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Antidepressants and elderly

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https://www.readbyqxmd.com/read/29752625/polypharmacy-among-headache-patients-a-cross-sectional-study
#1
Anna Ferrari, Carlo Baraldi, Manuela Licata, Cecilia Rustichelli
BACKGROUND: Polypharmacy can appropriately treat multiple chronic conditions, but it can also increase potential harm. Polypharmacy information for primary headaches is minimal, despite drugs being the main tools to manage headaches. OBJECTIVE: The aim was to evaluate the prevalence, characteristics and risk factors of polypharmacy in patients with primary headaches and examine whether these variables differ between episodic and chronic headache patients. METHODS: We analysed polypharmacy (simultaneous use of five or more medications), medication type, comorbidity, and risk factors in 300 patients (mean age 42...
May 11, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29749006/predictors-of-recurrence-in-remitted-late-life-depression
#2
Yi Deng, Douglas R McQuoid, Guy G Potter, David C Steffens, Kimberly Albert, Meghan Riddle, John L Beyer, Warren D Taylor
BACKGROUND: Late-life depression (LLD) is associated with a fragile antidepressant response and high recurrence risk. This study examined what measures predict recurrence in remitted LLD. METHODS: Individuals of age 60 years or older with a Diagnostic and Statistical Manual - IV (DSM-IV) diagnosis of major depressive disorder were enrolled in the neurocognitive outcomes of depression in the elderly study. Participants received manualized antidepressant treatment and were followed longitudinally for an average of 5 years...
May 10, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29732910/lurasidone-adjunctive-with-antidepressants-in-an-elderly-patient-with-severe-illness-anxiety-disorder
#3
Pei-Yin Pan, Chin-Bin Yeh
No abstract text is available yet for this article.
May 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29702755/association-of-up-regulated-plasma-adiponectin-with-risk-of-incident-depression-in-a-community-dwelling-elderly-population
#4
Dae Jong Oh, Ji Won Han, Beom Jun Min, Hyun-Ghang Jeong, Tae Hui Kim, Sung Hee Choi, Soo Lim, Jung Jae Lee, Joon Hyuk Park, Seok Bum Lee, Young Joo Park, Hak Chul Jang, Ki Woong Kim
OBJECTIVE: Despite robust interest in the association between inflammation and depression, anti-inflammatory markers have been scarcely investigated as predictors of the future risk of depression. The aim of this study is to determine whether up-regulation of plasma adiponectin, an anti-inflammatory adipokine, precedes and predicts the development of depression in the elderly. METHODS: This prospective cohort study was launched in 2005. Among 1,000 participants who were randomly sampled from community-dwelling individuals 65 years or older, 633 euthymic individuals without prior history of depressive disorders were enrolled for a baseline evaluation and follow-up after 5 years...
April 10, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29659205/executive-function-predicts-antidepressant-treatment-noncompletion-in-late-life-depression
#5
Pilar Cristancho, Eric J Lenze, David Dixon, J Philip Miller, Benoit H Mulsant, Charles F Reynolds, Meryl A Butters
OBJECTIVE: To examine whether executive function (EF) is associated with nonremission and noncompletion of antidepressant pharmacotherapy in older adults with depression. DESIGN: In this prospective study (July 2009 to May 2014), older adults (aged ≥ 60 years; n = 468) with a DSM-IV-defined major depressive episode diagnosed via structured interview received 12 weeks of venlafaxine extended release with the goal of achieving remission. A hypothesis was made that worse baseline EF would predict both nonremission and noncompletion (primary outcomes)...
April 3, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29593860/potential-drug-drug-interactions-with-direct-oral-anticoagulants-in-elderly-hospitalized-patients
#6
Heather L Forbes, Thomas M Polasek
Background: To determine the prevalence and nature of potential drug-drug interactions (DDIs) with direct oral anticoagulants (DOACs) in elderly hospitalized patients. Methods: This was a retrospective observational study. Inclusion criteria were: aged over 65 years; taking apixaban, rivaroxaban or dabigatran; and admitted to the Repatriation General Hospital between April 2014 and July 2015. A list of clinically relevant 'perpetrator' drugs was compiled from product information, the Australian Medicines Handbook, the Australian National Prescribing Service resources, and local health network guidelines...
October 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29589292/adherence-to-antidepressants-and-mortality-in-elderly-patients-with-cardiovascular-disease
#7
Annalisa Biffi, Lorenza Scotti, Federico Rea, Ersilia Lucenteforte, Alessandro Chinellato, Davide L Vetrano, Cristiana Vitale, Nera Agabiti, Janet Sultana, Giuseppe Roberto, Alessandro Mugelli, Giovanni Corrao
BACKGROUND AND OBJECTIVE: Conflicting findings from studies evaluating the association between use of antidepressant drugs and mortality have been reported. We tested the hypothesis that better adherence to antidepressant therapy may reduce mortality. METHODS: The cohort included 29,845 individuals aged ≥ 65 years from several Italian health units who were newly treated with antidepressant drugs after hospital discharge with a diagnosis for cardiovascular disease during 2008-2010...
