keyword
MENU ▼
Read by QxMD icon Read
search

ISUP

keyword
https://www.readbyqxmd.com/read/28058701/correlation-between-chromosome-9p21-locus-deletion-and-prognosis-in-clinically-localized-prostate-cancer
#1
Érika Aparecida Felix de Barros, José Pontes-Junior, Sabrina Thalita Reis, Amanda Eunice Ramos Lima, Isida C Souza, Jose Lucas Salgueiro, Douglas Fontes, Humberto Dellê, Rafael Ferreira Coelho, Nayara Izabel Viana, Kátia Ramos Moreira Leite, William C Nahas, Miguel Srougi
BACKGROUND: Some studies have reported that deletions at chromosome arm 9p occur frequently and represent a critical step in carcinogenesis of some neoplasms. Our aim was to evaluate the deletion of locus 9p21 and chromosomes 3, 7 and 17 in localized prostate cancer (PC) and correlate these alterations with prognostic factors and biochemical recurrence after surgery. METHODS: We retrospectively evaluated surgical specimens from 111 patients with localized PC who underwent radical prostatectomy...
January 5, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28042788/-update-of-the-gleason-system-and-other-prognostic-pathological-data-in-prostate-cancer-tumor-load
#2
Ricardo García-González, Ricardo García-Navas, José Montáns-Araújo
Desde que D. F. Gleason creara su sistema en 1966 (1 ) y que él mismo modificó en 1974 (2), su método ha sido universalmente aceptado y recomendado por la OMS (3)como factor pronóstico del carcinoma prostático (CaP). Pero, la generalización de la prueba del PSA a partir de 1979 (4), del desarrollo de la TRUS (5) y de la "biopty-gun" para la toma de biopsias en sextantes en los años 80 (6), y sus posteriores modificaciones, son hechos que han cambiado paulatinamente la postura ante el CaP y, con la experiencia adquirida, algunas de las reglas iniciales de Gleason han evolucionado...
December 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28034440/-urothelial-tumors-in-children
#3
REVIEW
Christine Grapin-Dagorno, Matthieu Peycelon, Pascale Philippe-Chomette, Dominique Berrebi, Alaa El Ghoneimi, Daniel Orbach
Urothelial tumors are very rare in children (to date, only about 150 cases have been reported worlwide). Only 20 % occur before the age of ten. The aim of this study is to specify the clinicopathologic features of urothelial tumor in young patients, which require a slightly different approach to treatment. On the basis of the WHO/ISUP (World Health Organisation/International Society of Urological Pathology) consensus classification report, these lesions are usually low-grade lesions, non invasive, and rarely recurrent...
December 26, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/28032311/prognostic-factors-for-renal-cell-carcinoma-subtypes-diagnosed-according-to-the-2016-who-renal-tumor-classification-a-study-involving-928-patients
#4
Levente Kuthi, Alex Jenei, Adrienn Hajdu, István Németh, Zoltán Varga, Zoltán Bajory, László Pajor, Béla Iványi
The morphotype and grade of renal cell carcinoma (RCC) in 928 nephrectomies were reclassified according to the 2016 WHO classification in order to analyze the distribution and outcomes of RCC subtypes in Hungary, to assess whether microscopic tumor necrosis is an independent prognostic factor in clear cell RCC, and to study whether a two-tiered grading (low/high) for clear cell and papillary RCC provides similar prognostic information to that of the four-tiered ISUP grading system. 83.4% of the cohort were clear cell, 6...
December 28, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27986368/extraprostatic-extension-is-extremely-rare-for-contemporary-gleason-score-6-prostate-cancer
#5
Blake B Anderson, Daniel T Oberlin, Aria A Razmaria, Bonnie Choy, Gregory P Zagaja, Arieh L Shalhav, Joshua J Meeks, Ximing J Yang, Gladell P Paner, Scott E Eggener
BACKGROUND: A significant proportion of men with Gleason score 6 (GS6) prostate cancer undergo treatment with radiation or surgery. OBJECTIVE: To assess pathologic stage of pure GS6 at radical prostatectomy (RP). DESIGN, SETTING, AND PARTICIPANTS: In the period 2003-2014, 7817 patients underwent RP at two institutions. Of 2502 patients with GS6 at surgery, 60 were identified as stage pT3a-b on initial pathologic review, 55 with pT3a (extraprostatic extension, EPE), and five with pT3b (seminal vesicle invasion; SVI)...
