keyword
https://read.qxmd.com/read/37874922/inflammatory-bowel-disease-in-adults-and-elderly-the-use-of-selected-non-ibd-medication-examined-in-a-nationwide-cohort-study
#21
JOURNAL ARTICLE
Ken Lund, Floor Dijkstra Zegers, Jan Nielsen, Jacob Broder Brodersen, Torben Knudsen, Jens Kjeldsen, Michael Due Larsen, Bente Mertz Nørgård
BACKGROUND: Real-world data on medications used for conditions other than inflammatory bowel disease (IBD) are sparse. We examined how the onset of IBD affects the prescription pattern of selected non-IBD medication and the risk of becoming an incident user. METHODS: This nationwide cohort study utilized data from Danish health registers. We included incident patients with young adult-onset IBD (18-39 years of age), adult-onset IBD (40-59 years of age), and elderly-onset IBD (60+ years of age), from 1998 to 2018 and followed all for 3 years...
October 24, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37873025/does-the-association-between-psychosocial-factors-and-opioid-use-after-elective-spine-surgery-differ-by-sex-in-older-adults
#22
JOURNAL ARTICLE
Linda S Aglio, Elisabetta Mezzalira, Sarah M Corey, Kara G Fields, Blake M Hauser, Maria J Susano, Deborah J Culley, Kristin L Schreiber, Nicole J Kelly-Aglio, Megan E Patton, Rania A Mekary, Robert R Edwards
PURPOSE: Psychosocial disorders have been linked to chronic postoperative opioid use and the development of postoperative pain. The potential interaction between sex and psychosocial factors with respect to opioid use after elective spine surgery in the elderly has not yet been evaluated. Our aim was to assess whether any observed association of anxiety or depression indicators with opioid consumption in the first 72 hours after elective spine surgery varies by sex in adults ≥65 years...
2023: Journal of Pain Research
https://read.qxmd.com/read/37840789/an-elderly-patient-with-depression-and-a-suicide-attempt-during-the-covid-19-pandemic-a-case-report
#23
Hajar Mohd Salleh Sahimi, Marhani Midin, Jane Tze Yn Lim, Mohd Wafiy Ariffin Anwar, Farah Deena Abdul Samad, Nurul Ain Mohamad Kamal
OBJECTIVE: Elderly individuals are among the age groups with the highest risk of suicide. The coronavirus (COVID-19) pandemic forced isolation and resulted in an increased risk of depression, hopelessness, and perceived burdensomeness among the elderly, thereby increasing the risk of suicide. METHODS: This is a case report of an elderly single retired school principal with obsessive-compulsive personality traits who developed depression with psychotic symptoms after being isolated following the movement control order (MCO) during the COVID-19 pandemic...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37840180/-chinese-guidelines-for-the-treatment-of-chronic-pain-disorders-with-non-opioid-analgesics
#24
JOURNAL ARTICLE
(no author information available yet)
Non-opioid analgesics are one of the important clinical treatment drugs for chronic pain disorders, which mainly include non-steroidal anti-inflammatory analgesics, ion channel drugs, antidepressants, glucocorticoids, neurotrophic drugs, muscle relaxants, α2 adrenergic receptor agonists, bone metabolism regulating drugs, N-methyl-D-aspartate receptor antagonists and traditional Chinese patent medicines. The guidelines for the treatment of chronic pain disorders based on international classification of diseases (ICD)-11 with non-opioid analgesics have not been reported...
October 24, 2023: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/37806715/treatment-resistant-depression-in-elderly
#25
JOURNAL ARTICLE
Sheng-Chiang Wang, Jennifer S Yokoyama, Nian-Sheng Tzeng, Chia-Fen Tsai, Mu-N Liu
Treatment refractory depression (TRD) in the elderly is a common psychiatric disorder with high comorbidity and mortality. Older adults with TRD often have complicated comorbidities and several predisposing risk factors, which may lead to neuropsychiatric dysfunction and poor response to treatment. Several hypotheses suggest the underlying mechanisms, including vascular, immunological, senescence, or abnormal protein deposition. Treatment strategies for TRD include optimization of current medication dose, augmentation, switching to an alternative agent or class, and combination of different antidepressant classes, as well as nonpharmacological adjuvant interventions such as biophysical stimulation and psychotherapy...
