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https://www.readbyqxmd.com/read/28199320/the-use-of-urinary-proteomics-in-the-assessment-of-suitability-of-mouse-models-for-ageing
#1
Esther Nkuipou-Kenfack, Joost P Schanstra, Seerat Bajwa, Martin Pejchinovski, Claire Vinel, Cédric Dray, Philippe Valet, Jean-Loup Bascands, Antonia Vlahou, Thomas Koeck, Melanie Borries, Hauke Busch, Wibke Bechtel-Walz, Tobias B Huber, Karl L Rudolph, Andreas Pich, Harald Mischak, Petra Zürbig
Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can pave the way for therapeutic interventions and managing complications. Animal models such as mice are commonly used in ageing research as they have a shorter lifespan in comparison to humans and are also genetically close to humans. To assess the translatability of mouse ageing to human ageing, the urinary proteome in 89 wild-type (C57BL/6) mice aged between 8-96 weeks was investigated using capillary electrophoresis coupled to mass spectrometry (CE-MS)...
2017: PloS One
https://www.readbyqxmd.com/read/28163989/authigenic-10-be-9-be-ratio-signatures-of-the-cosmogenic-nuclide-production-linked-to-geomagnetic-dipole-moment-variation-since-the-brunhes-matuyama-boundary
#2
Quentin Simon, Nicolas Thouveny, Didier L Bourlès, Jean-Pierre Valet, Franck Bassinot, Lucie Ménabréaz, Valéry Guillou, Sandrine Choy, Luc Beaufort
Geomagnetic dipole moment variations associated with polarity reversals and excursions are expressed by large changes of the cosmogenic nuclide beryllium-10 ((10)Be) production rates. Authigenic (10)Be/(9)Be ratios (proxy of atmospheric (10)Be production) from oceanic cores therefore complete the classical information derived from relative paleointensity (RPI) records. This study presents new authigenic (10)Be/(9)Be ratio results obtained from cores MD05-2920 and MD05-2930 collected in the west equatorial Pacific Ocean...
November 2016: Journal of Geophysical Research. Solid Earth
https://www.readbyqxmd.com/read/28119126/cognitive-deficit-in-hippocampal-dependent-tasks-in-werner-syndrome-mouse-model
#3
Khaoula Rekik, Bernard Francés, Philippe Valet, Cédric Dray, Cédrick Florian
Mammalian aging is often characterized by metabolic disturbances, cognitive declines and DNA repairs deficiency, but the underlying molecular mechanisms are still not well understood. Alterations in DNA repair can significantly exacerbate aging. Mammalian neuronal cells which accumulate unrepaired DNA damage over time could potentially lead to brain functions disorders. Focusing on the ATP-dependent RecQ-type DNA helicase, an enzyme involved in repair of double strand DNA, a mouse model of Werner syndrome (WS) had been proposed as a model of accelerated aging...
January 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28045920/alterations-in-evoked-otoacoustic-emissions-by-the-use-of-meglumine-antimoniate-in-american-tegumentary-leishmaniasis-patients
#4
Débora Cristina de Oliveira Bezerra, Renata Oliveira de Barcelos, Ellen Carvalho de Castro, Claudia Cristina Jardim Duarte, Raquel de Vasconcellos Carvalhaes Oliveira, Tania Salgado de Sousa Torraca, Maria Helena de Araújo-Melo, Frederico Pereira Bom Braga, Benivaldo Ramos Ferreira Terceiro, Lúcia Regina do Nascimento Brahim Paes, Armando de Oliveira Schubach, Cláudia Maria Valete-Rosalino
INTRODUCTION: Tegumentary Leishmaniasis (TL) is a neglected, non-contagious, infectious disease, caused by different protozoa species of the Leishmania genus that affects skin and mucous membranes. Meglumine Antimoniate (MA), the first drug of choice for TL treatment in Brazil, has already been associated with cochlear toxicity, which is defined as damages of the cochlea caused by exposure to chemical substances, resulting in reversible or irreversible hearing loss. Auditory monitoring for cochlear toxicity aims at the early detection of auditory disorders, enabling, when possible, hearing to be preserved or an early auditory rehabilitation...
