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https://www.readbyqxmd.com/read/28554811/the-impact-of-prostate-cancer-zonal-origin-on-pathological-parameters-at-radical-prostatectomy-and-subsequent-biochemical-failure
#1
Patrick E Teloken, Jian Li, Clifton G Woods, Ronald J Cohen
PURPOSE: To assess the impact of prostatic zone tumour origin on the pathological prognostic features and subsequent biochemical outcomes after radical prostatectomy. MATERIALS AND METHODS: A total of 7051 patients undergoing radical prostatectomy between September 1998 and December 2016 in Western Australia were divided into high-grade (Gleason sum 4+3, 8 and ≥9, ISUP groups 3, 4 and 5) and low-grade (Gleason sum ≤6 and 3+4, ISUP groups 1 and 2) groups. The t-test and Pearson Chi-square test were used to evaluate differences between the transition zone and peripheral/central zone cancer...
May 26, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28498816/the-prostate-health-index-phi-predicts-oncological-outcome-and-biochemical-recurrence-after-radical-prostatectomy-analysis-in-437-patients
#2
Andreas Maxeiner, Ergin Kilic, Julia Matalon, Frank Friedersdorff, Kurt Miller, Klaus Jung, Carsten Stephan, Jonas Busch
The purpose of this study was to investigate the Prostate-Health-Index (PHI) for pathological outcome prediction following radical prostatectomy and also for biochemical recurrence prediction in comparison to established parameters such as Gleason-score, pathological tumor stage, resection status (R0/1) and prostate-specific antigen (PSA).Out of a cohort of 460 cases with preoperative PHI-measurements (World Health Organization calibration: Beckman Coulter Access-2-Immunoassay) between 2001 and 2014, 437 patients with complete follow up data were included...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28470873/bmp9-induces-osteogenesis-and-adipogenesis-in-the-immortalized-human-cranial-suture-progenitors-from-the-patent-sutures-of-craniosynostosis-patients
#3
Dongzhe Song, Fugui Zhang, Russell R Reid, Jixing Ye, Qiang Wei, Junyi Liao, Yulong Zou, Jiaming Fan, Chao Ma, Xue Hu, Xiangyang Qu, Liqun Chen, Li Li, Yichun Yu, Xinyi Yu, Zhicai Zhang, Chen Zhao, Zongyue Zeng, Ruyi Zhang, Shujuan Yan, Tingting Wu, Xingye Wu, Yi Shu, Jiayan Lei, Yasha Li, Wenwen Zhang, Jia Wang, Michael J Lee, Jennifer Moriatis Wolf, Dingming Huang, Tong-Chuan He
The cranial suture complex is a heterogeneous tissue consisting of osteogenic progenitor cells and mesenchymal stem cells (MSCs) from bone marrow and suture mesenchyme. The fusion of cranial sutures is a highly coordinated and tightly regulated process during development. Craniosynostosis is a congenital malformation caused by premature fusion of cranial sutures. While the progenitor cells derived from the cranial suture complex should prove valuable for studying the molecular mechanisms underlying suture development and pathogenic premature suture fusion, primary human cranial suture progenitors (SuPs) have limited life span and gradually lose osteoblastic ability over passages...
May 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28422303/smoking-increased-the-risk-of-prostate-cancer-with-grade-group%C3%A2-%C3%A2-%C3%A2-4-and-intraductal-carcinoma-in-a-prospective-biopsy-cohort
#4
Bo Tang, Cheng-Tao Han, Hua-Lei Gan, Gui-Ming Zhang, Cui-Zhu Zhang, Wei-Yi Yang, Ying Shen, Yao Zhu, Ding-Wei Ye
OBJECTIVE: To investigate the association between smoking and different prostate cancer (PCa) pathological subtypes incidence in Chinese men. PATIENTS AND METHODS: We prospectively included 1795 patients who underwent prostate biopsies in one tertiary center between March 2013 and April 2016. Clinical data and biopsy outcomes were collected. Logistic regression was used to evaluate the association between cigarette smoking and PCa incidence. RESULTS: A total of 737 men, 480 men and 58 men were diagnosed with PCa, high-grade PCa (HGPCa, grade group ≥ 4 as accepted by the 2014 ISUP) and intraductal carcinoma of the prostate (IDC-P), respectively...
