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https://www.readbyqxmd.com/read/28035546/disequilibrium-in-the-cd8-cd28-cd8-cd28-t-lymphocyte-balance-is-related-to-prognosis-in-rats-with-trinitrobenzenesulfonic-acid-induced-colitis
#1
Shixue Dai, Hongxiang Gu, Qianyi Lin, Tiaosi Xing, Minhua Chen, Tao Zhong, Gang Wu, Yanling Feng, Hongbo Liu, Yong Gao, Hongjian Jian, Minhai Zhang, Hongmei Mo, Huanjie Zhu, Dongsheng Chen, Jun Xu, Ying Zou, Honggang Chi, Yuzhen Zhu
PURPOSE: The CD8(+)CD28(+)/CD8(+)CD28(-) T lymphocyte balance is vital for human ulcerative colitis (UC) but has not been defined in experimental colitis. This investigation will try to identify the changes that occur in the CD8(+)CD28(+)/CD8(+)CD28(-) T lymphocyte balance during the progression of trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. METHODS: The frequencies of blood CD8(+)CD28(+) and CD8(+)CD28(-) T lymphocytes were detected in the rats belonging to the normal, model, and treated groups on five days using flow cytometry...
December 29, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28027214/ibd-like-features-in-syndromic-diarrhea-trichohepatoenteric-syndrome
#2
Veronica B Busoni, Julie Lemale, Beatrice Dubern, Fernando Frangi, Patrice Bourgeois, Marina Orsi, Catherine Badens, Alexandre Fabre
BACKGROUND: Very early onset inflammatory bowel disease (VEOIBD) (inflammatory bowel disease [IBD] before 6 years of age) may manifest as a monogenic disease affecting the gastrointestinal tract. Syndromic diarrhea/trichohepatoenteric syndrome (SD/THE), a rare disorder caused by alteration of a complex involved in RNA degradation, has been reported to present with some degree of colitis and in some cases an IBD-like presentation. METHODS: We reviewed clinical and biological data of 4 previously published cases and added detailed data of 2 new cases of SD/THE with an IBD-like presentation...
January 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28026200/what-is-the-real-life-maintenance-mesalazine-dose-in-ulcerative-colitis
#3
Alicia Algaba, Iván Guerra, Ana García García de Paredes, María Hernández Tejero, Carlos Ferre, Daniel Bonillo, Lara Aguilera, Antonio López-Sanromán, Fernando Bermejo
OBJECTIVE: To describe how mesalazine (MSZ) is used in our practice in ulcerative colitis (UC), at what dose, and the success rate (regarding adherence to therapy). METHODS: Observational, transversal study, including all patients with UC and with MSZ maintenance therapy seen from September 2014 to February 2015 at two IBD units in Spain. Treatment adherence was measured by the Morisky-Green scale. RESULTS: We included 203 patients (mean MSZ dose: 2...
December 27, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27988004/pectin-silica-gels-as-matrices-for-controlled-drug-release-in-gastrointestinal-tract
#4
Fedor V Vityazev, Maiia I Fedyuneva, Victoria V Golovchenko, Olga A Patova, Elena U Ipatova, Eugene A Durnev, Ekaterina A Martinson, Sergey G Litvinets
The synthesis of pectin-silica gels for controlled drug release in gastrointestinal tract (GIT) using low methoxyl (LM) and high methoxy (HM) pectins and tetraethoxysilane (TEOS) as precursor is described. The FTIR spectra of the pectin-silica gels show intense absorption bands at 1246cm(-1) and 802cm(-1) corresponding to the vibrations COSi bonds, which absent in the FTIR spectra of the native pectins that indicate the formation covalent bond between silica and pectin macromolecules in the pectin-silica gels...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27973463/rationale-and-evidences-for-treatment-of-symptomatic-uncomplicated-diverticular-disease
#5
Rosario Cuomo, Martina Cargiolli, Paolo Andreozzi, Francesco P Zito, Giovanni Sarnelli
INTRODUCTION: Symptomatic uncomplicated diverticular disease (SUDD) is one of the possible clinical manifestations of diverticular disease. It is a common disorder characterized by chronic abdominal symptoms ranging from lower left abdominal pain to alteration of bowel habit, that significantly reduce quality of life of subject affected. The present article aims to review the current data for medical management of SUDD. EVIDENCE ACQUISITION: We analyzed the existing literature on the factors involved in the pathogenesis of SUDD and we highlighted the possible target for treatment...
December 14, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27941189/clinical-evaluation-of-children-with-ulcerative-colitis-treated-between-2013-2015-own-experience
#6
Monika Meglicka, Michał Szczepański, Maciej Dądalski, Jarosław Kierkuś
AIM: Evaluation of the changes in the endoscopic, laboratory and clinical status in children with ulcerative colitis (UC) with regard to the duration of the disease. MATERIAL AND METHODS: 91 children with UC were involved in the study. Each of them had colonoscopy and their laboratory values were tested. We assessed the colonoscopy results by the Paris classification and by the Baron score. Moreover, demographic, clinical and anthropometric data were collected. We divided our patients into five subgroups depending on the duration of the disease...
