keyword
MENU ▼
Read by QxMD icon Read
search

mesalazine

keyword
https://www.readbyqxmd.com/read/29669052/cancer-associated-chemotherapy-induces-less-ibd-exacerbations-and-a-reduction-of-ibd-medication-afterwards
#1
Özgür M Koc, Roel J W van Kampen, Adriaan A van Bodegraven
Background: The prevalence of inflammatory bowel disease (IBD) is increasing and, consequently, more IBD patients will develop cancer with need for cancer-associated chemotherapy. Physicians are therefore confronted with whether they should continue, stop, or restart IBD medication in relation with chemotherapy. The current strategy in our hospital is to discontinue immunomodulating IBD medication, comprising corticosteroids, anti-tumour necrosis factor (anti-TNF), and other immunosuppressives, before starting chemotherapy...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29657613/relationship-between-physician-based-assessment-of-disease-activity-quality-of-life-and-costs-of-ulcerative-colitis-in-poland
#2
Paweł Kawalec, Ewa Stawowczyk
Introduction: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disorder, which requires lifelong treatment. It generates substantial direct and indirect costs, and significantly affects the quality of life, especially in the active state of the disease. Aim: To evaluate the direct and indirect costs of UC as well as to assess disease activity and quality of life reported by patients with UC in Polish settings. Material and methods: A questionnaire, cross-sectional study among UC patients as well as physicians involved in the therapy of the patients was conducted...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29623099/treatment-of-diverticular-disease-an-update-on-latest-evidence-and-clinical-implications
#3
REVIEW
Marilia Carabotti, Bruno Annibale
Background: Diverticular disease (DD) is a common condition, especially in Western countries. In about 80% of patients, colonic diverticula remain asymptomatic (diverticulosis), while approximately 20% of patients may develop abdominal symptoms (symptomatic uncomplicated diverticular disease, SUDD) and, eventually complications as acute diverticulitis (AD). The management of this condition has been improved, and in the last five years European countries and the USA have published guidelines and recommendations...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29600982/variant-of-rare-hermansky-pudlak-syndrome-associated-with-granulomatous-colitis-diagnostics-clinical-course-and-treatment
#4
L Y Lozynska, A Plawski, M R Lozynska, I Vytvytskyi, R Y Lozynskyi, N Prokopchuk, B Tretiak
AIM: To study the relationship between the genotype and the phenotype in the patients with Hermansky - Pudlak syndrome (HPS) associated with granulomatous colitis; to monitor clinical course of the disease for adequate treatment, cancer surveillance and genetic counseling. MATERIALS AND METHODS: The diagnosis of HPS is established by physical examination, chest X-ray, computed tomography, endoscopic examination with biopsy, and laboratory tests, including histology, baseline laboratory blood, urine and feces tests, determination of ASCA-C and ANCA antibodies using an ELISA...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29588843/protracted-severe-systemic-cytomegalovirus-disease-in-an-immunosuppressed-patient-with-ulcerative-colitis
#5
Matthew James Armstrong, Tom Thomas, Tariq Iqbal, Ralph Boulton, Jason Goh
A 33-year-old man with ulcerative colitis presented with 5-day history of fever, night sweats, abdominal pain and increased stool frequency. He was on mesalazine M/R 1 g once daily, 6-mercaptopurine (6-MP) 75 mg once daily and prednisolone 40 mg once daily. Examination revealed fever and tachycardia. Blood examinations identified a persistent leucopenia, C reactive protein of 23 mg/L and an initial alanine transaminase of 855 IU/L. Flexible sigmoidoscopy revealed well-demarcated, punched-out ulcers in the proximal rectum and distal sigmoid, with histology pathognomonic of cytomegalovirus (CMV)...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29561196/modulation-of-colonic-hydrogen-sulfide-production-by-diet-and-mesalazine-utilizing-a-novel-gas-profiling-technology
#6
Chu K Yao, Asaf Rotbart, Jian Z Ou, Kourosh Kalantar-Zadeh, Jane G Muir, Peter R Gibson
Excessive hydrogen sulfide (H2 S) production from gut microbial metabolism may have clinically important relevance in the pathogenesis of gut disorders, including ulcerative colitis. However, little is known regarding factors that alter its production. Using a newly-designed in vitro gas-profiling technology, the study aimed to verify real-time H2 S measurement reproducibility and thereafter, assess its production following exposure to dietary factors and 5-aminosalicylate acid (5-ASA). Measurements of H2 S, carbon dioxide, hydrogen and methane measurements were compared between gas-profiling systems...