June 2017: Prostate
https://www.readbyqxmd.com/read/28416108/tumor-necrosis-adds-prognostically-significant-information-to-grade-in-clear-cell-renal-cell-carcinoma-a-study-of-842-consecutive-cases-from-a-single-institution-khor-ly-dhakal-hp-jia-x-reynolds-jp-mckenney-jk-rini-bi-magi-galluzzi-c-przybycin-cg-am-j-surg
#5
Oleksandr N Kryvenko
Tumor necrosis has been shown to be an independent predictor of adverse outcome in renal cell carcinoma. A modification of the International Society of Urological Pathology (ISUP) grading system for renal cell carcinomas has recently been proposed, which incorporates the presence of tumor necrosis into grade. The investigators proposing this system found that necrosis added significant prognostic information to ISUP grade. We attempted to describe our experience with the effect of tumor necrosis in relationship to nuclear grade by reviewing the slides from a large consecutive series of localized clear cell renal cell carcinomas from our institution and obtaining long-term clinical follow-up information (overall survival)...
June 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28389514/histopathology-of-prostate-cancer
#6
Peter A Humphrey
This review focuses on histopathological aspects of carcinoma of the prostate. A tissue diagnosis of adenocarcinoma is often essential for establishing a diagnosis of prostate cancer, and the foundation for a tissue diagnosis is currently light microscopic examination of hematoxylin and eosin (H&E)-stained tissue sections. Markers detected by immunohistochemistry on tissue sections can support a diagnosis of adenocarcinoma that is primary in the prostate gland or metastatic. Histological variants of carcinoma of the prostate are important for diagnostic recognition of cancer or as clinicopathologic entities that have prognostic and/or therapeutic significance...
April 7, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28373133/prospective-evaluation-of-prostate-imaging-reporting-and-data-system-version-2-using-the-international-society-of-urological-pathology-prostate-cancer-grade-group-system
#7
Sherif Mehralivand, Sandra Bednarova, Joanna H Shih, Francesca V Mertan, Sonia Gaur, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
PURPOSE: The Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) scoring system, introduced in 2015, is based on expert consensus. In the same time; frame, a new pathologic scoring system for prostate cancer was introduced by the International Society of Urological Pathology (ISUP). Our goal was to prospectively evaluate the cancer detection rates for each PI-RADSv2 category and compare to ISUP group scores in patients undergoing systematic biopsy and MRI/transrectal ultrasound fusion-guided biopsy...
March 31, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28371244/predictive-value-of-the-2014-international-society-of-urological-pathology-grading-system-for-prostate-cancer-in-radical-prostatectomy-patients-with-long-term-follow-up
#8
Judith Grogan, Ruta Gupta, Kate L Mahon, Phillip D Stricker, Anne-Maree Haynes, Warick Delprado, Jennifer Turner, Lisa G Horvath, James G Kench
OBJECTIVE: To assess the relationship between the ISUP 2014 grading system, biochemical relapse (BCR) and clinical relapse (CLR) following radical prostatectomy, to determine whether the 2014 ISUP grading system is a better predictor of survival compared to the previous Gleason scoring systems, and to investigate whether incorporation of the tertiary pattern/grade into the ISUP scoring system significantly improves its efficacy. PATIENTS AND METHODS: 635 radical prostatectomy cases (1991-1999) were identified from a database at a single institution...
March 28, 2017: BJU International
https://www.readbyqxmd.com/read/28370140/global-gleason-grade-groups-in-prostate-cancer-concordance-of-biopsy-and-radical-prostatectomy-grades-and-predictors-of-upgrade-and-downgrade
#9
Daniel Athanazio, Geoffrey Gotto, Melissa Shea-Budgell, Asli Yilmaz, Kiril Trpkov
AIMS: To evaluate concordance, upgrades and downgrades from biopsy to prostatectomy, and associated clincopathological parameters, using the recently proposed Gleason grade groups/International Society of Urologic Pathology (ISUP) grades. METHODS AND RESULTS: We evaluated 2529 patients who underwent biopsy and prostatectomy in our institution from 2005 to 2014. A global grade group (GR)/Gleason score (GS) was used. Factors associated with GR1/GS ≤6 upgrades and GR2/GS3 + 4 downgrades were analysed by multivariable logistic regression...
February 2, 2017: Histopathology
https://www.readbyqxmd.com/read/28368923/reporting-and-staging-of-testicular-germ-cell-tumors-the-international-society-of-urological-pathology-isup-testicular-cancer-consultation-conference-recommendations
#10
Clare Verrill, Asli Yilmaz, John R Srigley, Mahul B Amin, Eva Compérat, Lars Egevad, Thomas M Ulbright, Satish K Tickoo, Daniel M Berney, Jonathan I Epstein
The International Society of Urological Pathology held a conference devoted to issues in testicular and penile pathology in Boston in March 2015, which included a presentation and discussion led by the testis microscopic features working group. This conference focused on controversies related to staging and reporting of testicular tumors and was preceded by an online survey of the International Society of Urological Pathology members. The survey results were used to initiate discussions, but decisions were made by expert consensus rather than voting...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28249616/tumor-to-tumor-metastases-papillary-thyroid-carcinoma-into-a-clear-cell-renal-cell-carcinoma
#11
Jin Soo Andy Song, S Mark Taylor, Jonathan Trites, Matthew H Rigby, Martin Joseph Bullock, Jennifer Merrimen, Ricardo Rendon, Robert D Hart
BACKGROUND: Thyroid metastases to distant sites are uncommon incidents, most often metastasizing to the lungs and bones. Rates of metastasis to the kidney are particularly low, ranging from 2.8-3.8% for papillary and 6-20% for follicular variants of well-differentiated thyroid cancers (WDTCs). In rare instances, tumor-to-tumor metastasis between two true primary neoplasms can occurs. This medical phenomenon has previously occurred as a clear cell renal cell carcinoma (CCRCC) spreading to a WDTC...
