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https://www.readbyqxmd.com/read/28431755/fever-induced-by-mesalazine
#1
Izaskun Pizarro Carbajo, Alfonso Gutiérrez Macías, Markel Cea Gómez, Itxaso Lombide Aguirre
No abstract text is available yet for this article.
April 18, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28422836/fecal-microbiota-transplantation-is-a-rescue-treatment-modality-for-refractory-ulcerative-colitis
#2
Ahmet Uygun, Kadir Ozturk, Hakan Demirci, Cem Oger, Ismail Yasar Avci, Turker Turker, Mustafa Gulsen
BACKGROUND: Fecal microbial transplantation (FMT) provides to replace beneficial bacteria with more favorable microbiomes in recipient with dysbiosis. The aim of the present study was to prospectively investigate the efficacy of FMT by assessing the clinical and endoscopic response in patients with ulcerative colitis (UC) who had failed anti-inflammatory and immunosuppressive therapy. METHODS: In this prospective and uncontrolled study, 30 patients with UC were included...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28411286/rapid-induction-therapy-with-oral-tacrolimus-in-elderly-patients-with-refractory-ulcerative-colitis-can-easily-lead-to-elevated-tacrolimus-concentrations-in-blood-a-report-of-5-cases
#3
Haruna Kawamura, Satohiro Matsumoto, Noriyuki Nakamura, Hiroyuki Miyatani, Hirosato Mashima
BACKGROUND Tacrolimus is reportedly effective for the treatment of refractory ulcerative colitis (UC). At our hospital, there has been an increase in the number of patients, including elderly patients, with refractory UC treated with tacrolimus. Here, we review the data from 5 patients with elderly-onset UC treated with tacrolimus as remission induction therapy. CASE REPORT The subjects were 5 patients ≥65 years of age with refractory UC who had received oral tacrolimus as remission induction therapy between 2009 and 2014 (3 men and 2 women; median age at onset, 75 years)...
April 15, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28387885/retrospective-comparison-of-long-term-ten-day-month-rifaximin-or-mesalazine-in-prevention-of-relapse-in-acute-diverticulitis
#4
V Festa, S Spila Alegiani, F Chiesara, A Moretti, M Bianchi, A Dezi, G Traversa, M Koch
OBJECTIVE: Diverticular disease (DD) of the colon has an increasing burden on health services. The effectiveness of rifaximin for the treatment of DD, is not yet established. The aim of this study is to assess the impact of long-term treatment with rifaximin or mesalazine in a 10-day schedule for the prevention of recurrent diverticulitis. PATIENTS AND METHODS: This is a retrospective study. We identified all consecutive patients with DD and previous acute diverticulitis (AD) in our outpatients' database; 124 patients, were included...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28371296/population-exposure-to-phthalate-containing-drugs
#5
Anne Broe, Zandra Nymand Ennis, Anton Pottegård, Jesper Hallas, Thomas Ahern, Per Damkier
Phthalates are known endocrine disruptors. Not commonly recognised, phthalates are used as excipients in a number of drug formulations. We aimed to describe the sale of phthalate-containing drugs in Denmark from 2004 to 2015. National data on annual sale of medications (tablets only) were accessed from medstat.dk. Data from the Danish Medicines Agency on phthalate content per tablet were merged with data on total sale for each active substance and drug formulation. We used the 'defined daily dose' (DDD) as the unit of sale and calculated the total amount of phthalate (mg) dispensed per 1,000 inhabitants...
March 29, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28364315/mucosal-healing-of-crohn-s-disease-in-a-patient-with-concurrent-systemic-lupus-erythematosus-using-infliximab
#6
Yuka Kagaya, Hirotsugu Sakamoto, Tomonori Yano, Keijiro Sunada, Alan Kawarai Lefor, Toshiro Niki, Hironori Yamamoto
We describe a patient with Crohn's disease (CD) concurrent with systemic lupus erythematosus (SLE). Continuous prednisolone and cyclosporine treatment resulted in no recurrent symptoms. However, diarrhea, vomiting, and fever occurred for approximately 3 months. A colonoscopy was then performed, which showed a discontinuous cobblestone appearance and longitudinal ulcers extending from the sigmoid colon to the descending colon and distal ileum. A biopsy revealed a noncaseating granulomatous lesion in the colonic mucosa...
March 31, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28353200/asymptomatic-acute-hepatitis-e-in-a-female-patient-with-ulcerative-colitis
#7
Kazuyuki Suzuki, Ichiro Kumagai, Yuichi Yoshida, Akio Miyasaka, Yasuhiro Takikawa, Ryoichi Kamiya, Kouryo Kondo, Akinobu Kato, Toshimi Chiba, Hiroaki Okamoto
We present a 60-year-old female patient with asymptomatic acute hepatitis E that was fortuitously detected during the course of ulcerative colitis (UC). She was admitted to hospital on October 30, 2015. Endoscopy and histological examination of the colon showed typical findings of UC. All parameters of liver function tests were normal on this date. Combination therapy with oral prednisolone and mesalazine was started and intravenous administration of infliximab once every 8 weeks was added later. Her symptoms gradually improved after these treatments, and she was discharged on February 7, 2016...
