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https://www.readbyqxmd.com/read/28078130/radiographic-and-endoscopic-regression-of-metastatic-gastric-cancer-to-the-colon-in-the-setting-of-5-aminosalicylic-acid-use
#1
Yuval A Patel, Shannon J McCall, Xuefeng Zhang, Tracy Jaffe, Rahul A Shimpi
Colonic metastases from gastric cancer are a rare phenomenon and sparsely reported in the literature. We report a case of a 59-year-old woman who presented with vague abdominal symptoms and initial computer tomography (CT) imaging suggestive of a colonic apple-core lesion with serial colonoscopic biopsies diagnostic of metastatic signet ring cell gastric adenocarcinoma. This case is unique given the evolving CT and endoscopic findings that suggested a regression in colonic wall thickening in the setting of 5-aminosalicylic acid (5-ASA) use prior to histologic diagnosis...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28071183/5-aminosalicylic-acid-inhibits-inflammatory-responses-by-suppressing-jnk-and-p38-activity-in-murine-macrophages
#2
Tingli Qu, Erbing Wang, Baofen Jin, Weiping Li, Ruiling Liu, Zheng-Bao Zhao
CONTEXT: 5-Aminosalicylic acid (5-ASA), as an anti-inflammatory drug, has been extensively used for the treatment of mild to moderate active ulcerative colitis (UC), but the possible mechanisms of action remain unclear. OBJECTIVE: To investigate the effects of 5-ASA on the production of inflammatory mediators by murine macrophages stimulated with lipopolysaccharide (LPS), and determine the underlying pharmacological mechanism of action. MATERIALS AND METHODS: The levels of nitric oxide (NO) and interleukin-6 (IL-6) were measured by Varioskan Flash and IL-6 Enzyme-Linked Immunosorbent Assay sets...
February 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28063246/exacerbation-caused-by-5-asa-intolerance-in-children-with-ulcerative-colitis
#3
Hirotaka Shimizu, Katsuhiro Arai, Julian Tang, Kenji Hosoi, Rie Funayama
BACKGROUND: 5-aminosalicylate (5-ASA) is widely used as the first-line drug for ulcerative colitis (UC). 5-ASA is mostly a safe and effective drug, but it can bring about exacerbation due to 5-ASA intolerance. 5-ASA intolerance can be confusing and it can mislead physicians to consider unnecessary treatment escalation plan including corticosteroid (CS), biologics, or even surgery. In spite of the clinical importance of 5-ASA intolerance, there have been few publications about its incidence, clinical features, and diagnosis...
January 7, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28036129/synthesis-and-in-vitro-bioactivity-evaluation-of-new-galactose-and-fructose-ester-derivatives-of-5-aminosalicylic-acid
#4
Samira Yousefi, Saadi Bayat, Mohd Basyaruddin Abdul Rahman, Zalikha Ibrahim, Emilia Abdulmalek
Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is common in patients of all ages. 5-aminosalicylic acid (5-ASA), structurally related to the salicylates, is highly active in the treatment of IBD with minor side effects. In this study, the synthesis of galactose and fructose esters of 5-ASA was planned to evaluate the role of glycoconjugation on the bioactivity of the parent drug. The antibacterial activity of the new compounds were evaluated against two Gram-negative and two Gram-positive species of bacteria, with a notable effect observed against Staphylococcus aureus and Escherichia coli in comparisons with the 5-ASA...
December 30, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28009518/measurement-of-in-vivo-gastrointestinal-release-and-dissolution-of-three-locally-acting-mesalamine-formulations-in-regions-of-the-human-gastrointestinal-tract
#5
Alex Yu, Jason R Baker, Ann F Fioritto, Ying Wang, Ruijuan Luo, Siwei Li, Bo Wen, Michael Bly, Yasuhiro Tsume, Mark J Koenigsknecht, Xinyuan Zhang, Robert Lionberger, Gordon L Amidon, William L Hasler, Duxin Sun
As an orally administered, locally acting gastrointestinal drug, mesalamine products are designed to achieve high local drug concentration in the gastrointestinal (GI) tract for the treatment of ulcerative colitis. The aim of this study was to directly measure and compare drug dissolution of three mesalamine formulations in human GI tract and to correlate their GI concentration with drug concentration in plasma. Healthy human subjects were orally administered Pentasa, Apriso, or Lialda. GI fluids were aspirated from stomach, duodenum, proximal jejunum, mid jejunum, and distal jejunum regions...
