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Marcelo Rosandiski Lyra, Sonia Regina Lambert Passos, Maria Inês Fernandes Pimentel, Sandro Javier Bedoya-Pacheco, Cláudia Maria Valete-Rosalino, Erica Camargo Ferreira Vasconcellos, Liliane Fatima Antonio, Mauricio Naoto Saheki, Mariza Mattos Salgueiro, Ginelza Peres Lima Santos, Madelon Noato Ribeiro, Fatima Conceição-Silva, Maria Fatima Madeira, Jorge Luiz Nunes Silva, Aline Fagundes, Armando Oliveria Schubach
American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are the first choice drugs for cutaneous leishmaniasis (CL), although doses are controversial. In a clinical trial for CL we investigated the occurrence of pancreatic toxicity with different schedules of treatment with meglumine antimoniate (MA). Seventy-two patients were allocated in two different therapeutic groups: 20 or 5 mg of pentavalent antimony (Sb5+)/kg/day for 20 or 30 days, respectively...
2016: Revista do Instituto de Medicina Tropical de São Paulo
Maxime Valet, Gaëtan Stoquart, Yumiko Glibert, Jean-Claude Hakizimana, Thierry Lejeune
OBJECTIVE: Fatigue is the most common and disabling symptom among patients suffering from multiple sclerosis (MS). From the initial stages of the disease, a physical deconditioning is also observed among these patients. The aim of this study is to assess the cardiorespiratory endurance (i.e. exercise tolerance functions) and self-reported fatigue, as well as their associations, among patients suffering from MS with mild disability (expanded disability status scale≤4). MATERIALS/PATIENTS AND METHODS: 21 patients with MS (15 women; age: 26-64 years, median 46 years; duration of disease: 0...
September 2016: Annals of Physical and Rehabilitation Medicine
Fernanda N Morgado, Armando O Schubach, Maria Inês Pimentel, Marcelo R Lyra, Érica C F Vasconcellos, Claudia M Valete-Rosalino, Fátima Conceição-Silva
Fungus of the Sporothrix schenckii complex can produce skin lesions in humans, commonly lymphocutaneous (LC) and fixed (F) forms of sporotrichosis. Some authors have suggested that clinical forms are influenced by differences in virulence and genetic profile of isolates. But little is known about the role of immune response in determining the clinical outcome of sporotrichosis. To verify the profile of systemic and in situ IFN-γ and IL-10 expression in sporotrichosis patients, and consequently to detect any difference between the two compartments and/or clinical presentation, we quantified the number of IFN-γ and IL-10 producer peripheral blood mononuclear cells stimulated with S...
2016: PloS One
Anne Drougard, Audren Fournel, Alysson Marlin, Etienne Meunier, Anne Abot, Tereza Bautzova, Thibaut Duparc, Katie Louche, Aurelie Batut, Alexandre Lucas, Sophie Le-Gonidec, Jean Lesage, Xavier Fioramonti, Cedric Moro, Philippe Valet, Patrice D Cani, Claude Knauf
Apelin is a bioactive peptide involved in the control of energy metabolism. In the hypothalamus, chronic exposure to high levels of apelin is associated with an increase in hepatic glucose production, and then contributes to the onset of type 2 diabetes. However, the molecular mechanisms behind deleterious effects of chronic apelin in the brain and consequences on energy expenditure and thermogenesis are currently unknown. We aimed to evaluate the effects of chronic intracerebroventricular (icv) infusion of apelin in normal mice on hypothalamic inflammatory gene expression, energy expenditure, thermogenesis and brown adipose tissue functions...
2016: Scientific Reports
Victor Laurent, Adrien Guérard, Aurélie Toulet, Philippe Valet, Bernard Malavaud, Catherine Muller
No abstract text is available yet for this article.
June 2016: Médecine Sciences: M/S
Céline Pomié, Vincent Blasco-Baque, Pascale Klopp, Simon Nicolas, Aurélie Waget, Pascale Loubières, Vincent Azalbert, Anthony Puel, Frédéric Lopez, Cédric Dray, Philippe Valet, Benjamin Lelouvier, Florence Servant, Michael Courtney, Jacques Amar, Rémy Burcelin, Lucile Garidou
OBJECTIVE: To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk. METHODS: We triggered the immune system with microbial extracts specifically from the intestinal ileum contents of HFD-diabetic mice by the process of immunization. 35 days later, immunized mice were fed a HFD for up to two months in order to challenge the development of metabolic features. The immune responses were quantified...
June 2016: Molecular Metabolism
Nassim Dali-Youcef, Karim Hnia, Sébastien Blaise, Nadia Messaddeq, Stéphane Blanc, Catherine Postic, Philippe Valet, Catherine Tomasetto, Marie-Christine Rio
No abstract text is available yet for this article.