March 21, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29560753/adherence-risk-factors-of-non-adherence-and-patient-s-preferred-treatment-strategy-of-mesalazine-in-ulcerative-colitis-multicentric-observational-study
#7
Radan Keil, Martin Wasserbauer, Zdena Zádorová, Vladimír Kojecký, Štěpán Hlava, Jan Št'ovíček, Jakub Chudý, Markéta Roznětinská, Jiří Drábek, Nikola Kubišová, Jindra Lochmannová
OBJECTIVES: Compliance to therapy is a key factor in the efficacy of treatment in clinical practice. The aim of our study was to evaluate the rate of compliance with mesalazine in patients with ulcerative colitis (UC), to examine risk factors of noncompliance and especially find ways on how adherence can be improved. MATERIALS AND METHODS: A total of 198 outpatients with UC completed two anonymous questionnaires including information on basic demographics, details of patient´s disease and the use of mesalazine medication and quality of life...
March 21, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29520987/effect-of-mesalazine-on-recurrence-of-diverticulitis-in-patients-with-symptomatic-uncomplicated-diverticular-disease-a-meta-analysis-with-trial-sequential-analysis-of-randomised-controlled-trials
#8
REVIEW
Rao Muhammad Asaf Khan, Baqar Ali, Shahin Hajibandeh, Shahab Hajibandeh
OBJECTIVES: To investigate the effect of mesalazine on recurrence of diverticulitis in patients with symptomatic uncomplicated diverticular disease (SUDD). METHODS: We performed a systematic review and conducted a search of electronic information sources to identify all randomised controlled trials (RCTs) investigating the effect of mesalazine on the recurrence of diverticulitis in patients with SUDD. We used the Cochrane tool to assess the quality of included studies...
March 9, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29518435/ziziphus-spina-christi-fruit-extract-suppresses-oxidative-stress-and-p38-mapk-expression-in-ulcerative-colitis-in-rats-via-induction-of-nrf2-and-ho-1-expression
#9
Rafa S Almeer, Sahar M Mahmoud, Hatem K Amin, Ahmed E Abdel Moneim
In this study, we aimed to evaluate the anti-inflammatory and protective effects of Ziziphus spina-christi fruit extract (ZFE) against acetic acid (AcOH)-induced colitis in rats. Before a single AcOH instillation, ZFE (100, 200, and 400 mg/kg/day) was administered for 5 days by oral gavage. Pretreatment with ZFE at different doses suppressed the spread of inflammation and inhibited mucosal damage; in addition, it reduced ulcer size and mitigated colitis markers. Administration of ZFE (400 mg/kg) resulted in a greater reduction of inflammatory colonic injury than that after reference drug, mesalazine (MLZ), administration...
March 5, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29499277/a-bio-predictive-in-vitro-comparison-of-oral-locally-acting-mesalazine-formulations-by-a-novel-dissolution-model-for-assessing-intraluminal-drug-release-in-individual-subjects
#10
Frank Karkossa, Sandra Klein
Drug release and availability at the site of action are the major factors determining the clinical response for locally-acting gastrointestinal (GI) drug products. The present work focused on the prediction of site and extent of in vivo mesalazine release after oral administration to a variety of subjects using individualized in vitro drug release experiments. First, experiments mimicking GI passages in average adult subjects were performed. Then, results from a study screening fasted in vivo pH- and transit profiles in individual subjects were translated into a novel in vitro dissolution model enabling to mimic individual GI pH-profiles and transit times with physiologically relevant dissolution media...
February 27, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29483924/-portulaca-extract-attenuates-development-of-dextran-sulfate-sodium-induced-colitis-in-mice-through-activation-of-ppar-%C3%AE
#11
Rui Kong, Hui Luo, Nan Wang, Jingjing Li, Shizan Xu, Kan Chen, Jiao Feng, Liwei Wu, Sainan Li, Tong Liu, Xiya Lu, Yujing Xia, Yanhong Shi, Yingqun Zhou, Weigang He, Qi Dai, Yuejuan Zheng, Jie Lu
Portulaca oleracea L. is a traditional Chinese medicine, which has been used as adjuvant therapy for inflammatory bowel disease (IBD). However, the mechanism of its activity in IBD still remains unclear. Since previous studies have documented the anti-inflammatory effect of peroxisome proliferator activated receptors- γ (PPAR- γ ), Portulaca regulation of PPAR- γ in inflammation was examined in current study. Ulcerative colitis (UC) was generated by 5% dextran sulfate sodium (DSS) in mice and four groups were established as normal control, DSS alone, DSS plus mesalamine, and DSS plus Portulaca ...