December 23, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27995656/the-effects-of-aminosalicylates-or-thiopurines-on-the-risk-of-colorectal-cancer-in-inflammatory-bowel-disease
#6
F Carrat, P Seksik, J-F Colombel, L Peyrin-Biroulet, L Beaugerie
BACKGROUND: Whether aminosalicylates or thiopurines reduce the risk of colorectal cancer (CRC) in inflammatory bowel (IBD) disease is controversial. AIM: To assess simultaneously the chemopreventive effect of aminosalicylates or thiopurines in a case-control study nested in the CESAME observational cohort that enrolled consecutive patients with IBD between May 2004 and June 2005. Patients were followed up to December 2007. METHODS: Study population comprised 144 case patients who developed CRC from the diagnosis of IBD (65 and 79 cases diagnosed, respectively, before and from 2004, starting year of the prospective observational period of CESAME) and 286 controls matched for gender, age, IBD subtype and year of diagnosis, and cumulative extent of colitis...
December 19, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27933686/risk-of-incident-mycobacterium-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-a-nationwide-population-based-study-in-south-korea
#7
S N Hong, H J Kim, K H Kim, S-J Han, I M Ahn, H S Ahn
BACKGROUND: The low incidence of Mycobacterium tuberculosis infection and lack of adequate controls have prevented researchers from estimating tuberculosis (TB) risk in inflammatory bowel disease (IBD) patients. AIM: To evaluate the risk of incident TB among IBD patients. METHODS: Using the 2011-2013 data of the South Korean National Health Insurance (NHI) system, we calculated the incidence rates (IRs), standardised incidence ratio (SIR) and number needed to screen (NNS) for incident TB in IBD patients compared to the general population in terms of subtype, age, gender and IBD medications...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27908270/the-importance-of-wireless-capsule-endoscopy-for-research-into-the-intestinal-absorption-window-of-5-aminosalicylic-acid-in-experimental-pigs
#8
Jaroslav Kvetina, Ilja Tacheci, Milan Nobilis, Marcela Kopacova, Martin Kunes, Jan Bures
BACKGROUND: Absorption windows in particular segments of the small intestine can contribute to the development of orally administered drug formulations and can limit the bioavailability of released compounds. OBJECTIVE: The aim of this study was to evaluate use of wireless capsule enteroscopy regarding the disintegration kinetic process of tablets in the small intestine and its comparison with the levels of the model drug (5-aminosalicylic acid; 5-ASA), and its majority metabolite (N-acetyl-5-aminosalicylic acid; N-acetyl-5-ASA) in blood plasma...
December 1, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27906680/chemopreventive-effects-of-5-aminosalicylic-acid-on-inflammatory-bowel-disease-associated-colorectal-cancer-and-dysplasia-a-systematic-review-with-meta-analysis
#9
Xinyun Qiu, Jingjing Ma, Kai Wang, Hongjie Zhang
BACKGROUND AND AIMS: The chemopreventive effect of 5-aminosalicylic acid (5-ASA) in patients with inflammatory bowel disease (IBD) has been widely studied; however, the results remain conflicting. The aim of this study was to systematically review the literature and update evidence concerning effects of 5-ASA on the risk of colorectal cancer (CRC) and dysplasia (Dys) in patients with ulcerative colitis (UC) or Crohn's disease (CD). RESULTS: 5-ASA showed a chemopreventive effect against CRC/Dys in IBD patients (OR = 0...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27851980/co-delivery-of-zinc-and-5-aminosalicylic-acid-from-alginate-n-succinyl-chitosan-blend-microspheres-for-synergistic-therapy-of-colitis
#10
Haogang Duan, Shaoyu Lü, Hongyan Qin, Chunmei Gao, Xiao Bai, Yuhui Wei, Xin'an Wu, Mingzhu Liu, Xinyu Zhang, Zhen Liu
The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis. Physicochemical characterization of blend MS was assessed using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and energy dispersive X-ray spectrometer (EDS). In vitro release studies demonstrated that blend MS has a pH-dependent release property. Both 5-ASA and zinc have lower release in acid medium and higher release in colonic environment...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27846307/efficacy-and-safety-of-oral-beclomethasone-dipropionate-in-ulcerative-colitis-a-systematic-review-and-meta-analysis
#11
Francesco Manguso, Raffaele Bennato, Giovanni Lombardi, Elisabetta Riccio, Giuseppe Costantino, Walter Fries
BACKGROUND AND AIM: We performed a systematic review and meta-analysis of all the available evidence comparing efficacy and safety of oral prolonged released beclomethasone dipropionate (BDP) to active oral controls in patients with mild-to-moderate ulcerative colitis (UC). A subgroup-analysis compared the effectiveness of BDP and 5-ASA. METHODS: Literature research was performed in different databases, as well as manual search to identify abstracts from international meetings with data not included in extensive publications...