March 28, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28321036/a-highly-potent-and-selective-histone-deacetylase-6-inhibitor-prevents-dss-induced-colitis-in-mice
#8
Ting Liu, Renping Wang, Haojie Xu, Yunlong Song, Yunpeng Qi
Inflammatory bowel disease (IBD) is a refractory illness with remarkably increasing incidence rate all over the world. However, no desirable treatment scheme is available. Therefore, research and development of new drugs for treating IBD are urgently needed. Histone deacetylase 6 (HDAC6) is considered to be a pro-inflammatory factor, thus the inhibitors specifically-targeting HDAC6 may find their way in IBD treatment. In this study, we evaluated the anti-inflammatory activity of a novel potent and selective HDAC6 inhibitor, LTB2, in dextran sulfate sodium (DSS)-induced colitis mouse model...
March 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28316762/mesalazine-has-no-effect-on-mucosal-immune-biomarkers-in-patients-with-diarrhea-dominant-irritable-bowel-syndrome-referred-to-shariati-hospital-a-randomized-double-blind-placebo-controlled-trial
#9
Mohammad Reza Ghadir, Mehri Poradineh, Masoud Sotodeh, Reza Ansari, Shadi Kolahdoozan, Ahmad Hormati, Mohammad Hosein Yousefi, Samaneh Mirzaei, Homayoon Vahedi
BACKGROUND Intestinal mast cells may cause gastrointestinal symptoms in patients with diarrhea-dominant irritable bowel syndrome (IBS). The objective of this study was to determine the effect of mesalazine on the number of lamina propria mast cells and clinical manifestations of patients with diarrhea-dominant IBS referred to Shariati Hospital affiliated to Tehran University of Medical Sciences. METHODS This was a randomized placebo-controlled double-blind trial conducted on 49 patients with diarrhea-dominant IBS...
January 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28271435/adalimumab-therapy-in-a-patient-with-crohn-s-disease-with-a-giant-pelvic-paraganglioma-after-chemotherapy
#10
Tsutomu Mizoshita, Masashi Ando, Hiroyuki Sagawa, Yoshinori Mori, Takahito Katano, Keiji Ozeki, Satoshi Tanida, Yasuyuki Okamoto, Takaya Shimura, Eiji Kubota, Hiromi Kataoka, Takeshi Kamiya, Takashi Joh
A 23-year-old man was diagnosed with a giant pelvic paraganglioma in September 2013, and a 6-month chemotherapy course was performed. The chemotherapy resulted in stable disease of the tumor for about 1 year. However, in April 2015, the patient complained of fever and diarrhea of more than ten times a day. Endoscopy showed serpiginous (snake-like) ulcers in the cecum, ascending, descending, and sigmoid colons, with granulomas without caseation histologically. The patient was diagnosed with the active stage of Crohn's disease (CD) in June 2015...
March 7, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28261835/systematic-review-with-meta-analysis-use-of-5-aminosalicylates-and-risk-of-colorectal-neoplasia-in-patients-with-inflammatory-bowel-disease
#11
REVIEW
S Bonovas, G Fiorino, T Lytras, G Nikolopoulos, L Peyrin-Biroulet, S Danese
BACKGROUND: The relationship of 5-aminosalicylates' use with the risk of colorectal neoplasia in patients with inflammatory bowel disease (IBD) has been the focus of a growing body of research. AIM: To investigate this association through an updated meta-analysis of observational studies. METHODS: PubMed, Scopus and major conference proceedings were searched up to December 2016. The identified studies were evaluated for publication bias and heterogeneity...
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28256148/accumulation-of-mesalazine-pills-in-the-medium-ileum-in-a-patient-with-crohn%C3%A2-s-disease
#12
Carmen Martínez Huertas, Paloma Garcia-Villanova Ruiz, José Pozo Sánchez, Cristina Dávila Arias
Crohn´s disease is an inflammatory disease that can involve any portion of the gastrointestinal tract, although terminal ileum is the most commonly affected portion. It is characterized by a transmural and discontinuous distribution pattern, with alternating periods of active disease and remission. We present the case of a 23-year-old patient diagnosed with Crohn´s disease, in treatment with extended release Mesalazine and corticoids. The CT Enterography showed activity signs and a great dilatation of medium ileum with lots of Mesalazine pills accumulated inside...
