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https://www.readbyqxmd.com/read/29783804/-acquired-cystic-kidney-disease-associated-renal-cell-carcinoma-a-clinicopathologic-study-of-three-cases
#1
W Zhang, L L Xu, W J Yu, Q Wang, Y X Jiang, Y Liu, Y J Li
Objective: To study the clinicopathologic, immunohistochemical (IHC), histogenetic and prognostic features of acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC). Methods: Three cases of ACKD-RCC, including two from 401 Hospital of PLA and one from the Affiliated Hospital of Qingdao University were studied by clinical, histological and IHC analysis with review of relevant literature. Results: All the three patients were male, ranging from 46 to 78 years old. All patients had history of chronic renal failure; two patients were treated with hemodialysis for 9 years and 11 years, respectively...
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29770853/predominantly-cystic-clear-cell-renal-cell-carcinoma-and-multilocular-cystic-renal-neoplasm-of-low-malignant-potential-form-a-low-grade-spectrum
#2
Maria Tretiakova, Vikas Mehta, Masha Kocherginsky, Agata Minor, Steven S Shen, Sahussapont Joseph Sirintrapun, Jorge L Yao, Isabel Alvarado-Cabrero, Tatjana Antic, Scott E Eggener, Maria M Picken, Gladell P Paner
Multilocular cystic renal cell carcinoma has been recently excluded from clear cell renal cell carcinoma (CCRCC) category and re-designated as multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) due to its uniformly good outcomes. While strict distinction between MCRNLMP from predominantly cystic CCRCC (pc-CCRCC) is being emphasized, the significance of extensive true cystic component in CCRCC has not been investigated. Herein, we analyzed 57 MCRNLMP, 69 pc-CCRCC, and 46 non-cystic CCRCC...
May 17, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29733838/validation-of-pi-rads-version-2-for-the-detection-of-prostate-cancer
#3
Sebastian L Hofbauer, Beatrice Kittner, Andreas Maxeiner, Robin Heckmann, Maximillian Reimann, Laura Wiemer, Patrick Asbach, Matthias Haas, Tobias Penzkofer, Carsten Stephan, Frank Friedersdorff, Florian Fuller, Kurt Miller, Hannes Cash
PURPOSE: The second version of the Prostate Imaging Reporting and Data System (PI-RADSv2) was introduced in 2015 to standardize the interpretation and reporting of multiparametric prostate magnetic resonance imaging (mpMRI). Recently, low cancer detection rates (CDR) for PI-RADSv2 category 4 lesions were reported. Therefore the aim of the study was to evaluate the CDR of PI-RADSv2 in a large prospective cohort. METHODS: The study included 704 consecutive men with primary or prior negative biopsies who underwent MRI/ultrasound fusion-guided targeted biopsy (TB) and 10-core systematic prostate biopsy (SB) between September 2015 and May 2017...
May 4, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29733695/can-apparent-diffusion-coefficient-values-assist-pi-rads-version-2-dwi-scoring-a-correlation-study-using-the-pi-radsv2-and-international-society-of-urological-pathology-systems
#4
Sonia Gaur, Stephanie Harmon, Lauren Rosenblum, Matthew D Greer, Sherif Mehralivand, Mehmet Coskun, Maria J Merino, Bradford J Wood, Joanna H Shih, Peter A Pinto, Peter L Choyke, Baris Turkbey
OBJECTIVE: The purposes of this study were to assess correlation of apparent diffusion coefficient (ADC) and normalized ADC (ratio of tumor to nontumor tissue) with the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and updated International Society of Urological Pathology (ISUP) categories and to determine how to optimally use ADC metrics for objective assistance in categorizing lesions within PI-RADSv2 guidelines. MATERIALS AND METHODS: In this retrospective study, 100 patients (median age, 62 years; range, 44-75 years; prostate-specific antigen level, 7...
May 7, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29730837/contemporary-assessment-of-the-correlation-between-bosniak-classification-and-histological-characteristics-of-surgically-removed-atypical-renal-cysts-uroccr-12-study
#5
François-Xavier Nouhaud, Jean-Christophe Bernhard, Pierre Bigot, Zine-Eddine Khene, François Audenet, Herve Lang, Sebastien Bergerat, Guillaume Fraisse, Nicolas Grenier, François Cornelis, Cosmina Nedelcu, Sofiane Béjar, Gaëlle Fromont-Hankard, Yves Allory, Véronique Lindner, Virginie Verkarre, Laurent Daniel, Mokrane Yacoub, Jean-Michel Correas, Arnaud Méjean, Nathalie Rioux-Leclercq, Karim Bensalah
PURPOSE: To evaluate and compare pathological characteristics of renal cysts Bosniak IIF, III and IV in light of recent histological classification. PATIENTS AND METHODS: The French research network for kidney cancer UroCCR conducted a multicentre study on patients treated surgically for a renal cyst between 2007 and 2016. Independent radiological and centralized pathological reviews were performed for every patient. Pathological characteristics were compared to the Bosniak classification...
