keyword
MENU ▼
Read by QxMD icon Read
search

mesalamine

keyword
https://www.readbyqxmd.com/read/29128422/ampholytic-starch-excipients-for-high-loaded-drug-formulations-mechanistic-insights
#1
Khalil Sakeer, Pompilia Ispas-Szabo, Nassim Benyerbah, Mircea Alexandru Mateescu
Ampholytic starch derivatives are proposed as a new class of excipients carrying simultaneously anionic carboxymethyl (CM) and cationic aminoethyl (AE) groups on starch (St) polymeric chains. Three different types of derivatives were obtained by using the same reagents and varying only the order of their addition in the reaction medium: in one step method (OS) the two reactants were added simultaneously, whereas in two steps method (TS) either CMSt or AESt were prepared separately in the first step, followed by subsequent addition of the second reactant...
November 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29127772/interventions-for-treating-collagenous-colitis
#2
REVIEW
Tahir S Kafil, Tran M Nguyen, Petrease H Patton, John K MacDonald, Nilesh Chande, John Wd McDonald
BACKGROUND: Collagenous colitis is a cause of chronic diarrhea. This updated review was performed to identify therapies for collagenous colitis that have been assessed in randomized controlled trials (RCTs). OBJECTIVES: The primary objective was to assess the benefits and harms of treatments for collagenous colitis. SEARCH METHODS: We searched CENTRAL, the Cochrane IBD Group Specialized Register, MEDLINE and EMBASE from inception to 7 November 2016...
November 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29110631/preparation-of-mesalamine-nanoparticles-using-a-novel-polyurethane-chitosan-graft-copolymer
#3
Farzad Mirabbasi, Abolghasem Moghimi, Shadab Shahsavari, Niloofar Babanejad, Simin Seifirad, Farid Dorkoosh
BACKGROUND: Chitosan nanoparticles have the potential to be used as hydrophilic carrier systems since they can deliver drugs to specific sites and control the drug release rate. Moreover, control released systems are designed to minimize systemic absorption and to achieve optimum delivery of the biologically active mesalamine to the distal small intestine and the colon. OBJECTIVE: The current study investigated the development of new nanoparticulate drug delivery systems based on polyurethane-chitosan copolymers...
November 3, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29030290/ex-vivo-evaluation-of-degradation-rates-of-metronidazole-and-olsalazine-in-distal-ileum-and-in-cecum-the-impact-of-prandial-state
#4
Eleni Karatza, Constantinos Goumas, Uwe Muenster, Christos Reppas, Maria Vertzoni
PURPOSE: Evaluate ex vivo the bacterial metabolism induced degradation rates of mesalamine (negative control), metronidazole and olsalazine in distal ileum and in cecum. METHODS: The contents of distal ileum and cecum were collected during colonoscopy under anaerobic conditions from twelve healthy adults in the fasted and in the fed state. To eliminate potential effects of enzymes that may exist in the fluid of lower intestine, each sample was ultracentrifuged and the precipitate was diluted with a volume of normal saline equivalent to that of the supernatant, after ultracentrifugation of intestinal contents from which the specific precipitate had been obtained...
October 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28981976/inflammatory-bowel-disease-in-chronic-granulomatous-disease-an-emerging-problem-over-a-twenty-years-experience
#5
Giulia Angelino, Paola De Angelis, Simona Faraci, Francesca Rea, Erminia Francesca Romeo, Filippo Torroni, Renato Tambucci, Alessia Claps, Paola Francalanci, Maria Chiriaco, Gigliola Di Matteo, Caterina Cancrini, Paolo Palma, Patrizia D'Argenio, Luigi Dall'Oglio, Paolo Rossi, Andrea Finocchi
BACKGROUND: Chronic Granulomatous Disease (CGD) is a primary immunodeficiency of phagocytes, characterized by life-threatening infections and hyperinflammation. Due to survival improvement, Inflammatory Bowel Disease (IBD) is becoming increasingly relevant. Here we report our 20-year experience. METHODS: We retrospectively analyzed clinical, endoscopic and histologic features, as well as the management of CGD-IBD patients referred to the Bambino Gesù Children's Hospital in Rome, Italy...