March 1, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28235401/expression-of-socs1-and-the-downstream-targets-of-its-putative-tumor-suppressor-functions-in-prostate-cancer
#12
Martin Chevrier, Diwakar Bobbala, Alberto Villalobos-Hernandez, Md Gulam Musawwir Khan, Sheela Ramanathan, Caroline Saucier, Gerardo Ferbeyre, Sameh Geha, Subburaj Ilangumaran
BACKGROUND: Suppressor of cytokine signaling 1 (SOCS1) is considered a tumor suppressor due to frequent epigenetic and micro-RNA-mediated repression of its gene expression in diverse cancers. In prostate cancer (PCa), elevated expression of miR-30d that targets SOCS1 mRNA is associated with increased risk of disease recurrence. SOCS1 can mediate its tumor suppressor functions by diverse mechanisms such as inhibiting the JAK-STAT signaling pathway, promoting the tumor suppressor functions of p53, attenuating MET receptor tyrosine kinase signaling and blocking the oncogenic potential of the cell cycle inhibitor p21(CIP1) (p21)...
February 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28199742/genetic-analysis-and-clinicopathological-features-of-alk-rearranged-renal-cell-carcinoma-in-a-large-series-of-resected-chinese-renal-cell-carcinoma-patients-and-literature-review
#13
Wenjuan Yu, Yuewei Wang, Yanxia Jiang, Wei Zhang, Yujun Li
AIMS: Anaplastic lymphoma kinase (ALK)-rearranged renal cell carcinoma (RCC) is a rare subtype of RCC reported in recent years, with eight cases so far. The aims of the present study were to screen ALK-rearranged cases from a large cohort of RCCs in China to determine the frequency of ALK rearrangement and investigate the clinicopathological features and outcomes. METHODS AND RESULTS: Tissues from a total of 477 RCC patients in China were embedded into tissue microarrays for immunostaining...
February 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28185421/fine-needle-aspiration-findings-of-xp11-translocation-renal-cell-carcinoma-metastatic-to-a-hilar-lymph-node
#14
Reima El Naili, Marlo Nicolas, Amanda Gorena, Maria Luisa C Policarpio-Nicolas
Xp11 translocation renal cell carcinoma (RCC) is a specific type of renal cell carcinoma recently placed under the "MiT family translocation RCC" at the last 2013 ISUP Vancouver classification of renal neoplasia. This tumor contains variable proportions of clear cells and could easily mimic papillary RCC, clear cell type, and clear cell papillary RCC. Given the small number of published cytologic findings of this tumor, it could easily present as a diagnostic pitfall. We describe a case of a 23-year-old man with a history of prior nephrectomy who presented with multiple mediastinal lymphadenopathies on imaging surveillance follow-up...
May 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28177964/contemporary-gleason-grading-of-prostatic-carcinoma-an-update-with-discussion-on-practical-issues-to-implement-the-2014-international-society-of-urological-pathology-isup-consensus-conference-on-gleason-grading-of-prostatic-carcinoma
#15
Jonathan I Epstein, Mahul B Amin, Victor E Reuter, Peter A Humphrey
The primary proceedings of the 2014 International Society of Urological Pathology Grading Conference were published promptly in 2015 and dealt with: (1) definition of various grading patterns of usual acinar carcinoma, (2) grading of intraductal carcinoma; and (3) support for the previously proposed new Grade Groups. The current manuscript in addition to highlighting practical issues to implement the 2014 recommendations, provides an updated perspective based on numerous studies published after the 2014 meeting...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28162815/improving-the-rotterdam-european-randomized-study-of-screening-for-prostate-cancer-risk-calculator-for-initial-prostate-biopsy-by-incorporating-the-2014-international-society-of-urological-pathology-gleason-grading-and-cribriform-growth
#16
Monique J Roobol, Jan F M Verbeek, Theo van der Kwast, Intan P Kümmerlin, Charlotte F Kweldam, Geert J L H van Leenders
BACKGROUND: The survival rate for men with International Society of Urological Pathology (ISUP) grade 2 prostate cancer (PCa) without invasive cribriform (CR) and intraductal carcinoma (IDC) is similar to that for ISUP grade 1. If updated into the European Randomized Study of Screening for Prostate Cancer (ERSPC Rotterdam) risk calculator number 3 (RC3), this may further improve upfront selection of men who need a biopsy. OBJECTIVE: To improve the number of possible biopsies avoided, while limiting undiagnosed clinically important PCa by applying the updated RC3 for risk-based patient selection...
