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https://www.readbyqxmd.com/read/29908479/incident-thyroid-disease-in-female-spouses-of-private-pesticide-applicators
#1
Srishti Shrestha, Christine G Parks, Whitney S Goldner, Freya Kamel, David M Umbach, Mary H Ward, Catherine C Lerro, Stella Koutros, Jonathan N Hofmann, Laura E Beane Freeman, Dale P Sandler
BACKGROUND: Little is known about modifiable risk factors for thyroid disease. Several pesticides have been implicated in thyroid disruption, but clinical implications are not clear. OBJECTIVE: We assessed associations between pesticide use and other farm exposures and incident hypothyroidism and hyperthyroidism in female spouses of farmers in the Agricultural Health Study (AHS). METHODS: We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals for risk of thyroid disease in 24,092 spouses who completed at least one follow-up questionnaire...
June 13, 2018: Environment International
https://www.readbyqxmd.com/read/29908437/studies-on-2-phenylquinoline-staphylococcus-aureus-nora-efflux-pump-inhibitors-new-insights-on-the-c-6-position
#2
Tommaso Felicetti, Rolando Cannalire, Maria Giulia Nizi, Oriana Tabarrini, Serena Massari, Maria Letizia Barreca, Giuseppe Manfroni, Bryan D Schindler, Violetta Cecchetti, Glenn W Kaatz, Stefano Sabatini
The alarming and rapid spread of antimicrobial resistance among bacteria represents a high risk for global health. Targeting factors involved in resistance to restore the activity of failing antibiotics is a promising strategy to overcome this urgent medical need. Efflux pump inhibitors are able to increase antibiotic concentrations in bacteria, thus they can be considered true antimicrobial resistance breakers. In this work, continuing our studies on inhibitors of the Staphylococcus aureus NorA pump, we designed, synthesized and biologically evaluated novel 2-phenylquinoline derivatives starting from our hits 1 and 2...
June 6, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908410/beyond-the-walls-risk-factors-for-overdose-mortality-following-release-from-the-philadelphia-department-of-prisons
#3
Lia N Pizzicato, Rebecca Drake, Reed Domer-Shank, Caroline C Johnson, Kendra M Viner
BACKGROUND: High overdose mortality after release from state prison systems is well documented; however, little is known about overdose mortality following release from local criminal justice systems (CJS). The purpose of this study was to assess overdose mortality following release from a local CJS in Philadelphia, PA. METHODS: We conducted a retrospective cohort study of individuals released to the community from a local CJS between 2010 and 2016. Incarceration records were linked to overdose fatality data from the Medical Examiner's Office and death certificate records...
June 5, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29908404/the-association-between-cortisol-oxytocin-and-immune-cell-mitochondrial-oxygen-consumption-in-postpartum-women-with-childhood-maltreatment
#4
Christina Boeck, Anja Maria Gumpp, Enrico Calzia, Peter Radermacher, Christiane Waller, Alexander Karabatsiakis, Iris-Tatjana Kolassa
Childhood maltreatment (CM) is associated with an increased risk for the development of psychiatric and somatic diseases in later life. Individual risk and resilience factors may, however, influence how deep psychological stress gets under the skin. We hypothesized that the stress-related hormone cortisol and the attachment-related hormone oxytocin constitute biological factors that might moderate the biological sequelae and long-term health outcomes associated with CM. As biological outcome, we thereby focused on immunocellular oxygen consumption, which we previously found to be increased with a higher severity of CM experiences...
June 1, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29908389/development-and-validation-of-a-clinical-prediction-tool-to-estimate-the-individual-risk-of-depressive-relapse-or-recurrence-in-individuals-with-recurrent-depression
#5
Nicola S Klein, Gea A Holtman, Claudi L H Bockting, Martijn W Heymans, Huibert Burger
OBJECTIVES: Many studies examined predictors of depressive relapse/recurrence but no simple tool based on well-established risk factors is available that estimates the risk within an individual. We developed and validated such a prediction tool in remitted recurrently depressed individuals. METHODS: The tool was developed using data (n = 235) from a pragmatic randomised controlled trial in remitted recurrently depressed participants and externally validated using data (n = 209) from a similar randomised controlled trial of remitted recurrently depressed participants using maintenance antidepressants...
