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https://www.readbyqxmd.com/read/28734192/trajectories-of-risk-behaviors-across-adolescence-and-young-adulthood-the-role-of-race-and-ethnicity
#1
Eunhee Park, Thomas P McCoy, Jennifer Toller Erausquin, Robin Bartlett
INTRODUCTION: Despite important advances of longitudinal research in substance use behaviors, most studies stratify analyses by gender or race, which limits the ability to directly compare the likelihood of a particular developmental pathway across demographic groups. Thus, there is critical need for well-designed research to examine the associations of race/ethnicity with developmental trajectories of substance use behaviors across adolescence through adulthood. METHODS: Using an accelerated longitudinal design, we examined behaviors across ages 12-31 from Waves I-IV of the National Longitudinal Study of Adolescent to Adult Health...
July 15, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734154/reducing-alcohol-consumption-to-minimize-weight-gain-and-facilitate-smoking-cessation-among-military-beneficiaries
#2
Mark B Sobell, Alan L Peterson, Linda Carter Sobell, Antoinette Brundige, Christopher M Hunter, Christine M Hunter, Jeffrey L Goodie, Sangeeta Agrawal, Ann S Hrysko-Mullen, William C Isler
INTRODUCTION: Smoking cessation-related weight gain can have significant negative health and career consequences for military personnel. Alcohol reduction combined with smoking cessation may decrease weight gain and relapse. METHOD: A randomized clinical trial of military beneficiaries compared a standard smoking cessation (i.e., brief informational) intervention (N=159), with a brief motivational smoking cessation intervention that emphasized reduced drinking to lessen caloric intake and minimize weight gain (N=158)...
June 30, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734152/trajectories-of-alcohol-use-in-the-uk-military-and-associations-with-mental-health
#3
L Goodwin, S Norton, N T Fear, M Jones, L Hull, S Wessely, R J Rona
INTRODUCTION: There are higher levels of alcohol misuse in the military compared to the general population. Yet there is a dearth of research in military populations on the longitudinal patterns of alcohol use. This study aims to identify group trajectories of alcohol consumption in the UK military and to identify associations with childhood adversity, deployment history and mental disorder. METHODS: Data on weekly alcohol consumption across an eight year period and three phases of a UK military cohort study (n=667) were examined using growth mixture modelling...
July 12, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28732374/the-protective-effect-of-pft%C3%AE-on-alcohol-induced-osteonecrosis-of-the-femoral-head
#4
Yi-Xuan Chen, Dao-Yu Zhu, Jun-Hui Yin, Wen-Jing Yin, Yue-Lei Zhang, Hao Ding, Xiao-Wei Yu, Jiong Mei, You-Shui Gao, Chang-Qing Zhang
Epidemiologic studies have shown alcohol plays a pivotal role in the development of osteonecrosis of the femoral head (ONFH). The aim of this study was to explore the underlying mechanism of alcohol-induced ONFH and the protective effect of pifithrin-α (PFTα). In vitro, we found ethanol treatment significantly activated p53, suppressed Wnt/β-catenin signaling and inhibited osteogenic-related proteins. Furthermore, by separating the cytoplasmic and nuclear proteins, we found ethanol inhibited osteogenesis by impairing the accumulation of β-catenin in both the cytoplasm and nucleus in human bone mesenchymal stem cells (hBMSCs), which resulted from activating glycogen synthase kinase-3β (GSK-3β)...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732370/silibinin-an-old-drug-for-hematological-disorders
#5
REVIEW
Hai Zou, Xing-Xing Zhu, Guo-Bing Zhang, Yuan Ma, Yi Wu, Dong-Sheng Huang
Silibinin (silybin), a non-toxic natural polyphenolic flavonoid, is the principal and the most biologically active component of silymarin. It is efficient in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol, hepatitis, and gall bladder disorders. Further, in our previous studies, we explored the anti-cancer efficacy in common cancers, such as lung, prostatic, colon, breast, bladder, as well as, hepatocellular carcinoma. Interestingly, silibinin is still not solely limited to the treatment of these diseases...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732348/alcohol-consumption-and-gastric-cancer-risk-a-meta-analysis-of-prospective-cohort-studies