October 5, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28978458/a-crossover-crossback-prospective-study-of-dibutyl-phthalate-exposure-from-mesalamine-medications-and-serum-reproductive-hormones-in-men
#6
Feiby L Nassan, Brent A Coull, Niels E Skakkebaek, Anna-Maria Andersson, Michelle A Williams, Lidia Mínguez-Alarcón, Stephen A Krawetz, Janet E Hall, Elizabeth J Hait, Joshua R Korzenik, Jennifer B Ford, Alan C Moss, Russ Hauser
BACKGROUND: Phthalates, such as dibutyl phthalate (DBP), are endocrine disruptors used in some medication coatings e.g., mesalamine to treat inflammatory bowel disease (IBD). OBJECTIVES: Taking advantage of different mesalamine formulations with/without DBP, we assessed whether DBP from mesalamine (>1000x background) altered serum hormones. METHODS: Men (N=73) with IBD participated in a crossover-crossback prospective study and provided up to 6 serum samples (2:baseline, 2:crossover, 2:crossback)...
October 1, 2017: Environmental Research
https://www.readbyqxmd.com/read/28974350/a-novel-2-day-desensitization-protocol-to-oral-mesalamine
#7
Christine Marie Panganiban, Deena Pourang, Shefali Anil Samant
No abstract text is available yet for this article.
September 30, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28973845/mesalamine-5-asa-for-the-prevention-of-recurrent-diverticulitis
#8
REVIEW
Flloyd Carter, Majd Alsayb, John K Marshall, Yuhong Yuan
BACKGROUND: Diverticular disease is a common condition that increases in prevalence with age. Recent theories on the pathogenesis of diverticular inflammation have implicated chronic inflammation similar to that seen in ulcerative colitis. Mesalamine, or 5-aminosalicylic acid (5-ASA), is a mainstay of therapy for individuals with ulcerative colitis. Accordingly, 5-ASA has been studied for prevention of recurrent diverticulitis. OBJECTIVES: To evaluate the efficacy of mesalamine (5-ASA) for prevention of recurrent diverticulitis...
October 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28958891/new-mesalamine-polymeric-conjugate-for-controlled-release-preparation-characterization-and-biodistribution-study
#9
Aina L A Cesar, Fernanda A Abrantes, Luana Farah, Rachel O Castilho, Valbert Cardoso, Simone O Fernandes, Ivana D Araújo, André A G Faraco
Mesalamine (5-ASA) consists of the first-line therapy for the treatment of ulcerative colitis; however, it has low bioavailability, can cause several systemic adverse events, and has low treatment adherence due to the inconvenient dosing scheme. In this work, a new drug delivery system consisting of chondroitin sulfate linked to 5-ASA was synthesized using a carbodiimide as conjugating agent. The system was characterized by spectroscopic techniques (UV, ATR-FTIR, XRD, and NMR (1)H) and thermal analysis (TG/DTG and DSC), suggesting the conjugation between the drug and the polymer...
September 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28948467/post-infectious-irritable-bowel-syndrome
#10
REVIEW
Yeong Yeh Lee, Chandramouli Annamalai, Satish S C Rao
PURPOSE OF REVIEW: Post-infectious irritable bowel syndrome (PI-IBS) is characterized by persistent abdominal pain and diarrhea, typically following an episode of infectious gastroenteritis. The mechanisms that underlie IBS-D remain elusive, but PI-IBS provides a mechanistic model of this disorder. This review provides an up-to-date appraisal of the pathophysiology, clinical features, and management approaches for PI-IBS. RECENT FINDINGS: Disordered immune reactions and release of cytokines with resultant gut inflammation and dysfunction appear to be key features of PI-IBS...
