Daniel R Calabrese, Tasha Tsao, Mélia Magnen, Colin Valet, Ying Gao, Beñat Mallavia, Jennifer J Tian, Emily A Aminian, Kristin M Wang, Avishai Shemesh, Elman B Punzalan, Aartik Sarma, Carolyn S Calfee, Stephanie A Christenson, Charles R Langelier, Steven R Hays, Jeff A Golden, Lorriana E Leard, Mary E Kleinhenz, Nicholas A Kolaitis, Rupal J Shah, Aida Venado, Lewis L Lanier, John R Greenland, David M Sayah, Abbas Ardehali, Jasleen Kukreja, S Sam Weigt, John A Belperio, Jonathan P Singer, Mark R Looney
Clinical outcomes after lung transplantation, a life-saving therapy for patients with end-stage lung diseases, are limited by primary graft dysfunction (PGD). PGD is an early form of acute lung injury with no specific pharmacologic therapies. Here, we present a large multicenter study of plasma and bronchoalveolar lavage (BAL) samples collected on the first post-transplant day, a critical time for investigations of immune pathways related to PGD. We demonstrated that ligands for NKG2D receptors were increased in the BAL from participants who developed severe PGD and were associated with increased time to extubation, prolonged intensive care unit length of stay, and poor peak lung function...
November 8, 2022: JCI Insight