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https://www.readbyqxmd.com/read/28903944/a-dual-role-for-the-class-iii-pi3k-vps34-in-platelet-production-and-thrombus-growth
#1
Colin Valet, Marie Levade, Gaëtan Chicanne, Benoit Bilanges, Cendrine Cabou, Julien Viaud, Marie-Pierre Gratacap, Frédérique Gaits-Iacovoni, Bart Vanhaesebroeck, Bernard Payrastre, Sonia Severin
To uncover the role of Vps34, the sole class III phosphoinositide 3-kinase, in megakaryocytes (MKs) and platelets, we created a mouse model with Vps34 deletion in the MK/platelet lineage (Pf4-Cre/Vps34(lox/lox)). Deletion of Vps34 in MKs led to the loss of its regulator protein Vps15, and was associated with microthrombocytopenia and platelet granule abnormalities. While Vps34 deficiency did not impact on MK polyploidisation or proplatelet formation, it dampened MK granule biogenesis and directional migration towards an SDF1α gradient, leading to ectopic platelet release within the bone marrow...
September 13, 2017: Blood
https://www.readbyqxmd.com/read/28793868/clinical-and-laboratory-profiles-of-patients-with-early-spontaneous-healing-in-cutaneous-localized-leishmaniasis-a-historical-cohort-study
#2
Carla Oliveira-Ribeiro, Maria Inês Fernandes Pimentel, Raquel de Vasconcellos Carvalhaes Oliveira, Aline Fagundes, Maria de Fatima Madeira, Cintia Xavier Mello, Eliame Mouta-Confort, Claudia Maria Valete-Rosalino, Erica de Camargo Ferreira Vasconcellos, Marcelo Rosandiski Lyra, Leonardo Pereira Quintella, Liliane de Fatima Antonio, Armando Schubach, Fatima Conceição-Silva
BACKGROUND: Skin ulcers in American cutaneous leishmaniasis (ACL) may heal spontaneously after months/years. However, few cases may present quick heal even during diagnosis procedure (early spontaneous healing- ESH). The main objective of this study was to compare ESH patients with cases requiring specific treatment [non-ESH (NESH)]. METHODS: A historical cohort study of ACL patients (n = 445) were divided into 2 groups: ESH - spontaneously healed patients (n = 13; 2...
August 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28681996/apelin-administration-improves-insulin-sensitivity-in-overweight-men-during-an-hyperinsulinemic-euglycemic-clamp
#3
Pierre Gourdy, Laurent Cazals, Claire Thalamas, Agnès Sommet, Fabienne Calvas, Monique Galitzky, Claire Vinel, Cédric Dray, Hélène Hanaire, Isabelle Castan-Laurell, Philippe Valet
AIMS: Apelin is a recently identified adipokine known to improve glucose tolerance and insulin sensitivity in murine models. This study was dedicated to the proof of concept that apelin administration also enhances insulin sensitivity in humans. MATERIALS AND METHODS: Healthy overweight men were enrolled in this randomized, double-blind, placebo-controlled, cross-over study that successively considered the efficacy and the tolerance of two doses of (pyr1)-Apelin-13...
July 6, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28658030/fatigue-and-physical-fitness-of-mildly-disabled-persons-with-multiple-sclerosis-a-cross-sectional-study
#4
Maxime Valet, Thierry Lejeune, Yumiko Glibert, Jean C Hakizimana, Vincent Van Pesch, Souraya El Sankari, Christine Detrembleur, Gaëtan Stoquart
Fatigue is frequent and disabling in persons with multiple sclerosis (pwMS) with mild neurological disability. These patients also have impaired physical fitness. Whether mildly disabled pwMS are deconditioned, and this deconditioning is linked to fatigue, remains unknown. Our aim is to determine the physical fitness of mildly disabled patients with multiple sclerosis and study its relationship with perceived fatigue and to link perceived fatigue with other parameters. Twenty patients (14 women; mean age: 45...