September 25, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28804515/mmx-%C3%A2-technology-and-its-applications-in-gastrointestinal-diseases
#11
REVIEW
Silvia Nardelli, Laura Francesca Pisani, Gian Eugenio Tontini, Maurizio Vecchi, Luca Pastorelli
The Multimatrix(®) (MMX(®)) preparation MMX(®) is a recently obtained drug formulation developed to facilitate release of high concentrations of active drugs into the colon, with a homogeneous distribution along all colonic segments, particularly the most distal ones; the distal colonic tracts, indeed, are the most difficult to reach in significant amounts when a drug is given orally. The MMX(®) formulation is characterized by a lipophilic matrix dispersed in a hydrophilic structure. Indeed, in the last few years, MMX(®) technology has been widely used in the development of various drugs for the treatment of inflammatory and infectious gastrointestinal diseases localized in the colon...
July 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28797991/an-unusual-case-of-proctosigmoiditis-secondary-to-arteriovenous-fistulization
#12
Veljko Strjina, Scott R Kelley
Refractory chronic colitis presents a medical and surgical challenge, and underlying etiologies are diverse with potential for misclassification as inflammatory bowel disease. We present an unusual case of chronic proctosigmoiditis with rare vascular etiology. A 48-year-old Caucasian male presented with severe diarrhea, weight loss, and abdominal pain. Computed tomography (CT) suggested proctosigmoiditis. Colonoscopy and biopsy findings were non-specific but were suggestive of ischemic etiology and venous congestion...
August 9, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28795780/pseudomonas-aeruginosa-defense-systems-against-microbicidal-oxidants
#13
Bastian Groitl, Jan-Ulrik Dahl, Jeremy W Schroeder, Ursula Jakob
The most abundant oxidants controlling bacterial colonization on mucosal barrier epithelia are hypochlorous acid (HOCl), hypobromous acid (HOBr) and hypothiocyanous acid (HOSCN). All three oxidants are highly antimicrobial but little is known about their relative efficacies, their respective cellular targets, or what specific responses they elicit in bacteria. To address these important questions, we directly tested the individual oxidants on the virulent Pseudomonas aeruginosa strain PA14. We discovered that HOCl and HOBr work almost interchangeably, impacting non-growing bacterial cultures more significantly than actively growing bacteria, and eliciting similar stress responses, including the heat shock response...
November 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28728316/use-of-novel-oral-anticoagulant-to-treat-pulmonary-thromboembolism-in-patient-with-ulcerative-colitis-superinfected-cytomegalovirus-colitis
#14
Seok Hwan Kim, Sunhee Jang, Yegyu Sung, Jun Kyu Park, Yunjung Park, Jintak Yun, Sang Bum Kang
Crohn's disease and ulcerative colitis are the two major types of inflammatory bowel disease, and affect mainly the gastrointestinal tract but also have extraintestinal sequelae, such as arterial and venous thromboembolism. Thromboembolic complications, particularly pulmonary thromboembolism, can be life threatening and require prompt management with anticoagulants. Conventional vitamin K antagonists have been used for the treatment of thromboembolic complications, but the development of novel oral anticoagulants has shifted the paradigm...