May 5, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29726071/a-prospective-randomised-multi-centre-study-of-the-impact-of-ga-68-psma-pet-ct-imaging-for-staging-high-risk-prostate-cancer-prior-to-curative-intent-surgery-or-radiotherapy-propsma-study-clinical-trial-protocol
#6
Michael S Hofman, Declan G Murphy, Scott G Williams, Tatenda Nzenza, Alan Herschtal, Richard De Abreu Lourenco, Dale L Bailey, Ray Budd, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk
INTRODUCTION: Accurate staging of patients with prostate cancer is important for therapeutic decision making. Relapse following surgery or radiotherapy of curative intent is not uncommon and, in part, represents a failure of staging with current diagnostic imaging techniques to detect disease spread. Prostate-specific-membrane-antigen (PSMA) positron emission tomography / computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of prostate cancer with high contrast...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29699428/prostate-cancer-with-cribriform-morphology-diagnosis-aggressiveness-molecular-pathology-and-possible-relationships-with-intraductal-carcinoma
#7
Rodolfo Montironi, Alessia Cimadamore, Silvia Gasparrini, Roberta Mazzucchelli, Matteo Santoni, Francesco Massari, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli
The Gleason grading system is one of the most important prognostic factors in prostate cancer (PCa). From the 2005 to the 2014 conference organized by the International Society of Urological Pathology (ISUP), the histological criteria for the Gleason patterns were improved, resulting in the shrinkage of the Gleason pattern (GP) 3 and expansion of the GP 4. Areas Covered: Cribriform, fused, ill-defined and glomeruloid glands are part of the morphologic spectrum of the current GP 4. Cribriform, derived from the Latin word cribrum (i...
April 27, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29672311/inverse-association-of-prostatic-chronic-inflammation-among-prostate-cancer-tumor-grade-groups-retrospective-study-of-738-consecutive-cases-elected-to-a-first-random-biopsy-set
#8
Antonio Benito Porcaro, Alessandro Tafuri, Giovanni Novella, Marco Sebben, Arianna Mariotto, Davide Inverardi, Paolo Corsi, Tania Processali, Marco Pirozzi, Nelia Amigoni, Riccardo Rizzetto, Matteo Brunelli, Matteo Balzarro, Salvatore Siracusano, Walter Artibani
OBJECTIVES: The study aimed to evaluate associations of prostatic chronic inflammation (PCI) with prostate cancer (PCA) grade groups by the International Society of Urological Pathology (ISUP). METHODS: The study evaluated retrospectively 738 cases. The patient population was sampled into 3 groups collecting cases without and with PCA including subjects with lSUP grade group 1 and grade groups 2-5. RESULTS: PCI was assessed in 185 patients (25...
April 19, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29611638/the-macrostructure-and-microstructure-of-the-urinary-bladder-and-urethral-mucosa-in-dogs-with-lower-urinary-tract-diseases
#9
M Grzegory, K Kubiak, M Jankowski, J Spużak, K Glińska-Suchocka, A Hałoń
The aim of the study was to assess the macrostructure and the microstructure of the bladder and urethral mucosa in dogs with lower urinary tract disease as well as to evaluate the usefulness of the WHO/ISUP grading of invasive and non-invasive tumours of the bladder and urethral mucosa. The study was carried out on 37 dogs of different breeds and of both sexes, from 9 months to 15 years old. An urethrocystoscopy and a histopathological evaluation of mucosal biopsies were carried out in all the studied dogs...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29594551/pair-matched-patient-reported-quality-of-life-and-early-oncological-control-following-focal-irreversible-electroporation-versus-robot-assisted-radical-prostatectomy
#10
Matthijs J Scheltema, John I Chang, Maret Böhm, Willemien van den Bos, Alexandar Blazevski, Ilan Gielchinsky, Anton M F Kalsbeek, Pim J van Leeuwen, Tuan V Nguyen, Theo M de Reijke, Amila R Siriwardana, James E Thompson, Jean J de la Rosette, Phillip D Stricker
PURPOSE: The design, conduct and completion of randomized trials for curative prostate cancer (PCa) treatments are challenging. To evaluate the effect of robot-assisted radical prostatectomy (RARP) versus focal irreversible electroporation (IRE) on patient-reported quality of life (QoL) and early oncological control using propensity-scored matching. METHODS: Patients with T1c-cT2b significant PCa (high-volume ISUP 1 or any 2/3) who received unifocal IRE were pair-matched to patients who received nerve-sparing RARP...
