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https://www.readbyqxmd.com/read/29051786/the-prognostic-value-of-histology-in-ulcerative-colitis-in-clinical-remission-with-mesalazine
#1
Giuseppe Frieri, Brigida Galletti, Mirko Di Ruscio, Rachele Tittoni, Annalisa Capannolo, Donatella Serva, Giovanni Latella, Laura Sollima, Pietro Leocata, Stefano Necozione, Rosamarie Frieri, Angelo Viscido
BACKGROUND: The aim of the study was to compare the prognostic value of histological and endoscopic activity in patients with ulcerative colitis (UC). METHODS: Patients in clinical remission for 1 year under treatment with mesalazine underwent a planned colonoscopy with biopsies. Histological activity was scored using the histological activity index (HAI). Endoscopic activity was scored using the Mayo endoscopic subscore (MES). The clinical course was evaluated measuring relapses needing steroids during a follow up of 3 years...
October 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29038259/novel-gene-encoding-5-aminosalicylate-1-2-dioxygenase-from-comamonas-sp-qt12-and-catalytic-properties-of-the-purified-enzyme
#2
Hao Yu, Shuxue Zhao, Lizhong Guo
The 1,125-bp mabB gene encoding 5-aminosalicylate (5ASA) 1,2-dioxygenase, a nonheme iron dioxygenase in the bicupin family that catalyzes the cleavage of the 5ASA aromatic ring to form cis-4-amino-6-carboxy-2-oxohexa-3,5-dienoate in the biodegradation of 3-aminobenzoate, was cloned from Comamonas sp. QT12 and characterized. The deduced amino acid sequence of the enzyme has low sequence identity with that of other reported ring-cleaving dioxygenases. MabB was heterologously expressed in Escherichia coli cells and purified as a His-tagged enzyme...
October 16, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/29030981/mesalazine-treatment-in-organotypic-culture-of-celiac-patients-comparative-study-with-gluten-free-diet
#3
EDITORIAL
Benedetti E, A Viscido, V Castelli, C Maggiani, M d'Angelo, E Di Giacomo, A Antonosante, A Picarelli, G Frieri
Given the central role of gluten in the pathogenesis of celiac disease (CD), a strict gluten-free diet (GFD) is the only validated treatment able to restore epithelium integrity and eliminate risks of complications. The risk of gluten contamination and the persistence of inflammation, even in patients strictly adhering to GFD, may render this treatment not always effective claiming the necessity of different new solutions. Oxidative and nitrosative stress have been indicated to play a pathophysiological role in CD...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28988395/effect-of-roxithromycin-on-mucosal-damage-oxidative-stress-and-pro-inflammatory-markers-in-experimental-model-of-colitis
#4
Hilal Ahmad, Sneh Verma, Vijay L Kumar
OBJECTIVE AND DESIGN: Roxithromycin, a macrolide antibiotic, exhibits anti-inflammatory property. The present study was designed to evaluate its protective effect in a rat model of colitis. METHODS: The anti-inflammatory property of roxithromycin was first validated in rat paw edema model at 5 and 20 mg/kg doses where it produced 19 and 51% inhibition of paw swelling induced by carrageenan. The efficacy of roxithromycin was evaluated at these doses in a rat model where colitis was induced by intra-colonic instillation of acetic acid...
