Read by QxMD icon Read


Hakushi Kim, Chie Inomoto, Takato Uchida, Hiroyuki Furuya, Tomoyoshi Komiyama, Hiroshi Kajiwara, Hiroyuki Kobayashi, Naoya Nakamura, Akira Miyajima
The aim of the present study was to evaluate the validity of potential prognostic parameters of clear cell renal cell carcinoma (ccRCC) recommended by the 2012 International Society of Urological Pathology (ISUP) Consensus Conference in the Japanese population. We reviewed 406 Japanese patients with localized or locally advanced ccRCC who underwent curative surgery during 2004-2014 at Tokai University Hospital (Isehara, Japan) and were followed up for >2 years after surgery. A single pathologist reviewed all the histological slides...
April 2018: International Journal of Oncology
Raffaella Santi, Tommaso Cai, Stefania Nobili, Ilaria Camilla Galli, Andrea Amorosi, Eva Comperat, Gabriella Nesi
The current WHO/ISUP classification and grading system subdivides urothelial tumours into prognostically distinct categories. Understanding the molecular pathways involved in bladder cancer development can improve patient stratification and management. This study aims to investigate the relationship between Snail, Slug and E-cadherin expressions and clinico-pathological features of non-muscle invasive bladder carcinoma (NMIBC). All patients attending the same urological centre from January to May 2002, who were pathologically diagnosed with NMIBC, were enrolled in this longitudinal cohort study...
March 10, 2018: Virchows Archiv: An International Journal of Pathology
Yuri Tolkach, Eva-Maria Niehoff, Anna Franziska Stahl, Chenming Zhao, Glen Kristiansen, Stefan C Müller, Jörg Ellinger
OBJECTIVE: To study the expression of YRNAs (Ro-associated Y), a novel class of non-coding RNAs, in prostate cancer (PCA) patients. METHODS: The expression of all four YRNAs (RNY1, RNY3, RNY4, RNY5) was determined in archival PCA (prostate adenocarcinoma, n = 56), normal (n = 36) and benign prostatic hyperplasia (BPH; n = 28) tissues using quantitative real-time PCR. Associations with clinicopathological parameters and prognostic role for biochemical recurrence-free survival were analysed...
February 28, 2018: World Journal of Urology
Raj P Pal, Ros Ahmad, Shaun Trecartan, James Voss, Shaista Ahmed, Alvaro Bazo, Jon Lloyd, Thomas J Walton
OBJECTIVES: This study evaluated the diagnostic performance of Transrectal-ultrasound guided biopsy (TRUSB) and Multiparametric MRI (mpMRI) in detecting prostate cancer (CaP) against Transperineal prostate mapping biopsy (TPM) as the reference test. METHODS: Between April 2012 and January 2016 426 patients underwent TRUS biopsy, mpMRI and TPM. Patients initially underwent systematic 12 core TRUSB, followed 3 months later by mpMRI (1.5T, high resolution T2 images, DWI, DCE)...
February 22, 2018: Journal of Urology
Masahiro Uno, Makoto Kawase, Daiki Kato, Takashi Ishida, Seiichi Kato, Yoshinori Fujimoto
The 2014 International Society of Urological Pathology (ISUP) has proposed a new grade group (GG) classification for Gleason scores (GS). The usefulness of the new GG classification was investigated with 518 prostate cancer patients who underwent androgen deprivation therapy. According to the new GG classification, Stages B‒D and the new GG classification relapse-free rate for each stage were calculated using the Kaplan‒Meier method. The new GG classification revealed a significant difference for the relapse-free rate only between some groups...
January 2018: Hinyokika Kiyo. Acta Urologica Japonica
Sabine Lubig, Thore Thiesler, Stefan Müller, Roland Vorreuther, Norbert Leipner, Glen Kristiansen
This study aimed to investigate the prognostic value of a quantitative, detailed, yet practical analysis of perineural invasion in radical prostatectomy specimens in a high-risk prostate cancer cohort. A total of 114 patients with prostate cancer who underwent radical prostatectomy between 2000 and 2013 were analysed. Using S100 protein immunohistochemistry assisted in the detection of nerves. In the area of closest proximity of the tumour to the dorso-lateral margins, nerves were counted and the infiltration of nerves was categorised (0-3)...