June 27, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28646246/identification-of-particles-in-raw-materials
#5
Kathryn Lee, Markus Lankers, Oliver Valet
Raw materials need to be of a certain quality with respect to physical and chemical composition. They also need to have no contaminants in the form of particles because these could get into the product or indicate the raw materials are not pure enough to make a good quality product. When particles are found, it is important to identify their chemical and elemental composition to correct any process errors that can cause them and to have acceptable quality of the final product. Sources of materials can be the environment, process equipment and processing, and packaging...
June 23, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28614788/apelin-modulates-pathological-remodeling-of-lymphatic-endothelium-after-myocardial-infarction
#6
Florence Tatin, Edith Renaud-Gabardos, Anne-Claire Godet, Fransky Hantelys, Francoise Pujol, Florent Morfoisse, Denis Calise, Fanny Viars, Philippe Valet, Bernard Masri, Anne-Catherine Prats, Barbara Garmy-Susini
Lymphatic endothelium serves as a barrier to control fluid balance and immune cell trafficking to maintain tissue homeostasis. Long-term alteration of lymphatic vasculature promotes edema and fibrosis, which is an aggravating factor in the onset of cardiovascular diseases such as myocardial infarction. Apelin is a bioactive peptide that plays a central role in angiogenesis and cardiac contractility. Despite an established role of apelin in lymphangiogenesis, little is known about its function in the cardiac lymphatic endothelium...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28591261/sporotrichoid-leishmaniasis-a-cross-sectional-clinical-epidemiological-and-laboratory-study-in-rio-de-janeiro-state-brazil
#7
COMPARATIVE STUDY
Livia Martins Veloso de Carvalho, Maria Inês Fernandes Pimentel, Fátima Conceição-Silva, Érica de Camargo Ferreira E Vasconcellos, Cláudia Maria Valete-Rosalino, Marcelo Rosandiski Lyra, Mariza de Matos Salgueiro, Maurício Naoto Saheki, Maria de Fátima Madeira, Eliame Mouta-Confort, Liliane de Fátima Antonio, Aline Fagundes da Silva, Leonardo Pereira Quintella, Sandro Javier Bedoya-Pacheco, Armando de Oliveira Schubach
Background: Atypical presentations of cutaneous leishmaniasis include sporotrichoid leishmaniasis (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway. Aims: To assess the differences between patients with sporotrichoid leishmaniasis and typical cutaneous leishmaniasis (CL). Methods: From January 2004 to December 2010, 23 cases of SL (4.7%) were detected among 494 CL patients diagnosed at a reference center for the disease in Rio de Janeiro State, Brazil...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28583268/voice-disorders-in-residual-paracoccidioidomycosis-in-upper-airways-and-digestive-tract
#8
Ananda Dutra da Costa, Amanda Pereira Vargas, Marcia Mendonça Lucena, Ana Cristina Nunes Ruas, Fernanda da Silva Santos Braga, Mateus Pereira Bom-Braga, Frederico Pereira Bom-Braga, Antonio Carlos Francesconi do Valle, Ricardo Pereira Igreja, Cláudia Maria Valete-Rosalino
BACKGROUND: Paracoccidioidomycosis (PCM) is a systemic mycosis of acute and chronic evolution, caused by species belonging to the genus Paracoccidioides. It is considered the most prevalent systemic endemic mycosis in Latin America, with cases in the tropical and subtropical regions. Residual PCM refers to the fibrotic scar sequelae resulting from the disease treatment which, when associated with collagen accumulation, leads to functional and anatomic alterations in the organs. AIMS: The aim of this study was to evaluate the vocal function of patients with residual PCM in upper airways and digestive tract...
July 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28565895/quality-of-the-tools-used-to-assess-aerobic-capacity-in-persons-with-multiple-sclerosis-a-systematic-review
#9
Maxime Valet, Thierry Lejeune, Jean C Hakizimana, Gaëtan Stoquart
BACKGROUND: Assessments of physical fitness, including exercise tolerance functions, are valuable in persons with Multiple Sclerosis (MS). Many tools with widely varying advantages and disadvantages have been used to assess physical fitness in research and clinical practice. To date, there are no recommendations regarding the best tools to use for this purpose in persons with MS. AIM: This study aimed to systematically review the psychometric properties of the tools used to assess exercise tolerance functions in persons with MS and to propose recommendations regarding the best test to use...
