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5-aminosalicylic acid

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https://www.readbyqxmd.com/read/28333203/budesonide-mmx-add-on-to-5-aminosalicylic-acid-therapy-in-mild-to-moderate-ulcerative-colitis-a-favourable-risk-benefit-profile
#1
Silvio Danese, Stefanos Bonovas, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
February 21, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28329471/first-report-of-mesalamine-5-aminosalicylic-acid-as-the-causative-agent-in-a-case-of-acute-generalized-exanthamous-pustulosis
#2
Erin Rocci, Kelly Park, Kelli Hutchens, Laura Winterfield
Acute generalized exanthamous pustulosis (AGEP)is a rare eruption of non-follicular sterile pustuleson a diffuse background of erythema and edema,commonly associated with fever and leukocytosis.Antibiotics are implicated in most cases; however,other drugs have been reported to cause AGEP. Wereport a case of a 73-year-old man with a historyof ulcerative colitis who presented with a diffusepustular rash, renal failure, elevated liver functiontests, and leukocytosis with neutrophilia. A week priorto admission, the patient was started on mesalamineto treat colitis...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329021/comparison-of-anti-inflammatory-activities-of-an-anthocyanin-rich-fraction-from-portuguese-blueberries-vaccinium-corymbosum-l-and-5-aminosalicylic-acid-in-a-tnbs-induced-colitis-rat-model
#3
Sónia R Pereira, Rita Pereira, Isabel Figueiredo, Victor Freitas, Teresa C P Dinis, Leonor M Almeida
Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms and efficacy as compared with established drugs still require more clarification. The main aim of this study was to compare the anti-inflammatory action of a chemically characterized anthocyanin-rich fraction (ARF), obtained from Portuguese blueberries (Vaccinium corymbosum L...
2017: PloS One
https://www.readbyqxmd.com/read/28297817/-distribution-and-drug-resistance-of-nontuberculous-mycobacteria-in-beijing
#4
J Zhang, J R Su, B C Ding, J W Liu, J L Yi, X Y Yang, N H Wang, S M Wang
Objective: To analyze the distribution and drug resistance of nontuberculous mycobacteria(NTM) in Beijing. Methods: Using PCR-fluorescence probe method we identified 1 552 mycobacterial isolates in 2009 and 1 553 mycobacterial isolates in 2013, which were stored by Beijing Research Institute for Tuberculosis Control.All identified NTM strains were confirmed by 16S rRNA gene sequencing, and drug sensitivity testing was performed by using 1% ratio method.SPSS 13.0 was used for statistical analysis. Results: The isolation rate for NTM in 2009 and 2013 was 3...
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28292983/origins-of-combination-therapy-for-tuberculosis-lessons-for-future-antimicrobial-development-and-application
#5
REVIEW
Christopher A Kerantzas, William R Jacobs
Tuberculosis is a global health problem that causes the death of approximately 1.5 million people worldwide each year (WHO, p. 1-126, Global Tuberculosis Report, 2015). Treatment of drug-susceptible tuberculosis requires combination antimicrobial therapy with a minimum of four antimicrobial agents applied over the course of 6 months. The first instance of combination antimicrobial therapy applied to tuberculosis was the joint use of streptomycin and para-aminosalicylic acid as documented by the Medical Research Council of the United Kingdom in 1950...
March 14, 2017: MBio
https://www.readbyqxmd.com/read/28275298/jianpi-qingchang-decoction-alleviates-ulcerative-colitis-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-activation
#6
Lie Zheng, Ya-Li Zhang, Yan-Cheng Dai, Xuan Chen, De-Liang Chen, Yue-Ting Dai, Zhi-Peng Tang
AIM: To investigate the therapeutic effect of Jianpi Qingchang decoction (JPQCD) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. METHODS: C57BL/c mice were injected intragastrically with 5% DSS instead of drinking water for 7 d, and their body weight, diarrhea severity and fecal bleeding were monitored, while the mice in the control group were treated with standard drinking water, without DSS. After 7 d, the DSS drinking water was changed to normal water and the DSS group continued with DSS water...