July 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28724171/beta-glucan-inositol-and-digestive-enzymes-improve-quality-of-life-of-patients-with-inflammatory-bowel-disease-and-irritable-bowel-syndrome
#15
R Spagnuolo, C Cosco, R M Mancina, G Ruggiero, P Garieri, V Cosco, P Doldo
OBJECTIVE: To evaluate the efficacy of a mixture of beta-glucan, inositol and digestive enzymes in improving gastrointestinal symptoms in patients affected by inflammatory bowel disease (IBD)-irritable bowel syndrome (IBS). PATIENTS AND METHODS: The study was conducted at the IBD Unit of the University of Catanzaro. Forty-three IBD patients with IBS symptoms were included in the study. IBD diagnosis was performed by clinical, endoscopic, histological and radiological criteria...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28697227/postoperative-pyoderma-gangrenosum-following-video-assisted-thoracic-surgery
#16
Stanislav N Tolkachjov, Philip Y Sun, Alina G Bridges
<p>Pyoderma gangrenosum (PG) is a neutrophilic, ulcerative dermatosis that can develop at sites of cutaneous trauma, including surgical incisions, a phenomenon known as pathergy. The characteristic lesion is a painful, rapidly expanding ulceration with a violaceous undermined border.<sup>1</sup> A biopsy taken from the expanding violaceous border shows predominantly neutrophilic dermal inflammation with neutrophilic abscess formation.</p> <p>The etiology of PG appears to be variable among patients, as about a half of the reported cases are associated with systemic disease such as inflammatory bowel disease, rheumatoid arthritis, or myeloproliferative disorders, while the other half seem to be idiopathic...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28670932/alicaforsen-for-the-treatment-of-inflammatory-bowel-disease
#17
REVIEW
Vipul Jairath, Reena Khanna, Brian G Feagan
Intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein of the immunoglobulin family, constitutively expressed on vascular endothelial cells and upregulated in inflamed colonic tissue. Alicaforsen, a 20 base ICAM-1 anti-sense oligonucleotide and highly selective ICAM-1 inhibitor, down-regulates ICAM-1 mRNA. Areas covered: We review mechanism of action, pharmacokinetics, pre-clinical, clinical and safety data of alicaforsen for the treatment of ulcerative colitis (UC), pouchitis and Crohn's disease (CD)...
August 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28669550/sulfasalazine-induced-crystalluria-causing-severe-acute%C3%A2-kidney%C3%A2-injury
#18
Michael Durando, Hannah Tiu, James Soo Kim
Sulfasalazine is an anti-inflammatory agent commonly used in the treatment of autoimmune conditions such as inflammatory bowel disease and rheumatoid arthritis. Sulfasalazine is converted by gut bacteria into sulfapyridine and the clinically active metabolite 5-aminosalicylic acid (5-ASA), and its efficacy is proportional to the 5-ASA concentration within the intestinal lumen. Renal complications are commonly reported for the chemically similar 5-ASA derivative mesalamine, but are not well-known side effects of sulfasalazine therapy...
June 29, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28656793/regulatory-framework-on-bioequivalence-criteria-for-locally-acting-gastrointestinal-drugs-the-case-for-oral-modified-release-mesalamine-formulations
#19
REVIEW
Gianluca Sferrazza, Paolo D Siviero, Giuseppe Nicotera, Paola Turella, Annalucia Serafino, Corrado Blandizzi, Pasquale Pierimarchi
Bioequivalence testing for locally acting gastrointestinal drugs is a challenging issue for both regulatory authorities and pharmaceutical industries. The international regulatory framework has been characterized by the lack of specific bioequivalence tests that has generated a negative impact on the market competition and drug use in clinical practice. Areas covered: This review article provides an overview of the European Union and United States regulatory frameworks on bioequivalence criteria for locally acting gastrointestinal drugs, also discussing the most prominent scientific issues and advances that has been made in this field...
September 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28638838/kaposi-sarcoma-mimicking-acute-flare-of-ulcerative-colitis
#20
Vivek Kumar, Parita Soni, Mohit Garg, Madina Abduraimova, Jonathan Harris
Besides an AIDS-defining illness, Kaposi sarcoma (KS) is also seen in individuals on long-term immunosuppressant therapy. We report KS in a 70-year-old immunocompetent man, which initially mimicked acute flare of ulcerative colitis (UC). He was hospitalized multiple times for complaints of watery diarrhea and tenesmus. Despite treatment with mesalamine, short courses of methylprednisolone, and one dose of infliximab, his symptoms improved only partially. He underwent colonoscopy, which revealed mild active colitis and a mass in the ascending colon...
April 2017: Journal of Investigative Medicine High Impact Case Reports
keyword
keyword
35708
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"