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https://www.readbyqxmd.com/read/29345721/sectioned-images-and-surface-models-of-a-cadaver-head-with-reference-to-botulinum-neurotoxin-injection
#1
Dong Sun Shin, Young Joo Shim, Bong Chul Kim
BACKGROUND: The aim of this study is to elucidate the anatomical considerations with reference to botulinum neurotoxin Type A (BTX) injection, on sectioned images and surface models, using Visible Korean. These can be used for medical education and clinical training in the field of facial surgery. MATERIALS AND METHODS: Serially sectioned images of the head were obtained from a cadaver. Significant anatomic structures in the sectioned images were outlined and assembled to create a surface model...
January 18, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29344685/long-term-safety-and-efficacy-of-botulinum-toxin-a-treatment-in-adolescent-patients-with-axillary-bromhidrosis
#2
Tao Wang, Jiasheng Dong, Jinguang He
BACKGROUND: For adolescent bromhidrosis, the long-term safety and efficacy of botulinum toxin type A (BTX-A) treatment are not clear to date. PATIENTS AND METHODS: From June 2011 to July 2016, 62 adolescent patients with primary axillary bromhidrosis were recruited and 50 U of BTX-A was administered in each axilla. Repetitive injections were performed when the malodor returned. RESULTS: The average follow-up was 2.64 years. There were no reported local or systemic adverse effects...
January 17, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29344324/treatment-of-lateral-periorbital-lines-with-different-dilutions-of-incobotulinumtoxina
#3
Gabriele F Muti, Matteo Basso
BACKGROUND: IncobotulinumtoxinA is a botulinum neurotoxin type A that is free from complexing proteins and is used in various therapeutic indications and aesthetic medicine. It is approved for the treatment of glabellar frown lines in the United States. In Europe, it is also approved for the treatment of lateral periorbital lines (crow's feet) and for the combined treatment of upper facial lines, including glabellar frown lines, crow's feet, and horizontal forehead lines. METHODS: In the present study, incobotulinumtoxinA was injected at two different dilutions to treat female subjects aged 40 to 50 years who had moderate-to-severe lateral periorbital lines at maximum contraction according to a score of 2 or 3 points on the 5-point Merz Aesthetics Scales (MAS)...
September 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29343468/onabotulinum-toxin-a-injections-for-sleep-bruxism-a-double-blind-placebo-controlled-study
#4
William G Ondo, Jerald H Simmons, Muhammad H Shahid, Vera Hashem, Christine Hunter, Joseph Jankovic
OBJECTIVES: To test the safety and efficacy of onabotulinum toxin-A (BoNT-A) injections into the masseter and temporalis muscles in patients with symptomatic sleep bruxism. METHODS: Participants 18 to 85 years old with clinically diagnosed sleep bruxism confirmed by polysomnography were enrolled in this randomized, placebo-controlled, 1:1, parallel-design trial with open-label extension. Participants were injected with BoNT-A 200 units (60 into each masseter and 40 into each temporalis) or placebo and were evaluated at 4 to 8 weeks after the initial treatment visit...
January 17, 2018: Neurology
https://www.readbyqxmd.com/read/29342463/sensation-of-cold-during-the-ice-water-test-corresponds-to-the-perception-of-pain-during-botulinum-toxin-bladder-wall-injections
#5
André Reitz, Tanja Hüsch, Regula Doggweiler, Stephan Buse, Axel Haferkamp
AIMS: To investigate the association of bladder cold sensation (BCS) during the ice water test (IWT) and pain perception when botulinum toxin injections (BTI) are administered into the bladder wall. MATERIAL AND METHODS: In 86 patients with idiopathic overactive bladder, the BCS during the IWT was investigated. Patients were divided into 2 groups: with and without BCS. During subsequent administration of BTI, the number of perceived and painful injections as well as the pain levels on a 0-100 pain scale were compared in both groups using Student t test...