June 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29908371/the-addition-of-minute-ventilation-to-rate-responsive-pacing-improves-heart-rate-score-more-than-accelerometer-alone
#6
Mark Richards, Brian Olshansky, Arjun D Sharma, Nicholas Wold, Paul Jones, David Perschbacher, Bruce L Wilkoff
BACKGROUND: Heart Rate Score (HRSc)≥70%, a novel parameter, predicts risk of mortality in patients with implantable defibrillators and identifies patients who have survival benefit with DDDR versus DDD pacing. OBJECTIVE: DDDR pacing lowers HRSc and dual-sensor with minute ventilation (MV) and accelerometer (XL) improves HRSc more than accelerometer (XL) alone in patients requiring pacemakers (PM). METHODS: HRSc, the percent of all beats in the predominant 10 bpm bin, was calculated...
June 13, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29908353/the-impact-of-prenatal-diagnosis-on-congenital-anomaly-outcomes-data-from-1997-to-2016
#7
REVIEW
Paula Braz, Ausenda Machado, Carlos Matias Dias
The term prenatal diagnosis comprises a variety of techniques aimed to determine the health and condition of the embryo or foetus. Its main goal is to identify at an early stage of the pregnancy, if possible, malformations or other conditions that could increase the risk of a negative outcome in the pregnancy. The aim of this study was to assess the impact of prenatal diagnosis in Portugal in pregnancies with congenital anomalies. A cross sectional study was implemented using data for the years 1997-2016 from the Portuguese registry of congenital anomalies (RENAC), a population-based registry that follows EUROCAT guidelines...
June 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29908340/ureterolysis-for-laparoscopic-hysterectomy
#8
Haider Jan, Vishalli Ghai
STUDY OBJECTIVE: To demonstrate techniques of ureterolysis during complex laparoscopic hysterectomy. DESIGN: Technical video demonstrating different approaches to ureterolysis for complex benign pathology during laparoscopic hysterectomy. (Canadian Task force classification level III) SETTING: Benign gynaecology department at a University Hospital. INTERVENTION: We perform ureterolysis during laparoscopic hysterectomy for benign pathology...
June 13, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29908335/platelet-derived-growth-factor-coated-decellularized-meniscus-scaffold-for-integrative-healing-of-meniscus-tears
#9
Kwang Il Lee, Merissa Olmer, Jihye Baek, Darryl D D'Lima, Martin K Lotz
The aim of this study was to examine the potential of platelet-derived growth factor (PDGF)-coated decellularized meniscus scaffold in mediating integrative healing of meniscus tears by inducing endogenous cell migration. Fresh bovine meniscus was chemically decellularized and covalently conjugated with heparin and PDGF-BB. In vitro PDGF release kinetics was measured. The scaffold was transplanted into experimental tears in avascular bovine meniscus explants and cultured for 2 and 4 weeks. The number migrating and proliferating cells at the borderline between the scaffold and injured explant and PDGF receptor-β (PDGFR β) expressing cells were counted...
June 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29908329/the-incidence-of-vocal-fold-motion-impairment-after-primary-thyroid-and-parathyroid-surgery-for-a-single-high-volume-academic-surgeon-determined-by-pre-and-immediate-post-operative-fiberoptic-laryngoscopy
#10
Vaninder K Dhillon, Eleni Rettig, Salem I Noureldine, Dane J Genther, Ahmed Hassoon, Mai G Al Khadem, Ozan B Ozgursoy, Ralph P Tufano, Charles W Cummings
BACKGROUND: Vocal fold motion impairment (VFMI) is a well-recognized complication of thyroid and parathyroid surgery. Preoperative counseling requires a thorough understanding of the incidence, risk factors, and value of early diagnosis of postoperative VFMI. Our objective is to describe the incidence of and risk factors for VFMI for a single high-volume academic surgeon, and to assess the utility of immediate postoperative fiberoptic laryngoscopy (FOL) in early diagnosis of VFMI. METHODS: Retrospective cohort study of patients undergoing primary thyroid and parathyroid procedures by a single high-volume surgeon at an academic tertiary care center...