February 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28260866/adherence-in-ulcerative-colitis-an-overview
#7
REVIEW
Anna Testa, Fabiana Castiglione, Olga Maria Nardone, Giorgio L Colombo
Medication adherence is an important challenge while treating chronic illnesses, such as ulcerative colitis (UC), that require a long-term management to induce and maintain clinical remission. This review provides an overview of the role that medication adherence plays in the routine management of UC, with a focus on the results of a recent Italian study reporting the perception of patients with UC regarding adherence to treatment. A literature analysis was conducted on topics, such as measurement of adherence in real practice, causes, risk factors and consequences of non-adherence and strategies, to raise patients' adherence...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28213866/5-aminosalicylic-acid-attenuates-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats-by-increasing-the-expression-of-nur77
#8
Ling-Yue Sun, Zong-Ye Cai, Jun Pu, Jian Li, Jie-Yan Shen, Cheng-de Yang, Ben He
The aim of this study is to investigate the effect of 5-aminosalicylic acid (5-ASA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats and its molecular mechanism. Sixty male Sprague-Dawley rats (250-300 g) were evenly randomized into six groups: control group; PAH group induced by MCT intraperitoneal injection (50 mg/kg) on day 1; and four PAH groups treated for 30 days from day 2 with 5-ASA at 50 (5-ASA-50 group), 100 (5-ASA-100 group), 150 (5-ASA-150 group), and 200 mg/kg/day (5-ASA-200 group), respectively...
February 17, 2017: Inflammation
https://www.readbyqxmd.com/read/28203059/what-strategies-do-ulcerative-colitis-patients-employ-to-facilitate-adherence
#9
Aki Kawakami, Makoto Tanaka, Makoto Naganuma, Shin Maeda, Reiko Kunisaki, Noriko Yamamoto-Mitani
BACKGROUND: Overall, 30%-45% of patients with ulcerative colitis (UC) are non-adherent and have difficulties taking their medications; this non-adherence increases the risk of clinical relapse 1.4- to 5.5-fold. This study aimed to clarify the strategies patients employ to facilitate adherence and determine whether the strategies had an impact on good adherence. METHODS: This was a cross-sectional survey using a self-administered questionnaire and review of medical records...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28183605/obtaining-the-palygorskite-chitosan-composite-for-modified-release-of-5-aminosalicylic-acid
#10
Ana Cristina Sousa Gramoza Vilarinho Santana, José Lamartine Soares Sobrinho, Edson Cavalcanti da Silva Filho, Livio Cesar Cunha Nunes
This study's aim was to obtain composites from palygorskite (PLG) and chitosan (CS) in order to modify 5-aminosalicylic (5-ASA) release. Initially, the PLG:CS composite was obtained using glutaraldehyde (GLA) as a reticular agent. Then, PLG, CS and PLG:CS were characterized by means of analytical techniques such as CHN elemental analysis, surface area analysis, XRD, FTIR, DSC and TG, SEM, adsorption tests and release profiles. Based on analytical data, the formation of the PLG:CS composite which showed the presence about 19% of CS, decrease in specific surface area, morphological analysis modified, visible change of crystallinity, of FTIR and thermal analysis...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28182985/a-new-fluorogenic-sensing-platform-for-salicylic-acid-derivatives-based-on-%C3%AF-%C3%AF-and-nh-%C3%AF-interactions-between-electron-deficient-and-electron-rich-aromatics
#11
Anup Pandith, Giridhari Hazra, Hong-Seok Kim
A novel simple fluorescent probe was designed for the recognition of electron-rich salicylic acid derivatives (SAs). The imidazole-appended aminomethyl perylene probe 1 selectively differentiated between electron-rich amino-SAs and electron-deficient nitro-SAs in EtOH, exhibiting the highest selectivity and sensitivity toward 5-aminosalicylic acid (5-ASA) and showing strong 1:1 binding (Ka=1.37×10(7)M(-1)). This high selectivity and sensitivity resulted from the synergistic multiple hydrogen bonding interactions of secondary amine and imidazole units and π-π interactions between electron-rich and electron-deficient rings, along with the unusual NH-π interactions between 5-ASA and the perylene moiety of 1...