December 13, 2016: European Urology
https://www.readbyqxmd.com/read/27939865/pitx2-dna-methylation-as-biomarker-for-individualized-risk-assessment-of-prostate-cancer-in-core-biopsies
#6
Barbara Uhl, Heidrun Gevensleben, Yuri Tolkach, Verena Sailer, Michael Majores, Maria Jung, Sebastian Meller, Johannes Stein, Jörg Ellinger, Dimo Dietrich, Glen Kristiansen
Hypermethylation of the paired-like homeodomain transcription factor 2 (PITX2) gene is a strong predictor of the risk of biochemical recurrence in patients with prostate cancer (PCa) after radical prostatectomy. We investigate whether PITX2 methylation is feasible for individualized risk assessment in prostate core biopsies before surgery. A quantitative, methylation-specific real-time PCR was used to measure PITX2 in three cohorts: i) matched samples of neoplastic and nonneoplastic tissue from 24 patients with PCa, ii) a well-characterized cohort of 300 patients with PCa after radical prostatectomy, and iii) core biopsy specimens from 32 patients with PCa and 31 patients with benign prostatic disease...
January 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27931799/oncocytic-papillary-renal-cell-carcinoma-a-clinicopathological-and-genetic-analysis-and-indolent-clinical-course-in-14-cases
#7
Guiyan Han, Wenjuan Yu, Jing Chu, Yan Liu, Yanxia Jiang, Yujun Li, Wei Zhang
A sort of PRCC with distinct eosinophilic cytoplasm named Oncocytic Papillary Renal Cell Carcinoma (OPRCC) has been increasingly attracting the attention of researchers recently. However, owing to the rarity of OPRCC, the clinicopathological and genetic features of the tumor have still not been well elucidated and whether it should be regarded as an independent subtype of PRCC remains controversial. Herein, a cohort of 14 OPRCCs was studied with the aim of revealing the distinct clinicopathological features, facilitating the classification and correct diagnosis of OPRCC...
January 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27920423/de-novo-renal-neoplasia-after-kidney-transplantation-according-to-new-2016-who-classification-of-renal-tumors
#8
Albino Eccher, Luigino Boschiero, Brett Delahunt, Luca Cima, Francesca Fior, Francesco Nacchia, Momo Rostand, Amedeo Carraro, Umberto Tedeschi, Gianluigi Zaza, Marilena Casartelli Liviero, Laura Zampicinini, Marco Chilosi, Giuseppe Feltrin, Claudio Rago, Antonietta D'Errico, Claudio Ghimenton, Guido Martignoni, Matteo Brunelli
BACKGROUND De novo renal neoplasia developing after kidney transplantation at Verona Kidney Transplant Center were reviewed according to new 2016 WHO Renal Tumor Classification. MATERIAL AND METHODS Primary renal tumors developed in native or transplanted kidneys de novo following renal transplantation were retrieved and histologically reviewed by three expert uropathologists. Immunoexpression of the diagnostic antigens CD13, CD10, CK7, CK34bE12, AMACR, CAIX, AE1/AE3, CK14, GATA-3, HMB-45, cathepsin-k, S100A1, and parvalbumin was assessed...
December 6, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27864107/should-hypoechoic-lesions-on-trus-be-sampled-during-mri-targeted-prostate-biopsy
#9
Nabeel A Shakir, M Minhaj Siddiqui, Arvin K George, Michael Kongnyuy, Richard Ho, Michele Fascelli, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
OBJECTIVES: To determine whether supplemental biopsy of hypoechoic ultrasound lesions (HUL) incidentally found during MRI-transrectal ultrasound (TRUS) fusion-targeted prostate biopsy results in improved prostate cancer (PCa) detection. METHODS: Patients underwent MRI-TRUS targeted biopsy as part of an ongoing prospective trial from August 2007 to February 2015. For men with HUL, the biopsy pathology of HUL and MRI lesions was classified according to the updated 2014 International Society of Urological Pathology (ISUP) grading system...
November 15, 2016: Urology
https://www.readbyqxmd.com/read/27800056/one-is-the-new-six-the-international-society-of-urological-pathology-isup-patient-focused-approach-to-gleason-grading
#10
REVIEW
John R Srigley, Brett Delahunt, Lars Egevad, Hemamali Samaratunga, John Yaxley, Andrew J Evans
No abstract text is available yet for this article.