March 28, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29579010/intraoperative-consultation-and-macroscopic-handling-the-international-society-of-urological-pathology-isup-testicular-cancer-consultation-conference-recommendations
#11
Clare Verrill, Joanna Perry-Keene, John R Srigley, Ming Zhou, Peter A Humphrey, Antonio Lopez-Beltran, Lars Egevad, Thomas M Ulbright, Satish K Tickoo, Jonathan I Epstein, Eva Compérat, Daniel M Berney
The International Society of Urological Pathology held a conference on issues in testicular and penile pathology in Boston in March 2015, which included a presentation by the testis macroscopic features working group. The presentation focused on current published guidance for macroscopic handling of testicular tumors and retroperitoneal lymph node dissections with a summary of results from an online survey of members preceding the conference. The survey results were used to initiate discussions, but decisions on practice were made by expert consensus rather than voting...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29576444/biparametric-prostate-imaging-reporting-and-data-system-version2-and-international-society-of-urological-pathology-grade-predict-biochemical-recurrence-after-radical-prostatectomy
#12
Nobuyoshi Takeuchi, Shinichi Sakamoto, Akira Nishiyama, Takuro Horikoshi, Yasutaka Yamada, Junpei Iizuka, Maihulan Maimaiti, Yusuke Imamura, Koji Kawamura, Takashi Imamoto, Akira Komiya, Yuzuru Ikehara, Koichiro Akakura, Tomohiko Ichikawa
BACKGROUND: We retrospectively assessed the clinical significance of the Prostate Imaging Reporting and Data System (PI-RADS), version 2, criteria based on biparametric magnetic resonance imaging (bp-MRI), together with the International Society of Urological Pathology (ISUP) grade, for predicting biochemical recurrence (BCR) after radical prostatectomy. MATERIALS AND METHODS: The data from 126 patients who had undergone radical prostatectomy were retrospectively analyzed...
February 24, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29571325/does-the-fuhrman-or-world-health-organization-international-society-of-urological-pathology-grading-system-apply-to-the-xp11-2-translocation-renal-cell-carcinoma-a-10-year-single-center-study
#13
Ning Liu, Weidong Gan, Feng Qu, Zhen Wang, Wenyuan Zhuang, Sezim Agizamhan, Linfeng Xu, Juanjuan Yin, Hongqian Guo, Dongmei Li
The Fuhrman and World Health Organization/International Society of Urological Pathology (WHO/ISUP) grading systems are widely used to predict survival for patients with conventional renal cell carcinoma. To determine the validity of nuclear grading systems (both the Fuhrman and the WHO/ISUP) and the individual components of the Fuhrman grading system in predicting the prognosis of Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC), we identified and followed up 47 patients with Xp11.2 tRCC in our center from January 2007 to June 2017...
April 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29569320/primary-mri-us-fusion-guided-biopsy-of-the-prostate
#14
Andreas Maxeiner, Beatrice Kittner, Carsten Stephan, Thomas Fischer, Patrick Asbach, Matthias Haas, Tobias Penzkofer, Florian Fuller, Kurt Miller, Hannes Cash
OBJECTIVE: To examine the performance of a primary MRI/ultrasound fusion guided targeted biopsy (TB) and in combination with an added systematic biopsy (SB). PATIENTS AND METHODS: Analysis of 318 consecutive biopsy naïve men with suspicious mpMRI (PI-RADS score ≥3) undergoing transrectal TB and 10-core systematic biopsy (SB) between January 2012 and December 2016. The indication for performing a mpMRI was based on clinical parameters and decided by the treating urologist prior to admittance...
March 22, 2018: BJU International
https://www.readbyqxmd.com/read/29532874/verification-of-the-international-society-of-urological-pathology-recommendations-in-japanese-patients-with-clear-cell-renal-cell-carcinoma
#15
Hakushi Kim, Chie Inomoto, Takato Uchida, Hiroyuki Furuya, Tomoyoshi Komiyama, Hiroshi Kajiwara, Hiroyuki Kobayashi, Naoya Nakamura, Akira Miyajima
The aim of the present study was to evaluate the validity of potential prognostic parameters of clear cell renal cell carcinoma (ccRCC) recommended by the 2012 International Society of Urological Pathology (ISUP) Consensus Conference in the Japanese population. We reviewed 406 Japanese patients with localized or locally advanced ccRCC who underwent curative surgery during 2004-2014 at Tokai University Hospital (Isehara, Japan) and were followed up for >2 years after surgery. A single pathologist reviewed all the histological slides...