June 13, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29908285/evaluating-the-effect-of-multiple-genetic-risk-score-models-on-colorectal-cancer-risk-prediction
#11
Junyi Xin, Haiyan Chu, Shuai Ben, Yuqiu Ge, Wei Shao, Yang Zhao, Yongyue Wei, Gaoxiang Ma, Shuwei Li, Dongying Gu, Zhengdong Zhang, Mulong Du, Meilin Wang
Currently, genetic risk score (GRS) model has been a widely used method to evaluate the genetic effect of cancer risk prediction, but seldom studies investigated their discriminatory power, especially for colorectal cancer (CRC) risk prediction. In this study, we applied both simulation and real data to comprehensively compare the discriminability of different GRS models. The GRS models were fitted by logistic regression with three scenarios, including simple count GRS (SC-GRS), logistic regression weighted GRS (LR-GRS, including DL-GRS and OR-GRS) and explained variance weighted GRS (EV-GRS, including EV_DL-GRS and EV_OR-GRS) models...
June 13, 2018: Gene
https://www.readbyqxmd.com/read/29908251/management-and-outcomes-of-staphylococcus-aureus-bacteraemia-at-a-south-african-referral-hospital-a-prospective-observational-study
#12
Nicola Steinhaus, Mohammed Al-Talib, Prudence Ive, Tom Boyles, Colleen Bamford, Mary-Ann Davies, Marc Mendelson, Sean Wasserman
OBJECTIVES: Limited evidence exists on the management and outcomes of Staphylococcus aureus bacteraemia (SAB) in resource-limited settings. The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death. METHOD: A prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB. RESULTS: One hundred SAB infection episodes occurring in 98 patients were included...
June 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29908230/additional-cytogenetic-abnormalities-with-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-on-allogeneic-stem-cell-transplantation-in-the-tyrosine-kinase-inhibitor-era
#13
Yu Akahoshi, Shuichi Mizuta, Hiroaki Shimizu, Naoyuki Uchida, Takahiro Fukuda, Heiwa Kanamori, Makoto Onizuka, Yukiyasu Ozawa, Kazuteru Ohashi, Shuichi Ohta, Tetsuya Eto, Junji Tanaka, Yoshiko Atsuta, Shinichi Kako
Cytogenetic abnormalities are well-known and powerful independent prognostic factor for various hematological disorders. Although the combination of chemotherapy with tyrosine kinase inhibitor (TKI) is now considered the standard of care in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia, little is known about the impact of additional cytogenetic abnormalities (ACAs). Therefore, we retrospectively evaluated 1375 adult patients who underwent their first allogeneic hematopoietic stem cell transplantation in the TKI era...
June 13, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29908137/personality-high-risk-behaviors-and-elevated-risk-of-unintentional-deaths-related-to-drug-poisoning-among-individuals-with-spinal-cord-injury
#14
James S Krause, Yue Cao, Nicole D DiPiro, Emma Cuddy
OBJECTIVE: To identify risk and protective factors for unintentional death related to drug poisoning from prescription medications, including opioid-related deaths, and death due to all other causes among participants with spinal cord injury (SCI). DESIGN: Prospective cohort study. SETTING: Large specialty hospital in the Southeastern United States. PARTICIPANTS: Two cohorts of SCI participants, totaling 3070 adults (>18 years old) with chronic (>1 year) traumatic SCI...