October 7, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28979689/interleukin-25-primed-mesenchymal-stem-cells-achieve-better-therapeutic-effects-on-dextran-sulfate-sodium-induced-colitis-via-inhibiting-th17-immune-response-and-inducing-t-regulatory-cell-phenotype
#5
Weizi Cheng, Jingling Su, Yiqun Hu, Qingwen Huang, Huaxiu Shi, Lin Wang, Jianlin Ren
AIM: This study aimed to investigate the anti-inflammatory mechanism of IL-25 mediated mesenchymal stem cells (MSC) treatment for inflammatory bowel disease (IBD) in a DSS-induced rat colitis model. METHODS: Rats with DSS-induced colitis were divided into control and treatment groups: normal control group (rats fed with water), DSS group (rats fed with DSS solution), MSC group (DSS-treated rats injected intravenously with GFP-MSCs), IL-25-MSC group (DSS-treated rats injected intravenously with IL-25 primed GFP-MSCs), and mesalazine group (DSS-treated rats fed with mesalazine)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28973005/a-systematic-review-of-cost-effectiveness-studies-comparing-conventional-biological-and-surgical-interventions-for-inflammatory-bowel-disease
#6
Nadia Pillai, Mark Dusheiko, Bernard Burnand, Valérie Pittet
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic disease placing a large health and economic burden on health systems worldwide. The treatment landscape is complex with multiple strategies to induce and maintain remission while avoiding long-term complications. The extent to which rising treatment costs, due to expensive biologic agents, are offset by improved outcomes and fewer hospitalisations and surgeries needs to be evaluated. This systematic review aimed to assess the cost-effectiveness of treatment strategies for IBD...
2017: PloS One
https://www.readbyqxmd.com/read/28962154/interleukin-6-inhibition-by-triptolide-prevents-inflammation-in-a-mouse-model-of-ulcerative-colitis
#7
Haifeng Zhang, Weichang Chen
The present study aimed to assess interleukin (IL)-6 expression in a murine model of ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) and its potential association with the anti-colitis effects of triptolide (TL). Serum IL-6 levels were measured by ELISA. IL-6 gene expression levels in colonic mucosa specimens were assessed by reverse-transcription quantitative PCR and protein expression was evaluated by western blot analysis and immunohistochemistry. The expression of IL-6 was weak in mucosa specimens from normal control animals and upregulated in DSS-induced mice...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28948431/vulvar-involvement-in-pediatric-crohn-s-disease-a-systematic-review
#8
REVIEW
Roberta Granese, Gloria Calagna, Giuliana Morabito, Carmine Carriero, Antonio Perino, Gabriele Tonni, Claudio Romano
PURPOSE: The aim of the study is to report a systematic review (from 2000 to 2017) of all pediatric cases of vulvar Crohn's disease (VCD) and to highlight the key-points for a correct diagnosis and management of this rare condition. METHODS: An electronic search using the Pubmed/Medline, Scopus, EMBASE, Cochrane database and Google Scholar database was performed according to PRISMA guidelines. RESULTS: Twenty pediatric studies and 22 cases of VCD were included for analysis...
September 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28942590/conservative-treatment-of-acute-colonic-diverticulitis
#9
REVIEW
S T van Dijk, S J Rottier, A A W van Geloven, M A Boermeester
PURPOSE OF REVIEW: Since the treatment of acute diverticulitis has become more conservative over the last years, knowledge of conservative treatment strategies is increasingly important. RECENT FINDINGS: Several treatment strategies that previously have been imposed as routine treatment are now obsolete. Uncomplicated diverticulitis patients can be treated without antibiotics, without bed rest, and without dietary restrictions; and a selected group of patients can be treated as outpatients...
September 23, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28939374/factors-associated-with-early-outcomes-following-standardised-therapy-in-children-with-ulcerative-colitis-protect-a-multicentre-inception-cohort-study
#10
Jeffrey S Hyams, Sonia Davis, David R Mack, Brendan Boyle, Anne M Griffiths, Neal S LeLeiko, Cary G Sauer, David J Keljo, James Markowitz, Susan S Baker, Joel Rosh, Robert N Baldassano, Ashish Patel, Marian Pfefferkorn, Anthony Otley, Melvin Heyman, Joshua Noe, Maria Oliva-Hemker, Paul Rufo, Jennifer Strople, David Ziring, Stephen L Guthery, Boris Sudel, Keith Benkov, Prateek Wali, Dedrick Moulton, Jonathan Evans, Michael D Kappelman, Alison Marquis, Francisco A Sylvester, Margaret H Collins, Suresh Venkateswaran, Marla Dubinsky, Vin Tangpricha, Krista L Spada, Ashley Britt, Bradley Saul, Nathan Gotman, Jessie Wang, Jose Serrano, Subra Kugathasan, Thomas Walters, Lee A Denson
BACKGROUND: Previous retrospective studies of paediatric ulcerative colitis have had limited ability to describe disease progression and identify predictors of treatment response. In this study, we aimed to identify characteristics associated with outcomes following standardised therapy after initial diagnosis. METHODS: The PROTECT multicentre inception cohort study was based at 29 centres in the USA and Canada and included paediatric patients aged 4-17 years who were newly diagnosed with ulcerative colitis...