April 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29525824/snail-immunohistochemical-overexpression-correlates-to-recurrence-risk-in-non-muscle-invasive-bladder-cancer-results-from-a-longitudinal-cohort-study
#16
Raffaella Santi, Tommaso Cai, Stefania Nobili, Ilaria Camilla Galli, Andrea Amorosi, Eva Comperat, Gabriella Nesi
The current WHO/ISUP classification and grading system subdivides urothelial tumours into prognostically distinct categories. Understanding the molecular pathways involved in bladder cancer development can improve patient stratification and management. This study aims to investigate the relationship between Snail, Slug and E-cadherin expressions and clinico-pathological features of non-muscle invasive bladder carcinoma (NMIBC). All patients attending the same urological centre from January to May 2002, who were pathologically diagnosed with NMIBC, were enrolled in this longitudinal cohort study...
April 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29492585/yrna-expression-in-prostate-cancer-patients-diagnostic-and-prognostic-implications
#17
Yuri Tolkach, Eva-Maria Niehoff, Anna Franziska Stahl, Chenming Zhao, Glen Kristiansen, Stefan C Müller, Jörg Ellinger
OBJECTIVE: To study the expression of YRNAs (Ro-associated Y), a novel class of non-coding RNAs, in prostate cancer (PCA) patients. METHODS: The expression of all four YRNAs (RNY1, RNY3, RNY4, RNY5) was determined in archival PCA (prostate adenocarcinoma, n = 56), normal (n = 36) and benign prostatic hyperplasia (BPH; n = 28) tissues using quantitative real-time PCR. Associations with clinicopathological parameters and prognostic role for biochemical recurrence-free survival were analysed...
February 28, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29477717/a-single-centre-evaluation-of-the-diagnostic-accuracy-of-multiparametric-mri-against-transperineal-prostate-mapping-biopsy-an-analysis-of-men-with-bengin-histology-and-insignificant-cancer-following-trus-biopsy
#18
Raj P Pal, Ros Ahmad, Shaun Trecartan, James Voss, Shaista Ahmed, Alvaro Bazo, Jon Lloyd, Thomas J Walton
OBJECTIVES: This study evaluated the diagnostic performance of Transrectal-ultrasound guided biopsy (TRUSB) and Multiparametric MRI (mpMRI) in detecting prostate cancer (CaP) against Transperineal prostate mapping biopsy (TPM) as the reference test. METHODS: Between April 2012 and January 2016 426 patients underwent TRUS biopsy, mpMRI and TPM. Patients initially underwent systematic 12 core TRUSB, followed 3 months later by mpMRI (1.5T, high resolution T2 images, DWI, DCE)...
February 22, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29471597/-clinical-study-of-2014-isup-new-grade-group-classification-for-prostate-cancer-patients-treated-by-androgen-deprivation-therapy
#19
Masahiro Uno, Makoto Kawase, Daiki Kato, Takashi Ishida, Seiichi Kato, Yoshinori Fujimoto
The 2014 International Society of Urological Pathology (ISUP) has proposed a new grade group (GG) classification for Gleason scores (GS). The usefulness of the new GG classification was investigated with 518 prostate cancer patients who underwent androgen deprivation therapy. According to the new GG classification, Stages B‒D and the new GG classification relapse-free rate for each stage were calculated using the Kaplan‒Meier method. The new GG classification revealed a significant difference for the relapse-free rate only between some groups...
January 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29448999/quantitative-perineural-invasion-is-a-prognostic-marker-in-prostate-cancer
#20
Sabine Lubig, Thore Thiesler, Stefan Müller, Roland Vorreuther, Norbert Leipner, Glen Kristiansen
This study aimed to investigate the prognostic value of a quantitative, detailed, yet practical analysis of perineural invasion in radical prostatectomy specimens in a high-risk prostate cancer cohort. A total of 114 patients with prostate cancer who underwent radical prostatectomy between 2000 and 2013 were analysed. Using S100 protein immunohistochemistry assisted in the detection of nerves. In the area of closest proximity of the tumour to the dorso-lateral margins, nerves were counted and the infiltration of nerves was categorised (0-3)...
April 2018: Pathology
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