February 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28175192/p638-release-of-5-aminosalicylic-acid-from-mesalazine-formulations-a-novel-dynamic-dissolution-model-simulating-gastrointestinal-ph-changes
#12
E Demyanova, T Vakhitov, S Sitkin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172831/p045-5-aminosalicylates-promote-inflammation-resolution-in-ulcerative-colitis-through-generation-of-anti-inflammatory-hydroxy-fatty-acids
#13
R Wysoczanski, A Kendall, M Motwani, R Vega, F Rahman, S McCartney, S Bloom, A Nicolaou, D Gilroy, A Segal, D Marks
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172639/p461-comparison-of-efficacy-of-different-oral-5-aminosalicylic-acid-doses-for-maintenance-of-remission-in-ulcerative-colitis-a-systematic-review-and-meta-analysis
#14
C H Choi, Y S Kim, W Moon, B I Lee, E S Kim, Y Jung, D I Park, Y S Yoon, H Lee, D S Han
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169975/simple-urine-test-to-evaluate-adherence-to-oral-5-asa-in-teenagers-with-ulcerative-colitis-proof-of-concept
#15
Alie Dijkstra, Daan J Touw, Patrick F van Rheenen
OBJECTIVES: 5-aminosalicylic acid (5-ASA) is an important maintenance drug for patients with ulcerative colitis. A proportion of the ingested dose is excreted in the urine. Measuring 5-ASA and its metabolites in urine requires mass spectrometry, which is not widely available for this purpose. Urinary 5-ASA can be measured by colorimetry using the serum salicylic acid assay and is a surrogate marker of recent 5-ASA ingestion. We evaluated whether measuring 5-ASA in first morning voids or in random spot urine samples correctly identifies teenagers with poor adherence to oral 5-ASA...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28147380/promises-and-dangers-of-combination-therapy
#16
REVIEW
Wolfgang Kruis, Phuong G Nguyen, Julia Morgenstern
The efficiency of the existing methods of treating inflammatory bowel disease (IBD) is limited. There are 2 ways to address this problem - either create new treatment modalities or optimize current therapies. Optimisation may be accomplished by using combinations of established therapeutic strategies. With regard to topically acting compounds such as 5-aminosalicylic acid, combining oral and rectal preparations is a commonly used method. Another commonly used combination is anti-tumor necrosis factor (TNF)-α antibody modalities together with immunosuppressants (thiopurines, methotrexate)...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28138699/5-asa-loaded-sio2-nanoparticles-a-novel-drug-delivery-system-targeting-therapy-on-ulcerative-colitis-in-mice
#17
Haiying Tang, Dan Xiang, Feng Wang, Jingwei Mao, Xiaoyan Tan, Yingde Wang
The targeting of 5-aminosalicylic acid (5-ASA), a first-line therapeutic agent for mild to moderate active ulcerative colitis (UC), to the site of inflammation has remained a challenge and an unmet requirement in the treatment of UC. However, nanoscale carriers for targeted drug delivery are promising for pharmacotherapy, and nanoparticles improve the pharmacokinetics of the loaded therapeutics based on their physical properties. To design and prepare 5‑ASA‑loaded silicon dioxide nanoparticles (5‑ASA‑SiO2 NPs), a micro‑emulsion method was conducted, and their respective therapeutic effects were validated in a mouse model of UC...
January 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28133684/antioxidant-effect-of-vitamin-e-and-5-aminosalicylic-acid-on-acrylamide-induced-kidney-injury-in-rats
#18
Nisreen A Rajeh, Najlaa M Al-Dhaheri
To explore renal toxicity caused by sub-acute exposure of acrylamide and to study the protective effect of 5-Aminosalicylic acid (5-ASA) and Vitamin E (vit-E)on Acrylamide (ACR) induced renal toxicity. Methods: This study was conducted at King Fahad Medical Research Centre, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia, between August and November 2015. A total of 49 adult Wistar rats (250 ± 20g) aged 60 days were kept in a controlled environment and used in the present study. The rats were divided into 7 groups (control, ACR alone, ACR+5-ASA, ACR+vit-E, ACR+ASA+vit-E, vit-E alone, and ASA alone)...
February 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28123193/5-aminosalicylic-acid-associated-myocarditis-and-pericarditis-a-narrative-review
#19
REVIEW
Glen Brown
BACKGROUND: Use of medications containing the 5-aminosalicylic acid (5-ASA) moiety may cause a rare but potentially lethal side effect involving inflammation of the heart (myocarditis) or pericardium (pericarditis) or both (myopericarditis). Early recognition of 5-ASA as the cause is important to prevent progression of the inflammation. OBJECTIVE: To provide clinicians with information to assist in recognizing the signs and symptoms of 5-ASA-induced cardiac inflammation and the characteristics of the suspected therapy, and in determining the appropriate approach to treatment...
November 2016: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28121001/anti-inflammatory-effects-of-dioscorea-alata-l-anthocyanins-in-a-tnbs-induced-colitis-model
#20
Tao Chen, Shihui Hu, Haiwen Zhang, Qingfeng Guan, Yuhui Yang, Xuemei Wang
The purple yam, Dioscorea alata L., is an important source of starch, vitamins and polyphenols. Five different pigments from the purple tubers of this plant were separated by high-performance liquid chromatography-mass spectrometry, and the anthocyanin fraction (DACN) was collected. The anti-inflammatory effects of DACNs were investigated at different concentrations and compared with the standard colitis treatment, 5-aminosalicylic acid, in a trinitrobenzenesulfonic acid (TNBS)-induced colitis mouse model. Macro- and microscopic parameters including body weight change, disease activity index (DAI) and intestinal histology were used for the determination of the anti-inflammatory effects of DACNs...
January 25, 2017: Food & Function
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