January 18, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29341502/advances-in-intravesical-therapy-for-bladder-pain-syndrome-bps-interstitial-cystitis-ic
#6
REVIEW
En Meng, Yu-Chao Hsu, Yao-Chi Chuang
Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic symptom complex that may cause bothersome storage symptoms and pain or discomfort of the bladder, adversely affecting a patient's quality of life. The etiology of IC/BPS remains unclear, and its cause may be multifactorial. Diagnosis of IC/BPS is based on clinical features, and the possibility of other conditions must be ruled out first. Although no definitive treatment is currently available for IC/BPS, various intravesical therapies are used for IC/BPS, including heparin, hyaluronic acid, chondroitin sulfate, pentosan polysulfate, dimethylsulfoxide, liposomes, and botulinum onabotulinumtoxinA (BoNT-A)...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29340715/postural-control-and-the-relation-with-cervical-sensorimotor-control-in-patients-with-idiopathic-adult-onset-cervical-dystonia
#7
J De Pauw, R Mercelis, A Hallemans, G Van Gils, S Truijen, P Cras, W De Hertogh
Cervical dystonia (CD) is a movement disorder characterized by involuntary muscle contractions leading to an abnormal head posture or movements of the neck. Dysfunctions in somatosensory integration are present and previous data showed enlarged postural sway in stance. Postural control during quiet sitting and the correlation with cervical sensorimotor control were investigated. Postural control during quiet sitting was measured via body sway parameters in 23 patients with CD, regularly receiving botulinum toxin treatment and compared with 36 healthy controls...
January 16, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29340596/commentary-on-effect-of-botulinum-toxin-a-on-muscle-healing-and-its-implications-in-aesthetic-and-reconstructive-surgery
#8
Allen Gabriel, G Patrick Maxwell
No abstract text is available yet for this article.
January 11, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29339959/medical-cannabis-a-beneficial-high-in-treatment-of-blepharospasm-an-early-observation
#9
Phillip M Radke, Ali Mokhtarzadeh, Michael S Lee, Andrew R Harrison
The objective of this study was to observe the effect of medical cannabis in benign essential blepharospasm (BEB) as an adjunct to botulinum toxin. A retrospective chart review was performed on patients certified for medical cannabis use for BEB from September 2015 to May 2016. Patient demographics and responses, cannabis history, and severity indices were collected. Ten patients were certified for medical cannabis use. Five met the inclusion criteria, which was any patient with a diagnosis of BEB receiving standard botulinum toxin treatment who had started medical cannabis treatment by a registered distributor within the state, and was contactable by phone...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339424/clostridium-sordellii-pathogenicity-locus-plasmid-pcs1-1-encodes-a-novel-clostridial-conjugation-locus
#10
Callum J Vidor, Thomas D Watts, Vicki Adams, Dieter Bulach, Edward Couchman, Julian I Rood, Neil F Fairweather, Milena Awad, Dena Lyras
A major virulence factor in Clostridium sordellii-mediated infection is the toxin TcsL, which is encoded within a region of the genome called the pathogenicity locus (PaLoc). C. sordellii isolates carry the PaLoc on the pCS1 family of plasmids, of which there are four characterized members. Here, we determined the potential mobility of pCS1 plasmids and characterized a fifth unique pCS1 member. Using a derivative of the pCS1-1 plasmid from strain ATCC 9714 which had been marked with the ermB erythromycin resistance gene, conjugative transfer into a recipient C...
January 16, 2018: MBio
https://www.readbyqxmd.com/read/29335879/current-approaches-and-new-developments-in-the-pharmacological-management-of-tourette-syndrome
#11
REVIEW
Julio Quezada, Keith A Coffman
Tourette syndrome (TS) is a neurodevelopmental disorder of unknown etiology characterized by spontaneous, involuntary movements and vocalizations called tics. Once thought to be rare, TS affects 0.3-1% of the population. Tics can cause physical discomfort, emotional distress, social difficulties, and can interfere with education and desired activities. The pharmacologic treatment of TS is particularly challenging, as currently the genetics, neurophysiology, and neuropathology of this disorder are still largely unknown...