May 31, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28558061/low-versus-high-dose-of-antimony-for-american-cutaneous-leishmaniasis-a-randomized-controlled-blind-non-inferiority-trial-in-rio-de-janeiro-brazil
#10
Mauricio Naoto Saheki, Marcelo Rosandiski Lyra, Sandro Javier Bedoya-Pacheco, Liliane de Fátima Antônio, Maria Inês Fernandes Pimentel, Mariza de Matos Salgueiro, Érica de Camargo Ferreira E Vasconcellos, Sonia Regina Lambert Passos, Ginelza Peres Lima Dos Santos, Madelon Novato Ribeiro, Aline Fagundes, Maria de Fátima Madeira, Eliame Mouta-Confort, Mauro Célio de Almeida Marzochi, Cláudia Maria Valete-Rosalino, Armando de Oliveira Schubach
BACKGROUND: Although high dose of antimony is the mainstay for treatment of American cutaneous leishmaniasis (ACL), ongoing major concerns remain over its toxicity. Whether or not low dose antimony regimens provide non-inferior effectiveness and lower toxicity has long been a question of dispute. METHODS: A single-blind, non-inferiority, randomized controlled trial was conducted comparing high dose with low dose of antimony in subjects with ACL treated at a referral center in Rio de Janeiro, an endemic area of Leishmania (Viannia) braziliensis transmission...
2017: PloS One
https://www.readbyqxmd.com/read/28398656/a-biomimetic-hydrogel-functionalized-with-adipose-ecm-components-as-a-microenvironment-for-the-3d-culture-of-human-and-murine-adipocytes
#11
Fiona Louis, Pauline Pannetier, Zied Souguir, Didier Le Cerf, Philippe Valet, Jean-Pierre Vannier, Guillaume Vidal, Elise Demange
The lack of relevant in vitro models for adipose tissue makes necessary the development of a more physiological environment providing spatial and chemical cues for the effective maturation of adipocytes. We developed a biofunctionalized hydrogel with components of adipose extracellular matrix: collagen I, collagen VI, and the cell binding domain of fibronectin and we compared it to usual 2D cultures on plastic plates. This scaffold allowed 3D culture of mature adipocytes from the preadipocytes cell lines 3T3-L1 and 3T3-F442A, as well as primary Human White Preadipocytes (HWP), acquiring in vivo-like organization, with spheroid shaped adipocytes forming multicellular aggregates...
April 11, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28396567/inhibition-of-pikfyve-prevents-myocardial-apoptosis-and-hypertrophy-through-activation-of-sirt3-in-obese-mice
#12
Helene Tronchere, Mathieu Cinato, Andrei Timotin, Laurie Guitou, Camille Villedieu, Helene Thibault, Delphine Baetz, Bernard Payrastre, Philippe Valet, Angelo Parini, Oksana Kunduzova, Frederic Boal
PIKfyve is an evolutionarily conserved lipid kinase that regulates pleiotropic cellular functions. Here, we identify PIKfyve as a key regulator of cardiometabolic status and mitochondrial integrity in chronic diet-induced obesity. In vitro, we show that PIKfyve is critical for the control of mitochondrial fragmentation and hypertrophic and apoptotic responses to stress. We also provide evidence that inactivation of PIKfyve by the selective inhibitor STA suppresses excessive mitochondrial ROS production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts...