March 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28229616/invasive-pulmonary-aspergillosis-in-an-immunocompromised-patient-with-severe-ulcerative-colitis
#13
David Marti Aguado, María Pilar Ballester, Marta Maia Bosca Watts
Inflammatory Bowel Disease patients at risk of opportunistic infections are those treated with immunomodulators. Toruner and colleagues found that corticosteroid use was more commonly associated with fungal infections. We present a case of invasive pulmonary Aspergillosis due to corticosteroid therapy in the context of a severe Ulcerative Colitis flare. We want to highlight the relationship between Aspergillus fumigatus and horses; and the use of leucocitapheresis combined with mesalazine as an effective treatment option in this patients who can not take more immunosuppressive therapy...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28217376/current-practice-and-clinicians-perception-of-medication-non-adherence-in-patients-with-inflammatory-bowel-disease-a-survey-of-98-clinicians
#14
Anisah Soobraty, Sarah Boughdady, Christian P Selinger
AIM: The survey ascertains perceptions and describes current practice of clinicians regarding medication non-adherence in patients with Inflammatory Bowel Disease. METHODS: Gastroenterologists, trainees and inflammatory bowel disease (IBD) specialist nurses from the United Kingdom were invited to a web based survey collecting data on clinician demographics, patient volume and level of interest in IBD. Respondents were asked to estimate non-adherence levels and report use of screening tools and interventions to improve adherence...
February 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28175192/p638-release-of-5-aminosalicylic-acid-from-mesalazine-formulations-a-novel-dynamic-dissolution-model-simulating-gastrointestinal-ph-changes
#15
E Demyanova, T Vakhitov, S Sitkin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175103/p492-cumulative-safety-signal-review-confirmed-the-established-safety-profile-of-asacol%C3%A2-%C3%A2-mesalazine
#16
S Timeus, P Marchi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28165294/bovine-lactoferrin-and-crohn-s-disease-a-case-study
#17
David B Alexander, Masaaki Iigo, Mohamed Abdelgied, Keiji Ozeki, Satoshi Tanida, Takashi Joh, Satoru Takahashi, Hiroyuki Tsuda
A 22-year-old male suffering from abdominal pain, repeated diarrhea, and weight loss visited the Digestive Disease Department of Nagoya City University Hospital on 19 December 2011. He was hospitalized and diagnosed with Crohn's colitis. His Crohn's Disease Activity Index (CDAI) was 415. Treatment by granulocyte apheresis, mesalazine, and adalimumab was started. His CDAI was 314 on 30 December and 215 on 5 January. A colonoscopic examination on 19 January showed almost complete remission in the transverse colon and marked remission in the rectum...
February 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28160250/thiopurines-and-methotrexate-use-in-ibd-patients-in-a-biologic-era
#18
REVIEW
Gerassimos J Mantzaris
Although we have been living in the era of biologic therapy for several decades, the use of immunomodulators (primarily thiopurines [azathioprine and mercaptopurine] and less so methotrexate) still remains an important component of the inflammatory bowel disease (IBD) pharmaceutical arsenal. Thiopurines as monotherapy exert corticosteroid-sparing effects and can maintain long-term remission in a considerable proportion of patients who have frequent relapses and are or have become mesalazine and/or corticosteroid intolerant or refractory...
March 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28147350/late-onset-of-acute-severe-ulcerative-colitis-clinical-case
#19
A E Dorofeyev, O A Rassokhina, A A Dorofeyeva
Ulcerative colitis (UC) in adult age requires more careful examination because more often it turns out to be a complication related to the precancer condition. The onset of colitis in older age is predicted to follow a more aggressive clinical course and requires more frequent hospitalizations and steroids prescription in contrast to its onset in young patients. Even as this remains unclear, we present here a clinical case of late onset of acute severe UC to represent interesting clinical peculiarities and response to the therapy...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28035546/disequilibrium-in-the-cd8-cd28-cd8-cd28-t-lymphocyte-balance-is-related-to-prognosis-in-rats-with-trinitrobenzenesulfonic-acid-induced-colitis
#20
Shixue Dai, Hongxiang Gu, Qianyi Lin, Tiaosi Xing, Minhua Chen, Tao Zhong, Gang Wu, Yanling Feng, Hongbo Liu, Yong Gao, Hongjian Jian, Minhai Zhang, Hongmei Mo, Huanjie Zhu, Dongsheng Chen, Jun Xu, Ying Zou, Honggang Chi, Yuzhen Zhu
PURPOSE: The CD8(+)CD28(+)/CD8(+)CD28(-) T lymphocyte balance is vital for human ulcerative colitis (UC) but has not been defined in experimental colitis. This investigation will try to identify the changes that occur in the CD8(+)CD28(+)/CD8(+)CD28(-) T lymphocyte balance during the progression of trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. METHODS: The frequencies of blood CD8(+)CD28(+) and CD8(+)CD28(-) T lymphocytes were detected in the rats belonging to the normal, model, and treated groups on five days using flow cytometry...
December 29, 2016: Digestive Diseases and Sciences
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