2016: Scientific Reports
Ikrame Lazar, Emily Clement, Stéphanie Dauvillier, Delphine Milhas, Manuelle Ducoux-Petit, Sophie LeGonidec, Cédric Moro, Vanessa Soldan, Stéphane Dalle, Stéphanie Balor, Muriel Golzio, Odile Burlet-Schiltz, Philippe Valet, Catherine Muller, Laurence Nieto
Malignant progression results from a dynamic cross-talk between stromal and cancer cells. Recent evidence suggests that this cross-talk is mediated to a significant extent by exosomes, nanovesicles secreted by most cell types and which allow the transfer of proteins, lipids, and nucleic acids between cells. Adipocytes are a major component of several tumor microenvironments, including that of invasive melanoma, where cells have migrated to the adipocyte-rich hypodermic layer of the skin. We show that adipocytes secrete exosomes in abundance, which are then taken up by tumor cells, leading to increased migration and invasion...
July 15, 2016: Cancer Research
Maëlle Lempereur, Claire Majewska, Amandine Brunquers, Sumalee Wongpramud, Bénédicte Valet, Philippe Janssens, Monique Dillemans, Laurence Van Nedervelde, Dominique Gallo
Tetrahydro-iso-alpha acids commonly called THIAA or Tetra are modified hop acids extracted from hop (Humulus lupulus L.) which are frequently used in brewing industry mainly in order to provide beer bitterness and foam stability. Interestingly, molecular structure of tetrahydro-iso-alpha acids is close to a new type of estrogen receptor alpha (ERα) antagonists aimed at disrupting the binding of coactivators containing an LxxLL motif (NR-box). In this work we show that THIAA decreases estradiol-stimulated proliferation of MCF-7 (ERα-positive breast cancer cells)...
2016: International Journal of Endocrinology
Sebastian Valet, Bernhard Weisse, Beatrice Fischer, Dominik C Meyer
PURPOSE: To determine conditions for the safe use of radiofrequency (RF) tissue ablation probes that avoid damaging suture material. METHODS: Four sutures made of 3 different materials commonly used in arthroscopic procedures were analyzed in a saline bath related to effects of RF-produced heat by proximity, duration, and intensity settings measuring burn-through time and ultimate load to failure. The parameters tested were electrode-to-suture distance, power setting, and the presence of tendon tissue or metallic anchor eyelets...
May 12, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Aude Dupuy, Pauline Le Faouder, Claire Vigor, Camille Oger, Jean-Marie Galano, Cédric Dray, Jetty Chung-Yung Lee, Philippe Valet, Cécile Gladine, Thierry Durand, Justine Bertrand-Michel
Isoprostanoids are a group of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids. It belongs to oxylipins group, which are important lipid mediators in biological processes, such as tissue repair, blood clotting, blood vessel permeability, inflammation and immunity regulation. Recently, isoprostanoids from eicosapentaenoic, docosahexaenoic, adrenic and α-linolenic namely F3-isoprostanes, F4-neuroprostanes, F2-dihomo-isoprostanes and F1-phytoprostanes, respectively have attracted attention because of their putative contribution to health...
May 19, 2016: Analytica Chimica Acta
Nassim Dali-Youcef, Karim Hnia, Sébastien Blaise, Nadia Messaddeq, Stéphane Blanc, Catherine Postic, Philippe Valet, Catherine Tomasetto, Marie-Christine Rio
MMP11 overexpression is a bad prognostic factor in various human carcinomas. Interestingly, this proteinase is not expressed in malignant cells themselves but is secreted by adjacent non-malignant mesenchymal/stromal cells, such as cancer associated fibroblasts (CAFs) and adipocytes (CAAs), which favors cancer cell survival and progression. As MMP11 negatively regulates adipogenesis in vitro, we hypothesized that it may play a role in whole body metabolism and energy homeostasis. We used an in vivo gain- (Mmp11-Tg mice) and loss- (Mmp11-/- mice) of-function approach to address the systemic function of MMP11...
2016: Scientific Reports
João Gustavo Corrêa Reis, Clarissa Souza Mota Reis, Daniel César Silva da Costa, Márcia Mendonça Lucena, Armando de Oliveira Schubach, Raquel de Vasconcellos Carvalhaes Oliveira, Valéria Cavalcanti Rolla, Fátima Conceição-Silva, Cláudia Maria Valete-Rosalino
INTRODUCTION: Laryngeal tuberculosis (LTB) is the most frequent granulomatous disease of the larynx and represents less than 2% of extrapulmonary TB cases. There are no pathognomonic clinical and endoscopic features of this disease and studies on LTB that can assist in its diagnostic characterization are lacking. OBJECTIVE: To identify factors associated with clinical and topographical features of LTB. METHOD: a retrospective cross-sectional study was conducted from the medical records of 36 patients with confirmed LTB diagnosis...
2016: PloS One
Frederic Boal, Andrei Timotin, Jessica Roumegoux, Chiara Alfarano, Denis Calise, Rodica Anesia, Angelo Parini, Philippe Valet, Helene Tronchere, Oksana Kunduzova
BACKGROUND AND PURPOSE: Apelin-13, an endogenous ligand for the apelin (APJ) receptor, behaves as a potent modulator of metabolic and cardiovascular disorders. Here, we examined the effects of apelin-13 on myocardial injury in a mouse model combining ischaemia/reperfusion (I/R) and obesity and explored their underlying mechanisms. EXPERIMENTAL APPROACH: Adult male C57BL/6J mice were fed a normal diet (ND) or high-fat diet (HFD) for 6 months and then subjected to cardiac I/R...