2017: PloS One
https://www.readbyqxmd.com/read/28001228/standardization-of-intralesional-meglumine-antimoniate-treatment-for-cutaneous-leishmaniasis
#5
Maria Cristina de Oliveira Duque, Érica de Camargo Ferreira E Vasconcellos, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Sandro Javier Bedoya Pacheco, Mauro Celio de Almeida Marzochi, Cláudia Maria Valete Rosalino, Armando de Oliveira Schubach
INTRODUCTION: Intralesional treatment for cutaneous leishmaniasis has been applied for over 30 years at the Oswaldo Cruz Foundation, Rio de Janeiro, with good therapeutic results and without relevant systemic toxicity. METHODS: Meglumine antimoniate was injected subcutaneously, using a long medium-caliber needle (for example, 30mm × 0.8mm); patients received 1-3 injections, with 15-day intervals. RESULTS: The technique is described in detail sufficient to enable replication...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27886511/theory-of-spin-loss-at-metallic-interfaces
#6
K D Belashchenko, Alexey A Kovalev, M van Schilfgaarde
Interfacial spin-flip scattering plays an important role in magnetoelectronic devices. Spin loss at metallic interfaces is usually quantified by matching the magnetoresistance data for multilayers to the Valet-Fert model, while treating each interface as a fictitious bulk layer whose thickness is δ times the spin-diffusion length. By employing the properly generalized circuit theory and the scattering matrix approaches, we derive the relation of the parameter δ to the spin-flip transmission and reflection probabilities at an individual interface...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27680173/pancreatic-toxicity-as-an-adverse-effect-induced-by-meglumine-antimoniate-therapy-in-a-clinical-trial-for-cutaneous-leishmaniasis
#7
Marcelo Rosandiski Lyra, Sonia Regina Lambert Passos, Maria Inês Fernandes Pimentel, Sandro Javier Bedoya-Pacheco, Cláudia Maria Valete-Rosalino, Erica Camargo Ferreira Vasconcellos, Liliane Fatima Antonio, Mauricio Naoto Saheki, Mariza Mattos Salgueiro, Ginelza Peres Lima Santos, Madelon Noato Ribeiro, Fatima Conceição-Silva, Maria Fatima Madeira, Jorge Luiz Nunes Silva, Aline Fagundes, Armando Oliveria Schubach
American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are the first choice drugs for cutaneous leishmaniasis (CL), although doses are controversial. In a clinical trial for CL we investigated the occurrence of pancreatic toxicity with different schedules of treatment with meglumine antimoniate (MA). Seventy-two patients were allocated in two different therapeutic groups: 20 or 5 mg of pentavalent antimony (Sb5+)/kg/day for 20 or 30 days, respectively...
September 22, 2016: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/27676916/is-fatigue-associated-with-cardiorespiratory-endurance-among-patients-suffering-from-multiple-sclerosis
#8
Maxime Valet, Gaëtan Stoquart, Yumiko Glibert, Jean-Claude Hakizimana, Thierry Lejeune
OBJECTIVE: Fatigue is the most common and disabling symptom among patients suffering from multiple sclerosis (MS). From the initial stages of the disease, a physical deconditioning is also observed among these patients. The aim of this study is to assess the cardiorespiratory endurance (i.e. exercise tolerance functions) and self-reported fatigue, as well as their associations, among patients suffering from MS with mild disability (expanded disability status scale≤4). MATERIALS/PATIENTS AND METHODS: 21 patients with MS (15 women; age: 26-64 years, median 46 years; duration of disease: 0...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27622513/is-there-any-difference-between-the-in-situ-and-systemic-il-10-and-ifn-%C3%AE-production-when-clinical-forms-of-cutaneous-sporotrichosis-are-compared
#9
Fernanda N Morgado, Armando O Schubach, Maria Inês Pimentel, Marcelo R Lyra, Érica C F Vasconcellos, Claudia M Valete-Rosalino, Fátima Conceição-Silva
Fungus of the Sporothrix schenckii complex can produce skin lesions in humans, commonly lymphocutaneous (LC) and fixed (F) forms of sporotrichosis. Some authors have suggested that clinical forms are influenced by differences in virulence and genetic profile of isolates. But little is known about the role of immune response in determining the clinical outcome of sporotrichosis. To verify the profile of systemic and in situ IFN-γ and IL-10 expression in sporotrichosis patients, and consequently to detect any difference between the two compartments and/or clinical presentation, we quantified the number of IFN-γ and IL-10 producer peripheral blood mononuclear cells stimulated with S...