January 15, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29334040/botulinum-toxin-type-a-for-pain-in-advanced-parkinson-s-disease
#12
Veronica Bruno, Maria Eliza Freitas, Deborah Mancini, Jane P Lui, Janis Miyasaki, Susan H Fox
Background and Objective Pain is a frequent symptom in Parkinson's disease (PD), and the therapeutic alternatives are scarce. The goal of this trial was to measure the effects of botulinum toxin type A (BTXA) in the treatment of limb pain in advanced PD. Methods A randomized double-blind crossover versus placebo study of BTXA for limb pain in advanced Parkinson's disease was conducted. Subjects received individualized BTXA/placebo dosing per pain distribution in limbs. The primary outcome was a measure of change in global pain on a numeric rating scale (NRS) at 4 and 12 weeks postinjection and on a visual analogue scale 12 weeks after treatment...
January 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29332140/identification-of-cross-reactive-antigens-of-c-botulinum-types-a-b-e-f-by-immunoproteomic-approach
#13
Arti Sharma, Sarkaraisamy Ponmariappan, Rani Sarita, Syed Imtiaz Alam, Dev Vrat Kamboj, Sangeeta Shukla
Diseases triggered by microorganisms can be controlled by vaccines, which need neutralizing antigens. Hence, it is very crucial to identify extremely efficient immunogens for immune prevention. Botulism, a fatal neuroparalytic disease, is caused by botulinum neurotoxins produced by the anaerobic, Gram-positive spore-forming bacteria, Clostridium botulinum. Food-borne botulism and iatrogenic botulism are caused by botulinum toxin. Wound botulism, infant botulism, and adult intestinal botulism are caused by primarily C...
January 13, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29332075/patient-evaluation-and-selection-for-movement-disorders-surgery-the-changing-spectrum-of-indications
#14
Steffen Paschen, Günther Deuschl
This report summarizes the state-of-the-art and controversies around patient selection for deep brain stimulation (DBS) for various conditions. Parkinson's disease (PD): several class I studies have shown superiority of DBS over best medical treatment for advanced PD with fluctuations and further inclusion criteria. One class I study suggests that PD patients with early motor complications might gain more quality of life if operated within 3 years after the onset of fluctuations. The subthalamic nucleus (STN) is still the standard target...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29329897/-botulinium-toxin-and-idiopathic-overactive-bladder-multicentric-contempory-management-in-bourgogne
#15
A Schneider, B Tourlonias, L Cormier, E Mourey, N Koutlidis, E Delorme, J Pasquale, I Kermarec, A-D Foahom-Kamwa, V Bonniaud
INTRODUCTION: Since 2014, OnabotulinumtoxinA Botox® (Allergan, Inc., Irvine, USA) represents a new therapeutic option for second-line treatment of idiopathic overactive bladder. The purpose of the current study was to evaluate practices of surgeons using onabotulinium toxin (BoNTA) in this indication. MATERIAL AND METHODS: All urogynecology centers of the country were asked in order to list all patients who were treated since marketing autorisation. Patient symptoms, previous treatments, paraclinic evaluations, data of surgery and the characteristics of the follow up were collected and analyzed...