2016: PloS One
https://www.readbyqxmd.com/read/27818126/anti-inflammatory-protection-afforded-by-cyanidin-3-glucoside-and-resveratrol-in-human-intestinal-cells-via-nrf2-and-ppar-%C3%AE-comparison-with-5-aminosalicylic-acid
#12
Diana Serra, Leonor M Almeida, Teresa C P Dinis
This study investigated the involvement of nuclear factor erythroid 2 (Nrf2) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathways in the protection afforded by two polyphenols abundant in diet, cyanidin-3-glucoside and resveratrol, against cytokine-induced inflammation and oxidative insult in HT-29 intestinal cells, in comparison with the drug 5-aminosalicylic acid (5-ASA). Our data show for the first time that in cytokine-challenged cells, cyanidin-3-glucoside and resveratrol induced Nrf2 activation, increased hemoxygenase-1 and glutamate cysteine ligase mRNA expression, enhanced reduced glutathione to oxidized glutathione ratio and inhibited reactive species production, at much lower concentrations than 5-ASA...
December 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27773555/increased-expression-of-markers-of-early-atherosclerosis-in-patients-with-inflammatory-bowel-disease
#13
Maria Cappello, Anna Licata, Vincenza Calvaruso, Ivana Bravatà, Alessandra Aiello, Daniele Torres, Vittoriano Della Corte, Antonino Tuttolomondo, Maria Perticone, Giuseppe Licata, Antonio Craxì, Calogero Cammà
BACKGROUND & AIMS: Recent studies documented an increased cardiovascular risk in patients with inflammatory bowel disease (IBD). Our study aimed at investigating the prevalence of intima-media thickness (IMT) of the carotid arteries and the arterial stiffness indices as markers of early atherosclerosis in young IBD patients. METHODS: We recruited 68 consecutive IBD patients, and 38 matched healthy controls less than 45years old (median age 31.6±8.1years). Clinical and demographic features, cardiovascular risk factors, history of cardiovascular events, concomitant therapies were registered on a dedicate database...
October 20, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27769943/mucoadhesive-chitosan-hydrogels-as-rectal-drug-delivery-vessels-to-treat-ulcerative-colitis
#14
Jinke Xu, Mifong Tam, Sepideh Samaei, Sophie Lerouge, Jake Barralet, Mary M Stevenson, Marta Cerruti
: Mucoadhesive drug delivery systems stick to mucosal tissues and prolong the local retention time of drugs. Since the colon is covered by a mucosal layer, mucoadhesive rectal formulations may improve treatment of such diseases as hypertension or colon cancer. Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation of the colonic mucosa. It is commonly treated with sulfasalazine (SSZ), which is metabolized by the intestinal flora into the therapeutic 5-aminosalicylic acid (5-ASA) and a toxic by-product sulfapyridine (SP)...
October 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27716592/discovery-and-preclinical-development-of-a-novel-prodrug-conjugate-of-mesalamine-with-eicosapentaenoic-acid-and-caprylic-acid-for-the-treatment-of-inflammatory-bowel-diseases
#15
Mahesh Kandula, K B Sunil Kumar, Sivanesan Palanichamy, Ashok Rampal
Mesalamine (5-ASA) is one of the drugs indicated as first line therapy in ulcerative colitis for induction and maintenance of remission. Sulfasalazine and formulations of 5-ASA (pH-dependent and controlled release formulations) were developed to minimize the systemic absorption and maximize the delivery of the mesalamine to colon. Although, its efficacy and safety is well documented there are approximately 30% nonresponders to 5-ASA therapy. This necessitates the need for novel therapeutic options to improve the efficacy and safety of the currently available 5-ASA therapy...
