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https://www.readbyqxmd.com/read/29245186/endothelial-dysfunction-in-early-systemic-lupus-erythematosus-patients-and-controls-without-previous-cardiovascular-events
#1
Mara Taraborelli, Edoardo Sciatti, Ivano Bonadei, Vincenzo Terlizzi, Micaela Fredi, Roberta Zani, Giovanni Cancarini, Angela Tincani, Franco Franceschini, Enrico Vizzardi, Ilaria Cavazzana
OBJECTIVES: To assess the prevalence and risk factors for endothelial dysfunction detected by peripheral artery tonometry in systemic lupus erythematosus patients with early disease without cardiovascular disease and risk factors. METHODS: All the consecutive adult lupus patients, with a disease duration less than 5 years, seen in our Hospital from December 2014 to March 2016 were considered. We excluded patients with any history of cardiovascular disease or risk factors possibly affecting peripheral artery tonometry...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245104/who-goes-first-understanding-hepatitis-c-risk-among-injecting-networks-in-the-prison-setting
#2
Lise Lafferty, Jake Rance, Carla Treloar
BACKGROUND: Hepatitis C (HCV) is a blood-borne virus that is most commonly transmitted through shared injecting equipment. Due to the criminalisation of injecting drug use, HCV is highly prevalent among those incarcerated. Using a risk environment framework, this qualitative study sought to understand the role of HCV risk within injecting networks in the prison setting. METHODS: Thirty-two adult prisoners (n=24 men; n=8 women) with a history of injecting drug use participated in this qualitative sub-study...
December 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29245082/adolescent-mental-health-and-behavioural-problems-and-intergenerational-social-mobility-a-decomposition-of-health-selection-effects
#3
Lewis Robert Anderson
According to the health selection hypothesis, poor mental health and behavioural problems in adolescence limit socioeconomic attainment. But to what extent is health selection driven by prior social causation? This paper quantifies the extent to which health selection - here, restricted or downward intergenerational social class mobility due to poor mental health or behavioural problems - can be attributed to the influence of modifiable childhood risk factors. The UK National Child Development Study provides measures of socioeconomic deprivation and childhood adversities, as well as multiple-informant ratings of adolescents' mental health and behavioural problems, for which confirmatory factor analysis supports a three-factor model...
November 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29245061/risk-and-prognosis-of-cancer-after-upper-extremity-deep-venous-thrombosis-a-population-based-cohort-study
#4
Kasper Adelborg, Erzsébet Horváth-Puhó, Jens Sundbøll, Paolo Prandoni, Anne Ording, Henrik Toft Sørensen
INTRODUCTION: The association between lower-extremity venous thrombosis and cancer is well-established. However, the extent to which upper-extremity deep venous thrombosis (U-DVT) is a marker of cancer and a prognostic factor for all-cause mortality remains poorly understood. We examined the risk of cancer after a diagnosis of U-DVT compared with cancer risk in the general population. MATERIALS AND METHODS: Using Danish nationwide population-based medical registries, we identified all patients with first-time U-DVT during 1980-1993 and 2000-2013...
November 22, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29245039/prenatal-arsenic-exposure-child-marriage-and-pregnancy-weight-gain-associations-with-preterm-birth-in-bangladesh
#5
Mohammad L Rahman, Molly L Kile, Ema G Rodrigues, Linda Valeri, Anita Raj, Maitreyi Mazumdar, Golam Mostofa, Quazi Quamruzzaman, Mahmudur Rahman, Russ Hauser, Andrea Baccarelli, Liming Liang, David C Christiani
BACKGROUND: Preterm birth is a disease of multifactorial etiologies that has environmental, social, and maternal health components. Individual studies have shown that exposure to arsenic contaminated drinking water, child marriage, and low maternal weight gain during pregnancy contribute to preterm birth. These factors are highly prevalent and often co-exist in Bangladesh, a country in South Asia with one of the world's highest prevalences of preterm birth. OBJECTIVE: To evaluate the individual and interactive effects of prenatal arsenic exposure, child marriage, and pregnancy weight gain on preterm birth in a prospective birth cohort in Bangladesh...