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27747907/the-world-health-organization-2016-classification-of-testicular-germ-cell-tumours-a-review-and-update-from-the-international-society-of-urological-pathology-testis-consultation-panel
#11
REVIEW
Sean R Williamson, Brett Delahunt, Cristina Magi-Galluzzi, Ferran Algaba, Lars Egevad, Thomas M Ulbright, Satish K Tickoo, John R Srigley, Jonathan I Epstein, Daniel M Berney
Since the last World Health Organization (WHO) classification scheme for tumours of the urinary tract and male genital organs, there have been a number of advances in the understanding, classification, immunohistochemistry and genetics of testicular germ cell tumours. The updated 2016 draft classification was discussed at an International Society of Urological Pathology Consultation on Testicular and Penile Cancer. This review addresses the main updates to germ cell tumour classification. Major changes include a pathogenetically derived classification using germ cell neoplasia in situ (GCNIS) as a new name for the precursor lesion, and the distinction of prepubertal tumours (non-GCNIS-derived) from postpubertal-type tumours (GCNIS-derived), acknowledging the existence of rare benign prepubertal-type teratomas in the postpubertal testis...
February 2017: Histopathology
https://www.readbyqxmd.com/read/27721283/incidentally-detected-clear-cell-renal-cell-carcinoma-with-rhabdoid-differentiation
#12
Venkatesh Krishnamoorthy, Kiran Krishne Gowda, Raman Narayana Rao
Renal cell carcinoma with rhabdoid differentiation (RCC-R) has an aggressive biologic behavior and poor prognosis. A recent consensus statement of the International Society of Urological Pathology (ISUP) proposed a nucleolar grading system (ISUP grade) for RCC to replace Fuhrman system and recommended reporting the presence of rhabdoid differentiation and considering tumors with rhabdoid differentiation to be ISUP Grade 4. We report a case of incidentally detected clear cell RCC-R in a 52-year-old man. This is one of the earliest cases of RCC-R (pT1b) detected and first such case from Indian subcontinent...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27659696/newly-proposed-prognostic-grade-group-system-for-prostate-cancer-genesis-utility-and-its-implications-in-clinical-practice
#13
REVIEW
Makarand Khochikar
We know about the Gleason pattern and Gleason score which are of paramount importance in tailoring the treatment of a prostate cancer. However, there are certain deficiencies in this current scoring system. To simplify the treatment options and have a better idea about the prognosis, a new grade group system has been proposed by ISUP/WHO in 2015. This has been validated in the clinical practice. This commentary takes you through its genesis, utility and its implications on the clinical practice.
November 2016: Current Urology Reports
https://www.readbyqxmd.com/read/27623354/independent-association-of-pd-l1-expression-with-noninactivated-vhl-clear-cell-renal-cell-carcinoma-a-finding-with-therapeutic-potential
#14
Solène-Florence Kammerer-Jacquet, Laurence Crouzet, Angélique Brunot, Julien Dagher, Adélaïde Pladys, Julien Edeline, Brigitte Laguerre, Benoit Peyronnet, Romain Mathieu, Grégory Verhoest, Jean-Jacques Patard, Alexandra Lespagnol, Jean Mosser, Marc Denis, Yosra Messai, Sophie Gad-Lapiteau, Salem Chouaib, Marc-Antoine Belaud-Rotureau, Karim Bensalah, Nathalie Rioux-Leclercq
Clear cell renal cell carcinoma (ccRCC) is an aggressive tumor that is characterized in most cases by inactivation of the tumor suppressor gene VHL. The VHL/HIF/VEGF pathway thus plays a major role in angiogenesis and is currently targeted by anti-angiogenic therapy. The emergence of resistance is leading to the use of targeted immunotherapy against immune checkpoint PD1/PDL1 that restores antitumor immune response. The correlation between VHL status and PD-L1 expression has been little investigated. In this study, we retrospectively reviewed 98 consecutive cases of ccRCC and correlated PD-L1 expression by immunohistochemistry (IHC) with clinical data (up to 10-year follow-up), pathological criteria, VEGF, PAR-3, CAIX and PD-1 expressions by IHC and complete VHL status (deletion, mutation and promoter hypermethylation)...
January 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27613356/magnetic-resonance-imaging-transrectal-ultrasound-guided-fusion-biopsy-to-detect-progression-in-patients-with-existing-lesions-on-active-surveillance-for-low-and-intermediate-risk-prostate-cancer
#15
Thomas P Frye, Arvin K George, Amichai Kilchevsky, Mahir Maruf, M Minhaj Siddiqui, Michael Kongnyuy, Akhil Muthigi, Hui Han, Howard L Parnes, Maria Merino, Peter L Choyke, Baris Turkbey, Brad Wood, Peter A Pinto
PURPOSE: Active surveillance is an established option for men with low risk prostate cancer. Multiparametric magnetic resonance imaging with magnetic resonance imaging-transrectal ultrasound fusion guided biopsy may better identify patients for active surveillance compared to systematic 12-core biopsy due to improved risk stratification. To our knowledge the performance of multiparametric magnetic resonance imaging in following men on active surveillance with visible lesions is unknown...