2016: Developmental Period Medicine
https://www.readbyqxmd.com/read/27906680/chemopreventive-effects-of-5-aminosalicylic-acid-on-inflammatory-bowel-disease-associated-colorectal-cancer-and-dysplasia-a-systematic-review-with-meta-analysis
#7
Xinyun Qiu, Jingjing Ma, Kai Wang, Hongjie Zhang
BACKGROUND AND AIMS: The chemopreventive effect of 5-aminosalicylic acid (5-ASA) in patients with inflammatory bowel disease (IBD) has been widely studied; however, the results remain conflicting. The aim of this study was to systematically review the literature and update evidence concerning effects of 5-ASA on the risk of colorectal cancer (CRC) and dysplasia (Dys) in patients with ulcerative colitis (UC) or Crohn's disease (CD). RESULTS: 5-ASA showed a chemopreventive effect against CRC/Dys in IBD patients (OR = 0...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898520/mesalazine-in-the-treatment-of-symptomatic-uncomplicated-diverticular-disease
#8
Cong Dai, Min Jiang, Ming-Jun Sun
No abstract text is available yet for this article.
November 28, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875358/-mesalazine-in-the-treatment-of-symptomatic-uncomplicated-diverticular-disease-reply
#9
Antonio Tursi
No abstract text is available yet for this article.
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27864028/anti-tnf-therapy-is-able-to-stabilize-bowel-damage-progression-in-patients-with-crohn-s-disease-a-study-performed-using-the-l%C3%A3-mann-index
#10
Giorgia Bodini, Edoardo G Giannini, Costanza De Maria, Pietro Dulbecco, Manuele Furnari, Elisa Marabotto, Vincenzo Savarino, Edoardo Savarino
AIMS: The Lémann Index (LI) was developed to assess the cumulative structural damage of the intestinal tract in patients with Crohn's Disease (CD) independently of clinical and biochemical activity. Recently, the goal of CD focused on obtaining mucosal healing and deep remission rather than simple symptom control. These new therapeutic aims emphasize the need to prevent progression of bowel damage. In this study we aimed to evaluate the influence of different treatments on structural damage progression, assessed by means of LI in a series of CD patients consistently treated with various drugs...
November 2, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27805459/the-problem-of-adherence-to-therapy-in-ulcerative-colitis-and-the-potential-utility-of-multi-matrix-system-mmx-technology
#11
Cristina Bezzio, Federica Fascì-Spurio, Chiara Viganò, Gianmichele Meucci, Claudio Papi, Simone Saibeni
Ulcerative colitis (uc) is a chronic condition and for the vast majority of patients, life-long treatment is required. low adherence to therapy is an emerging issue. since low adherence is associated with poor clinical outcomes and increased costs, it is becoming crucial to identify strategies in order to improve it. Areas covered: We performed literature searches in PubMed using the terms 'adherence', 'mesalamine', 'budesonide MMX', 'MMX technology' in combination with 'ulcerative colitis'. Firstly, we present the key-concepts of therapy for UC and discuss the problem of the adherence and how to measure it...
January 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27802156/recent-advances-in-clinical-practice-a-systematic-review-of-isolated-colonic-crohn-s-disease-the-third-ibd
#12
REVIEW
Sreedhar Subramanian, Anders Ekbom, Jonathan M Rhodes
The genetics of isolated colonic Crohn's disease place it approximately midway between Crohn's disease with small intestinal involvement and UC, making a case for considering it as a separate condition. We have therefore systematically reviewed its epidemiology, pathophysiology and treatment. Key findings include a higher incidence in females (65%) and older average age at presentation than Crohn's disease at other sites, a mucosa-associated microbiota between that found in ileal Crohn's disease and UC, no response to mesalazine, but possibly better response to antitumour necrosis factor than Crohn's disease at other sites...
February 2017: Gut
https://www.readbyqxmd.com/read/27761147/the-rhizome-mixture-of-anemarrhena-asphodeloides-and-coptis-chinensis-attenuates-mesalazine-resistant-colitis-in-mice
#13
Su-Min Lim, Hyun Sik Choi, Jin-Ju Jeong, Seung-Won Han, Dong-Hyun Kim
We investigated the effect of DWac on the gut microbiota composition in mice with 2,3,6-trinitrobenzenesulfonic acid- (TNBS-) induced colitis. Treatment with DWac restored TNBS-disturbed gut microbiota composition and attenuated TNBS-induced colitis. Moreover, we examined the effect of DWac in mice with mesalazine-resistant colitis (MRC). Intrarectal injection of TNBS in MRC mice caused severe colitis, as well as colon shortening, edema, and increased myeloperoxidase activity. Treatment with mesalazine (30 mg/kg) did not attenuate TNBS-induced colitis in MRC mice, whereas treatment with DWac (30 mg/kg) significantly attenuated TNBS-induced colitis...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27743389/mesalazine-induced-enteritis-causing-refractory-diarrhea
#14
LETTER
Ichiro Otani, Shiro Oka, Shinji Tanaka
No abstract text is available yet for this article.
