Kuriyama, Masami Matsumura
BACKGROUND AND AIM: Prevalence of colonic diverticulosis is increasing worldwide with age, and up to 25% of patients who have colonic diverticulosis might experience diverticulitis. However, a definitive approach of preventing recurrent diverticulitis remains unknown. 5-aminosalicylic acid (5-ASA) agents are anti-inflammatory agents and have been used to prevent recurrent diverticulitis, and there have been some randomized, clinical trials (RCTs). However, the efficacy results for secondary prevention in uncomplicated diverticulitis differed across studies...
June 17, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28611570/development-and-improvement-of-simple-colonic-mucosal-ulcer-during-treatment-of-severe-ulcerative-colitis-with-tacrolimus
#11
Ayumi Ito, Bunei Iizuka, Teppei Omori, Shinichi Nakamura, Katsutoshi Tokushige
Diarrhea, melena, and lower abdominal pain developed in a male in his 20s and colonoscopy showed pancolitis-type severe ulcerative colitis (UC). Treatment was initiated with 4,000 mg of 5-aminosalicylic acid and 60 mg/day of prednisolone, but the symptoms and inflammatory reaction worsened with prednisolone dose reduction. Tacrolimus was added to the treatment, which subsequently induced remission. Serial colonoscopies during the treatment showed improvement in ulcer and mucosal edema throughout the entire large intestine, but a new solitary round ulcer appeared at the end of the ileum...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28555169/strongyloides-colitis-as-a-harmful-mimicker-of-inflammatory-bowel-disease
#12
Julio Poveda, Farah El-Sharkawy, Leopoldo R Arosemena, Monica T Garcia-Buitrago, Claudia P Rojas
Autoinfection caused by Strongyloides stercoralis frequently becomes a life-long disease unless it is effectively treated. There is overlapping histomorphology between Strongyloides colitis and inflammatory bowel disease; a low index of suspicion can lead to misdiagnosis and fatal consequences. We present a case of Strongyloides colitis mimicking the clinical and pathologic features of inflammatory bowel disease. A 64-year-old female presented to the emergency department with a four-day history of abdominal pain, diarrhea, and hematochezia...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28475813/direct-health-care-cost-utilization-in-hong-kong-inflammatory-bowel-disease-patients-in-the-initial-2-years-following-diagnosis
#13
Lung-Yi Mak, Siew C Ng, Irene O L Wong, Michael K K Li, F H Lo, Marc T L Wong, C M Leung, Steven W C Tsang, K H Chan, S F Sze, Edwin H S Shan, Belsy C Y Lam, Aric J Hui, Ivan F N Hung, Wai K Leung
BACKGROUND AND AIM: There is scanty data on the healthcare utilization from Asia where the incidence of inflammatory bowel disease (IBD) is rising rapidly. We aim to determine the direct healthcare costs in the first two-year of diagnosis in an IBD cohort from Hong Kong, and the factors associated with high cost-outliers. METHODS: This is a retrospective cohort study which included patients newly diagnosed with IBD in a territory-wide IBD registry. Patients' clinical information, hospitalization records, investigations and IBD treatments were retrieved for up to two years following diagnosis of IBD...
May 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28475382/dysplasia-and-colorectal-cancer-surveillance-in-inflammatory-bowel-disease
#14
Samba Siva Reddy Pulusu, Ian C Lawrance
Inflammatory bowel disease (IBD) patients are at an increased risk of developing colorectal cancer (CRC), a devastating complication of which intestinal dysplasia is the precursor. Considerable progress has been made to determine CRC risk in IBD, identification & management of dysplasia and preventative methods. Traditionally, surveillance colonoscopies with random colonic biopsies was used. However recent data suggests that chromoendoscopy is a better method of surveillance. Using 5-aminosalicylic acid agents primarily for chemoprevention is an ongoing debate however, when prescribed along with other strategies to control inflammation, their use is considered of benefit...
May 16, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28473247/oxidized-5-aminosalicylic-acid-activates-nrf2-ho-1-pathway-by-covalently-binding-to-keap1-implication-in-anti-inflammatory-actions-of-5-aminosalicylic-acid
#15
Sookjin Kang, Wooseong Kim, Seongkeun Jeong, Yonghyun Lee, Joon Nam, Sunyoung Lee, Yunjin Jung
Mesalazine (5-aminosalicylic acid, 5-ASA), a currently used drug for anti-inflammatory bowel disease, is easily oxidized by HOCl, a strong oxidant generated in gut inflammation, to produce electrophilic quinones. We investigated whether this chemical feature has an implication in the anti-inflammatory pharmacology of 5-ASA. Human colon carcinoma HCT116 cells were treated with HOCl-reacted 5-ASA. Oxidized 5-ASA activated Nrf2 while 5-ASA itself was not effective. Activation of Nrf2 led to induction of hemeoxygenase (OH)-1, an anti-inflammatory enzyme...
