Jihee Kim, Gina Ryu, Jeongmin Seo, Miyeon Go, Gyungmin Kim, Sol Yi, Suwon Kim, Hana Lee, June-Yong Lee, Han Sung Kim, Min-Chan Park, Dong Hae Shin, Hyunbo Shim, Wankyu Kim, Soo Young Lee
Osteoarthritis (OA) is a progressive and irreversible degenerative joint disease that is characterized by cartilage destruction, osteophyte formation, subchondral bone remodeling, and synovitis. Despite affecting millions of patients, effective and safe disease-modifying osteoarthritis drugs are lacking. Here we reveal an unexpected role for the small molecule 5-aminosalicylic acid (5-ASA), which is used as an anti-inflammatory drug in ulcerative colitis. We show that 5-ASA competes with extracellular-matrix collagen-II to bind to osteoclast-associated receptor (OSCAR) on chondrocytes...
February 3, 2024: Nature Communications