October 15, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27697784/once-versus-twice-daily-mesalazine-to-induce-remission-in-paediatric-ulcerative-colitis-a-randomized-controlled-trial
#15
Dan Turner, Baruch Yerushalmi, Michal Kori, Efrat Broide, Yael Mozer-Glassberg, Ron Shaoul, Kaija-Leena Kolho, Eyal Shteyer, Hussein Shamaly, Oren Ledder, Shlomi Cohen, Sarit Peleg, Avi On, Arie Levine
BACKGROUND: Trials in adults suggested once-daily (QD) dosing of 5-ASA may be as or more effective as twice-daily (BID) dosing in ulcerative colitis (UC). In this induction of remission, investigator-blinded, randomized-controlled-trial we aimed to compare effectiveness and safety of once vs. twice daily mesalazine (Pentasa®), in paediatric UC. METHODS: Children, 4-18 years with a PUCAI ( Paediatric Ulcerative Colitis Activity Index) of 10-55 points at inclusion, were randomized in blocks of 6 with blinded allocation to QD or BID mesalamine using a weight-based dosing table...
October 3, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27687648/-efficacy-of-yunnan-baiyao-as-an-adjuvant-treatment-for-active-ulcerative-colitis-an-open-label-randomized-controlled-study
#16
Wen-Zhen Zhao, Na Diao, Yi-Xiu Gu, Xiao-Tong Zhu, Ming-Song Li
OBJECTIVE: To investigate the efficacy of Yunnan Baiyao (YNBY)as an adjuvant treatment of active ulcerative colitis. METHODS: A total of 221 patients with active ulcerative colitis were randomized into YNBY group (78 cases) and control group (143 cases). The patients were followed up for 26 weeks and time of remission and serological data (WBC, HGB, PLT, and CRP) were recorded. RESULTS: The patients receiving YNBY as an adjuvant therapy had a median remission time of 9 weeks (95% CI: 8...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27659382/delayed-diagnosis-of-central-skull-base-osteomyelitis-with-abscess-case-report-and-learning-points
#17
G Chawdhary, S Hussain, R Corbridge
Central skull-base osteomyelitis (CSBO) is a rare life-threatening infection, usually resulting from medial spread of necrotising otitis externa. Here, we describe a case with no identifiable source of infection, causing a delay in diagnosis. An 80-year-old man with Crohn's disease treated with mesalazine presented with collapse and tonic-clonic seizure. Computed tomography and magnetic resonance imaging showed a nasopharyngeal mass that was initially thought to be a neoplasm. Awaiting formal biopsy, he represented with collapse and repeat imaging showed features of abscess formation...
January 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27650488/systematic-review-second-generation-vs-conventional-corticosteroids-for-induction-of-remission-in-ulcerative-colitis
#18
G D'Haens
BACKGROUND: Oral corticosteroids are the mainstay treatment for induction of ulcerative colitis remission in patients failing or intolerant to aminosalicylate therapy, but the poor tolerability profile of these drugs limits their usefulness. Second-generation, gut-selective corticosteroids may offer a safe alternative to systemic agents. AIM: To review the efficacy and safety of systemic and second-generation oral corticosteroids for the induction of remission in ulcerative colitis...
November 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27648296/usefulness-of-sulfasalazine-for-patients-with-refractory-ulcerative-colits
#19
Takuya Yoshino, Makoto Sono, Shujiro Yazumi
BACKGROUND: Patients with refractory-ulcerative colitis (UC) require therapy escalation. Sulfasalazine (SASP) could deliver a high concentration of 5-aminosalicylic acid to the colon. The usefulness of SASP for refractory-UC patients, however, is unclear. AIM: The aim was to evaluate the usefulness of SASP for refractory-UC patients. METHOD: We retrospectively analysed 36 (11.4%) of 316 patients with refractory-UC who had been treated with SASP...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27623957/the-long-term-effects-of-probiotics-in-the-therapy-of-ulcerative-colitis-a-clinical-study
#20
Vincenzo Davide Palumbo, Marcello Romeo, Antonella Marino Gammazza, Francesco Carini, Provvidenza Damiani, Giuseppe Damiano, Salvatore Buscemi, Attilio Ignazio Lo Monte, Alice Gerges-Geagea, Abdo Jurjus, Giovanni Tomasello
AIM: Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (mesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity...
September 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
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