May 1, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28471622/combination-of-corticosteroids-with-5-aminosalicylic-acids-compared-to-corticosteroids-alone-for-hospitalized-patients-with-active-ulcerative-colitis
#16
Ofir Har-Noy, Bun Kim, Rivi Haiat, Tal Engel, Bella Ungar, Rami Eliakim, Won Ho Kim, Jae Hee Cheon, Shomron Ben-Horin
BACKGROUND: Although 5-amino-salycilic acids (5-ASA) are often used with corticosteroid treatment in moderate-to-severe ulcerative colitis, the value of continuing/initiating 5-ASA in this clinical setting has not been explored. OBJECTIVES: To investigate the impact of a combination 5-ASA+corticosteroid therapy on the outcome of hospitalized patients with acute moderate-severe ulcerative colitis. METHODS: We conducted a retrospective study of patients hospitalized with moderate-severe ulcerative colitis in two centers, Israel and South Korea...
October 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28466633/management-of-diverticulosis-what-s-new
#17
REVIEW
Walter Elisei, Giovanni Brandimarte, Antonio Tursi
The incidence of diverticulosis and diverticular disease (DD) of the colon, including acute diverticulitis, is increasing worldwide, and becoming a significant burden on national health systems in terms of direct and indirect costs. Thus, significant efforts are now being focused to identify the correct therapeutic approach to treat symptomatic patients and to prevent diverticulitis. Fiber, non-absorbable antibiotics, 5-aminosalicylic acid and probioticsare currently being investigated in this way. Unfortunately, current evidences on the effectiveness of some medical treatment in preventing acute diverticulitis recurrence are still lacking...
October 2017: Minerva Medica
https://www.readbyqxmd.com/read/28451776/acetylsalicylic-acid-tris-hydroxymethyl-aminomethane-reduces-colon-mucosal-damage-without-causing-gastric-side-effects-in-a-rat-model-of-colitis
#18
Gabriella Varga, Melinda Ugocsai, Petra Hartmann, Norbert Lajkó, Réka Molnár, Szilárd Szűcs, Dávid Kurszán Jász, Dániel Érces, Miklós Ghyczy, Gábor Tóth, Mihály Boros
BACKGROUND: We have developed a novel compound from acetylsalicylic acid (ASA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) precursors with ASA-like anti-inflammatory efficacy and reduced the mucosa-damaging side-effects. Our aim was to examine local and remote consequences of ASA-Tris administration in 2-,4-,6-trinitrobenzene-sulfonic acid (TNBS)-induced colitis as compared to ASA or mesalamine (5-aminosalicylate) treatment. METHODS: Sprague-Dawley rats were randomized to five groups (n = 6, each), and TNBS enemas were performed...
April 27, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28440311/efficacy-and-safety-of-rectal-5-aminosalicylic-acid-versus-corticosteroids-in-active-distal-ulcerative-colitis-a-systematic-review-and-network-meta-analysis
#19
Xiaojing Zhao, Changcheng Zhou, Jingjing Ma, Yunjuan Zhu, Min Sun, Peixue Wang, Yi Zhang, Haiqin Ma, Hongjie Zhang
Topical 5-aminosalicylic acid (5-ASA) and corticosteroids are used frequently in the treatment of active distal ulcerative colitis (UC). Our study aimed to determine the efficacy and safety of different topical drugs used to treat active distal UC. A random-effects model within a Bayesian framework was utilized to compare treatment effects and safety as odds ratios (ORs) with corresponding 95% credible intervals (CrI). The surface under the cumulative ranking area (SUCRA) and median rank (MR) with corresponding 95% CrI were calculated to rank the treatment outcomes...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424670/azathioprine-mercaptopurine-and-5-aminosalicylic-acid-affect-the-growth-of-ibd-associated-campylobacter-species-and-other-enteric-microbes
#20
Fang Liu, Rena Ma, Stephen M Riordan, Michael C Grimm, Lu Liu, Yiming Wang, Li Zhang
Campylobacter concisus is a bacterium that is associated with inflammatory bowel disease (IBD). Immunosuppressive drugs including azathioprine (AZA) and mercaptopurine (MP), and anti-inflammatory drug such as 5-aminosalicylic acid (5-ASA) are commonly used to treat patients with IBD. This study aimed to examine the effects of AZA, MP, and 5-ASA on the growth of IBD-associated bacterial species and to identify bacterial enzymes involved in immunosuppressive drug metabolism. A total of 15 bacterial strains of five species including 11 C...
2017: Frontiers in Microbiology
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