March 27, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29581817/medications-polypharmacy-influence-on-recurrent-fallers-in-community-a-systematic-review
#8
REVIEW
Yu Ming, Aleksandra Zecevic
The purpose of this systematic review is to summarize information about the impact different classes of medications and polypharmacy have on recurrent falls, defined as two or more falls in a 12-month period, in community-dwelling older adults. After adjustment for confounders such as age, gender, weight or depression symptoms, the reviewed studies suggested that older adults who use antidepressants, sedatives or hypnotics and anti-epileptics were more likely to experience recurrent falls than non-users. Polypharmacy (use of four or more prescription medications daily) caused 1...
March 2018: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/29578393/prevalence-and-predictors-of-tricyclic-antidepressant-use-in-primary-care-and-specialty-clinics-among-the-korean-elderly
#9
Jung Eun Hwang, Inmyung Song, Eui-Kyung Lee, Dongmun Ha, Ju-Young Shin
OBJECTIVES: Tricyclic antidepressants (TCAs) are prescribed with caution in the elderly due to diverse side effects. We analyzed the patterns of TCA use in elderly patients in primary-care and specialty clinics and investigated factors influencing TCA prescriptions. MATERIALS AND METHODS: Elderly patients (≥ 65 years old) prescribed antidepressants in primary-care clinics in 2013 were included from the Health Insurance Review and Assessment Service-Aged Patient Sample (HIRA-APS)...
March 26, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29543325/pharmacological-interventions-for-benzodiazepine-discontinuation-in-chronic-benzodiazepine-users
#10
REVIEW
Lone Baandrup, Bjørn H Ebdrup, Jesper Ø Rasmussen, Jane Lindschou, Christian Gluud, Birte Y Glenthøj
BACKGROUND: Prolonged treatment with benzodiazepines is common practice despite clinical recommendations of short-term use. Benzodiazepines are used by approximately 4% of the general population, with increased prevalence in psychiatric populations and the elderly. After long-term use it is often difficult to discontinue benzodiazepines due to psychological and physiological dependence. This review investigated if pharmacological interventions can facilitate benzodiazepine tapering. OBJECTIVES: To assess the benefits and harms of pharmacological interventions to facilitate discontinuation of chronic benzodiazepine use...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29538576/religiousness-social-support-and-the-use-of-antidepressants-among-the-elderly-a-population-based-study
#11
Adriano Roberto Tarifa Vicente, Érico Castro-Costa, Josélia de Oliveira Araújo Firmo, Maria Fernanda Lima-Costa, Antônio Ignácio de Loyola Filho
The purpose of the study was to investigate whether religiousness and social support were associated with the use of antidepressants among community-dwelling elders. The research involved 1,606 older adults who make up the cohort of Bambuí Project, a study on ageing and health. The dependent variable was the use of antidepressants in the last 90 days, and the exposures of interest were social support and religiousness. Logistic regression was used to test the associations and to estimate crude and adjusted Odds Ratio and their 95% confidence intervals...
March 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29495136/characteristics-of-drugs-ingested-for-suicide-attempts-in-the-elderly
#12
Ji Yeon Lim, Duk Hee Lee
BACKGROUND: Suicide is a significant public health problem worldwide. Suicide rates among elderly persons (≥ 65 years of age) are three times higher than those of younger people in Korea. The emergency department is an important entry of drug-related suicide attempt patients. In this study, we compared the frequency of drug types by age subgroup. Furthermore, we provide suggestions for preventing suicide attempts in the elderly. METHODS: We investigated 433 patients who were admitted to the emergency department for drug-related suicide attempts between 1 May 2015 and 30 April 2017...
March 12, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29490259/neutrophil-lymphocyte-ratio-is-increased-in-elderly-patients-with-first-episode-depression-but-not-in-recurrent-depression
#13
Jaśmina Arabska, Anna Łucka, Radosław Magierski, Tomasz Sobów, Adam Wysokiński
Association between inflammation and depression, especially in elderly patients, leads to conclusions about their shared influence on risk of cardiovascular disease and death. It might be found useful to predict those issues by monitoring inflammatory parameters, such as neutrophil/lymphocyte ratio (NLR). The aim of this study was to determine the NLR in elderly patients with unipolar depression compared with non-depressed elderly patients. NLR was measured in 684 Caucasian subjects (depressed: n = 465, non-depressed: n = 219), aged ≥ 60 (depressed: mean age 74...