June 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28282585/improvement-of-cardiometabolic-markers-after-fish-oil-intervention-in-young-mexican-adults-and-the-role-of-ppar%C3%AE-l162v-and-ppar%C3%AE-2-p12a
#13
Aristea Binia, Carolina Vargas-Martínez, Mónica Ancira-Moreno, Laura M Gosoniu, Ivan Montoliu, Elí Gámez-Valdez, Diana C Soria-Contreras, Adriana Angeles-Quezada, Rocío Gonzalez-Alberto, Silvia Fernández, Diego Martínez-Conde, Brianda Hernández-Morán, Marisol Ramírez-Solano, Carlos Pérez-Ortega, Yanelli Rodríguez-Carmona, Isabelle Castan, Isabel Rubio-Aliaga, Felipe Vadillo-Ortega, Ricardo Márquez-Velasco, Rafael Bojalil, Juan Carlos López-Alvarenga, Philippe Valet, Martin Kussmann, Irma Silva-Zolezzi, M Elizabeth Tejero
Polyunsaturated fatty acids (PUFA) contained in fish oil (FO) are ligands for peroxisome proliferator-activated receptors (PPAR) that may induce changes in cardiometabolic markers. Variation in PPAR genes may influence the beneficial responses linked to FO supplementation in young adults. The study aimed to analyze the effect of FO supplementation on glucose metabolism, circulating lipids and inflammation according to PPARα L162V and PPARγ2 P12A genotypes in young Mexican adults. 191 young, non-smoking subjects between 18 and 40 years were included in a one-arm study...
February 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28242772/protamine-is-an-antagonist-of-apelin-receptor-and-its-activity-is-reversed-by-heparin
#14
Sophie Le Gonidec, Carline Chaves-Almagro, Yushi Bai, Hye Jin Kang, Allyson Smith, Estelle Wanecq, Xi-Ping Huang, Hervé Prats, Bernard Knibiehler, Bryan L Roth, Larry S Barak, Marc G Caron, Philippe Valet, Yves Audigier, Bernard Masri
Apelin signaling plays an important role during embryo development and regulates angiogenesis, cardiovascular activity, and energy metabolism in adulthood. Overexpression and hyperactivity of this signaling pathway is observed in various pathologic states, such as cardiovascular diseases and cancer, which highlights the importance of inhibiting apelin receptor (APJ); therefore, we developed a cell-based screening assay that uses fluorescence microscopy to identify APJ antagonists. This approach led us to identify the U...
June 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28239646/mammary-adipocytes-stimulate-breast-cancer-invasion-through-metabolic-remodeling-of-tumor-cells
#15
Yuan Yuan Wang, Camille Attané, Delphine Milhas, Béatrice Dirat, Stéphanie Dauvillier, Adrien Guerard, Julia Gilhodes, Ikrame Lazar, Nathalie Alet, Victor Laurent, Sophie Le Gonidec, Denis Biard, Caroline Hervé, Frédéric Bost, Guo Sheng Ren, Françoise Bono, Ghislaine Escourrou, Marc Prentki, Laurence Nieto, Philippe Valet, Catherine Muller
In breast cancer, a key feature of peritumoral adipocytes is their loss of lipid content observed both in vitro and in human tumors. The free fatty acids (FFAs), released by adipocytes after lipolysis induced by tumor secretions, are transferred and stored in tumor cells as triglycerides in lipid droplets. In tumor cell lines, we demonstrate that FFAs can be released over time from lipid droplets through an adipose triglyceride lipase-dependent (ATGL-dependent) lipolytic pathway. In vivo, ATGL is expressed in human tumors where its expression correlates with tumor aggressiveness and is upregulated by contact with adipocytes...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28199320/the-use-of-urinary-proteomics-in-the-assessment-of-suitability-of-mouse-models-for-ageing
#16
Esther Nkuipou-Kenfack, Joost P Schanstra, Seerat Bajwa, Martin Pejchinovski, Claire Vinel, Cédric Dray, Philippe Valet, Jean-Loup Bascands, Antonia Vlahou, Thomas Koeck, Melanie Borries, Hauke Busch, Wibke Bechtel-Walz, Tobias B Huber, Karl L Rudolph, Andreas Pich, Harald Mischak, Petra Zürbig
Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can pave the way for therapeutic interventions and managing complications. Animal models such as mice are commonly used in ageing research as they have a shorter lifespan in comparison to humans and are also genetically close to humans. To assess the translatability of mouse ageing to human ageing, the urinary proteome in 89 wild-type (C57BL/6) mice aged between 8-96 weeks was investigated using capillary electrophoresis coupled to mass spectrometry (CE-MS)...