December 12, 2017: Environment International
https://www.readbyqxmd.com/read/29245026/ketogenic-diet-induced-extension-of-longevity-in-epileptic-kcna1-null-mice-is-influenced-by-gender-and-age-at-treatment-onset
#6
Kyoung-Chul Chun, Shun-Chieh Ma, Hyoungil Oh, Jong M Rho, Do Young Kim
Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature mortality in patients with epilepsy, and has been linked to multiple risk factors, including gender and early age at seizure onset. Despite the lack of a targeted therapy for SUDEP, it has recently been shown that a high-fat, low carbohydrate ketogenic diet (KD) enhances longevity in the epileptic Kcna1-null (KO) mouse, a validated model of SUDEP. Here, we asked whether the KD-driven prolongation of lifespan in KO mice is dependent on sex and/or age at treatment onset...
November 21, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29245020/killing-two-birds-with-one-stone-association-between-tobacco-and-alcohol-consumption
#7
REVIEW
A M Reis, C Quintal, Ó Lourenço
OBJECTIVES: Tobacco and excessive alcohol consumption are addictive behaviours, listed among the 10 leading risk factors that cause death and disability in the world, and health consequences are greater if their consumption is combined. There is sparse empirical evidence on the variables that influence the simultaneous consumption of tobacco and alcohol. This study aims to identify the variables that influence the joint decision to consume alcohol and tobacco, and that encourage drinkers to smoke...
December 12, 2017: Public Health
https://www.readbyqxmd.com/read/29244999/mechanical-stress-increases-brain-amyloid-%C3%AE-tau-and-%C3%AE-synuclein-concentrations-in-wild-type-mice
#8
Marcel Levy Nogueira, Minoo Hamraz, Mohammad Abolhassani, Erwan Bigan, Olivier Lafitte, Jean-Marc Steyaert, Bruno Dubois, Laurent Schwartz
INTRODUCTION: Exposure to traumatic brain injury is a core risk factor that predisposes an individual to sporadic neurodegenerative diseases. We provide evidence that mechanical stress increases brain levels of hallmark proteins associated with neurodegeneration. METHODS: Wild-type mice were exposed to multiple regimens of repetitive mild traumatic brain injury, generating a range of combinations of impact energies, frequencies, and durations of exposure. Brain concentrations of amyloid β 1-42 (Aβ1-42), total tau, and α-synuclein were measured by sandwich enzyme-linked immunosorbent assay...
December 12, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29244986/breast-cancer-in-ghana-demonstrating-the-need-for-population-based-cancer-registries-in-low-and-middle-income-countries
#9
Abigail S Thomas, Kelley M Kidwell, Joseph K Oppong, Ernest K Adjei, Ernest Osei-Bonsu, Angela Boahene, Evelyn Jiggae, Kofi Gyan, Sofia D Merajver
Purpose Breast cancer, the most common cancer worldwide, is the leading cause of cancer mortality in Ghanaian women. Previous studies find Ghanaian women are diagnosed at a younger age and at more advanced stages (III and IV), and have tumors with characteristics similar to African American women. We sought to remedy gaps in knowledge about breast cancer survival in Ghana and its relation to demographic and biologic factors of the tumors at diagnosis to assist in cancer control and registration planning. Methods Individuals with a breast cancer diagnosis who sought care at Komfo Anokye Teaching Hospital from 2009 to 2014 were identified via medical records...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244900/the-bidirectional-relationship-between-anxiety-disorders-and-circulating-levels-of-inflammatory-markers-results-from-a-large-longitudinal-population-based-study
#10
Jennifer Glaus, Roland von Känel, Aurélie M Lasserre, Marie-Pierre F Strippoli, Caroline L Vandeleur, Enrique Castelao, Mehdi Gholam-Rezaee, Ciro Marangoni, En-Young N Wagner, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, Martin Preisig, Kathleen R Merikangas
BACKGROUND: Although there has been abundant research on chronic low-grade inflammation as a potential mechanism underlying the link between mood disorders and cardiovascular risk, less is known about the role of inflammatory factors and anxiety disorders. The aim of this paper is to evaluate the bi-directional associations between inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)-α, and high sensitivity C-reactive protein (hsCRP) with anxiety disorders and its subgroups...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29244844/diagnostic-markers-for-the-detection-of-ovarian-cancer-in-brca1-mutation-carriers
#11
Daphne Gschwantler-Kaulich, Sigrid Weingartshofer, Christine Rappaport-Fürhauser, Robert Zeilinger, Dietmar Pils, Daniela Muhr, Elena I Braicu, Marie-Therese Kastner, Yen Y Tan, Lorenz Semmler, Jalid Sehouli, Christian F Singer
BACKGROUND: Screening for ovarian cancer (OC) in women at high risk consists of a combination of carbohydrate antigen 125 (CA125) and transvaginal ultrasound, despite their low sensitivity and specificity. This could be improved by the combination of several biomarkers, which has been shown in average risk patients but has not been investigated until now in female BRCA mutation carriers. METHODS: Using a multiplex, bead-based, immunoassay system, we analyzed the concentrations of leptin, prolactin, osteopontin, insulin-like growth factor II, macrophage inhibitory factor, CA125 and human epididymis antigen 4 in 26 healthy wild type women, 26 healthy BRCA1 mutation carriers, 28 wildtype OC patients and 26 OC patients with BRCA1 mutation...
