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https://www.readbyqxmd.com/read/28426460/is-mesalamine-effective-for-the-induction-of-remission-in-crohn-s-disease
#1
Stefanos Bonovas, Laurent Peyrin-Biroulet, Silvio Danese
No abstract text is available yet for this article.
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28377939/endoscopic-treatment-of-bleeding-diversion-pouchitis-with-high-concentration-dextrose-spray
#2
Custon T Nyabanga, Bo Shen
Surgical closure of stoma with the reestablishment of gut continuity is the only curative intervention available for inflammatory bowel disease patients with diversion pouchitis, proctitis, or colitis. For patients who are not candidates for surgical reestablishment of bowel continuity, the alternative nonsurgical approaches, such as topical therapy with mesalamine, corticosteroids, or short-chain fatty acids, have only shown modest efficacy. The management of massive bleeding from diversion pouchitis has not been described...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28369299/mesalamine-enemas-for-induction-of-remission-in-oral-mesalamine-refractory-pediatric-ulcerative-colitis-a-prospective-cohort-study
#3
Arie Levine, Baruch Yerushalmi, Michal Kori, Efrat Broide, Yael Mozer-Glassberg, Ron Shaoul, Kaija-Leena Kolho, Eyal Shteyer, Hussein Shamaly, Oren Ledder, Shlomi Cohen, Sarit Peleg, Chen Sarbagili Shabat, Gili Focht, Ebby Shachmon, Mona Boaz, Avi On, Dan Turner
Background: Paediatric Ulcerative Colitis (UC) is more extensive than adult disease, and more often refractory to mesalamine. However, no prospective trials have evaluated mesalamine enemas for inducing remission in children. Our goal was to evaluate the ability of mesalamine enemas to induce remission in mild to moderate paediatric UC refractory to oral mesalamine. Methods: This was an open label arm of a previously reported randomized controlled trial of once daily mesalamine in active paediatric UC (MUPPIT trial)...
March 23, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28368909/2-4-g-mesalamine-asacol-400-mg-tablet-once-daily-is-as-effective-as-three-times-daily-in-maintenance-of-remission-in-ulcerative-colitis-a-randomized-noninferiority-multi-center-trial
#4
Yasuo Suzuki, Mitsuo Iida, Hiroaki Ito, Haruo Nishino, Toshihide Ohmori, Takehiro Arai, Tadashi Yokoyama, Takanori Okubo, Toshifumi Hibi
BACKGROUND: The noninferiority of pH-dependent release mesalamine (Asacol) once daily (QD) to 3 times daily (TID) administration was investigated. METHODS: This was a phase 3, multicenter, randomized, double-blind, parallel-group, active-control study, with dynamic and stochastic allocation using central registration. Patients with ulcerative colitis in remission (a bloody stool score of 0, and an ulcerative colitis disease activity index of ≤2), received the study drug (Asacol 2...
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28366853/pectin-chitosan-physical-hydrogels-as-potential-drug-delivery-vehicles
#5
Lena Neufeld, Havazelet Bianco-Peled
Pectin-chitosan hydrogels are intriguing and relatively new type of physically crosslinked hydrogels. Here we present for the first time a study exploring the suitability of pectin-chitosan hydrogels to serve as drug carriers and the mechanism controlling the release patterns. Using drug release assays, we demonstrated sustained release of three model drugs (mesalamine, curcumin and progesterone) over a period of 24h in physiological conditions. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) experiments were used to characterize the interactions between the investigated drugs and the polymers...
March 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28366005/evaluation-of-dissolution-in-the-lower-intestine-and-its-impact-on-the-absorption-process-of-high-dose-low-solubility-drugs
#6
Danai Georgaka, James Butler, Filippos Kesisoglou, Christos Reppas, Maria Vertzoni
PURPOSE: First, to optimize a recently proposed two-stage single-compartment in vitro test for the evaluation of dissolution in the lower intestine with the mini-paddle apparatus in the fasted and fed state using two model high dose, low solubility drugs [sulfasalazine (Azulfidine®) and micronized aprepitant] and one mesalamine colon targeting product (Asacol, 400mg/tablet). Second, to evaluate the impact of passive absorption from the lower intestine on the overall absorption process using three model high dose, low solubility drugs [micronized aprepitant, SB705498, and albendazole (Zentel®)]...