February 12, 2018: Pathology
Giorgio I Russo, Sebastiano Cimino, Giorgia Giranio, Federica Regis, Vincenzo Favilla, Salvatore Privitera, Fabio Motta, Rosario Caltabiano, Arnulf Stenzl, Tilman Todenhöfer, Giuseppe Morgia
INTRODUCTION AND OBJECTIVES: To evaluate the association between metabolic syndrome (MetS) and proliferative inflammatory atrophy (PIA) in patients with suspected prostate cancer (PCa). PATIENTS AND METHODS: From June 2015 to July 2016, we conducted the FIERY (Flogosis Increased Events of pRostatic biopsY) study at the Urology section, Department of Surgery of the University of Catania (Local registration number: #131/2015). A total of 205 patients with elevated prostate-specific antigen (≥ 4 ng/ml) or clinical suspicion of PCa who underwent primary transperineal prostate biopsy were included in this cross-sectional study...
February 8, 2018: Urologic Oncology
Jeong Hwan Park, Minsun Jung, Kyung Chul Moon
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), and it has an unfavourable prognosis compared to other RCCs. Plant homeodomain finger 2 (PHF2) and CCATT/enhancer binding protein α (C/EBPα) play a role in the epigenetic regulation of adipogenesis, and their tumour suppressive functions have been elucidated. This study aimed to assess the nuclear expression of PHF2 and C/EBPα in ccRCC and to evaluate their role in pathogenesis and prognosis. The nuclear expression of PHF2 and C/EBPα was evaluated in 344 cases of ccRCC by immunohistochemistry, and adipogenesis was assessed based on cytoplasmic features...
January 2, 2018: Oncotarget
Sandy Figiel, Michelle Pinault, Isabelle Domingo, Cyrille Guimaraes, Roseline Guibon, Pierre Besson, Elsa Tavernier, Pascal Blanchet, Luc Multigner, Franck Bruyère, Olivier Haillot, Romain Mathieu, Sebastien Vincendeau, Nathalie Rioux-Leclercq, Souhil Lebdai, Abdel-Rahmene Azzouzi, Marie-Aimee Perrouin-Verbe, Georges Fournier, Laurent Doucet, Jerome Rigaud, Karine Renaudin, Karine Mahéo, Gaëlle Fromont
BACKGROUND: Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. METHODS: From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3)...
March 2018: European Journal of Cancer
Marie Muller, Marine Guillaud-Bataille, Julia Salleron, Catherine Genestie, Sophie Deveaux, Abdelhamid Slama, Brigitte Bressac de Paillerets, Stéphane Richard, Patrick R Benusiglio, Sophie Ferlicot
Hereditary leiomyomatosis and renal cell carcinoma syndrome is characterized by an increased risk of agressive renal cell carcinoma, often of type 2 papillary histology, and is caused by FH germline mutations. A prominent eosinophilic macronucleolus with a perinucleolar clear halo is distinctive of hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma according to the 2012 ISUP and 2016 WHO kidney tumor classification. From an immunohistochemistry perspective, tumors are often FH-negative and S-(2-succino)-cysteine (2SC) positive...
February 6, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Cosimo De Nunzio, Antonio Luigi Pastore, Riccardo Lombardo, Giuseppe Simone, Costantino Leonardo, Riccardo Mastroianni, Devis Collura, Giovanni Muto, Michele Gallucci, Antonio Carbone, Andrea Fuschi, Lorenzo Dutti, John H Witt, Carlo De Dominicis, Andrea Tubaro
PURPOSE: To evaluate the differences between the old and the new Gleason score classification systems in upgrading and downgrading rates. MATERIALS AND METHODS: Between 2012 and 2015, we identified 9703 patients treated with retropubic radical prostatectomy (RP) in four tertiary centers. Biopsy specimens as well as radical prostatectomy specimens were graded according to both 2005 Gleason and 2014 ISUP five-tier Gleason grading system (five-tier GG system). Upgrading and downgrading rates on radical prostatectomy were first recorded for both classifications and then compared...