September 6, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27569435/molecular-analysis-of-low-grade-prostate-cancer-using-a-genomic-classifier-of-metastatic-potential
#16
Eric A Klein, María Santiago-Jiménez, Kasra Yousefi, Bruce A Robbins, Edward M Schaeffer, Bruce J Trock, Jeffrey Tosoian, Zaid Haddad, Seong Ra, R Jeffrey Karnes, Robert B Jenkins, John C Cheville, Robert B Den, Adam P Dicker, Elai Davicioni, Stephen J Freedland, Ashley E Ross
PURPOSE: We determined how frequently histological Gleason 3 + 3 = 6 tumors have the molecular characteristics of disease with metastatic potential. MATERIALS AND METHODS: We analyzed prostatectomy tissue from 337 patients with Gleason 3 + 3 disease. All tissue was re-reviewed in blinded fashion by genitourinary pathologists using 2005 ISUP (International Society of Urological Pathology) Gleason grading criteria. A previously validated Decipher® metastasis signature was calculated in each case based on a locked model...
January 2017: Journal of Urology
https://www.readbyqxmd.com/read/27569001/predictive-efficacy-of-the-2014-international-society-of-urological-pathology-gleason-grading-system-in-initially-diagnosed-metastatic-prostate-cancer
#17
Guang-Xi Sun, Peng-Fei Shen, Xing-Ming Zhang, Jing Gong, Hao-Jun Gui, Kun-Peng Shu, Jiang-Dong Liu, Jinge Zhao, Yao-Jing Yang, Xue-Qin Chen, Ni Chen, Hao Zeng
We compared the predictive ability of the 2014 and 2005 Gleason grading systems in 568 patients initially diagnosed with metastatic prostate cancer (PCa). Outcomes included the duration of castration-resistant prostate cancer-free survival (CFS) and overall survival (OS). Univariate analyses and log-rank tests were used to identify prognosis indicators and assess univariable differences in CFS and OS in Gleason score (GS) groups. Cox proportional hazards and area under the curves of receiver operator characteristics methods were used to evaluate the predictive efficacy of the 2005 and 2014 ISUP grading systems...
August 26, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27473787/-pathological-advances-in-renal-prostatic-bladder-and-testis-neoplasia
#18
N Rioux-Leclercq, E Comperat, S-F Kammerer-Jacquet, P Camparo, G Fromont
INTRODUCTION: The ISUP (International Society of Urological Pathology) Consensus Conferences between 2012 and 2015 made recommendations regarding the classification, staging, prognostic factors of adult tumors from kidney, prostate, bladder and testis. The main points of these recommendations are highlighted in this article. MATERIALS AND METHODS: This article is based on a systematic literature search by using different keywords "cancer, kidney, prostate, bladder, testis, pathology, classification" from Pubmed database...
June 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27428737/tumor-necrosis-adds-prognostically-significant-information-to-grade-in-clear-cell-renal-cell-carcinoma-a-study-of-842-consecutive-cases-from-a-single-institution
#19
Li-Yan Khor, Hari P Dhakal, Xuefei Jia, Jordan P Reynolds, Jesse K McKenney, Brian I Rini, Cristina Magi-Galluzzi, Christopher G Przybycin
Tumor necrosis has been shown to be an independent predictor of adverse outcome in renal cell carcinoma. A modification of the International Society of Urological Pathology (ISUP) grading system for renal cell carcinomas has recently been proposed, which incorporates the presence of tumor necrosis into grade. The investigators proposing this system found that necrosis added significant prognostic information to ISUP grade. We attempted to describe our experience with the effect of tumor necrosis in relationship to nuclear grade by reviewing the slides from a large consecutive series of localized clear cell renal cell carcinomas from our institution and obtaining long-term clinical follow-up information (overall survival)...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27416665/-risk-factors-of-isup-modified-gleason-score-upgrading-after-radical-prostatectomy
#20
Xiao-dong Li, Gen-yi Qu, Ning Xu, Xue-yi Xue, Yong Wei, Qing-shui Zheng, Jun-feng Li, Hai Cai, Yun-zhi Lin
OBJECTIVE: To investigate the factors upgrading the International Society of Urological Pathology (ISUP) Gleason score using the specimens from preoperative prostatic biopsy and radical prostatectomy. METHODS: A total of 164 patients diagnosed with prostate cancer by biopsy underwent radical prostatectomy. We retrospectively analyzed their age, prostate volume, preoperative PSA level, PSA density (PSAD) , the time interval between biopsy and surgery, the number of positive punctures, positive surgical margin, seminal vesicle invasion, lymphatic invasion, and Gleason scores from biopsy and prostatectomy...
May 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
keyword
keyword
35692
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"