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Antidepressants and elderly

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https://www.readbyqxmd.com/read/28105501/-diagnostics-and-multimodal-treatment-of-depression-in-old-age-new-developments
#1
Gerhard W Eschweiler
Depressive disorders in elderly persons are frequent and can either first be manifested at a younger age and show a recurrent pattern during later life (ICD 10, F33.*) or have an onset beyond 60 years, which is termed late onset depression (LOD). This LOD has a higher tendency to chronification and implies an increased risk of progression, especially to vascular dementia. The multifactorial genesis of depression in old age includes psychosocial, vascular and metabolic factors and requires multimodal therapy modules at the biological and psychosocial level, which is now increasingly being empirically proven...
January 19, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28103930/trends-in-hospital-admissions-due-to-antidepressant-related-adverse-drug-events-from-2001-to-2011-in-the-u-s
#2
Harish S Parihar, Hongjun Yin, Jennifer L Gooch, Shari Allen, Samuel John, Jianwei Xuan
BACKGROUND: Depression is a prevalent mental health disorder and the fourth leading cause of disability in the world as per the World Health Organization. Use of antidepressants can lead to adverse drug events (ADEs), defined as any injury resulting from medication use. This study aimed to examine changes in hospital admissions due to antidepressant-related ADEs (ArADEs) among different socio-demographic groups and changes in lengths of stay (LOS) and hospital charges in ArADE admissions from 2001 to 2011...
January 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28095959/general-aviation-pilots-over-70-years-old
#3
Alpo Vuorio, Saryani Asmayawati, Bruce Budowle, Robin Griffiths, Timo Strandberg, Jaana Kuoppala, Antti Sajantila
BACKGROUND: Currently it is not unusual for general aviation pilots in the United States to continue to fly beyond the age of 70, even into their 80s and 90s. Pilots have regular examinations according to protocols which do not specify special or additional requirements for pilots over 70 yr of age. Additionally, the third class medical reforms passed by the U.S. Senate on 15 July 2016 could potentially result in even less stringent medical certification requirements for general aviation pilots...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28079266/risk-of-mortality-in-elderly-nursing-home-patients-with-depression-using-paroxetine
#4
Vishal Bali, Satabdi Chatterjee, Michael L Johnson, Hua Chen, Ryan M Carnahan, Rajender R Aparasu
OBJECTIVE: Among selective serotonin reuptake inhibitors (SSRIs), paroxetine is strongly anticholinergic and might lead to higher risk of adverse outcomes such as mortality. This study examined the risk of mortality in depressed elderly nursing home patients using paroxetine and other SSRIs. METHODS: This study used 2007-2010 Minimum Data Set - linked Medicare data and propensity score-matched retrospective cohort study design to achieve the study objective. New users of paroxetine and other SSRIs were followed until they reached the end of the follow-up period (one year), switched to a different antidepressant class, used psychotherapy, or had a gap of more than 15 days in the use of index antidepressant class, whichever occurred earlier...
January 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28045347/depression-treatment-among-elderly-medicare-beneficiaries-with-incident-cases-of-cancer-and-newly-diagnosed-depression
#5
Monira Alwhaibi, Suresh Madhavan, Thomas Bias, Kimberly Kelly, Jamie Walkup, Usha Sambamoorthi
OBJECTIVE: Depression treatment can improve the health outcomes of elderly cancer survivors. There is a paucity of studies on the extent to which depression is treated among elderly cancer survivors. Therefore, this study estimated the rates of depression treatment among elderly cancer survivors and identified the factors affecting depression treatment. METHODS: A retrospective cohort study design was adopted, and data were obtained from the linked Surveillance, Epidemiology and End Results (SEER) and Medicare database...
January 3, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28024315/patient-physician-and-health-system-factors-influencing-the-quality-of-antidepressant-and-sedative-prescribing-for-older-community-dwelling-adults
#6
Rian Marie Extavour, Matthew Perri
OBJECTIVE: To identify determinants of potentially inappropriate (PI) antidepressant and anxiolytic/sedative prescribing for older, community-dwelling adults. DATA SOURCES/STUDY SETTING: Office visits from the 2010 National Ambulatory Medical Care Survey. STUDY DESIGN: A cross-sectional study measuring associations between various patient and physician factors and prescribing of PI antidepressants, and PI sedatives among elderly, using Beers 2012/2015 criteria, a clinical decision model, and multivariate logistic regressions...