2017: PloS One
https://www.readbyqxmd.com/read/28163989/authigenic-10-be-9-be-ratio-signatures-of-the-cosmogenic-nuclide-production-linked-to-geomagnetic-dipole-moment-variation-since-the-brunhes-matuyama-boundary
#17
Quentin Simon, Nicolas Thouveny, Didier L Bourlès, Jean-Pierre Valet, Franck Bassinot, Lucie Ménabréaz, Valéry Guillou, Sandrine Choy, Luc Beaufort
Geomagnetic dipole moment variations associated with polarity reversals and excursions are expressed by large changes of the cosmogenic nuclide beryllium-10 ((10)Be) production rates. Authigenic (10)Be/(9)Be ratios (proxy of atmospheric (10)Be production) from oceanic cores therefore complete the classical information derived from relative paleointensity (RPI) records. This study presents new authigenic (10)Be/(9)Be ratio results obtained from cores MD05-2920 and MD05-2930 collected in the west equatorial Pacific Ocean...
November 2016: Journal of Geophysical Research. Solid Earth
https://www.readbyqxmd.com/read/28119126/cognitive-deficit-in-hippocampal-dependent-tasks-in-werner-syndrome-mouse-model
#18
Khaoula Rekik, Bernard Francés, Philippe Valet, Cédric Dray, Cédrick Florian
Mammalian aging is often characterized by metabolic disturbances, cognitive declines and DNA repairs deficiency, but the underlying molecular mechanisms are still not well understood. Alterations in DNA repair can significantly exacerbate aging. Mammalian neuronal cells which accumulate unrepaired DNA damage over time could potentially lead to brain functions disorders. Focusing on the ATP-dependent RecQ-type DNA helicase, an enzyme involved in repair of double strand DNA, a mouse model of Werner syndrome (WS) had been proposed as a model of accelerated aging...
April 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28045920/alterations-in-evoked-otoacoustic-emissions-by-the-use-of-meglumine-antimoniate-in-american-tegumentary-leishmaniasis-patients
#19
Débora Cristina de Oliveira Bezerra, Renata Oliveira de Barcelos, Ellen Carvalho de Castro, Claudia Cristina Jardim Duarte, Raquel de Vasconcellos Carvalhaes Oliveira, Tania Salgado de Sousa Torraca, Maria Helena de Araújo-Melo, Frederico Pereira Bom Braga, Benivaldo Ramos Ferreira Terceiro, Lúcia Regina do Nascimento Brahim Paes, Armando de Oliveira Schubach, Cláudia Maria Valete-Rosalino
INTRODUCTION: Tegumentary Leishmaniasis (TL) is a neglected, non-contagious, infectious disease, caused by different protozoa species of the Leishmania genus that affects skin and mucous membranes. Meglumine Antimoniate (MA), the first drug of choice for TL treatment in Brazil, has already been associated with cochlear toxicity, which is defined as damages of the cochlea caused by exposure to chemical substances, resulting in reversible or irreversible hearing loss. Auditory monitoring for cochlear toxicity aims at the early detection of auditory disorders, enabling, when possible, hearing to be preserved or an early auditory rehabilitation...
2017: PloS One
https://www.readbyqxmd.com/read/28001228/standardization-of-intralesional-meglumine-antimoniate-treatment-for-cutaneous-leishmaniasis
#20
Maria Cristina de Oliveira Duque, Érica de Camargo Ferreira E Vasconcellos, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Sandro Javier Bedoya Pacheco, Mauro Celio de Almeida Marzochi, Cláudia Maria Valete Rosalino, Armando de Oliveira Schubach
INTRODUCTION: Intralesional treatment for cutaneous leishmaniasis has been applied for over 30 years at the Oswaldo Cruz Foundation, Rio de Janeiro, with good therapeutic results and without relevant systemic toxicity. METHODS: Meglumine antimoniate was injected subcutaneously, using a long medium-caliber needle (for example, 30mm × 0.8mm); patients received 1-3 injections, with 15-day intervals. RESULTS: The technique is described in detail sufficient to enable replication...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
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