2023: Progress in Brain Research
https://read.qxmd.com/read/37794715/the-efficacy-of-vortioxetine-for-the-delusional-disorder-of-cenesthopathy
#26
Shinji Sato, Koubun Imai
Cenesthopathy is a rare syndrome characterized by strange bodily and oral sensations and is classified as a delusional disorder, somatic type, according to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders. Cenesthopathy has been considered difficult to treat. However, to improve cenesthopathy, many pharmacotherapeutic options are reported, including antidepressants and antipsychotics. In this case report, vortioxetine significantly alleviated the distress of oral cenesthopathy in a patient with cerebral ischemia and depression without any adverse effects...
October 4, 2023: Neuropsychopharmacology Reports
https://read.qxmd.com/read/37787056/an-update-on-the-pharmacotherapeutic-strategies-for-the-treatment-of-dysthymic-disorder-a-systematic-review
#27
REVIEW
Laiana A Quagliato, Diego Primavera, Michele Fornaro, Antonio Preti, Mauro G Carta, Antonio E Nardi
INTRODUCTION: Longer treatment times, more comorbidity, more severe impairments in social, psychological, and emotional functioning, increased healthcare use, and more hospitalizations are all factors that are related to dysthymia. Given the significant prevalence of dysthymia (including persistent depressive disorder) worldwide, its comorbidity with several mental disorders, and the detrimental effects of these comorbidities, it is important to conduct a systematic review to compare the effects of pharmacological acute and maintenance treatments for dysthymia with placebo and standard care in the last 10 years, based on the publication of DSM5...
October 3, 2023: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/37776466/three-year-prognosis-of-late-life-depression-in-an-outpatient-geriatric-psychiatry-clinic-medical-comorbidities-worsen-outcomes
#28
JOURNAL ARTICLE
Nuray Uysal Cesur, Burç Çağrı Poyraz
Depression is one of the most important reasons for psychiatric referrals in elderly patients. Geriatric depression can be chronic and is associated with an increased risk of dementia. We aimed to determine the prognosis of major depression patients and associated risk factors regarding persistence of depression. Patients who were admitted to the tertiary geriatric psychiatric outpatient unit of Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul between January and December 2018 and were diagnosed with major depression according to DSM-5 diagnostic criteria were included in the study...
September 30, 2023: Psychiatric Quarterly
https://read.qxmd.com/read/37763134/pain-and-its-management-in-patients-referred-to-a-geriatric-outpatient-clinic
#29
JOURNAL ARTICLE
Krzysztof Rutkowski, Mateusz Wyszatycki, Krystian Ejdys, Natalia Maria Hawryluk, Małgorzata Stompór
(1) Background: A major problem affecting geriatric patients is pain. In addition to pain, a significant problem of old age is dementia and depression, which can hinder the diagnosis and treatment of pain. The aim of this study was to analyse the prevalence of pain in patients treated in a geriatric outpatient clinic and the treatment used. (2) Methods: The analysis was based on the records of 937 patients who visited the Geriatric Outpatient Clinic in Dobre Miasto between 2015 and 2020. Based on records containing data dating back to their first visit to the hospital, patients' experiences of pain, the presence of depressive symptoms and dementia, and the pharmacological treatment used for pain (analgesics and coanalgesics) were analysed...
September 8, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37700952/a-conspectus-of-euvolemic-hyponatremia-its-various-etiologies-and-treatment-modalities-a-comprehensive-review-of-the-literature
#30
REVIEW
Anit Ghosal, Hafiza Amna Qadeer, Sravan K Nekkanti, Priyanka Pradhan, Chiugo Okoye, Danish Waqar
Hyponatremia is the most prevalent electrolyte imbalance encountered among hospitalized patients, athletes, the elderly, patients with chronic ailments, postoperative patients, and a few asymptomatic individuals. Clinical manifestations of hyponatremia can be diverse, with characteristic neurological symptoms. Depending on in-depth medical history, physical examination (including volume status assessment), laboratory investigation, and drug history, patients can be classified broadly as undergoing hypervolemic, euvolemic, or hypovolemic hyponatremia...