February 2, 2017: European Urology
https://www.readbyqxmd.com/read/28156003/population-based-validation-of-the-2014-isup-gleason-grade-groups-in-patients-treated-with-radical-prostatectomy-brachytherapy-external-beam-radiation-or-no-local-treatment
#17
Raisa S Pompe, Helen Davis-Bondarenko, Emanuele Zaffuto, Zhe Tian, Shahrokh F Shariat, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To test discriminant ability of the 2014 ISUP Gleason grade groups (GGG) for prediction of prostate cancer specific mortality (PCSM) after radical prostatectomy (RP), brachytherapy (BT), external beam radiation (EBRT) or no local treatment (NLT) relative to traditional Gleason grading (TGG). METHODS: In the Surveillance, Epidemiology, and End Results (SEER)-database (2004-2009), 2,42,531 non-metastatic prostate cancer (PCa) patients were identified, who underwent local treatment (RP, BT, EBRT only) or NLT...
February 3, 2017: Prostate
https://www.readbyqxmd.com/read/28144985/socs3-immunohistochemical-expression-seems-to-support-the-2005-and-2014-international-society-of-urological-pathology-isup-modified-gleason-grading-system
#18
Francesco Pierconti, Maurizio Martini, Tonia Cenci, Gian Luigi Petrone, Riccardo Ricci, Emilio Sacco, Pier Francesco Bassi, Luigi Maria Larocca
BACKGROUND: In the 2014, The International Society of Urological Pathology (ISUP) consensus conference update the grading of prostate, last revised in 2005. In this study we evaluate the SOCS3 immunohistochemical protein expression in different Gleason prostatic adenocarcinoma: classical Gleason grade 3, classical Gleason grade 3 upgraded to Gleason grade 4 according to the ISUP modifications and classical and modified Gleason grade 4. The major conclusions were: (i) Cribriform glands should be assigned a Gleason pattern 4, regardless of morphology; (ii) Glomeruloid glands should be assigned a Gleason pattern 4, regardless of morphology; (iii) Grading of mucinous carcinoma of the prostate should be based on its underlying growth pattern rather than all as pattern 4; and (iv) Intraductal carcinoma of the prostate without invasive carcinoma should not assigned Gleason grade and a comment about aggressive carcinoma probably associated should be made...
February 1, 2017: Prostate
https://www.readbyqxmd.com/read/28058701/correlation-between-chromosome-9p21-locus-deletion-and-prognosis-in-clinically-localized-prostate-cancer
#19
Érika Aparecida Felix de Barros, José Pontes-Junior, Sabrina Thalita Reis, Amanda Eunice Ramos Lima, Isida C Souza, Jose Lucas Salgueiro, Douglas Fontes, Humberto Dellê, Rafael Ferreira Coelho, Nayara Izabel Viana, Kátia Ramos Moreira Leite, William C Nahas, Miguel Srougi
BACKGROUND: Some studies have reported that deletions at chromosome arm 9p occur frequently and represent a critical step in carcinogenesis of some neoplasms. Our aim was to evaluate the deletion of locus 9p21 and chromosomes 3, 7 and 17 in localized prostate cancer (PC) and correlate these alterations with prognostic factors and biochemical recurrence after surgery. METHODS: We retrospectively evaluated surgical specimens from 111 patients with localized PC who underwent radical prostatectomy...
May 4, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28042788/-update-of-the-gleason-system-and-other-prognostic-pathological-data-in-prostate-cancer-tumor-load
#20
Ricardo García-González, Ricardo García-Navas, José Montáns-Araújo
Desde que D. F. Gleason creara su sistema en 1966 (1 ) y que él mismo modificó en 1974 (2), su método ha sido universalmente aceptado y recomendado por la OMS (3)como factor pronóstico del carcinoma prostático (CaP). Pero, la generalización de la prueba del PSA a partir de 1979 (4), del desarrollo de la TRUS (5) y de la "biopty-gun" para la toma de biopsias en sextantes en los años 80 (6), y sus posteriores modificaciones, son hechos que han cambiado paulatinamente la postura ante el CaP y, con la experiencia adquirida, algunas de las reglas iniciales de Gleason han evolucionado...
December 2016: Archivos Españoles de Urología
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