Cecilia Gola, Lorella Maniscalco, Selina Iussich, Emanuela Morello, Matteo Olimpo, Eugenio Martignani, Paolo Accornero, Davide Giacobino, Eugenio Mazzone, Paola Modesto, Katia Varello, Luca Aresu, Raffaella De Maria
Canine oral malignant melanoma (COMM) is the most common neoplasm in the oral cavity characterized by local invasiveness and high metastatic potential. Hypoxia represents a crucial feature of the solid tumor microenvironment promoting cancer progression and drug resistance. Hypoxia-inducible factor-1α (HIF-1α) and its downstream effectors, vascular endothelial growth factor A (VEGF-A), glucose transporter isoform 1 (GLUT1), C-X-C chemokine receptor type 4 (CXCR4), and carbonic anhydrase IX (CAIX), are the main regulators of the adaptive response to low oxygen availability...
April 13, 2024: Veterinary Pathology