May 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29488058/fatal-intoxication-with-antidepressants-a-case-with-many-culprits
#14
Antonis Goulas, Nikolaos Raikos, Diamantis Krokos, Orthodoxia Mastrogianni, Amvrosios Orphanidis, Konstantinos Zisopoulos, Androniki Tsepa
Serotonin-specific reuptake inhibitors (SSRIs) are generally considered safe drugs but fatal adverse effects do sometimes occur, often as a consequence of interactions with other serotonin active drugs. Polypharmacy is usually a problem that the elderly encounter, but it can also have dire consequences for young people, especially when an underlying heart condition is present. Thus, failure to diagnose heart disease and the use of contraindicated medications can be a lethal combination, irrespective of age...
February 27, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29469245/antipsychotic-prescriptions-among-adults-with-major-depressive-disorder-in-office-based-outpatient-settings-national-trends-from-2006-to-2015
#15
Taeho Greg Rhee, Somaia Mohamed, Robert A Rosenheck
OBJECTIVE: A recent moderately long-term study found an antipsychotic to be more effective than an antidepressant as the next-step treatment of unresponsive major depressive disorder (MDD). It is thus timely to examine recent trends in the pharmacoepidemiology of antipsychotic treatment of MDD. METHODS: Data from the 2006-2015 National Ambulatory Medical Care Survey, nationally representative samples of office-based outpatient visits in adults with MDD (ICD-9-CM codes 296...
March 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29466824/qtc-time-correlates-with-amitriptyline-and-venlafaxine-serum-levels-in-elderly-psychiatric-inpatients
#16
Gudrun Hefner, Martina Hahn, Matthias Hohner, Sybille C Roll, Ansgar Klimke, Christoph Hiemke
INTRODUCTION: Many antidepressants cause QT prolongation but the classification of cardiac risk of these drugs varies markedly in different published lists. This retrospective study analyzed the correlation of QTc time with amitriptyline and venlafaxine serum level in elderly psychiatric inpatients. METHODS: Elderly inpatients aged≥65 years for whom venlafaxine or amitriptyline serum level had been measured were selected retrospectively from a therapeutic drug monitoring database and screened for an electrocardiogram measurement at the time of blood withdrawal...
February 21, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29454305/psychotropic-and-anti-dementia-treatment-in-elderly-persons-with-clinical-signs-of-dementia-with-lewy-bodies-a-cross-sectional-study-in-40-nursing-homes-in-sweden
#17
Iris Zahirovic, Gustav Torisson, Carina Wattmo, Elisabet Londos
BACKGROUND: Elderly persons with a dementia diagnosis often suffer from different neuropsychiatric symptoms (NPS) such as delusions, hallucinations, depression, anxiety, irritability and agitation. Currently, the medical treatment for NPS consists mostly of psychotropic medication such as hypnotics/sedatives, anxiolytics and antipsychotics. In elderly persons with dementia, usage of antipsychotics is less appropriate because of the risk of side effects such as parkinsonism, rapid cognitive decline, cerebrovascular events and finally mortality...
February 17, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29451109/-orthostatic-hypotension-in-elderly-patients
#18
J A H R Claassen
- Orthostatic hypotension is a condition in which there is insufficient recovery of the blood pressure drop which occurs after getting up, which causes a temporary reduction of cerebral perfusion. This increases the risk of falls resulting in injuries.- Orthostatic hypotension is most common in the elderly. The cause is usually multifactorial (including reduced circulating volume, reduced peripheral resistance and limited heart rate increase). Orthostatic hypotension caused by autonomic dysfunction is called neurogenic orthostatic hypotension...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29408973/analyzing-analgesic-medications-in-community-dwelling-older-adults
#19
Ann L Horgas, Urszula Snigurska, Michelle Z Farland, Michael Marsiske
Objectives: Analyzing medication data for research purposes is complex, and methods are rarely described in the literature. Our objective was to describe methods of quantifying opioid and nonopioid analgesics and to compare the utility of five different analgesic coding methods when analyzing relationships between pain, analgesic use, and clinical outcomes. In this study, we used physical function as the outcome variable for its clinical relevance and its relationship to pain in older adults...
February 2, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29397669/korean-medication-algorithm-for-depressive-disorders-2017-third-revision
#20
Jeong Seok Seo, Won-Myong Bahk, Hee Ryung Wang, Young Sup Woo, Young-Min Park, Jong-Hyun Jeong, Won Kim, Se-Hoon Shim, Jung Goo Lee, Duk-In Jon, Kyung Joon Min
Objective: In 2002, the Korean Society for Affective Disorders developed the guidelines for the treatment of major depressive disorder (MDD), and revised it in 2006 and 2012. The third revision of these guidelines was undertaken to reflect advances in the field. Methods: Using a 44-item questionnaire, an expert consensus was obtained on pharmacological treatment strategies for MDD 1) without or 2) with psychotic features, 3) depression subtypes, 4) maintenance, 5) special populations, 6) the choice of an antidepressant (AD) regarding safety and adverse effects, and 7) non-pharmacological biological therapies...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
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