November 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27710861/novel-indoline-derivatives-prevent-inflammation-and-ulceration-in-dinitro-benzene-sulfonic-acid-induced-colitis-in-rats
#16
Helena Shifrin, Dorit Moradov, Corina Bejar, Donna Schorer-Apelbaum, Marta Weinstock
BACKGROUND: In search of safer treatments for inflammatory bowel disease in subjects not responding to, or showing adverse effects to TNF-α antagonists, we tested three novel indoline carbamates in the 2,4-dinitrobenzene sulfonic acid (DNBS) model of colitis in rats. The compounds have anti-inflammatory activity in other disease models in mice. METHODS: AN827 (3-(2-(methoxy carbonyl) ethyl) indolin-4-ylethyl methyl) carbamate (0.1 or 1mg/kg), AN680 (3-(2-(methoxy carbonyl) ethyl) indolin-6-ylethyl methyl) carbamate (1...
December 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27703822/interstitial-nephritis-in-a-patient-with-inflammatory-bowel-disease
#17
Payaswini Vasanth, Michelle Parmley, Jose Torrealba, Tamim Hamdi
Tubulointerstitial nephritis in patients with inflammatory bowel disease has been linked to the use of 5-ASA derivatives. Various aspects of this theory have been challenged with a potential role for the underlying autoimmune disorder. Steroids are the mainstay of treatment and mycophenolate mofetil might be an effective alternative. We report a patient who responded well to mycophenolate despite continuing mesalamine, the suspected offending agent.
2016: Case Reports in Nephrology
https://www.readbyqxmd.com/read/27699641/recent-trends-and-future-directions-for-the-medical-treatment-of-ulcerative-colitis
#18
REVIEW
Makoto Naganuma, Shinta Mizuno, Kosaku Nanki, Shinya Sugimoto, Takanori Kanai
Recently, several medical treatments for ulcerative colitis (UC) have been developed, including 5-aminosalicylic acids (5-ASAs), corticosteroids, thiopurine, calcineurin inhibitors, and anti-tumor necrosis factor (TNF) α treatments. Treatment options including calcineurin inhibitors and anti-TNF treatment for refractory UC are discussed in this article. Furthermore, upcoming treatments are introduced, such as golimumab, vedolizumab, AJM300, tofacitinib. Budesonide foamwill be used as one treatment option in patients with distal colitis...
December 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27697784/once-versus-twice-daily-mesalazine-to-induce-remission-in-paediatric-ulcerative-colitis-a-randomized-controlled-trial
#19
Dan Turner, Baruch Yerushalmi, Michal Kori, Efrat Broide, Yael Mozer-Glassberg, Ron Shaoul, Kaija-Leena Kolho, Eyal Shteyer, Hussein Shamaly, Oren Ledder, Shlomi Cohen, Sarit Peleg, Avi On, Arie Levine
BACKGROUND: Trials in adults suggested once-daily (QD) dosing of 5-ASA may be as or more effective as twice-daily (BID) dosing in ulcerative colitis (UC). In this induction of remission, investigator-blinded, randomized-controlled-trial we aimed to compare effectiveness and safety of once vs. twice daily mesalazine (Pentasa®), in paediatric UC. METHODS: Children, 4-18 years with a PUCAI ( Paediatric Ulcerative Colitis Activity Index) of 10-55 points at inclusion, were randomized in blocks of 6 with blinded allocation to QD or BID mesalamine using a weight-based dosing table...
October 3, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27681657/oral-5-aminosalicylic-acid-for-maintenance-of-medically-induced-remission-in-crohn-s-disease
#20
Anthony K Akobeng, Dongni Zhang, Morris Gordon, John K MacDonald
BACKGROUND: The prevention of relapse is a major issue in the management of Crohn's disease. Corticosteroids, the mainstay of treatment of acute exacerbations, are not effective for maintenance of remission and its chronic use is limited by numerous adverse events. Randomised controlled trials assessing the efficacy of oral 5-aminosalicylic acid (5-ASA) agents for maintenance of medically-induced remission in Crohn's disease have produced conflicting results. OBJECTIVES: To conduct a systematic review to evaluate the efficacy and safety of oral 5-ASA agents for the maintenance of medically-induced remission in Crohn's disease...
September 28, 2016: Cochrane Database of Systematic Reviews
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