#6
Xue Han, Li Xiao, Yao Yu, Yu Chen, Hai-Hua Shu
We performed this meta-analysis to explore the precise quantification relationship between alcohol consumption and gastric cancer and to provide evidence for preventing gastric cancer. We searched PubMed, Embase, and Web of Science for articles published up to December 2016, and identified 23 cohort studies that included a total population of 5,886,792 subjects. We derived meta-analytic estimates using random-effects models, taking into account correlations between estimates. We also investigated the dose-response relationship between gastric cancer risk and alcohol consumption...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732319/did-the-dependent-coverage-expansion-increase-risky-substance-use-among-young-adults
#7
Joshua Breslau, Hao Yu, Bing Han, Rosalie L Pacula, Rachel M Burns, Bradley D Stein
BACKGROUND: The dependent coverage expansion (DCE) enacted through the Affordable Care Act increased health insurance coverage among young adults. Increasing insurance coverage in this age group has the potential for unintended consequences on risky substance use. METHODS: Repeated cross-sectional surveys were used to compare change in substance use during the period the DCE was implemented in the 19-25year old target age group (Pre-DCE n=15,772, Post-DCE n=22,719) with contemporaneous change in a slightly older age group that was not targeted by the policy (Pre-DCE=19,851, Post-DCE n=28,157)...
July 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28732317/cross-lagged-relations-between-motives-and-substance-use-can-use-strengthen-your-motivation-over-time
#8
Christine A Lee, Karen J Derefinko, Heather A Davis, Richard Milich, Donald R Lynam
Motives for substance use have garnered considerable attention due to the strong predictive utility of this construct, both in terms of use and problems associated with use. The current study examined the cross-lagged relations between alcohol use and motives, and marijuana use and motives over three yearly assessment periods in a large sample (N=526, 48% male) of college students. The relations between substance use and motives were assessed at each time point, allowing for the examination of these inter-relations over time...
June 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28732307/a-multisite-audit-to-assess-how-women-with-complex-social-factors-access-and-engage-with-maternity-services
#9
Hannah Rayment-Jones, Eleanor Butler, Chelsie Miller, Christine Nay, Jennifer O'Dowd
OBJECTIVE: to audit women with socially complex lives' documented access to and engagement with antenatal care provided by three inner city, UK maternity services in relation to birth and neonatal outcomes, and referral processes. BACKGROUND: women living socially complex lives, including young mothers, recently arrived immigrants, non-English speaking, and those experiencing domestic violence, poor mental health, drug and alcohol abuse, and poverty experience high rates of morbidity, mortality and poor birth outcomes...
June 27, 2017: Midwifery
https://www.readbyqxmd.com/read/28732265/chronic-work-stress-and-decreased-vagal-tone-impairs-decision-making-and-reaction-time-in-jockeys
#10
Kathleen Landolt, Paul Maruff, Ben Horan, Michael Kingsley, Glynda Kinsella, Paul D O'Halloran, Matthew W Hale, Bradley J Wright
The inverse relationship between acute stress and decision-making is well documented, but few studies have investigated the impact of chronic stress. Jockeys work exhaustive schedules and have extremely dangerous occupations, with safe performance requiring quick reaction time and accurate decision-making. We used the effort reward imbalance (ERI) occupational stress model to assess the relationship of work stress with indices of stress physiology and decision-making and reaction time. Jockeys (N=32) completed computerised cognitive tasks (Cogstate) on two occasions; September and November (naturally occurring lower and higher stress periods), either side of an acute stress test...