2018: PPAR Research
https://www.readbyqxmd.com/read/29480868/mesalazine-as-a-cause-of-fetal-anemia-and-hydrops-fetalis-a-case-report-erratum
#12
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#13
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29467009/mesalazine-induced-myocarditis-a-case-report
#14
Shiva T Radhakrishnan, Aruchuna Mohanaruban, Sami Hoque
BACKGROUND: Myocarditis is a rare complication of therapy with mesalazine, a drug widely prescribed in the treatment of inflammatory bowel disease. CASE PRESENTATION: We report a case of myocarditis occurring in a 49-year-old British man 10 days following initiation of mesalazine therapy for treatment of ulcerative colitis. He presented with troponin-positive chest pain, and the diagnosis of myocarditis was confirmed on the basis of cardiac magnetic resonance imaging, which showed subepicardial delayed gadolinium enhancement in the basal to middle inferior and inferolateral segments of the heart...
February 22, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29459564/-retention-of-patency-capsule-in-a-patient-with-crohn-s-disease
#15
Masaya Iwamuro, Shiho Takashima, Toshihiro Inokuchi, Masahiro Takahara, Seiji Kawano, Sakiko Hiraoka, Yoshitaka Kondo, Takehiro Tanaka, Hiroyuki Okada
A 40-year-old Japanese man with abdominal pain was referred to our hospital. The patient had been diagnosed with Crohn's disease at the age of 21 years and had since then received treatment with mesalazine and had been advocated an elemental diet. About 30 months before his visit to the hospital, he had swallowed a patency capsule, the retention of which in the ileum was subsequently detected on abdominal ultrasonography. The patient was advised to undergo the evaluation of stenosis, but he refused further investigation at that time...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29453848/postoperative-recurrence-of-crohn-s-disease-pathophysiology-diagnosis-and-treatment
#16
Antonio Di Sario, Paola Sassaroli, Luigi Daretti, Giulia Annulli, Laura Schiada, Giorgia Falcioni, Emanuele Bendia, Simone Antuono, Antonio Benedetti
BACKGROUND: Up to 80% of Crohn`s disease (CD) patients require at least one surgical intervention in their lifetime and up to 70% of these patients develop postoperative endoscopic recurrence within 1 year. The most important predictors of early postoperative recurrence are represented by smoking, prior intestinal surgery, penetrating disease and perianal location. Genetic factors, gut microbiota structure and immunological alterations may be involved in the pathogenesis of postoperative recurrence of CD, although their specific roles have to be determined yet...
February 16, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29446099/mesalazine-induced-bullous-fixed-drug-eruption
#17
Andac Salman, Dilek Seckin Gencosmanoglu, Yesim O Alahdab, Ana M Giménez-Arnau
No abstract text is available yet for this article.
February 15, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29435324/efficacy-and-safety-of-a-novel-high-dose-mesalazine-tablet-in-mild-to-moderate-active-ulcerative-colitis-a-double-blind-multicentre-randomised-trial
#18
Axel Dignass, Robert Schnabel, Jacek Romatowski, Vladimir Pavlenko, Andrey Dorofeyev, Jelena Derova, Laimas Jonaitis, Karin Dilger, Tanju Nacak, Roland Greinwald
Background: Adherence to mesalazine treatment is essential for the successful treatment of ulcerative colitis. Objective: The objective of this study was to compare the efficacy, safety and preference of a novel high-dose 1000 mg mesalazine tablet versus conventional treatment for ulcerative colitis remission. Methods: This pivotal phase III trial compared one 1000 mg mesalazine tablet (M1000 group) versus two registered 500 mg mesalazine tablets (M2x500 group), both taken three times daily, in patients with mild to moderately active ulcerative colitis...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29422812/hyperbaric-oxygen-therapy-for-pyoderma-gangrenosum-associated-with-ulcerative-colitis
#19
Hyun Il Seo, Hyun-Ju Lee, Koon Hee Han
Pyoderma gangrenosum (PG), an ulcerating skin condition, is rare in patients with ulcerative colitis (UC). We report a case of successful treatment of PG in a patient with UC using hyperbaric oxygen therapy (HBOT). The patient had UC that was in remission following treatment with mesalazine and azathioprine therapy. After visiting an orthopedic clinic, the patient opted for treatment with antibiotics and daily dressing of the ulcerative skin lesions, while azathioprine was discontinued. However, the lesions did not improve...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29422811/duodenal-amyloidosis-secondary-to-ulcerative-colitis
#20
Seung Woon Park, Sam Ryong Jee, Ji Hyun Kim, Sang Heon Lee, Jin Won Hwang, Ji Geon Jang, Dong Woo Lee, Sang Yong Seol
Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain...
January 2018: Intestinal Research
keyword
keyword
35710
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"