April 1, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28333362/budesonide-multi-matrix-is-efficacious-for-mesalamine-refractory-mild-to-moderate-ulcerative-colitis-a-randomized-placebo-controlled-trial
#7
David T Rubin, Russell D Cohen, William J Sandborn, Gary R Lichtenstein, Jeffrey Axler, Robert H Riddell, Cindy Zhu, Andrew C Barrett, Enoch Bortey, William P Forbes
Background and Aims.: Safety and efficacy of budesonide multimatrix, an oral extended-release second-generation corticosteroid designed for targeted delivery throughout the colon, was examined for induction of remission in patients with mild to moderate ulcerative colitis refractory to baseline mesalamine therapy. Methods.: A randomized, double-blind, placebo-controlled, multicenter trial evaluated efficacy and safety of budesonide multimatrix for induction of remission [ulcerative colitis disease activity index score ≥ 4 and ≤ 10] in 510 adults randomized to once-daily oral budesonide multimatrix 9 mg or placebo for 8 weeks...
March 4, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28329471/first-report-of-mesalamine-5-aminosalicylic-acid-as-the-causative-agent-in-a-case-of-acute-generalized-exanthamous-pustulosis
#8
Erin Rocci, Kelly Park, Kelli Hutchens, Laura Winterfield
Acute generalized exanthamous pustulosis (AGEP)is a rare eruption of non-follicular sterile pustuleson a diffuse background of erythema and edema,commonly associated with fever and leukocytosis.Antibiotics are implicated in most cases; however,other drugs have been reported to cause AGEP. Wereport a case of a 73-year-old man with a historyof ulcerative colitis who presented with a diffusepustular rash, renal failure, elevated liver functiontests, and leukocytosis with neutrophilia. A week priorto admission, the patient was started on mesalamineto treat colitis...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28286796/gastric-pharmacobezoar-of-mesalamine-tablets-retrieved-endoscopically
#9
Surender Sultania, Bhanwar Singh Dhandhu, Hemendra Bhardwaj, Sandeep Nijhawan
No abstract text is available yet for this article.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28284977/mesalamine-desensitization-in-a-patient-with-treatment-refractory-ulcerative-colitis-and-aspirin-and-nonsteroidal-anti-inflammatory-drug-hypersensitivity
#10
Jordan L Heath, Ryan D Heath, Cyrus Tamboli, Larry Johnson, Ashley S Wilson, Sheva Chervinskiy, Matthew C Bell, Joshua L Kennedy
No abstract text is available yet for this article.
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28261835/systematic-review-with-meta-analysis-use-of-5-aminosalicylates-and-risk-of-colorectal-neoplasia-in-patients-with-inflammatory-bowel-disease
#11
REVIEW
S Bonovas, G Fiorino, T Lytras, G Nikolopoulos, L Peyrin-Biroulet, S Danese
BACKGROUND: The relationship of 5-aminosalicylates' use with the risk of colorectal neoplasia in patients with inflammatory bowel disease (IBD) has been the focus of a growing body of research. AIM: To investigate this association through an updated meta-analysis of observational studies. METHODS: PubMed, Scopus and major conference proceedings were searched up to December 2016. The identified studies were evaluated for publication bias and heterogeneity...
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28260866/adherence-in-ulcerative-colitis-an-overview
#12
REVIEW
Anna Testa, Fabiana Castiglione, Olga Maria Nardone, Giorgio L Colombo
Medication adherence is an important challenge while treating chronic illnesses, such as ulcerative colitis (UC), that require a long-term management to induce and maintain clinical remission. This review provides an overview of the role that medication adherence plays in the routine management of UC, with a focus on the results of a recent Italian study reporting the perception of patients with UC regarding adherence to treatment. A literature analysis was conducted on topics, such as measurement of adherence in real practice, causes, risk factors and consequences of non-adherence and strategies, to raise patients' adherence...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28182023/a-randomized-single-blind-parallel-group-study-comparing-monoherbal-formulation-containing-holarrhena-antidysenterica-extract-with-mesalamine-in-chronic-ulcerative-colitis-patients
#13
Sarika Johari, Tejal Gandhi
BACKGROUND: Incidences of side effects and relapses are very common in chronic ulcerative colitis patients after termination of the treatment. AIMS AND OBJECTIVES: This study aims to compare the treatment with monoherbal formulation of Holarrhena antidysenterica with Mesalamine in chronic ulcerative colitis patients with special emphasis to side effects and relapse. SETTINGS AND DESIGN: Patients were enrolled from an Ayurveda Hospital and a private Hospital, Gujarat...