2017: PloS One
https://www.readbyqxmd.com/read/29244843/pathology-in-repeated-transurethral-resection-of-a-bladder-tumor-as-a-risk-factor-for-prognosis-of-high-risk-non-muscle-invasive-bladder-cancer
#12
Bum Sik Tae, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Kyung Chul Moon, Ja Hyeon Ku
The prognostic value of repeat transurethral resection of bladder tumor (TURBT) in patients with diagnosed high-risk, non-muscle-invasive bladder cancer (NMIBC) was investigated. We retrospectively reviewed the medical records of patients treated from October 2004 to December 2013 at Seoul National University who underwent repeated TURBT within 2-6 weeks after an initial resection. The study enrolled patients who had been diagnosed with NMIBC at both the initial and repeat TURBT; patients with muscle-invasive tumors on repeat TURBT were excluded...
2017: PloS One
https://www.readbyqxmd.com/read/29244840/high-expression-of-lncrna-pvt1-independently-predicts-poor-overall-survival-in-patients-with-primary-uveal-melanoma
#13
Haiming Xu, Jingwen Gong, Hui Liu
The plasmacytoma variant translocation 1 gene (PVT1) plays an oncogenic role in the initiation and progression of multiple cancers. In this study, by using deep-sequencing data and follow-up data in the Cancer Genome Atlas-Uveal melanomas (TCGA-UVM), we assessed the association between the expression of PVT1 and clinicopathological characteristics of patients with uveal melanoma, the mechanism of its dysregulation and its prognostic value. Results showed that high PVT1 expression group had a higher proportion of epithelioid cell dominant disease (a more malignant histological subtype than spindle cell dominant disease) and more cases of extrascleral extension (a risk factor for metastasis) compared with the low PVT1 expression group...
2017: PloS One
https://www.readbyqxmd.com/read/29244838/muscle-function-in-glenohumeral-joint-stability-during-lifting-task
#14
Yoann Blache, Mickaël Begon, Benjamin Michaud, Landry Desmoulins, Paul Allard, Fabien Dal Maso
Ensuring glenohumeral stability during repetitive lifting tasks is a key factor to reduce the risk of shoulder injuries. Nevertheless, the literature reveals some lack concerning the assessment of the muscles that ensure glenohumeral stability during specific lifting tasks. Therefore, the purpose of this study was to assess the stabilization function of shoulder muscles during a lifting task. Kinematics and muscle electromyograms (n = 9) were recorded from 13 healthy adults during a bi-manual lifting task performed from the hip to the shoulder level...
2017: PloS One
https://www.readbyqxmd.com/read/29244822/alcohol-consumption-and-breast-cancer-specific-and-all-cause-mortality-in-women-diagnosed-with-breast-cancer-at-the-new-york-site-of-the-breast-cancer-family-registry
#15
Nur Zeinomar, Ashley Thai, Ann J Cloud, Jasmine A McDonald, Yuyan Liao, Mary Beth Terry
PURPOSE: Alcohol consumption is an established and important risk factor for breast cancer incidence in the general population. However, the relationship between alcohol and mortality among women with breast cancer is less clear. This study examines the effect of alcohol consumption on mortality in women affected with breast cancer at baseline from a high-risk family breast and ovarian cancer registry. METHODS: We studied 1116 women affected with breast cancer at baseline from the Metropolitan New York Registry...