December 26, 2016: Health Services Research
https://www.readbyqxmd.com/read/27894225/agreement-between-the-2009-stopp-criteria-and-the-2003-beers-criteria-at-the-time-of-hospital-admission
#7
María Muñoz García, Eva Delgado Silveira, Sagrario Martín-Aragón Álvarez, Teresa Bermejo Vicedo, Alfonso José Cruz-Jentoft
: Potentially inappropriate prescription in elderly patients can be evaluated by different methods. The STOPP Criteria and Beers Criteria stand out among the explicit criteria most widely used. OBJECTIVE: The main objective of this study is to identify the agreement in the detection of potentially inappropriate prescribing between the STOPP criteria and the Beers Criteria, in elderly patients assessed at the time of hospital admission. METHOD: An observational retrospective study was designed in order to estimate the prevalence of potentially inappropriate prescription in the habitual treatment before admission, and to compare the agreement in detection capability between the 2003 Beers Criteria and the 2009 STOPP Criteria, in >70-yearold patients with an emergency hospital admission...
November 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27891701/depression-treatment-and-healthcare-expenditures-among-elderly-medicare-beneficiaries-with-newly-diagnosed-depression-and-incident-breast-colorectal-or-prostate-cancer
#8
Monira Alwhaibi, Usha Sambamoorthi, Suresh Madhavan, James T Walkup
OBJECTIVES: Depression is associated with high healthcare expenditures, and depression treatment may reduce healthcare expenditures. However, to date, there have not been any studies on the effect of depression treatment on healthcare expenditures among cancer survivors. Therefore, this study examined the association between depression treatment and healthcare expenditures among elderly with depression and incident cancer. METHODS: The current study utilized a retrospective longitudinal study design using the linked Surveillance, Epidemiology and End Results (SEER)-Medicare database...
November 28, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27828576/use-of-potentially-inappropriate-medications-by-the-elderly-at-home
#9
Lázara Montezano Lopes, Tácita Pires de Figueiredo, Soraya Coelho Costa, Adriano Max Moreira Reis
The goal of this study was to assess how often potentially inappropriate medicines are used by the elderly at home, and analyze its clinical significance. This is a retrospective cross-sectional study, a segment of a study on the use of medication conducted at a public hospital. Inappropriate medication was classified according to the three criteria in the 2012 Beers List. 190 elderly were included in this study; the prevalence of the use of inappropriate medicines was 44.2%. The therapeutic classes of most often used inappropriate medicines were non-steroid anti-inflammatories, cardiovascular agents, benzodiazepines and antidepressants...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27806704/vascular-depression-consensus-report-a-critical-update
#10
EDITORIAL
Howard J Aizenstein, Andrius Baskys, Maura Boldrini, Meryl A Butters, Breno S Diniz, Manoj Kumar Jaiswal, Kurt A Jellinger, Lev S Kruglov, Ivan A Meshandin, Milija D Mijajlovic, Guenter Niklewski, Sarah Pospos, Keerthy Raju, Kneginja Richter, David C Steffens, Warren D Taylor, Oren Tene
BACKGROUND: Vascular depression is regarded as a subtype of late-life depression characterized by a distinct clinical presentation and an association with cerebrovascular damage. Although the term is commonly used in research settings, widely accepted diagnostic criteria are lacking and vascular depression is absent from formal psychiatric manuals such as the Diagnostic and Statistical Manual of Mental Disorders, 5(th) edition - a fact that limits its use in clinical settings. Magnetic resonance imaging (MRI) techniques, showing a variety of cerebrovascular lesions, including extensive white matter hyperintensities, subcortical microvascular lesions, lacunes, and microinfarcts, in patients with late life depression, led to the introduction of the term "MRI-defined vascular depression"...
November 3, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27801932/antidepressant-exposure-and-risk-of-dementia-in-older-adults-with-major-depressive-disorder
#11
Joy E Brodrick, Monica L Mathys
OBJECTIVES: To identify whether duration of antidepressant use in depressed elderly veterans differed between those who later developed dementia and those who did not. DESIGN: Single-center, retrospective, observational, electronic chart review. SETTING: Medical charts from a Veterans Affairs Mental Health Clinic. PARTICIPANTS: Veterans aged 65 and older with history of depression. MEASUREMENTS: Information on sociodemographic characteristics; duration of antidepressant, antipsychotic, and benzodiazepine therapy; diagnosis of dementia; and comorbid disease states was collected...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27755157/antidepressant-associated-hyponatremia-in-the-elderly
#12
H Karl Greenblatt, David J Greenblatt
No abstract text is available yet for this article.
December 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27751669/review-of-safety-and-efficacy-of-sleep-medicines-in-older-adults
#13
REVIEW
Jennifer L Schroeck, James Ford, Erin L Conway, Kari E Kurtzhalts, Megan E Gee, Krista A Vollmer, Kari A Mergenhagen
PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia. METHODS: A literature search of Medline, PubMed, and Embase was conducted (January 1966-June 2016). It included systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on insomnia in an older population...