2016: PloS One
https://www.readbyqxmd.com/read/27549402/central-chronic-apelin-infusion-decreases-energy-expenditure-and-thermogenesis-in-mice
#10
Anne Drougard, Audren Fournel, Alysson Marlin, Etienne Meunier, Anne Abot, Tereza Bautzova, Thibaut Duparc, Katie Louche, Aurelie Batut, Alexandre Lucas, Sophie Le-Gonidec, Jean Lesage, Xavier Fioramonti, Cedric Moro, Philippe Valet, Patrice D Cani, Claude Knauf
Apelin is a bioactive peptide involved in the control of energy metabolism. In the hypothalamus, chronic exposure to high levels of apelin is associated with an increase in hepatic glucose production, and then contributes to the onset of type 2 diabetes. However, the molecular mechanisms behind deleterious effects of chronic apelin in the brain and consequences on energy expenditure and thermogenesis are currently unknown. We aimed to evaluate the effects of chronic intracerebroventricular (icv) infusion of apelin in normal mice on hypothalamic inflammatory gene expression, energy expenditure, thermogenesis and brown adipose tissue functions...
August 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27406759/-dissemination-of-prostate-cancer-a-way-paved-of-fat
#11
Victor Laurent, Adrien Guérard, Aurélie Toulet, Philippe Valet, Bernard Malavaud, Catherine Muller
No abstract text is available yet for this article.
June 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/27257599/triggering-the-adaptive-immune-system-with-commensal-gut-bacteria-protects-against-insulin-resistance-and-dysglycemia
#12
Céline Pomié, Vincent Blasco-Baque, Pascale Klopp, Simon Nicolas, Aurélie Waget, Pascale Loubières, Vincent Azalbert, Anthony Puel, Frédéric Lopez, Cédric Dray, Philippe Valet, Benjamin Lelouvier, Florence Servant, Michael Courtney, Jacques Amar, Rémy Burcelin, Lucile Garidou
OBJECTIVE: To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk. METHODS: We triggered the immune system with microbial extracts specifically from the intestinal ileum contents of HFD-diabetic mice by the process of immunization. 35 days later, immunized mice were fed a HFD for up to two months in order to challenge the development of metabolic features. The immune responses were quantified...
June 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27243941/corrigendum-matrix-metalloproteinase-11-protects-from-diabesity-and-promotes-metabolic-switch
#13
Nassim Dali-Youcef, Karim Hnia, Sébastien Blaise, Nadia Messaddeq, Stéphane Blanc, Catherine Postic, Philippe Valet, Catherine Tomasetto, Marie-Christine Rio
No abstract text is available yet for this article.
2016: Scientific Reports
https://www.readbyqxmd.com/read/27216185/adipocyte-exosomes-promote-melanoma-aggressiveness-through-fatty-acid-oxidation-a-novel-mechanism-linking-obesity-and-cancer
#14
Ikrame Lazar, Emily Clement, Stéphanie Dauvillier, Delphine Milhas, Manuelle Ducoux-Petit, Sophie LeGonidec, Cédric Moro, Vanessa Soldan, Stéphane Dalle, Stéphanie Balor, Muriel Golzio, Odile Burlet-Schiltz, Philippe Valet, Catherine Muller, Laurence Nieto
Malignant progression results from a dynamic cross-talk between stromal and cancer cells. Recent evidence suggests that this cross-talk is mediated to a significant extent by exosomes, nanovesicles secreted by most cell types and which allow the transfer of proteins, lipids, and nucleic acids between cells. Adipocytes are a major component of several tumor microenvironments, including that of invasive melanoma, where cells have migrated to the adipocyte-rich hypodermic layer of the skin. We show that adipocytes secrete exosomes in abundance, which are then taken up by tumor cells, leading to increased migration and invasion...
July 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27190515/tetrahydro-iso-alpha-acids-antagonize-estrogen-receptor-alpha-activity-in-mcf-7-breast-cancer-cells
#15
Maëlle Lempereur, Claire Majewska, Amandine Brunquers, Sumalee Wongpramud, Bénédicte Valet, Philippe Janssens, Monique Dillemans, Laurence Van Nedervelde, Dominique Gallo
Tetrahydro-iso-alpha acids commonly called THIAA or Tetra are modified hop acids extracted from hop (Humulus lupulus L.) which are frequently used in brewing industry mainly in order to provide beer bitterness and foam stability. Interestingly, molecular structure of tetrahydro-iso-alpha acids is close to a new type of estrogen receptor alpha (ERα) antagonists aimed at disrupting the binding of coactivators containing an LxxLL motif (NR-box). In this work we show that THIAA decreases estradiol-stimulated proliferation of MCF-7 (ERα-positive breast cancer cells)...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27180148/mechanical-effects-of-heat-exposure-from-a-bipolar-radiofrequency-probe-on-suture-under-simulated-arthroscopic-conditions
#16
Sebastian Valet, Bernhard Weisse, Beatrice Fischer, Dominik C Meyer
PURPOSE: To determine conditions for the safe use of radiofrequency (RF) tissue ablation probes that avoid damaging suture material. METHODS: Four sutures made of 3 different materials commonly used in arthroscopic procedures were analyzed in a saline bath related to effects of RF-produced heat by proximity, duration, and intensity settings measuring burn-through time and ultimate load to failure. The parameters tested were electrode-to-suture distance, power setting, and the presence of tendon tissue or metallic anchor eyelets...