June 13, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29908131/low-body-mass-index-is-a-risk-factor-for-hyperkalaemia-associated-with-angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-treatments
#15
T Hirai, R Yamaga, A Fujita, T Itoh
WHAT IS KNOWN AND OBJECTIVE: Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) represent the cornerstones of hypertension and congestive heart failure treatment. Risk factors for hyperkalaemia associated with ACEI and ARB are chronic kidney disease and concomitant medications which increase serum potassium level. Body mass index (BMI) also affects pharmacokinetics of ACEI and ARB and potassium disposition. We evaluated the relationship between BMI and hyperkalaemia associated with ACEI and ARB treatments...
June 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29908076/diabetes-associated-with-immune-checkpoint-inhibition-presentation-and-management-challenges
#16
A Galligan, W Xu, S Fourlanos, A Nankervis, C Chiang, A M Mant, P Parente, D Rischin, B Krishnamurthy, S Sandhu, P G Colman
BACKGROUND: In recent years, immune checkpoint blockade has become a standard therapy for a wide range of cancers. Adverse events including endocrinopathies result from the induction of autoimmunity. CASE REPORT: We report a case series of nine individuals who presented with immunotherapy-induced type 1 diabetes between 2015-2017. DISCUSSION: Onset of diabetes occurred within 12 weeks of commencing therapy. Anti- GAD antibodies were present in six people...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29908070/prediabetes-and-diabetes-are-both-risk-factors-for-adverse-outcomes-in-infective-endocarditis
#17
X-B Wei, Y-H Liu, J-L Huang, X-L Chen, D-Q Yu, N Tan, J-Y Chen, P-C He
AIM: Diabetes is a risk factor in infective endocarditis. However, few studies have focused on the prognostic value of prediabetes in infective endocarditis. This analysis aimed to explore the relationship between prediabetes and outcomes for people with infective endocarditis. METHODS: Diabetes and prediabetes definitions were based on the American Diabetes Association 2014 criteria. A total of 866 people who had been consecutively diagnosed with infective endocarditis between January 2009 and July 2015 were included in the analysis...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29908068/macrophages-in-patients-with-recurrent-endometrial-polyps-could-exacerbate-th17-responses
#18
Yali Zhu, Zhihong Liu, Miaomiao Du, Lisha Yi, Guifang Gong, Xiang Tang
Endometrial polyps (EPs) are outgrowths in the endometrium with unknown etiology. The fact that EPs can often recur after surgical removal suggests that EPs are not induced by random events but by continuous or recurrent processes in the patients. We previously demonstrated that the risk of EP development was positively associated with overactive Th17 responses. However, the requirements of Th17 upregulation are yet unclear. Here, we recruited twenty-six females with symptomatic EP and twenty-four females without EP, and peripheral mononuclear cells were harvested for the examination of circulating immunity...
June 16, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29908036/acquired-von-willebrand-syndrome-in-congenital-heart-disease-surgery-results-from-an-observational-case-series
#19
Vanya Icheva, Martina Nowak-Machen, Ulrich Budde, Karl Jaschonek, Felix Neunhoeffer, Matthias Kumpf, Michael Hofbeck, Christian Schlensak, Gesa Wiegand
BACKGROUND: Cardiac surgery of the newborn and infant with complex congenital heart disease (CHD) is associated with a high rate of intraoperative bleeding complications. CHD-related anatomic features such as valve stenoses or patent arterial ducts can lead to enhanced shear stress in blood stream and thus cause acquired von Willebrand syndrome (aVWS). OBJECTIVE: To evaluate the intraoperative incidence and impact of aVWS after cardiopulmonary bypass (CPB) in neonates and infants with complex CHD...
June 16, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29908021/burnout-among-primary-school-teachers-in-iraq-prevalence-and-risk-factors
#20
Jasim Al-Asadi, Shukrya Khalaf, Aqeel Al-Waaly, Alaa Abed, Sabah Shami
Background: Studies from various parts of the world have shown that teachers are likely to suffer from burnout. So far, there has been no research on burnout among primary school teachers in Basrah, Iraq. Aim: We aimed to determine the prevalence and predisposing factors of self-reported burnout among primary school teachers in Basrah. Methods: This was a cross-sectional study in 32 governmental primary schools during November 2014-February 2015...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
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