September 19, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28903094/effectiveness-of-mesalazine-thiopurines-and-tumour-necrosis-factor-antagonists-in-preventing-post-operative-crohn-s-disease-recurrence-in-a-real-life-setting
#11
Mariangela Allocca, Rosario Landi, Stefanos Bonovas, Gionata Fiorino, Alfredo Papa, Antonino Spinelli, Federica Furfaro, Laurent Peyrin-Biroulet, Alessandro Armuzzi, Silvio Danese
BACKGROUND: Most Crohn's disease (CD) patients develop endoscopic recurrence within one year of intestinal resection. The best treatment method to prevent post-operative CD recurrence remains uncertain. METHODS: A total of 155 CD patients from 2 referral centres, who were undergoing intestinal resection with ileo-colonic anastomosis (January 2004-January 2015), were included. All subjects received preventive therapy with tumour necrosis factor antagonists (anti-TNFs), thiopurinesor mesalazine...
September 14, 2017: Digestion
https://www.readbyqxmd.com/read/28891831/mucosal-cytokine-profiles-after-induction-therapy-with-granulocyte-monocyte-apheresis-in-new-onset-inflammatory-colitis
#12
Helena Rolandsdotter, Kerstin Jönsson-Videsäter, Ulrika L Fagerberg, Michasel Eberhardson, Yigael Finkel
Granulocyte/Monocyte Apheresis (GMA) selectively removes circulating granulocytes and monocytes; important producers of pro-inflammatory cytokines. Seven children with new onset inflammatory bowel disease (IBD) colitis were treated with GMA together with mesalazine, and had significant decreases in PUCAI (p = 0.018) and Mayo endoscopic score (p = 0.013). We investigated the colonic mucosal cytokine profiles (CMCP) (analyzed with real-time polymerase chain reaction, (PCR)), before and after induction treatment, and in 6 non-IBD controls...
September 7, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28821163/metformin-maintains-mucosal-integrity-in-experimental-model-of-colitis-by-inhibiting-oxidative-stress-and-pro-inflammatory-signaling
#13
Abhimanu Pandey, Sneh Verma, Vijay L Kumar
Metformin, an antidiabetic drug, is well known for its multifarious properties and its ability to modulate inflammatory cascade. Ulcerative colitis (UC) is an inflammatory condition of the colon where drugs exhibiting anti-inflammatory property have been shown to induce and maintain remission. The objective of the present study was to evaluate the efficacy of metformin against acetic-acid induced colitis in rat. The study included five groups of rats namely normal control, experimental control, drug treated groups (50 and 500mg/kg of metformin, MET50, MET500 and 300mg/kg of mesalazine, MSZ300)...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28797990/marked-improvement-in-gastric-involvement-in-beh%C3%A3-et-s-disease-with-adalimumab-treatment
#14
Akira Sonoda, Ryo Ogawa, Kazuhiro Mizukami, Kensuke Fukuda, Mitsutaka Shuto, Kazuhisa Okamoto, Osamu Matsunari, Tadayoshi Okimoto, Kazunari Murakami
Gastric involvement is the least frequent manifestation of Behçet's disease, and effective treatment for it unknown. Here the case of a patient with gastric involvement in Behçet's disease that was markedly improved with adalimumab therapy is presented. A 68-year-old man developed an oral ulcer, erythema, folliculitis, and arthralgia. Behçet's disease was suspected; then, prednisolone and colchicine were administered. Esophagogastroduodenoscopy showed a punched-out ulcer in the posterior wall of the gastric antrum...