January 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29327957/unusual-outbreak-of-fatal-clostridiosis-in-a-group-of-captive-brown-pelicans-pelecanus-occidentalis
#16
Imke Lueders, Carsten Ludwig, Johanna Kasberg, Christoph Georg Baums, Kerstin Klimke, Martin B Dorner, Dana Ströse, Volker Schmidt
Fatal clostridial infections and clostridial toxicoses are common in birds. Most fatalities are associated with toxin production and progress rapidly, often within 24 hours of infection. We describe an unusual and protracted course of disease in 6 captive brown pelicans ( Pelecanus occidentalis), which was believed to result from toxicosis by toxovar A produced by a mixed infection with Clostridium sordellii and Clostridium perfringens. Although the first death in the group occurred 3 days after signs of illness were documented, the remaining birds died over a 38-day period despite aggressive antibiotic and supportive therapy...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29327231/loading-of-the-condylar-cartilage-can-rescue-the-effects-of-botox-on-tmj
#17
Eliane H Dutra, Mara H O'Brien, Candice Logan, Aditya Tadinada, Ravindra Nanda, Sumit Yadav
The purpose of this study is to evaluate whether the effects of botulinum neurotoxin (botox) injection into the masseter in the mandibular condylar cartilage (MCC) and subchondral bone could be rescued by compressive loading of the temporomandibular joint (TMJ). Twenty-four 6-week-old female mice (C57BL/6J) were used. Mice were divided in three groups: (1) Botox (n = 8); (2) Botox plus loading (n = 8); (3) Pure control (n = 8). Bone labels (3 and 1 day before sacrifice) and the proliferation marker EdU (2 and 1 day before sacrifice) were intraperitoneally injected into all groups of mice...
January 11, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29326295/randomised-controlled-trial-of-escitalopram-for-cervical-dystonia-with-dystonic-jerks-tremor
#18
Evelien Zoons, Jan Booij, Catherine C S Delnooz, Joke M Dijk, Yasmine E M Dreissen, Johannes H T M Koelman, Sandra M A van der Salm, Matej Skorvanek, Marenka Smit, Majid Aramideh, Henriette Bienfait, Agnita J W Boon, Jeroen W M Brans, Edo Hoogerwaard, Ad Hovestadt, Daan J Kamphuis, Alexander G Munts, Johannes D Speelman, Marina A J Tijssen
OBJECTIVE: Trials for additional or alternative treatments for cervical dystonia (CD) are scarce since the introduction of botulinum neurotoxin (BoNT). We performed the first trial to investigate whether dystonic jerks/tremor in patients with CD respond to the selective serotonin reuptake inhibitor (SSRI) escitalopram. METHODS: In a randomised, double-blind, crossover trial, patients with CD received escitalopram and placebo for 6 weeks. Treatment with BoNT was continued, and scores on rating scales regarding dystonia, psychiatric symptoms and quality of life (QoL) were compared...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29325384/-diagnosis-and-treatment-of-strabismus-caused-by-nasal-endoscopic-surgery
#19
L K Ai, X Wu, J N Wang, J Li, Y Wu, J Zhou, W X Song, R L Guo
Objective: Strabismus with diplopia is the main orbital complication of functional endoscopic sinus surgery (FESS). This study was to analyze clinical findings, treatment and outcomes of such cases. Methods: Retrospective case series. Twenty-three cases were divided into 3 groups based on the disease severity: group A, partial transection of the medial rectus muscle, group B, complete transection of the medical rectus, group C, transection of the medial rectus combined with the other orbital injuries. Complete ophthalmology examinations, including eye alignment, eye motility, force duction test, force generation test, general eye exam, and medical imaging (orbital CT or MRI), were performed for each case...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29322963/botulinum-toxin-in-meige-s-syndrome-a-video-based-case-series
#20
Sanjay Pandey, Soumya Sharma
CONTEXT: Despite being the most common cause of cranial dystonia, Meige's syndrome remains a rare clinical entity. Characterized by blepharospasm and orofacial dystonia, patients suffering from Meige's syndrome benefit from the injection of botulinum toxin (BTX). AIMS: As the majority of the studies tend to discuss Meige's syndrome with blepharospasm patients, there is a paucity of case-based studies dealing exclusively with this syndrome. Hence, we intended to characterize and define the evolution of this syndrome and objectively determine the response of the patients suffering from this entity to BTX therapy...
January 2018: Neurology India
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