August 2023: Curēus
https://read.qxmd.com/read/37657019/repetitive-transcranial-magnetic-stimulation-in-the-treatment-of-middle-aged-and-elderly-major-depressive-disorder-a-randomized-controlled-trial
#31
RANDOMIZED CONTROLLED TRIAL
Xiaofang Wang, Xiubo Fan, Lihui Zhang, Xin Liu, Zhi Ji
BACKGROUND: Studies have reported the use of repetitive transcranial magnetic stimulation (rTMS) in patients with major depressive disorder (MDD). However, most studies focus on antidepressant effect of rTMS, but few on cognitive aspects. The present study aimed to explore the effect of rTMS on BDNF levels and cognitive function in the treatment of middle-aged and elderly MDD. METHODS: This was a randomized controlled trial. A total of 120 elderly patients with MDD treated in The Second Affiliated Hospital of Xi'an Medical University from January 2021 to January 2023 were selected as research subjects...
September 1, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37608991/case-report-application-of-pharmacogenetics-in-the-personalized-treatment-of-an-elderly-patient-with-a-major-depressive-episode
#32
Milica Pjevac, Sara Redenšek Trampuž, Tanja Blagus, Vita Dolžan, Jurij Bon
BACKGROUND: Pharmacogenetic analyses can predict interpersonal differences in response to psychopharmacotherapy, which greatly facilitates the selection of the most effective medication at optimal doses. By personalizing therapy in this way, we can minimize adverse drug reactions (ADR) and prevent polypharmacy. Most psychotropic medications are metabolized by the cytochrome P450 enzymes CYP2D6, CYP2C19, and CYPA3A4, which influence drug metabolism and concentration, affecting both efficacy and the occurrence of ADR...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37519085/-depression-in-older-adults-what-are-the-differences-in-clinical-practice
#33
JOURNAL ARTICLE
Guillaume Le Bivic, Frédéric Limosin, Cédric Lemogne, Nicolas Hoertel
BACKGROUND: Management of depression in the elderly is a growing public health issue in France. The objective of this study was to compare practitioners' perception of depression severity (i.e., intensity and suicidal risk) and clinical practice (i.e., clinical assessment and medication choice) in elderly versus younger adult patients with major depression. MATERIALS AND METHOD: The method consisted of an online questionnaire completed by general practitioners and psychiatrists...
June 1, 2023: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://read.qxmd.com/read/37510863/effectiveness-of-repetitive-transcranial-magnetic-stimulation-in-the-treatment-of-depression-in-the-elderly-a-retrospective-natural-analysis
#34
JOURNAL ARTICLE
Eisa Almheiri, Abdullah Alhelali, Mohamed A Abdelnaim, Franziska C Weber, Berthold Langguth, Martin Schecklmann, Tobias Hebel
INTRODUCTION: Depression in the elderly is an understudied condition. Psychopharmacological and psychotherapeutic approaches suffer from specific difficulties with this patient group. Brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) offer a therapeutic alternative. rTMS remains understudied in this age group when compared with younger patients. METHODS: A cohort of 505 patients with depression was analyzed in retrospect concerning their response to rTMS treatment...
July 18, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37482501/perioperative-anxiety-and-depression-in-older-adults-epidemiology-and-treatment
#35
REVIEW
Maytinee Srifuengfung, Joanna Abraham, Michael S Avidan, Eric J Lenze
The intervals before and after major surgery is a high-risk period for older adults; in this setting, anxiety and depression are common and serious problems. We comprehensively reviewed current evidence on perioperative anxiety and depression in older adults, focusing on epidemiology, impact, correlates, medication risks, and treatment. Principles of perioperative mental healthcare are proposed based on the findings. Prevalence estimates of clinically significant anxiety and depression range from 5% to 45% for anxiety and 6% to 52% for depression, depending on surgical populations and measurement tools...