June 2016: British Journal of Pharmacology
Dagna O Constenla
OBJECTIVE: A decision-analytic model was constructed to evaluate the economic impact of post-introduction pneumococcal conjugate vaccine (PCV) programs in Ecuador, Honduras, and Paraguay from the societal perspective. METHODS: Hypothetical birth cohorts were followed for a 20-year period in each country. Estimates of disease burden, vaccine effectiveness, and health care costs were derived from primary and secondary data sources. Costs were expressed in 2014 US$...
November 2015: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
Colin Valet, Sonia Severin, Gaëtan Chicanne, Pierre Alexandre Laurent, Frédérique Gaits-Iacovoni, Marie-Pierre Gratacap, Bernard Payrastre
Blood platelets play a pivotal role in haemostasis and are strongly involved in arterial thrombosis, a leading cause of death worldwide. Besides their critical role in pathophysiology, platelets represent a valuable model to investigate, both in vitro and in vivo, the biological roles of different branches of the phosphoinositide metabolism, which is highly active in platelets. While the phospholipase C (PLC) pathway has a crucial role in platelet activation, it is now well established that at least one class I phosphoinositide 3-kinase (PI3K) is also mandatory for proper platelet functions...
May 2016: Advances in Biological Regulation
Samira Alliouachene, Benoit Bilanges, Gaëtan Chicanne, Karen E Anderson, Wayne Pearce, Khaled Ali, Colin Valet, York Posor, Pei Ching Low, Claire Chaussade, Cheryl L Scudamore, Rachel S Salamon, Jonathan M Backer, Len Stephens, Phill T Hawkins, Bernard Payrastre, Bart Vanhaesebroeck
In contrast to the class I phosphoinositide 3-kinases (PI3Ks), the organismal roles of the kinase activity of the class II PI3Ks are less clear. Here, we report that class II PI3K-C2β kinase-dead mice are viable and healthy but display an unanticipated enhanced insulin sensitivity and glucose tolerance, as well as protection against high-fat-diet-induced liver steatosis. Despite having a broad tissue distribution, systemic PI3K-C2β inhibition selectively enhances insulin signaling only in metabolic tissues...
December 1, 2015: Cell Reports
Frédéric Adam, Abdel-Majid Khatib, Jose Javier Lopez, Camille Vatier, Sabrina Turpin, Adeline Muscat, Fabienne Soulet, Anne Aries, Isaac Jardin, Régis Bobe, Alain Stepanian, Dominique de Prost, Cédric Dray, Juan Antonio Rosado, Philippe Valet, Bruno Feve, Geraldine Siegfried
Apelin peptide and its receptor APJ are directly implicated in various physiological processes ranging from cardiovascular homeostasis to immune signaling. Here, we show that apelin is a key player in hemostasis with an ability to inhibit thrombin- and collagen-mediated platelet activation. Mice lacking apelin displayed a shorter bleeding time and a prothrombotic profile. Their platelets exhibited increased adhesion and a reduced occlusion time in venules, and displayed a higher aggregation rate after their activation by thrombin compared with wild-type platelets...
February 18, 2016: Blood
Audren Fournel, Anne Drougard, Thibaut Duparc, Alysson Marlin, Stuart M Brierley, Joel Castro, Sophie Le-Gonidec, Bernard Masri, André Colom, Alexandre Lucas, Perrine Rousset, Nicolas Cenac, Nathalie Vergnolle, Philippe Valet, Patrice D Cani, Claude Knauf
OBJECTIVE: The gut-brain axis is considered as a major regulatory checkpoint in the control of glucose homeostasis. The detection of nutrients and/or hormones in the duodenum informs the hypothalamus of the host's nutritional state. This process may occur via hypothalamic neurons modulating central release of nitric oxide (NO), which in turn controls glucose entry into tissues. The enteric nervous system (ENS) modulates intestinal contractions in response to various stimuli, but the importance of this interaction in the control of glucose homeostasis via the brain is unknown...
November 12, 2015: Gut
Frederic Boal, Jessica Roumegoux, Chiara Alfarano, Andrei Timotin, Denis Calise, Rodica Anesia, Anne Drougard, Claude Knauf, Christine Lagente, Jerome Roncalli, Franck Desmoulin, Helene Tronchere, Philippe Valet, Angelo Parini, Oksana Kunduzova
The increasing incidence of obesity accentuates the importance of identifying mechanisms and optimal therapeutic strategies for patients with heart failure (HF) in relation to obesity status. Here, we investigated the association between plasma level of apelin, an adipocyte-derived factor, and clinicopathological features of obese and non-obese patients with HF. We further explored potential regulatory mechanisms of cardiac cell fate responses in conditions combining myocardial injury and obesity. In a prospective, cross-sectional study involving patients with HF we show that obese patients (BMI ≥ 30 kg/m(2)) have higher left ventricular ejection fraction (LVEF) and greater levels of plasma apelin (p < 0...
2015: Scientific Reports
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