January 9, 2018: European Journal of Surgical Oncology
Lars Egevad, Brett Delahunt, Dan M Berney, David G Bostwick, John Cheville, Eva Comperat, Andrew J Evans, Samson W Fine, David J Grignon, Peter A Humphrey, Jonas Hörnblad, Kenneth A Iczkowski, James G Kench, Glen Kristiansen, Katia R M Leite, Cristina Magi-Galluzzi, Jesse McKenney, Jon Oxley, Chin-Chen Pan, Hemamali Samaratunga, John R Srigley, Hiroyuki Takahashi, Lawrence D True, Toyonori Tsuzuki, Theo van der Kwast, Murali Varma, Ming Zhou, Mark Clements
AIMS: Despite efforts to standardize grading of prostate cancer, there is still a considerable variation in grading practices even among experts. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. METHODS AND RESULTS: The International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pathology independently reviewed microphotographs of 90 cases of prostate needle biopsies with cancer...
January 23, 2018: Histopathology
Jérôme Verine, Delphine Colin, Mary Nheb, Dominique Prapotnich, Guillaume Ploussard, Xavier Cathelineau, François Desgrandchamps, Pierre Mongiat-Artus, Jean-Paul Feugeas
We developed and validated an architecture-based grading for clear cell renal cell carcinoma (ccRCC) in an observational retrospective cohort study including 506 tumors (principal cohort, n=254; validation cohort, n=252). Study endpoints were disease-free survival (DFS) and cancer-specific survival (CSS). Relationships with outcome were analyzed using Harrell concordance index, time-dependent receiver operating characteristic curve, area under curve, and Cox regression model. An architecture-based grading was devised on positive likelihood ratio (LR+) for DFS at 50 months as follows: grade 1 (LR+<0...
January 19, 2018: American Journal of Surgical Pathology
B Reix, J-C Bernhard, J-J Patard, P Bigot, A Villers, E Suer, N S Vuong, G Verhoest, Q Alimi, J-B Beauval, T Benoit, F-X Nouhaud, C Lenormand, N Hamidi, J Cai, M Eto, S Larre, A El Bakhri, G Ploussard, A Hung, N Koutlidis, A Schneider, J Carrouget, S Droupy, S Marchal, A Doerfler, S Seddik, T Matsugasumi, X Orsoni, A Descazeaud, C Pfister, K Bensalah, M Soulie, I Gill, V Flamand
BACKGROUND: Partial nephrectomy (PN) is recommended as first-line treatment for cT1 stage kidney tumors because of a better renal function and probably a better overall survival than radical nephrectomy (RN). For larger tumors, PN has a controversial position due to lack of evidence showing good cancer control. The aim of this study was to compare the results of PN and RN in cT2a stage on overall survival and oncological results. METHOD: A retrospective international multicenter study was conducted in the frame of the French kidney cancer research network (UroCCR)...
January 10, 2018: Progrès en Urologie
Gladell P Paner, Walter M Stadler, Donna E Hansel, Rodolfo Montironi, Daniel W Lin, Mahul B Amin
The Tumor-Node-Metastasis (TNM) classification on cancer staging, jointly developed by the American Joint Commission on Cancer (AJCC) and the Union for International Cancer Control (UICC), has been updated to its 8th edition with two contemporaneous versions published by the AJCC and UICC. While the goal of the AJCC and UICC is to have identical TNM staging systems, differences exist between these two publications including in the staging of urologic cancers. Among several new facets in the AJCC staging manual, a select few of greater import include an expanded section on imaging, presentation of levels of evidence for significant changes, and endorsement of risk assessment models that pass the AJCC quality criteria such as in prostate cancer...