November 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37450377/efficacy-and-tolerability-of-desvenlafaxine-in-the-real-world-treatment-of-patients-with-major-depression-a-narrative-review-and-an-expert-opinion-paper
#36
JOURNAL ARTICLE
Gaia Sampogna, Filippo Caraci, Claudia Carmassi, Bernardo Dell'Osso, Silvia Ferrari, Giovanni Martinotti, Gabriele Sani, Gianluca Serafini, Maria Salvina Signorelli, Andrea Fiorillo
INTRODUCTION: Major depressive disorder (MDD) is a common severe mental disorder, requiring a tailored and integrated treatment. Several approaches are available including different classes of antidepressants various psychotherapeutic approaches, and psychosocial interventions. The treatment plan for each patient with MDD should be differentiated on the basis of several clinical, personal, and contextual factors. AREAS COVERED: Desvenlafaxine - a serotonine-noradrenergic reuptake inhibitor (SNRI) antidepressant - has been approved in the United States in 2008 for the treatment of MDD in adults, and has been recently rediscovered by clinicians due to its good side-effect profile and its clinical effectiveness...
July 23, 2023: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/37383189/pharmacist-comprehensive-review-of-fall-risk-increasing-drugs-and-polypharmacy-in-elderly-spanish-community-patients-using-rstudio%C3%A2
#37
JOURNAL ARTICLE
Silvia González-Munguía, Obdulia Munguía-López, Esther Sánchez Sánchez
OBJECTIVE: The aim of this study is to identify and analyze adults aged ≥65 years living in the Canary Islands, Spain, who are prescribed medications that increase the risk of falls and are polymedicated. To do so we have made use of the electronic prescription and the RStudio®. METHOD: For the detection of Fall-Risk-Increasing Drugs (FRIDs), outpatient electronic prescription dispensing data were used in two pharmacies. A total of 118,890 dispensations grouped into 15,601 treatment plans for 2,312 patients were analyzed...
June 2023: Heliyon
https://read.qxmd.com/read/37343903/should-buprenorphine-be-considered-a-first-line-opioid-for-the-treatment-of-moderate-to-severe-cancer-pain
#38
JOURNAL ARTICLE
Marcin Chwistek, Dylan Sherry, Leigh Kinczewski, Maria J Silveira, Mellar Davis
Cancer pain remains a significant problem worldwide, affecting more than half of patients receiving anti-cancer treatment and most patients with advanced disease. Opioids remain the cornerstone of therapy, and morphine, given its availability, multiple formulations, price, and evidence base, is typically considered the first-line treatment for moderate to severe cancer pain. Buprenorphine has emerged in recent decades as an alternative opioid for treating chronic pain and substance use disorder (SUD). However, it remains controversial whether buprenorphine should be considered a first-line opioid for moderate to severe cancer pain...
November 2023: Journal of Pain and Symptom Management
https://read.qxmd.com/read/37288224/subjective-improvement-in-hearing-after-treatment-with-a-manic-episode-in-an-elderly-patient
#39
Alican Bulut, Kamadchisundaram Manoranjan, Justin Marley
This is a report of an 81-year-old woman presenting with hearing improvement after a reduction of antidepressant medication to manage a manic episode. The patient reported a subjective improvement in her hearing ability, not confirmed by audiometric testing. It was reported to us that she stopped using her hearing aids subsequently. This case highlights the potential for medications to impact hearing and the importance of monitoring for side effects in elderly patients with mood disorders.
May 2023: Curēus
https://read.qxmd.com/read/37277240/explicit-potentially-inappropriate-medications-criteria-for-older-population-in-asian-countries-a-systematic-review
#40
REVIEW
Chee Tao Chang, Siew Li Teoh, Philip Rajan, Shaun Wen Huey Lee
BACKGROUND: Explicit potentially inappropriate medications (PIM) criteria are commonly used to identify and deprescribe potentially inappropriate prescriptions among older patients. Most of these criteria were developed specifically for the Western population, which might not be applicable in an Asian setting. The current study summarizes the methods and drug lists to identify PIM in older Asian people. METHODS: A systematic review of published and unpublished studies were carried out...
June 1, 2023: Research in Social & Administrative Pharmacy: RSAP
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