July 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28732229/a-novel-approach-to-fabricate-dye-encapsulated-polymeric-micro-and-nanoparticles-by-thin-film-dewetting-technique
#11
Manosree Chatterjee, Abhiram Hens, Kuldeep Mahato, Namita Jaiswal, Nivedita Mahato, Nagahanumaiah, Nripen Chanda
A new method is reported for fabrication of polymeric micro- and nanoparticles from an intermediate patterned surface originated by dewetting of a polymeric thin film. Poly (d, l-lactide-co-glycolide) or PLGA, a biocompatible polymer is used to develop a thin film over a clean glass substrate which dewets spontaneously in the micro-/nano-patterned surface of size range 50nm to 3.5µm. Since another water-soluble polymer, poly vinyl alcohol (PVA) is coated on the same glass substrate before PLGA thin film formation, developed micro-/nano-patterns are easily extracted in water in the form of micro- and nanoparticle mixture of size range 50nm to 3...
July 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28732032/individual-and-area-level-characteristics-associated-with-alcohol-related-mortality-among-adult-lithuanian-males-a-multilevel-analysis-based-on-census-linked-data
#12
Pavel Grigoriev, Domantas Jasilionis, Daumantas Stumbrys, Vladislava Stankūnienė, Vladimir M Shkolnikov
BACKGROUND: Although excessive alcohol-related mortality in the post-Soviet countries remains the major public health threat, determinants of this phenomenon are still poorly understood. AIMS: We assess simultaneously individual- and area-level factors associated with an elevated risk of alcohol-related mortality among Lithuanian males aged 30-64. METHODS: Our analysis is based on a census-linked dataset containing information on individual- and area-level characteristics and death events which occurred between March 1st, 2011 and December 31st, 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28731995/-update-on-chronic-pancreatitis-review-article
#13
Frank Czul, Emmanuel Coronel, Jean A Donet
Chronic pancreatitis is a progressive fibro-inflammatory disease of the pancreas characterized by irreversible fibrosis of the gland with eventual failure of exocrine and endocrine functions and hallmark features of abdominal pain, malabsorption, malnutrition, diabetes mellitus and pancreatic calcifications. In many patients this disease results from a complex mix of environmental (eg, alcohol, cigarettes, and occupational chemicals), genetic factors and a few patients with hereditary or autoimmune disease...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28731984/the-association-of-cigarette-smoking-with-high-frequency-heart-rate-variability-an-ecological-momentary-assessment-study
#14
Fernando Bodin, Kathleen M McIntyre, Joseph E Schwartz, Paula S McKinley, Caitlyn Cardetti, Peter A Shapiro, Ethan Gorenstein, Richard P Sloan
OBJECTIVE: Evidence from both laboratory and observational studies suggests that acute and chronic smoking leads to reduced high frequency heart rate variability (HF-HRV), a measure of cardiac vagal regulation. We utilized ecological momentary assessment (EMA) to study the effect of smoking on concurrent HF-HRV in a trial measuring the effects of hostility reduction, and compared 24-hour HF-HRV in smokers and non-smokers. METHOD: Ambulatory ECG data were collected pre-randomization from 149 healthy, individuals with high hostility levels (20-45 years, BMI ≤ 32 kg/m) and paired with concurrent EMA ratings of smoking, and physical position during waking hours...
July 20, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28731961/joint-effect-of-alcohol-consumption-and-educational-level-on-alcohol-related-medical-events-a-danish-register-based-cohort-study
#15
Helene Nordahl Christensen, Finn Diderichsen, Ulla Arthur Hvidtfeldt, Theis Lange, Per Kragh Andersen, Merete Osler, Eva Prescott, Anne Tjønneland, Naja Hulvej Rod, Ingelise Andersen
BACKGROUND: Alcohol-related mortality is more pronounced in lower than higher socioeconomic groups in Western countries. Part of the explanation is differences in drinking patterns. However, differences in vulnerability to health consequences of alcohol consumption across socioeconomic groups may also play a role. We investigated the joint effect of alcohol consumption and educational level on the rate of alcohol-related medical events. METHODS: We pooled seven prospective cohorts from Denmark that enrolled 74 278 men and women aged 30-70 years (study period 1981 to 2009)...