August 9, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28746225/ulcerative-colitis-with-acute-pleurisy-a-case-report-and-review-of-the-literature
#15
REVIEW
Shuming Lu, Lihua Wang, Weisheng Zhang, Zhuqing Zhang, Lina Liu, Yingde Wang, Hua Meng
RATIONALE: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease, are associated with a large number of extraintestinal manifestations. Pulmonary manifestations are infrequently seen in patients with IBD. Moreover, serositis including pleural and pericardial manifestations in UC is rare. PATIENT CONCERNS: We report a case of UC with acute pleurisy in a 43-year-old man; review literature; and discuss the diagnosis, differential diagnosis, and treatment...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28726433/gastric-antral-vascular-ectasia-and-solitary-rectal-ulcer-syndrome-two-rare-diagnoses-as-the-cause-of-anemia-in-a%C3%A2-single-patient-case-report
#16
Lumír Kunovský, Milan Dastych, Radek Kroupa, Beata Hemmelova, Katarina Muckova, Miroslava Chovancova, Lenka Kucerova, Jiri Dolina
Gastric antral vascular ectasia (GAVE) and solitary rectal ulcer syndrome (SRUS) are both mentioned in the literature as rare causes of iron deficiency anemia and gastrointestinal (GI) bleeding. GAVE accounts for up to 4 % of upper non-variceal GI bleeding; SRUS is a rare benign disorder that presents with rectal bleeding. We present the case of a 75-year-old patient who was admitted to our facility with anemia. In the same patient, we encountered chronic bleeding from GAVE and SRUS. Both diagnoses were treated endoscopically: GAVE by argon plasma coagulation and a subsequent treatment with proton pump inhibitors and SRUS by adrenaline injection and clipping, consecutively treated with mesalazine enemas...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28707796/editorial-mesalazine-to-prevent-recurrent-acute-diverticulitis-the-final-nail-in-the-coffin
#17
EDITORIAL
D J Gracie, A C Ford
No abstract text is available yet for this article.
August 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28707787/editorial-mesalazine-to-prevent-recurrent-acute-diverticulitis-the-final-nail-in-the-coffin-authors-reply
#18
EDITORIAL
W Kruis, R Greinwald
No abstract text is available yet for this article.
August 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28702956/interventions-for-treating-lymphocytic-colitis
#19
REVIEW
Nilesh Chande, Noor Al Yatama, Tania Bhanji, Tran M Nguyen, John Wd McDonald, John K MacDonald
BACKGROUND: Lymphocytic colitis is a cause of chronic diarrhea. It is a subtype of microscopic colitis characterized by chronic, watery, non-bloody diarrhea and normal endoscopic and radiologic findings. The etiology of this disorder is unknown.Therapy is based mainly on case series and uncontrolled trials, or by extrapolation of data for treating collagenous colitis, a related disorder. This review is an update of a previously published Cochrane review. OBJECTIVES: To evaluate the efficacy and safety of treatments for clinically active lymphocytic colitis...
July 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28700534/clinical-predictors-of-future-nonadherence-in-inflammatory-bowel-disease
#20
Mirjam Severs, Marie-Josée J Mangen, Herma H Fidder, Mirthe E van der Valk, Mike van der Have, Ad A van Bodegraven, Cees H M Clemens, Gerard Dijkstra, Jeroen M Jansen, Dirk J de Jong, Nofel Mahmmod, Paul C van de Meeberg, Andrea E van der Meulen-de Jong, Marieke Pierik, Cyriel Y Ponsioen, Marielle J L Romberg-Camps, Peter D Siersema, Bindia Jharap, Janneke C van der Woude, Nicolaas P A Zuithoff, Bas Oldenburg
BACKGROUND: Nonadherence to medical therapy is frequently encountered in patients with inflammatory bowel disease (IBD). We aimed to identify predictors for future (non)adherence in IBD. METHODS: We conducted a multicenter prospective cohort study with adult patients with Crohn's disease (CD) and ulcerative colitis (UC). Data were collected by means of 3-monthly questionnaires on the course of disease and healthcare utilization. Medication adherence was assessed using a visual analogue scale, ranging from 0% to 100%...
July 11, 2017: Inflammatory Bowel Diseases
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