May 12, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27126789/simultaneous-quantitative-profiling-of-20-isoprostanoids-from-omega-3-and-omega-6-polyunsaturated-fatty-acids-by-lc-ms-ms-in-various-biological-samples
#17
Aude Dupuy, Pauline Le Faouder, Claire Vigor, Camille Oger, Jean-Marie Galano, Cédric Dray, Jetty Chung-Yung Lee, Philippe Valet, Cécile Gladine, Thierry Durand, Justine Bertrand-Michel
Isoprostanoids are a group of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids. It belongs to oxylipins group, which are important lipid mediators in biological processes, such as tissue repair, blood clotting, blood vessel permeability, inflammation and immunity regulation. Recently, isoprostanoids from eicosapentaenoic, docosahexaenoic, adrenic and α-linolenic namely F3-isoprostanes, F4-neuroprostanes, F2-dihomo-isoprostanes and F1-phytoprostanes, respectively have attracted attention because of their putative contribution to health...
May 19, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27126782/matrix-metalloproteinase-11-protects-from-diabesity-and-promotes-metabolic-switch
#18
Nassim Dali-Youcef, Karim Hnia, Sébastien Blaise, Nadia Messaddeq, Stéphane Blanc, Catherine Postic, Philippe Valet, Catherine Tomasetto, Marie-Christine Rio
MMP11 overexpression is a bad prognostic factor in various human carcinomas. Interestingly, this proteinase is not expressed in malignant cells themselves but is secreted by adjacent non-malignant mesenchymal/stromal cells, such as cancer associated fibroblasts (CAFs) and adipocytes (CAAs), which favors cancer cell survival and progression. As MMP11 negatively regulates adipogenesis in vitro, we hypothesized that it may play a role in whole body metabolism and energy homeostasis. We used an in vivo gain- (Mmp11-Tg mice) and loss- (Mmp11-/- mice) of-function approach to address the systemic function of MMP11...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27077734/factors-associated-with-clinical-and-topographical-features-of-laryngeal-tuberculosis
#19
João Gustavo Corrêa Reis, Clarissa Souza Mota Reis, Daniel César Silva da Costa, Márcia Mendonça Lucena, Armando de Oliveira Schubach, Raquel de Vasconcellos Carvalhaes Oliveira, Valéria Cavalcanti Rolla, Fátima Conceição-Silva, Cláudia Maria Valete-Rosalino
INTRODUCTION: Laryngeal tuberculosis (LTB) is the most frequent granulomatous disease of the larynx and represents less than 2% of extrapulmonary TB cases. There are no pathognomonic clinical and endoscopic features of this disease and studies on LTB that can assist in its diagnostic characterization are lacking. OBJECTIVE: To identify factors associated with clinical and topographical features of LTB. METHOD: a retrospective cross-sectional study was conducted from the medical records of 36 patients with confirmed LTB diagnosis...
2016: PloS One
https://www.readbyqxmd.com/read/27005319/apelin-13-administration-protects-against-ischaemia-reperfusion-mediated-apoptosis-through-the-foxo1-pathway-in-high-fat-diet-induced-obesity
#20
Frederic Boal, Andrei Timotin, Jessica Roumegoux, Chiara Alfarano, Denis Calise, Rodica Anesia, Angelo Parini, Philippe Valet, Helene Tronchere, Oksana Kunduzova
BACKGROUND AND PURPOSE: Apelin-13, an endogenous ligand for the apelin (APJ) receptor, behaves as a potent modulator of metabolic and cardiovascular disorders. Here, we examined the effects of apelin-13 on myocardial injury in a mouse model combining ischaemia/reperfusion (I/R) and obesity and explored their underlying mechanisms. EXPERIMENTAL APPROACH: Adult male C57BL/6J mice were fed a normal diet (ND) or high-fat diet (HFD) for 6 months and then subjected to cardiac I/R...
June 2016: British Journal of Pharmacology
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