January 8, 2018: European Urology
Esin Kaymaz, Elif Ozer, Hatice Unverdi, Sema Hucumenoglu
PURPOSE: The aim of this study was to investigate the usability of MUC1 and p53 for differential diagnosis of noninvasive papillary urothelial neoplasias, especially for distinguishing papillary urothelial neoplasm of low malignant potential (PUNLMP) from low-grade papillary urothelial carcinoma (LGPUC) when the histologic signs are not obvious. MATERIALS AND METHODS: Seventeen biopsy specimens of the patients with PUNLMP, 20 with LGPUC and 13 with high-grade papillary urothelial carcinoma (HGPUC) were stained for MUC1 and p53 protein by immunohistochemical methods...
October 2017: Indian Journal of Pathology & Microbiology
Tobias Nordström, Olof Akre, Markus Aly, Henrik Grönberg, Martin Eklund
BACKGROUND: Screening for prostate cancer using prostate-specific antigen (PSA) alone leads to un-necessary biopsying and overdiagnosis. PSA density is easily accessible, but early evidence on its use for biopsy decisions was conflicting and use of PSA density is not commonly recommended in guidelines. METHODS: We analyzed biopsy outcomes in 5291 men in the population-based STHLM3 study with PSA ≥ 3 ng/ml and ultrasound-guided prostate volume measurements by using percentages and regression models...
December 19, 2017: Prostate Cancer and Prostatic Diseases
Lars Egevad, Brett Delahunt, Glen Kristiansen, Hemamali Samaratunga, Murali Varma
Prognostic assessment is a key element in the management of patients with prostate cancer as it informs both treatment, follow-up and outcome prediction. Tumour grade should be based upon the novel and evidence-based recommendations of the International Society of Urological Pathology (ISUP) Consensus Conference of 2014, with ISUP grades 1-5 being derived from 2005 ISUP modified Gleason grading, i.e., ISUP grade 1 (3 + 3 = 6), grade 2 (3 + 4 = 7), grade 3 (4 + 3 = 7), grade 4 (3 + 5 = 8, 5 + 3 = 8, 4 + 4 = 8), and grade 5 (4 + 5 = 9 5 + 4 = 9, 5 + 5 = 10)...
January 2018: Pathology
Souhil Lebdai, Romain Mathieu, Julie Leger, Olivier Haillot, Sébastien Vincendeau, Nathalie Rioux-Leclercq, Georges Fournier, Marie-Aimée Perrouin-Verbe, Laurent Doucet, Abdel Rahmene Azzouzi, Jérome Rigaud, Karine Renaudin, Thomas Charles, Franck Bruyere, Gaelle Fromont
BACKGROUND: Previous studies have suggested a link between metabolic syndrome (MetS) and prostate cancer (PCa). In the present study, we aimed to assess the association between MetS and markers of PCa aggressiveness on radical prostatectomy (RP). METHODS: All patients consecutively treated for PCa by RP in 6 academic institutions between August 2013 and July 2016 were included. MetS was defined as at least 3 of 5 components (obesity, elevated blood pressure, diabetes, low high-density lipoprotein (HDL)-cholesterol, and hypertriglyceridemia)...
November 16, 2017: Urologic Oncology
Andreas Maxeiner, Ergin Kilic, Julia Matalon, Frank Friedersdorff, Kurt Miller, Klaus Jung, Carsten Stephan, Jonas Busch
The purpose of this study was to investigate the Prostate-Health-Index (PHI) for pathological outcome prediction following radical prostatectomy and also for biochemical recurrence prediction in comparison to established parameters such as Gleason-score, pathological tumor stage, resection status (R0/1) and prostate-specific antigen (PSA). Out of a cohort of 460 cases with preoperative PHI-measurements (World Health Organization calibration: Beckman Coulter Access-2-Immunoassay) between 2001 and 2014, 437 patients with complete follow up data were included...
October 3, 2017: Oncotarget
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"