July 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28175061/p409-mesalamine-enemas-for-induction-of-remission-in-pediatric-ulcerative-colitis-refractory-to-oral-mesalamine-a-prospective-cohort-study
#14
A Levine, B Yerushalmi, M Kori, E Broide, Y Mozer-Glassberg, R Shaoul, K-L Kolho, E Shteyer, H Shamaly, O Ledder, S Cohen, S Peleg, C Sarbagili-Shabat, G Focht, E Shachmon, M Boaz, A On, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172987/p656-is-there-a-role-for-additional-oral-mesalamine-therapy-in-the-treatment-of-ulcerative-proctitis-with-skip-inflammation
#15
Y S Choi, W J Kim, J K Kim, K-H Song, H-J Jung
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172645/p505-efficacy-of-mmx-mesalamine-monotherapy-for-maintenance-of-remission-in-ulcerative-colitis-patients-after-mucosal-healing
#16
J Lopez-Diaz, R Ferreiro, D De la Iglesia, A Lorenzo, J E Dominguez-Munoz, M Barreiro-de Acosta
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167113/investigating-the-potential-of-tamarindus-indica-pectin-chitosan-conjugate-for-reducing-recovery-period-in-tnbs-induced-colitis
#17
Sheshank Sethi, Rajneet Kaur Khurana, Sunil Kamboj, Radhika Sharma, Akashdeep Singh, Vikas Rana
The present study was aimed at exploiting the wound healing applications and tablet coating potential of Tamarindus indica pectin-chitosan (PCH) conjugate for reducing recovery period from TNBS induced colitis. The PCH (60:40, 3% w/v) solution when spray coated followed by drying at 50°C created hydrophobic surface, that may be due to interaction of pectin with chitosan as evident from temperature ramping rheological investigations. Further, the 15% w/v coating was sufficient to prevent Mesalamine (Ma) release in pH 1...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28150131/inflammatory-bowel-disease-unclassified-in-children-diagnosis-and-pharmacological-management
#18
REVIEW
Giulia D'Arcangelo, Marina Aloi
Inflammatory bowel diseases are chronic disorders of the gastrointestinal tract that include Crohn's disease (CD), ulcerative colitis (UC) and inflammatory bowel disease-unclassified (IBDU). The latter defines a subgroup of patients with clinical and endoscopic evidence of chronic colitis, without specific features of either CD or UC. These patients will possibly be re-classified as having UC or CD during the follow-up, although a significant percentage of them will keep the diagnosis of IBDU. IBDU is the rarest subtype of IBD, both in children and in adults, although it is twice as common among the pediatric population, especially in the younger ages...
April 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28147377/case-report-acute-flair-of-ulcerative-colitis-during-pregnancy-is-still-a-major-problem
#19
Marijana Protic, Srdjan Markovic, Dino Tarabar
Although severe flare of ulcerative colitis (UC) is uncommon, it significantly increases the risk of preterm delivery, low birth weight and other adverse fetal outcomes. It is critical to optimize aggressive medical treatment with both mother and fetal health. Here, we present a case of a 30-year-old woman with a severe flare of UC at the 16th gestational week. The diagnosis of extensive UC was established 8 years ago. From the time she was diagnosed, she had 5 moderate flares successfully treated with oral and topical mesalamine...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28147366/what-should-be-done-in-inflammatory-bowel-disease-patients-with-prior-malignancy
#20
REVIEW
Jacques Cosnes
BACKGROUND: Treatment of inflammatory bowel disease (IBD) in patients with prior malignancy is challenging because therapeutic immunosuppression required for controlling IBD activity may increase the risk of cancer recurrence. Key Messages: Contrary to the observations in the post-transplant population, retrospective observational studies of IBD patients with prior malignancy have not demonstrated that immunosuppressive drugs increased significantly the risk of new or recurrent cancer...
2017: Digestive Diseases
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