November 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27743842/non-tricyclic-and-non-selective-serotonin-reuptake-inhibitor-antidepressants-and-recurrent-falls-in-frail-older-women
#14
Jennifer G Naples, Mary P Kotlarczyk, Subashan Perera, Susan L Greenspan, Joseph T Hanlon
OBJECTIVE: To determine the risk of recurrent falls associated with antidepressants other than tricyclics (TCAs) and selective serotonin reuptake inhibitors (SSRIs) among frail older women. METHODS: This is a secondary analysis of the Zoledronic acid in frail Elders to STrengthen bone, or ZEST, trial data treated as a longitudinal cohort in 181 frail, osteoporotic women aged ≥65 years in long-term care. The primary exposure was individual non-TCA/non-SSRI antidepressants (i...
December 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27738376/paroxetine-the-antidepressant-from-hell-probably-not-but-caution-required
#15
REVIEW
Robert M Nevels, Samuel T Gontkovsky, Bryman E Williams
Paroxetine, also known by the trade names Aropax, Paxil, Pexeva, Seroxat, Sereupin and Brisdelle, was first marketed in the U.S. in 1992. Effective for major depression and various anxiety disorders, it quickly gained a sizable share of the antidepressant prescription market. By the late 1990s, paroxetine frequently was being associated with serious drug interactions and medication side effects. Most significantly, in a major Canadian epidemiological study examining the relationship between antidepressants and diseases, paroxetine was associated with a 620 percent increase in the rate of breast cancer in women who had taken it over a four-year period...
March 1, 2016: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/27716668/potentially-inappropriate-medication-in-community-dwelling-primary-care-patients-who-were-screened-positive-for-dementia
#16
Diana Wucherer, Tilly Eichler, Johannes Hertel, Ingo Kilimann, Steffen Richter, Bernhard Michalowsky, Jochen René Thyrian, Stefan Teipel, Wolfgang Hoffmann
BACKGROUND: Potentially inappropriate medication (PIM) in older people is a risk factor for adverse drug effects. This risk is even higher in older people with dementia (PWD). OBJECTIVE: Our study aimed to determine (1) the prevalence of PIM among primary care patients who were screened positive for dementia and (2) the sociodemographic and clinical variables associated with the use of PIM. METHODS: DelpHi-MV (Dementia: life- and person-centered help in Mecklenburg-Western Pomerania) is a general practitioner-based, cluster-randomized, controlled intervention study to implement and evaluate an innovative concept of collaborative dementia care management in Germany...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27672315/atypical-antipsychotics-as-add-on-treatment-in-late-life-depression
#17
Sibel Cakir, Zeynep Senkal
BACKGROUND: Second-generation antipsychotics (SGAs) have been used in the augmentation of treatment-resistant depression. However, little is known about their effectiveness, tolerability, and adverse events in the treatment of late-life depression, which were the aim of this study. METHODS: The retrospective data of patients aged >65 years who had a major depressive episode with inadequate response to antidepressant treatment and had adjuvant SGA treatment were analyzed...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27664059/pharmacy-use-by-dual-eligible-non-elderly-veterans-with-private-healthcare-insurance
#18
Brian C Lund, Mary E Charlton, Alan N West
BACKGROUND: Utilization of private sector healthcare services among dual enrolled veterans with private healthcare insurance plans (PHIP) has not been well-characterized. Concurrent use of Veterans Health Administration (VHA) and non-VHA pharmacies may increase risk for adverse outcomes. Thus, the objectives of this study were to determine the extent to which dual VHA-PHIP enrollees obtain medications through VHA and non-VHA pharmacies and to characterize medications obtained through non-VHA pharmacies...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27650670/psychotropic-drug-prescription-and-the-risk-of-falls-in-nursing-home-residents
#19
Claudia A Cox, Heike J van Jaarsveld, Saskia Houterman, John C G H van der Stegen, Arthur T M Wasylewicz, Rene J E Grouls, Carolien M J van der Linden
BACKGROUND: Falling is a common and serious problem in the elderly. Previous studies suggest that the use of psychotropic drugs increases the risk of falling. However, the contribution of these drugs on fall risk has not been quantified on a daily basis among the general population of nursing homes until now. OBJECTIVE: To assess the association between fall incidence and the prescription of psychotropic drugs and different categories of psychotropic drugs (antipsychotics, antidepressants, and benzodiazepines) among a general nursing home population...
December 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27605868/treatment-resistant-depression-or-dementia-a-case-report
#20
Zhongyong Shi, Shifu Xiao, Xia Li
The current case describes a 78-year-old female with two previous episodes of major depression who presented with both symptoms of depression (amotivation and flattened affect) and typical symptoms of dementia (impaired memory and executive functioning). Even after a detailed clinical exam and neuropsychiatric testing, it remained difficult to definitively classify the diagnosis as either treatment-resistant depression or old-age dementia. After 8 weeks of inpatient treatment, including changing her reserpine-based antihypertensive medication, adjusting her antidepressants, and providing psychotherapy, her depressive and anxiety symptoms improved, but most of her cognitive symptoms persisted...
April 25, 2016: Shanghai Archives of Psychiatry
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