2017: PloS One
https://www.readbyqxmd.com/read/29244821/genotyping-of-mycobacterium-leprae-for-better-understanding-of-leprosy-transmission-in-fortaleza-northeastern-brazil
#16
Amanda N B Fontes, Luana N G C Lima, Rosa M S Mota, Rosa L F Almeida, Maria A Pontes, Heitor de S Gonçalves, Cristiane C Frota, Varalakshmi D Vissa, Patrick J Brennan, Ricardo J P S Guimaraes, Carl Kendall, Ligia R F S Kerr, Philip N Suffys
Leprosy is endemic in large part of Brazil with 28,761 new patients in 2015, the second largest number worldwide and reaches 9/10.000 in highly endemic regions and 2.7/10.000 in the city of Fortaleza, Ceará, Northeast Brazil. For better understanding of risk factors for leprosy transmission, we conducted an epidemiologic study supplemented by 17 locus VNTR and SNP 1-4 typing of Mycobacterium leprae in skin biopsy samples from new multibacillary (MB) patients diagnosed at a reference center in 2009 and 2010...
December 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29244786/functional-assessment-as-a-predictor-of-cognitive-impairment-a-retrospective-cohort-study
#17
Gustavo Alberto Sandival Ampuero, Fernando M Runzer-Colmenares, José F Parodi
INTRODUCTION: It is estimated that major neurocognitive disorders will affect 115.4 million people by 2050, representing a significant financial burden for society. Likewise, functional dependence for basic or instrumental activities of daily life is usually a consequence of the greater prevalence of disabling pathologies, and of the progressive decrease of the physiological reserve due to aging. OBJECTIVES: To determine the ratio between the functional test and prediction of deterioration of cognitive function in geriatric patients...
December 12, 2017: Medwave
https://www.readbyqxmd.com/read/29244775/spatial-temporal-and-dietary-variables-associated-with-elevated-mercury-exposure-in-peruvian-riverine-communities-upstream-and-downstream-of-artisanal-and-small-scale-gold-mining
#18
Lauren Wyatt, Ernesto J Ortiz, Beth Feingold, Axel Berky, Sarah Diringer, Ana Maria Morales, Elvis Rojas Jurado, Heileen Hsu-Kim, William Pan
Artisanal and small-scale gold mining (ASGM) is a primary contributor to global mercury and its rapid expansion raises concern for human exposure. Non-occupational exposure risks are presumed to be strongly tied to environmental contamination; however, the relationship between environmental and human mercury exposure, how exposure has changed over time, and risk factors beyond fish consumption are not well understood in ASGM settings. In Peruvian riverine communities (n = 12), where ASGM has increased 4-6 fold over the past decade, we provide a large-scale assessment of the connection between environmental and human mercury exposure by comparing total mercury contents in human hair (2-cm segment, n = 231) to locally caught fish tissue, analyzing temporal exposure in women of child bearing age (WCBA, 15-49 years, n = 46) over one year, and evaluating general mercury exposure risks including fish and non-fish dietary items through household surveys and linear mixed models...
December 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29244754/evaluation-of-traffic-density-parameters-as-an-indicator-of-vehicle-emission-related-near-road-air-pollution-a-case-study-with-nexus-measurement-data-on-black-carbon
#19
Shi V Liu, Fu-Lin Chen, Jianping Xue
An important factor in evaluating health risk of near-road air pollution is to accurately estimate the traffic-related vehicle emission of air pollutants. Inclusion of traffic parameters such as road length/area, distance to roads, and traffic volume/intensity into models such as land use regression (LUR) models has improved exposure estimation. To better understand the relationship between vehicle emissions and near-road air pollution, we evaluated three traffic density-based indices: Major-Road Density (MRD), All-Traffic Density (ATD) and Heavy-Traffic Density (HTD) which represent the proportions of major roads, major road with annual average daily traffic (AADT), and major road with commercial annual average daily traffic (CAADT) in a buffered area, respectively...
December 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29244704/nonunion-of-a-nondisplaced-radial-neck-fracture-a-case-report
#20
John G Coury, Zachary C Lum, Marc A Trzeciak
CASE: We describe the case of a 66-year-old man who sustained a nondisplaced radial neck fracture and subsequently developed a symptomatic nonunion. After a period of unsuccessful conservative treatment, a radial head resection was performed. CONCLUSION: Radial neck fractures, unlike their radial head counterparts, have a low rate of nonunion. Our patient's only positive risk factor was age, but he developed a nonunion. At the 2-year follow-up after excision of the radial head, there was a lack of proximal migration of the radius during axial loading, demonstrating a positive outcome without the need for replacement of the radial head...
July 2017: JBJS Case Connector
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