July 19, 2017: Epidemiology
https://www.readbyqxmd.com/read/28731877/simple-preoperative-ink-test-as-a-novel-adjunct-to-intrastromal-keratopigmentation-for-post-laser-peripheral-iridotomy-dysphotopsias
#16
Stephan Ong Tone, Daniel Q Li, Zach Ashkenazy, Armand Borovik, Allan R Slomovic, David S Rootman, Clara C Chan
PURPOSE: To describe a simple preoperative ink test as a novel adjunct to intrastromal keratopigmentation for post-laser peripheral iridotomy (LPI) dysphotopsias. METHODS: A surgical marking pen is applied to the area over a peripheral iridotomy before intrastromal keratopigmentation. The patient can then assess whether there is any improvement in their symptoms of dysphotopsias. Manual intrastromal keratopigmentation can then be performed using a crescent blade into the clear cornea at 50% depth and tunneled centrally to create a pocket ensuring that the peripheral iridotomy is fully occluded...
July 19, 2017: Cornea
https://www.readbyqxmd.com/read/28731863/screening-adolescents-for-alcohol-use-tracking-practice-trends-of-massachusetts-pediatricians
#17
Sharon Levy, Rosemary E Ziemnik, Sion K Harris, Lily Rabinow, Louise Breen, Christina Fluet, Heather Strother, John H Straus
OBJECTIVES: Substance use screening is a recommended component of routine healthcare for adolescents. A 2008 survey of Massachusetts primary care physicians found high rates of screening, but low rates of validated tool use, leading to the concern that physicians may be missing substance use-related problems and disorders. In an effort to improve practice, a cross-disciplinary group developed and distributed an adolescent screening, brief intervention, and referral to treatment toolkit in 2009...
July 20, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28731621/metabolic-engineering-for-advanced-biofuels-production-and-recent-advances-towards-commercialization
#18
Corey W Meadows, Aram Kang, Taek Soon Lee
Research on renewable biofuels produced by microorganisms has enjoyed considerable advances in academic and industrial settings. As the renewable ethanol market approaches maturity, the demand is rising for the commercialization of more energy-dense fuel targets. Many strategies implemented in recent years have considerably increased the diversity and number of fuel targets that can be produced by microorganisms. Moreover, strain optimization for some of these fuel targets has ultimately led to their production at industrial scale...
July 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28731573/effect-of-alcohol-dehydrogenase-1b-and-7-polymorphisms-on-blood-ethanol-and-acetaldehyde-concentrations-in-healthy-subjects-with-a-history-of-moderate-alcohol-consumption
#19
Roberta Pastorino, Luigi Iuliano, Alessia Vecchioni, Dario Arzani, Mirta Milic, Francesca Annunziata, Chiara Zerbinati, Ettore Capoluongo, Stefano Bonassi, James D McKay, Stefania Boccia
AIMS: To evaluate the effect of ADH1B and ADH7 genotypes on blood acetaldehyde and ethanol levels after alcohol ingestion, and to measure the genotoxic effect of smoking and ethanol on the buccal cells, also controlling for ADH variants. METHODS: We recruited healthy Italian subjects with at least a moderate history of alcohol consumption. All subjects were given an alcoholic drink of 0.4 g ethanol /kg of body weight. Blood venous samples were collected at baseline, and 30, 60, 90 and 120 minutes after ingestion...
July 21, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28731564/alcohol-related-knowledge-and-alcohol-related-norms-in-four-to-six-year-olds-evidence-from-the-dutch-electronic-appropriate-beverage-task
#20
Carmen Voogt, Roy Otten, Marloes Kleinjan, Rutger Engels, Emmanuel Kuntsche
BACKGROUND: Limited research is available on children's alcohol-related knowledge and alcohol-related norms, yet a better comprehension of these factors may be crucial in explaining alcohol use later in life. This study provides insights into alcohol-related knowledge and alcohol-related norms in four- to six-year-olds. METHODS: Participating children (N=329; 48.9% boys) were shown, on a tablet, 18 drawings depicting 72 male and female adults and/or children in various situations and were asked to indicate what the depicted persons drank by touching one of 12 depicted beverages (four alcoholic; eight non-alcoholic)...
July 21, 2017: Alcoholism, Clinical and Experimental Research
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